journal
Journals Journal of the American Heart ...

Journal of the American Heart Association

https://read.qxmd.com/read/38818967/associations-between-genetically-predicted-iron-status-and-cardiovascular-disease-risk-a-mendelian-randomization-study
#41
JOURNAL ARTICLE
Alexa Barad, Andrew G Clark, Eva K Pressman, Kimberly O O'Brien
BACKGROUND: Mendelian randomization (MR) studies suggest a causal effect of iron status on cardiovascular disease (CVD) risk, but it is unknown if these associations are confounded by pleiotropic effects of the instrumental variables on CVD risk factors. We aimed to investigate the effect of iron status on CVD risk controlling for CVD risk factors. METHODS AND RESULTS: Iron biomarker instrumental variables (total iron-binding capacity [n=208 422], transferrin saturation [n=198 516], serum iron [n=236 612], ferritin [n=257 953]) were selected from a European genome-wide association study meta-analysis...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818962/outcomes-following-percutaneous-coronary-intervention-in-patients-with-multivessel-disease-who-were-recommended-for-but-declined-coronary-artery-bypass-graft-surgery
#42
JOURNAL ARTICLE
Anoop N Koshy, Gregg W Stone, Samantha Sartori, Vishal Dhulipala, Gennaro Giustino, Alessandro Spirito, Serdar Farhan, Kenneth F Smith, Yihan Feng, Manish Vinayak, Negar Salehi, Richard Tanner, Amit Hooda, Parasuram Krishnamoorthy, Joseph M Sweeny, Sahil Khera, George Dangas, Farzan Filsoufi, Roxana Mehran, Annapoorna S Kini, Valentin Fuster, Samin K Sharma
BACKGROUND: Patients may prefer percutaneous coronary intervention (PCI) over coronary artery bypass graft (CABG) surgery, despite heart team recommendations. The outcomes in such patients have not been examined. We sought to examine the results of PCI in patients who were recommended for but declined CABG. METHODS AND RESULTS: Consecutive patients with stable ischemic heart disease and unprotected left main or 3-vessel disease or Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery score >22 who underwent PCI after heart team review between 2013 and 2020 were included...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818945/hypertension-prevalence-and-related-risk-factors-among-mexican-american-adults-are-increasing-national-health-and-nutrition-examination-survey-1999-to-2018
#43
JOURNAL ARTICLE
Kathaleen Briggs Early, Sandra I Valencia, Nicole Stendell-Hollis, Dominic Klyve, David L Gee
BACKGROUND: Acculturation affects hypertension prevalence among Hispanic people, but there have been no recent analyses specifically focused on Mexican American (MA) people. We sought to determine age-adjusted hypertension prevalence, abdominal obesity, and acculturation trends among MA adults and non-Hispanic White adults. METHODS AND RESULTS: Data from the NHANES (National Health and Nutrition Examination Survey) were analyzed in 2-year increments to observe trends in hypertension and risk factors (age, sex, body mass index, smoking status, abdominal obesity, waist-to-height ratio (WHtR), education, and income)...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818944/comparison-of-the-feasibility-and-safety-of-a-deep-sedation-protocol-for-pulmonary-vein-isolation-with-pulsed-field-ablation-cryoballoon-ablation-and-radiofrequency-ablation
#44
JOURNAL ARTICLE
Oskar Marian Galuszka, Thomas Kueffer, Antonio Madaffari, Nikola Kozhuharov, Gregor Thalmann, Helge Servatius, Andreas Haeberlin, Fabian Noti, Hildegard Tanner, Laurent Roten, Tobias Reichlin
No abstract text is available yet for this article.
