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Advanced Healthcare Materials

Mengyao Zhao, Benhao Li, Yong Fan, Fan Zhang
The near-infrared range (NIR, 700-1700 nm) has been used as a superior optical window for non-invasive bioimaging. Increasing signal-to-noise ratio (SNR) is the most fundamental method to improve NIR bioimaging. However, the low delivery efficiency of fluorescent contrast agents leads to weak signal at lesions. Moreover, non-specific accumulation and "always on" signals will cause "false positive" signals and high background noise, all of which result in low SNR and potential long-term biotoxicity...
May 15, 2019: Advanced Healthcare Materials
Chenyu Wang, Naibo Feng, Fei Chang, Jincheng Wang, Baoming Yuan, Yilong Cheng, He Liu, Jiakuo Yu, Jun Zou, Jianxun Ding, Xuesi Chen
Ideal cartilage tissue engineering requires scaffolds featuring good biocompatibility, large pore structure, high mechanical strength, as well as minimal invasion procedure. Although significant progress has been made in the development of polymer scaffolds, the construction of smart systems with all the desired properties is still emerging as a challenge. The thermogels of stereocomplex 4-arm poly(ethylene glycol)-polylactide (PEG-PLA) (scPLAgel ) and stereocomplex cholesterol-modified 4-arm PEG-PLA (scPLA-Cholgel ) from the equimolar enantiomeric 4-arm PEG-PLA and 4-arm PEG-PLA-Chol, respectively, are fabricated as scaffolds for cartilage tissue engineering...
May 15, 2019: Advanced Healthcare Materials
Eri Niiyama, Koichiro Uto, Chun Man Lee, Kazuma Sakura, Mitsuhiro Ebara
Effective cancer therapy can be achieved by designing a smart nanofiber system with the combination of chemotherapy and hyperthermia. This study demonstrates the in vivo antitumor effect of a nanofiber mesh that can deliver heat and antitumor drug in a controlled manner. The mesh is composed of biodegradable poly(ε-caprolactone) (PCL) with paclitaxel (PTX) and magnetic nanoparticles (MNPs). The PCL mesh releases PTX slowly for at least 6 weeks when tested in vitro. The prolonged therapeutic effect is observed in vivo as a continuous release of medication from the mesh over an extended period of time compared with direct injection of PTX into the tumor site...
May 15, 2019: Advanced Healthcare Materials
Eunsook Park, Jeehee Lee, Kang Moo Huh, Soo Hyeon Lee, Haeshin Lee
Chitosan-catechol, inspired from mussel-adhesive-proteins, is characterized by the formation of an adhesive membrane complex through instant bonding with serum proteins not found in chitosan. Using this intrinsic property, chitosan-catechol is widely applied for hemostatic needles, general hemostatic materials, nanoparticle composites, and 3D printing. Despite its versatility, the practical use of chitosan-catechol in the clinic is limited due to its undesired immune responses. Herein, a catechol-conjugated glycol chitosan is proposed as an alternative hemostatic hydrogel with negligible immune responses enabling the replacement of chitosan-catechol...
May 15, 2019: Advanced Healthcare Materials
Leqian Yu, Junjun Li, Itsunari Minami, Xiang Qu, Shigeru Miyagawa, Nanae Fujimoto, Kouichi Hasegawa, Yong Chen, Yoshiki Sawa, Hidetoshi Kotera, Li Liu
Human pluripotent stem cells (hPSCs) have been widely used for various applications including disease modeling and regenerative medicine, among others. Recently, an increasing number of studies has focused on heterogeneity among hPSCs, which could affect cell quality and subsequent applications. In this study, a nanofibrous platform is developed for single human induced pluripotent stem cell isolation and culture. One type of single cell-derived subclone is established and found to have a distinct morphology compared to other subclones...
May 14, 2019: Advanced Healthcare Materials
Andrei Yosef, Olga Kossover, Iris Mironi-Harpaz, Arianna Mauretti, Sonia Melino, Joseph Mizrahi, Dror Seliktar
There is a need to further explore the convergence of mechanobiology and dimensionality with systematic investigations of cellular response to matrix mechanics in 2D and 3D cultures. Here, a semisynthetic hydrogel capable of supporting both 2D and 3D cell culture is applied to investigate cell response to matrix modulus and ligand density. The culture materials are fabricated from adducts of polyethylene glycol (PEG) or PluronicF127 and fibrinogen fragments, formed into hydrogels by free-radical polymerization, and characterized by shear rheology...
May 13, 2019: Advanced Healthcare Materials
Hongyan Li, Qing Liu, Bart J Crielaard, Jan W de Vries, Mark Loznik, Zhuojun Meng, Xintong Yang, Robert Göstl, Andreas Herrmann
Safety and efficacy, two significant parameters in drug administration, can be improved by site-specific delivery approaches. Here a fast, efficient, and targeted liposome delivery system steered by a DNA hybridization recognition mechanism is presented. For this purpose, lipid-terminated DNA is inserted in both liposome and cell membranes by simple mixing of the components. Cellular accumulation of cargo encapsulated in the liposomal core is substantially enhanced when the DNA sequence on the cell is complementary to that on the liposome...
