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Journals Journal of the American Heart ...

Journal of the American Heart Association

https://read.qxmd.com/read/38641856/ninety-day-stroke-recurrence-in-minor-stroke-systematic-review-and-meta-analysis-of-trials-and-observational-studies
#1
JOURNAL ARTICLE
Andy Lim, Henry Ma, S Claiborne Johnston, Shaloo Singhal, Subramanian Muthusamy, Yongjun Wang, Yuesong Pan, Shelagh B Coutts, Michael D Hill, Angel Ois, Moira K Kapral, Michael Knoflach, Lisa J Woodhouse, Philip M Bath, Thanh G Phan
BACKGROUND: Risk of recurrence after minor ischemic stroke is usually reported with transient ischemic attack. No previous meta-analysis has focused on minor ischemic stroke alone. The objective was to evaluate the pooled proportion of 90-day stroke recurrence for minor ischemic stroke, defined as a National Institutes of Health Stroke Scale severity score of ≤5. METHODS AND RESULTS: Published papers found on PubMed from 2000 to January 12, 2021, reference lists of relevant articles, and experts in the field were involved in identifying relevant studies...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639381/detection-of-epicardial-connection-through-intercaval-bundle-involving-right-pulmonary-veins-after-ipsilateral-circumferential-ablation-by-intra-atrial-activation-sequence-pacing-from-the-right-pulmonary-vein
#2
JOURNAL ARTICLE
Akio Chikata, Takeshi Kato, Kazuo Usuda, Shuhei Fujita, Keisuke Usuda, Mao Kanatani, Michiro Maruyama, Kan-Ichi Otowa, Takashi Kusayama, Toyonobu Tsuda, Kenshi Hayashi, Masayuki Takamura
BACKGROUND: An epicardial connection (EC) through the intercaval bundle (EC-ICB) between the right pulmonary vein (RPV) and right atrium (RA) is one of the reasons for the need for carina ablation for PV isolation and may reduce the acute and chronic success of PV isolation. We evaluated the intra-atrial activation sequence during RPV pacing after failure of ipsilateral RPV isolation and sought to identify specific conduction patterns in the presence of EC-ICB. METHODS AND RESULTS: This study included 223 consecutive patients who underwent initial catheter ablation of atrial fibrillation...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639380/patients-with-coronary-microvascular-dysfunction-have-less-circulating-%C3%AE-klotho
#3
JOURNAL ARTICLE
Nadia Akhiyat, Ilke Ozcan, Rajiv Gulati, Abhiram Prasad, Tamara Tchkonia, James L Kirkland, Bradley Lewis, Lilach O Lerman, Amir Lerman
BACKGROUND: Coronary microvascular dysfunction (CMD) represents an early functional characteristic of coronary vascular aging. Klotho (α-klotho) is a circulating protein inversely linked to physiological aging. We examined low klotho as a potential marker for vascular aging in patients with CMD and no coronary artery disease. METHODS AND RESULTS: Patients undergoing nonurgent angiogram for chest pain who had no coronary artery disease underwent invasive coronary microvascular and endothelial function testing...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639378/european-and-us-guideline-based-statin-eligibility-genetically-predicted-coronary-artery-disease-and-the-risk-of-major-coronary-events
#4
JOURNAL ARTICLE
Hanjin Park, Daehoon Kim, Seng Chan You, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Dong-Min Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Pil-Sung Yang, Boyoung Joung
BACKGROUND: A study was designed to investigate whether the coronary artery disease polygenic risk score (CAD-PRS) may guide lipid-lowering treatment initiation as well as deferral in primary prevention beyond established clinical risk scores. METHODS AND RESULTS: Participants were 311 799 individuals from the UK Biobank free of atherosclerotic cardiovascular disease, diabetes, chronic kidney disease, and lipid-lowering treatment at baseline. Participants were categorized as statin indicated, statin indication unclear, or statin not indicated as defined by the European and US guidelines on statin use...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639376/association-between-diagnosis-to-limb-revascularization-time-and-clinical-outcomes-in-outpatients-with-chronic-limb-threatening-ischemia-insights-from-the-clipper-cohort
#5
JOURNAL ARTICLE
Alexander C Fanaroff, Elias J Dayoub, Lin Yang, Kaitlyn Schultz, Omar I Ramadan, Grace J Wang, Scott M Damrauer, Elizabeth A Genovese, Eric A Secemsky, Sahil A Parikh, Ashwin S Nathan, Maureen P Kohi, Mitchell D Weinberg, Michael R Jaff, Peter W Groeneveld, Jay S Giri