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818936/chronic-obstructive-pulmonary-disease-exacerbations-increase-the-risk-of-subsequent-cardiovascular-events-a-longitudinal-analysis-of-the-copdgene-study
#45
JOURNAL ARTICLE
Han-Mo Yang, Min Hyung Ryu, Vincent J Carey, Gregory L Kinney, John E Hokanson, Mark T Dransfield, Craig P Hersh, Edwin K Silverman
BACKGROUND: Cardiovascular disease (CVD) is the most important comorbidity in patients with chronic obstructive pulmonary disease (COPD). COPD exacerbations not only contribute to COPD progression but may also elevate the risk of CVD. This study aimed to determine whether COPD exacerbations increase the risk of subsequent CVD events using up to 15 years of prospective longitudinal follow-up data from the COPDGene (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease) study...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818935/diabetes-related-macrovascular-complications-are-associated-with-an-increased-risk-of-diabetic-microvascular-complications-a-prospective-study-of-1518-patients-with-type-1-diabetes-and-20%C3%A2-802-patients-with-type-2-diabetes-in-the-uk-biobank
#46
JOURNAL ARTICLE
Xinyu Zhang, Shuzhi Zhao, Yikeng Huang, Mingming Ma, Bo Li, Chenxin Li, Xinyu Zhu, Xun Xu, Haibin Chen, Yili Zhang, Chuandi Zhou, Zhi Zheng
BACKGROUND: Diabetic vascular complications share common pathophysiological mechanisms, but the relationship between diabetes-related macrovascular complications (MacroVCs) and incident diabetic microvascular complications remains unclear. We aimed to investigate the impact of MacroVCs on the risk of microvascular complications. METHODS AND RESULTS: There were 1518 participants with type 1 diabetes (T1D) and 20 802 participants with type 2 diabetes from the UK Biobank included in this longitudinal cohort study...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818934/efficacy-and-safety-of-ongericimab-in-chinese-patients-with-primary-hypercholesterolemia-and-mixed-dyslipidemia
#47
JOURNAL ARTICLE
Xiaozeng Wang, Miaohan Qiu, Zhifeng Cheng, Xianyou Ji, Jiyan Chen, Hong Zhu, Yida Tang, Zhouqing Huang, Guohai Su, Gaopin Wang, Zhijun Huang, Zhuhua Yao, Jinxiu Lin, Yihong Sun, Shunhui Li, Cong Shao, Yi Zhao, Xuelian Bai, Yaling Han
BACKGROUND: A phase 3 trial was conducted to evaluate the efficacy and safety of ongericimab, a monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9, as an add-on treatment to optimized lipid-lowering therapy in Chinese patients with primary hypercholesterolemia and mixed dyslipidemia. METHODS AND RESULTS: A total of 806 patients who were receiving stable and optimized lipid-lowering therapy but did not achieve their low-density lipoprotein cholesterol (LDL-C) targets were enrolled and randomly assigned in a 2:1:2:1 ratio to receive either ongericimab 150 mg or matching placebo every 2 weeks, or ongericimab 300 mg or matching placebo every 4 weeks for 52 weeks...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818928/heme-oxygenase-1-gene-gt-n-polymorphism-linked-to-deep-white-matter-hyperintensities-not-periventricular-hyperintensities
#48
JOURNAL ARTICLE
Junting Chen, Jinrui Li, Xiaomian Wang, Xiaoli Fu, Jianxia Ke, Jintao Li, Jia Wen, Kailin Cheng, Shuen Li, Zhu Shi
BACKGROUND: Oxidative stress plays a principal role in the pathogenesis of white matter hyperintensities (WMHs). The induction of heme oxygenase-1 ( HO-1 ) gene in the brain represents 1 of the pivotal mechanisms to counteract the noxious effects of reactive oxygen species, and the transcriptional modulation of HO-1 induction depends on the length of a GT-repeat (GT)n in the promoter region. We investigated whether the HO-1 gene (GT)n polymorphism is associated with the risk of WMHs. METHODS AND RESULTS: A total of 849 subjects from the memory clinic were consecutively enrolled, and the HO-1 (GT)n genotype was determined...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38818927/transcriptome-study-of-2-black%C3%A2-cohorts-reveals-cis-long-noncoding-rnas-associated-with-hypertension-related-mrnas
#49
JOURNAL ARTICLE
Malak Abbas, Gabriel Goodney, Jose D Vargas, Amadou Gaye
BACKGROUND: Long noncoding RNAs (lncRNAs) have emerged as critical regulators of the expression of genes involved in cardiovascular diseases. This project aims to identify circulating lncRNAs associated with protein-coding mRNAs differentially expressed between hypertensive and normotensive individuals and establish their link with hypertension. METHODS AND RESULTS: The analyses were conducted in 3 main steps: (1) an unbiased whole blood transcriptome-wide analysis was conducted to identify and replicate protein-coding genes differentially expressed by hypertension status in 497 and 179 Black individuals from the GENE-FORECAST (Genomics, Environmental Factors and the Social Determinants of Cardiovascular Disease in African-Americans Study) and MH-GRID (Minority Health Genomics and Translational Research Bio-Repository Database) studies, respectively...