May 13, 2019: Advanced Healthcare Materials
Nan Jiang, Rajib Ahmed, Mylon Damayantharan, Barış Ünal, Haider Butt, Ali K Yetisen
Lateral flow assays (LFAs) have been the pillar of rapid point-of-care (POC) diagnostics due to their simplicity, rapid process, and low cost. Recent advances in sensitivity, selectivity, and chemical stability enhancement have ensured the foothold of LFAs in commercial POC diagnostics. This paper reviews recent developments in labeling strategies and detection methods of LFAs. Moreover, vertical flow assays (VFAs) have emerged as an alternate paper-based assay due to faster detection time and unique multiplexing capabilities...
May 13, 2019: Advanced Healthcare Materials
Yun Ni, Hang Zhang, Chou Chai, Bo Peng, Ang Zhao, Jie Zhang, Lin Li, Chengwu Zhang, Bo Ma, Hua Bai, Kah-Leong Lim, Wei Huang
Organelle-targeted photosensitizers have been reported to be effective cell apoptosis agents. Mitochondria is recognized as an ideal target for cancer treatment due to its central role in oxidative metabolism and apoptosis. Meanwhile, two-photon (TP) fluorescence microscopy has become a powerful tool for fluorescence imaging in biological events based on its minimizing photodamage/photobleaching and intrinsic 3D resolution in deep tissues and in vivo. In this study, a series of novel mitochondrial-targeted TP fluorescent photosensitizers (TP-tracers) are designed, synthesized, and systematically investigated...
May 13, 2019: Advanced Healthcare Materials
Girish Chundayil Madathil, Subramania Iyer, Krishnakumar Thankappan, G Siddaramana Gowd, Shantikumar Nair, Manzoor Koyakutty
Fabrication and testing of a novel nanostructured surface-enhanced Raman catheter device is reported for rapid detection, classification, and grading of normal, premalignant, and malignant tissues with high sensitivity and accuracy. The sensor part of catheter is formed by a surface-enhanced Raman scattering (SERS) substrate made up of leaf-like TiO2 nanostructures decorated with 30 nm sized Ag nanoparticles. The device is tested using a total of 37 patient samples wherein SERS signatures of oral tissues consisting of malignant oral squamous cell carcinoma (OSCC), verrucous carcinoma, premalignant leukoplakia, and disease-free conditions are detected and classified with an accuracy of 97...
May 13, 2019: Advanced Healthcare Materials
Luanluan Jia, Fengxuan Han, Huili Yang, Gareth Turnbull, Jiayuan Wang, Jon Clarke, Wenmiao Shu, Mingyu Guo, Bin Li
Nature has created many perfect helical microstructures, including DNA, collagen fibrils, and helical blood vessels, to achieve unique physiological functions. While previous studies have developed a number of microfabrication strategies, the preparation of complex helical structures and cell-laden helical structures for biomimetic applications remains challenging. In this study, a one-step microfluidics-based methodology is presented for preparing complex helical hydrogel microfibers and cell-laden helical hydrogel microfibers...
May 13, 2019: Advanced Healthcare Materials
Sunyoung Kang, Gee Ho Park, Seulah Kim, Jungah Kim, Yoonhwa Choi, Yan Huang, Yan Lee, Tae Hyun Choi
Two representative antibiotics, cephradine (CP) and moxifloxacin (MX), are covalently conjugated with a β-cyclodextrin (β-CD)-based carrier via pH-responsive 1-methyl-2-(2'-carboxyethyl) maleic acid amide (MCM) linkers with excellent conjugation efficiency via simple mixing. At pH 5.5, 90% and 80% of the CP and MX, respectively, are released from the carriers within 30 min, in contrast with the much-delayed release profile at pH 7.4. The in vitro inhibitory effect of β-CD-MCM-CP on the growth of Staphylococcus aureus is significantly lower than that of free CP at pH 7...
May 13, 2019: Advanced Healthcare Materials
Zhengwei Cai, Yibo Gan, Chunyan Bao, Wanjiang Wu, Xuebin Wang, Zetong Zhang, Qiang Zhou, Qiuning Lin, Yi Yang, Linyong Zhu
Photochemistry is considered to be a promising strategy for hydrogels to mimic the complex and dynamic properties of natural extracellular matrix. However, it is seldom applied in 3D tissue engineering and regenerative medicine due to the attenuation of light. In this study, phenyl azide photchemistry and optical fiber technology are first used to localize adhesive protein on the inner surface of the nerve guidance conduit in a 3D hydrogel scaffold. In vitro coculture assay of neural stem cells (NSCs) shows that photoimmobilization of collagen significantly improves the adhesion and survival of NSCs in the conduit, and exhibits synergistic effect with the sustainable release of growth factor...