BACKGROUND: The extent and consequences of ischemia in patients with chronic limb-threatening ischemia (CLTI) may change rapidly, and delays from diagnosis to revascularization may worsen outcomes. We sought to describe the association between time from diagnosis to endovascular lower extremity revascularization (diagnosis-to-limb revascularization [D2L] time) and clinical outcomes in outpatients with CLTI. METHODS AND RESULTS: In the CLIPPER cohort, comprising patients between 66 and 86 years old diagnosed with CLTI betweeen 2010 and 2019, we used Medicare claims data to identify patients who underwent outpatient endovascular revascularization within 180 days of diagnosis...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639374/systolic-blood-pressure-diastolic-blood-pressure-and-pulse-pressure-and-the-risk-of-subclinical-myocardial-injury-the-hunt-study
#6
JOURNAL ARTICLE
Juliet Young, Magnus Nakrem Lyngbakken, Kristian Hveem, Helge Røsjø, Torbjørn Omland
BACKGROUND: Subclinical myocardial injury expressed as higher cardiac troponin concentrations may represent an important intermediary between hypertension and the risk of cardiovascular disease. The study aimed to assess the relative strength of associations between systolic blood pressure (BP), diastolic BP, and pulse pressure, and subclinical myocardial injury, and how change in BP variables over time associates with subclinical myocardial injury. METHODS AND RESULTS: cTnl (cardiac troponin I) was measured in 32 968 participants of the fourth wave of the population-based cohort HUNT4 (Trøndelag Health Study) without a history of cardiovascular disease...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639373/predicting-outcomes-following-lower-extremity-endovascular-revascularization-using-machine-learning
#7
JOURNAL ARTICLE
Ben Li, Badr Aljabri, Raj Verma, Derek Beaton, Mohamad A Hussain, Douglas S Lee, Duminda N Wijeysundera, Charles de Mestral, Muhammad Mamdani, Mohammed Al-Omran
BACKGROUND: Lower extremity endovascular revascularization for peripheral artery disease carries nonnegligible perioperative risks; however, outcome prediction tools remain limited. Using machine learning, we developed automated algorithms that predict 30-day outcomes following lower extremity endovascular revascularization. METHODS AND RESULTS: The National Surgical Quality Improvement Program targeted vascular database was used to identify patients who underwent lower extremity endovascular revascularization (angioplasty, stent, or atherectomy) for peripheral artery disease between 2011 and 2021...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639372/a-practical-tool-for-measuring-home-based-cardiac-rehabilitation-self-management-behavior-a-multiphase-cross-sectional-study
#8
JOURNAL ARTICLE
Zhen Yang, Na Hu, Fengpei Zhang, Yu Gao, Chunqi Zhang, Aiping Wang
BACKGROUND: Optimal self-management is the key to home-based cardiac rehabilitation for patients with heart disease. At present, there is a lack of a specific assessment tool to evaluate the home-based cardiac rehabilitation self-management behavior in patients with heart disease. Therefore, the aim of this study was to develop the Home-Based Cardiac Rehabilitation Self-Management Scale and validate its psychometric properties among patients with coronary heart disease. METHODS AND RESULTS: A multiphase cross-sectional study was conducted that study covered 3 phases: (1) item generation and revision, (2) item evaluation and preliminary exploration, and (3) assessment of the psychometric properties of the scale...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639371/persistent-inequities-in-intravenous-thrombolysis-for-acute-ischemic-stroke-in-the-united-states-results-from-the-nationwide-inpatient-sample
#9
JOURNAL ARTICLE
Philip Sun, Ling Zheng, Michelle Lin, Steven Cen, Gmerice Hammond, Karen E Joynt Maddox, May Kim-Tenser, Nerses Sanossian, William Mack, Amytis Towfighi
BACKGROUND: Despite its approval for acute ischemic stroke >25 years ago, intravenous thrombolysis (IVT) remains underused, with inequities by age, sex, race, ethnicity, and geography. Little is known about IVT rates by insurance status. METHODS AND RESULTS: We assessed temporal trends from 2002 to 2015 in IVT for acute ischemic stroke in the Nationwide Inpatient Sample using adjusted, survey - weighted logistic regression. We calculated odds ratios for IVT for each category in 2002 to 2008 (period 1) and 2009 to 2015 (period 2)...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639370/risk-prediction-models-for-renal-function-decline-after-cardiac-surgery-within-different-preoperative-glomerular-filtration-rate-strata