May 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38808571/epigenetic-age-mediates-the-association-of-life-s-essential-8-with-cardiovascular-disease-and-mortality
#50
JOURNAL ARTICLE
Madeleine Carbonneau, Yi Li, Brenton Prescott, Chunyu Liu, Tianxiao Huan, Roby Joehanes, Joanne M Murabito, Nancy L Heard-Costa, Vanessa Xanthakis, Daniel Levy, Jiantao Ma
BACKGROUND: Life's Essential 8 (LE8) is an enhanced metric for cardiovascular health. The interrelations among LE8, biomarkers of aging, and disease risks are unclear. METHODS AND RESULTS: LE8 score was calculated for 5682 Framingham Heart Study participants. We implemented 4 DNA methylation-based epigenetic age biomarkers, with older epigenetic age hypothesized to represent faster biological aging, and examined whether these biomarkers mediated the associations between the LE8 score and cardiovascular disease (CVD), CVD-specific mortality, and all-cause mortality...
May 29, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804233/pivotal-trials-testing-the-efficacy-of-novel-anticoagulants-for-preventing-emerging-cardioembolic-risk-entities
#51
JOURNAL ARTICLE
Rolf Wachter, Karl Georg Haeusler
No abstract text is available yet for this article.
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804227/exaggerated-inspiratory-muscle-metaboreflex-in-arterial-hypertension
#52
JOURNAL ARTICLE
Gizem Cifci, Eric J Bruhn, Thomas G Bissen, Thomas P Olson, Joshua R Smith
No abstract text is available yet for this article.
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804226/patient-reported-outcome-measures-inform-clinic-visit-duration-in-patients-with-cerebrovascular-disease
#53
JOURNAL ARTICLE
Irene L Katzan, Nicolas R Thompson, Brittany R Lapin
No abstract text is available yet for this article.
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804222/predictive-value-of-midregional-pro-atrial-natriuretic-peptide-for-cardioembolic-stroke-in-hyperacute-ischemic-stroke
#54
JOURNAL ARTICLE
Hajime Ikenouchi, Satoshi Saito, Hiroyuki Ishiyama, Akihiro Kitamura, Tomotaka Tanaka, Manabu Inoue, Yukako Takahashi, Teruhide Koyama, Nagato Kuriyama, Masatoshi Koga, Kazunori Toyoda, Makoto Urushitani, Masafumi Ihara
No abstract text is available yet for this article.
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804220/percutaneous-microaxial-ventricular-assist-device-versus-intra-aortic-balloon-pump-for-nonacute-myocardial-infarction-cardiogenic-shock
#55
JOURNAL ARTICLE
Atsuyuki Watanabe, Yoshihisa Miyamoto, Hiroki Ueyama, Hiroshi Gotanda, Yusuke Tsugawa, Toshiki Kuno
BACKGROUND: Evidence on the comparative outcomes following percutaneous microaxial ventricular assist devices (pVAD) versus intra-aortic balloon pump for nonacute myocardial infarction cardiogenic shock is limited. METHODS AND RESULTS: We included 704 and 2140 Medicare fee-for-service beneficiaries aged 65 to 99 years treated with pVAD and intra-aortic balloon pump, respectively, for nonacute myocardial infarction cardiogenic shock from 2016 to 2020. Patients treated using pVAD compared with those treated using intra-aortic balloon pump were more likely to be concurrently treated with mechanical ventilation, renal replacement therapy, and blood transfusions...
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804218/lack-of-prognostic-value-of-t-wave-alternans-for-implantable-cardioverter-defibrillator-benefit-in-primary-prevention
#56
JOURNAL ARTICLE
Ari Pelli, Tuomas V Kenttä, M Juhani Junttila, Cynthia Huber, Simon Schlögl, Markus Zabel, Marek Malik, Rik Willems, Marc A Vos, Markus Harden, Tim Friede, Christian Sticherling, Heikki V Huikuri
BACKGROUND: New methods to identify patients who benefit from a primary prophylactic implantable cardioverter-defibrillator (ICD) are needed. T-wave alternans (TWA) has been shown to associate with arrhythmogenesis of the heart and sudden cardiac death. We hypothesized that TWA might be associated with benefit from ICD implantation in primary prevention. METHODS AND RESULTS: In the EU-CERT-ICD (European Comparative Effectiveness Research to Assess the Use of Primary Prophylactic Implantable Cardioverter-Defibrillators) study, we prospectively enrolled 2327 candidates for primary prophylactic ICD...
