Kathryn MacPherson, Nigel Whittle, Marguerite Camp, Ozge Gunduz-Cinar, Nicolas Singewald, Andrew Holmes
BACKGROUND: Various neuropsychiatric conditions, including posttraumatic stress disorder (PTSD), are characterized by deficient fear extinction, but individuals differ greatly in risk for these. While there is growing evidence that fear extinction is influenced by certain procedural variables, it is unclear how these influences might vary across individuals and subpopulations. To model individual differences in fear extinction, prior studies identified a strain of inbred mouse, 129S1/SvImJ (S1), which exhibits a profound deficit in fear extinction, as compared to other inbred strains, such as C57BL/6J (B6)...
July 5, 2013: Biology of Mood & Anxiety Disorders