#10
JOURNAL ARTICLE
Chunrong Wang, Yuchen Gao, Bingyang Ji, Jun Li, Jia Liu, Chunhua Yu, Yuefu Wang
BACKGROUND: Our goal was to create a simple risk-prediction model for renal function decline after cardiac surgery to help focus renal follow-up efforts on patients most likely to benefit. METHODS AND RESULTS: This single-center retrospective cohort study enrolled 24 904 patients who underwent cardiac surgery from 2012 to 2019 at Fuwai Hospital, Beijing, China. An estimated glomerular filtration rate (eGFR) reduction of ≥30% 3 months after surgery was considered evidence of renal function decline...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639369/secondary-prevention-in-patients-with-stroke-versus-myocardial-infarction-analysis-of-2-national-cohorts
#11
JOURNAL ARTICLE
Cyprien A Rivier, Julian N Acosta, Audrey C Leasure, Rachel Forman, Richa Sharma, Adam de Havenon, Erica S Spatz, Silvio E Inzucchi, Walter N Kernan, Guido J Falcone, Kevin N Sheth
BACKGROUND: The implementation of preventive therapies among patients with stroke remains inadequately explored, especially when compared with patients with myocardial infarction (MI), despite sharing similar vascular risk profiles. We tested the hypothesis that participants with a history of stroke have a worse cardiovascular prevention profile in comparison to participants with MI. METHODS AND RESULTS: In cross-sectional analyses within the UK Biobank and All of Us Research Program, involving 14 760 (9193 strokes, 5567 MIs) and 7315 (2948 strokes, 4367 MIs) participants, respectively, we evaluated cardiovascular prevention profiles assessing low-density lipoprotein (<100 mg/dL), blood pressure (systolic, <140 mm Hg; and diastolic, <90 mm Hg), statin and antiplatelet use, and a cardiovascular prevention score that required meeting at least 3 of these criteria...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639368/plasma-metabolome-predicts-aortic-stiffness-and-future-risk-of-coronary-artery-disease-and-mortality-after-23%C3%A2-years-of-follow-up-in-the-general-population
#12
JOURNAL ARTICLE
Filip Ottosson, Gunnar Engström, Marju Orho-Melander, Olle Melander, Peter M Nilsson, Madeleine Johansson
BACKGROUND: Increased aortic stiffness (arteriosclerosis) is associated with early vascular aging independent of age and sex. The underlying mechanisms of early vascular aging remain largely unexplored in the general population. We aimed to investigate the plasma metabolomic profile in aortic stiffness (vascular aging) and associated risk of incident cardiovascular disease and mortality. METHODS AND RESULTS: We included 6865 individuals from 2 Swedish population-based cohorts...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639366/trends-and-disparities-in-treatment-and-control-of-atherosclerotic-cardiovascular-disease-in-us-adults-1999-to-2018
#13
JOURNAL ARTICLE
Jingen Li, Jie Zhang, Virend K Somers, Naima Covassin, Lijing Zhang, Hao Xu
BACKGROUND: Although cardiovascular mortality continued declining from 2000 to 2019, the rate of this decrease decelerated. We aimed to assess the trends and disparities in risk factor control and treatment among US adults with atherosclerotic cardiovascular disease to find potential causes of the deceleration. METHODS AND RESULTS: A total of 55 ,021 participants, aged ≥20 years, from the 1999 to 2018 National Health and Nutrition Examination Survey were included, of which 5717 were with atherosclerotic cardiovascular disease...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639365/impact-of-vaccination-status-on-outcome-of-patients-with-covid-19-and-acute-ischemic-stroke-undergoing-mechanical-thrombectomy
#14
JOURNAL ARTICLE
Cornelius Deuschl, Lukas Goertz, Christoph Kabbasch, Martin Köhrmann, Christoph Kleinschnitz, Ansgar Berlis, Christoph Johannes Maurer, Iris Mühlen, Bernd Kallmünzer, Matthias Gawlitza, Daniel P O Kaiser, Joachim Klisch, Donald Lobsien, Daniel Behme, Maximilian Thormann, Fabian Flottmann, Laurens Winkelmeier, Elke Ruth Gizewski, Lukas Mayer-Suess, Markus Holtmannspoetter, Christoph Moenninghoff, Martin Schlunz-Hendann, Dominik Grieb, Christophe T Arendt, Ferdinand O Bohmann, Jens Altenbernd, Yan Li, Ulrich Sure, Ruben Mühl-Benninghaus, Thomas Rodt, Kai Kallenberg, Alexandru Durutya, Mohamed Elsharkawy, Christian-Paul Stracke, Mathias Gerhard Schumann, Alexander Bock, Omid Nikoubashman, Martin Wiesmann, Hans Henkes, Sebastian Dolff, Aydin Demircioglu, Michael Forsting, Hanna Styczen