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804217/technical-and-clinical-outcomes-after-transcatheter-edge-to-edge-repair-of-mitral-regurgitation-in-male-and-female-patients-is-equality-achieved
#57
JOURNAL ARTICLE
Luigi Biasco, Gregorio Tersalvi, Catherine Klersy, Giovanni Benfari, Patric Biaggi, Roberto Corti, Moreno Curti, Oliver Gaemperli, Raban Jeger, Francesco Maisano, Olivier Mueller, Barbara Naegeli, Stephane Noble, Fabien Praz, Stefan Toggweiler, Marco Valgimigli, Yvonne Cristoforetti, Maurice Enriquez-Sarano, Giovanni Pedrazzini
BACKGROUND: Currently, no clear impact of sex on short- and long-term survival following transcatheter edge-to-edge mitral valve repair (TEER) is evident, although no data are available on postprocedural life expectancy. Our aim was to assess sex-specific differences in outcomes of patients with mitral regurgitation (MR) treated by TEER. METHODS AND RESULTS: Short-term and 5-year outcomes in men and women undergoing TEER between 2011 and 2018 who were included in the large, multicenter, real-world MitraSwiss registry were analyzed...
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804216/review-of-the-ticagrelor-trials-evidence-base
#58
REVIEW
Grace C Herron, Eric R Bates
Ticagrelor is a platelet P2Y12 receptor inhibitor approved for use in patients with acute coronary syndromes, coronary artery disease, and low-moderate risk acute ischemic stroke or high-risk transient ischemic attack. Clinical trials have evaluated the efficacy and safety of ticagrelor on ischemic and bleeding outcomes for different indications and with varying treatment approaches. As a result, there is a large body of clinical evidence demonstrating different degrees of net clinical benefit compared with other platelet inhibitor drugs based on indication, patient characteristics, clinical presentation, treatment duration, and other factors...
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804212/safety-tolerability-and-pharmacodynamics-of-azd3366-optimized-human-cd39l3-apyrase-alone-and-in-combination-with-ticagrelor-and-acetylsalicylic-acid-a-phase-1-randomized-placebo-controlled-study
#59
JOURNAL ARTICLE
Dimitris Kardassis, Ann-Charlotte Egnell, Magnus Åstrand, Samuel J Daniels, Carl Whatling, Ola Fjellström, Anders Gabrielsen
BACKGROUND: ADP and ATP are importantly involved in vascular and thrombotic homeostasis, via multiple receptor pathways. Blockade of ADP P2Y12 receptors inhibits platelet aggregation and represents an effective cardiovascular disease prevention strategy. AZD3366 (APT102), a long-acting recombinant form of an optimized CD39L3 human apyrase, has effectively reduced ATP, ADP, and platelet aggregation and provided tissue protection in preclinical models, features that could be very beneficial in treating patients with cardiovascular disease...
May 28, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38804208/cardiovascular-complications-with-delivery-hospitalizations-in-patients-with-pulmonary-hypertension-a-nationwide-study-from-2011-to-2020
#60
JOURNAL ARTICLE
Ankit Agrawal, Suryansh Bajaj, Umesh Bhagat, Abdullah Yesilyaprak, Sanya Chandna, Aro Daniela Arockiam, Yasser Jamil, Mahmoud El Iskandarani, Rahul Gupta, Muhammad Majid, Divya Nayar, Erin D Michos
BACKGROUND: Pregnancy in patients with pulmonary hypertension (PH) is associated with a heightened risk of medical complications including right heart failure, pulmonary edema, and arrhythmias. Our study investigated the association between PH and these complications during delivery. METHODS AND RESULTS: The National Inpatient Sample was used to identify delivery hospitalizations from 2011 to 2020. Multivariable logistic regression was performed to study the association of PH with the primary outcomes of in-hospital medical and obstetric complications...
May 28, 2024: Journal of the American Heart Association
journal
journal
43995
3
4
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.