May 9, 2019: Advanced Healthcare Materials
Minhuan Lan, Shaojing Zhao, Weimin Liu, Chun-Sing Lee, Wenjun Zhang, Pengfei Wang
As an emerging clinical modality for cancer treatment, photodynamic therapy (PDT) takes advantage of the cytotoxic activity of reactive oxygen species (ROS) that are generated by light irradiating photosensitizers (PSs) in the presence of oxygen (O2 ). However, further advancements including tumor selectivity and ROS generation efficiency are still required. Substantial efforts are devoted to design and synthesize smart PSs with optimized properties for achieving a desirable therapeutic efficacy. This review summarizes the recent progress in developing intelligent PSs for efficient PDT, ranging from single molecules to delicate nanomaterials...
May 8, 2019: Advanced Healthcare Materials
Charles W Peak, Kanwar Abhay Singh, Mu'ath Adlouni, Jeffrey Chen, Akhilesh K Gaharwar
A nanoengineered bioink loaded with therapeutic proteins is designed to direct cell function in a 3D printed construct. The bioink is developed from a hydrolytically degradable polymer and 2D synthetic nanoparticle. The synthesis of poly(ethylene glycol)-dithiothreitol (PEGDTT) via a Michael-like step growth polymerization results in acrylate terminated degradable macromer. The addition of 2D nanosilicates to PEGDTT results in formation of shear-thinning bioinks with high printability and structural fidelity...
May 8, 2019: Advanced Healthcare Materials
Deepanjan Ghosh, Russell Urie, Andy Chang, Rajeshwar Nitiyanandan, Jung Keun Lee, Jacquelyn Kilbourne, Kaushal Rege
Sutures are typically the primary means of soft tissue repair in surgery and trauma. Despite their widespread use, sutures do not result in immediate sealing of approximated tissues, which can result in bacterial infection and leakage. Nonabsorbable sutures and staples can be traumatic to tissue, and the trauma can be exacerbated by their subsequent removal. Use of cyanoacrylate glues is limited because of their brittleness and toxicity. In this work, laser-activated tissue-integrating sutures (LATIS) are described as novel nanodevices for soft tissue approximation and repair...
May 8, 2019: Advanced Healthcare Materials
Francesco Lodola, Vito Vurro, Silvia Crasto, Elisa Di Pasquale, Guglielmo Lanzani
The use of light for triggering skeletal and cardiac muscles allows lower invasiveness higher selectivity and unprecedented possibility to target individual cells or even subcellular compartments in a temporally and spatially precise manner. Because cells are in general transparent, this requires the development of suitable interfaces that bestow light sensitivity to living matter. In the present work, successfully demonstrated is the use of conjugated polymer films as transducer to optically enhance the contraction rate of a human and patient-specific cardiac in vitro cell model...
May 8, 2019: Advanced Healthcare Materials
Ashley L Beckwith, Luis F Velásquez-García, Jeffrey T Borenstein
Presented is the first demonstration of real-time monitoring of the response of resident lymphocyte populations in biopsied tumor tissue to immunotherapeutic agents in a perfused tumor microenvironment. This technology comprises a microfluidic tumor trapping device constructed from a novel 3D-printed, transparent, noncytotoxic substrate. The 3D-printed device sustains viability of biopsied tissue fragments under dynamic perfusion for at least 72 h while enabling simultaneous administration of various drug treatments, illustrating a useful tool for drug development and precision medicine for immunotherapy...
May 6, 2019: Advanced Healthcare Materials
Joshua Kim, En-Fan Chou, Jamie Le, Sabrina Wong, Michael Chu, Michelle Khine
Wrinkled gold thin films on elastomeric substrates are used as robust parallel plate electrodes for soft capacitive pressure sensors. The wrinkled structures create a robust integration with the polymer, allowing repeated normal force to deform the thin film without failure. By incorporating microridged structures that support the counter electrodes to create air cavities within the elastomeric dielectric layer, pressure sensitivity is further increased to 0.148 kPa-1 over a wide dynamic range of up to 10 kPa...
April 29, 2019: Advanced Healthcare Materials
Matthew J Haney, Natalia L Klyachko, Emily B Harrison, Yuling Zhao, Alexander V Kabanov, Elena V Batrakova
Extracellular vesicles (EVs) are promising natural nanocarriers for delivery of various types of therapeutics. Earlier engineered EV-based formulations for neurodegenerative diseases and cancer are reported. Herein, the use of macrophage-derived EVs for brain delivery of a soluble lysosomal enzyme tripeptidyl peptidase-1, TPP1, to treat a lysosomal storage disorder, Neuronal Ceroid Lipofuscinoses 2 (CLN2) or Batten disease, is investigated. TPP1 is loaded into EVs using two methods: i) transfection of parental EV-producing macrophages with TPP1-encoding plasmid DNA (pDNA) or ii) incorporation therapeutic protein TPP1 into naive empty EVs...
April 18, 2019: Advanced Healthcare Materials
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