BACKGROUND: Data on impact of COVID-19 vaccination and outcomes of patients with COVID-19 and acute ischemic stroke undergoing mechanical thrombectomy are scarce. Addressing this subject, we report our multicenter experience. METHODS AND RESULTS: This was a retrospective analysis of patients with COVID-19 and known vaccination status treated with mechanical thrombectomy for acute ischemic stroke at 20 tertiary care centers between January 2020 and January 2023. Baseline demographics, angiographic outcome, and clinical outcome evaluated by the modified Rankin Scale score at discharge were noted...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639364/association-between-hemoglobin-a1c-and-development-of-cardiovascular-disease-in-canadian-men-and-women%C3%A2-without-diabetes-at-baseline-a-population-based-study-of-608%C3%A2-474-adults
#15
JOURNAL ARTICLE
Sonia Butalia, Luan Manh Chu, Douglas C Dover, Darren Lau, Roseanne O Yeung, Dean T Eurich, Peter Senior, Padma Kaul
BACKGROUND: We examined the association between hemoglobin A1c (HbA1c) and the development of cardiovascular disease (CVD) in men and women, without diabetes or CVD at baseline. METHODS AND RESULTS: This retrospective cohort study included adults aged 40 to <80 years in Alberta, Canada. Men and women were divided into categories based on a random HbA1c during a 3-year enrollment period. The primary outcome of CVD hospitalization and secondary outcome of combined CVD hospitalization/mortality were examined during a 5-year follow-up period until March 31, 2021...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639363/biomarker-periodic-repolarization-dynamics-indicates-enhanced-risk-for-arrhythmias-and-sudden-cardiac-death-in-myocardial-infarction-in-pigs
#16
JOURNAL ARTICLE
Julia Bauer, Julia Vlcek, Valerie Pauly, Nora Hesse, Ruibing Xia, Li Mo, Aparna Sharma Chivukula, Hannes Villgrater, Marie Dressler, Bianca Hildebrand, Eckhard Wolf, Konstantinos D Rizas, Axel Bauer, Stefan Kääb, Philipp Tomsits, Dominik Schüttler, Sebastian Clauss
BACKGROUND: Periodic repolarization dynamics (PRD) is an electrocardiographic biomarker that captures repolarization instability in the low frequency spectrum and is believed to estimate the sympathetic effect on the ventricular myocardium. High PRD indicates an increased risk for postischemic sudden cardiac death (SCD). However, a direct link between PRD and proarrhythmogenic autonomic remodeling has not yet been shown. METHODS AND RESULTS: We investigated autonomic remodeling in pigs with myocardial infarction (MI)-related ischemic heart failure induced by balloon occlusion of the left anterior descending artery (n=17) compared with pigs without MI (n=11)...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639362/independent-relationship-of-lipoprotein-a-and-carotid-atherosclerosis-with-long-term-risk-of-cardiovascular-disease
#17
JOURNAL ARTICLE
Yue Qi, Youling Duan, Qiuju Deng, Na Yang, Jiayi Sun, Jiangtao Li, Piaopiao Hu, Jun Liu, Jing Liu
BACKGROUND: Lipoprotein(a) (Lp(a)) is considered to be a causal risk factor of atherosclerotic cardiovascular disease (ASCVD), but whether there is an independent or joint association of Lp(a) and atherosclerotic plaque with ASCVD risk remains uncertain. This study aims to assess ASCVD risk independently or jointly conferred by Lp(a) and carotid atherosclerotic plaque. METHODS AND RESULTS: A total of 5471 participants with no history of cardiovascular disease at baseline were recruited and followed up for ASCVD events (all fatal and nonfatal acute coronary and ischemic stroke events) over a median of 11...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639361/influence-of-socioeconomic-status-on-functional-outcomes-after-stroke-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Mai T H Nguyen, Yuki Sakamoto, Toshiki Maeda, Mark Woodward, Craig S Anderson, Jayson Catiwa, Amelia Yazidjoglou, Cheryl Carcel, Min Yang, Xia Wang
BACKGROUND: This review aimed to quantify the impact of socioeconomic status on functional outcomes from stroke and identify the socioeconomic status indicators that exhibit the highest magnitude of association. METHODS AND RESULTS: We performed a systematic literature search across Medline and Embase from inception to May 2022, to identify observational studies (n≥100, and in English). Risk of bias was assessed using the modified Newcastle Ottawa Scale. Random effects meta-analysis was used to pool data...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639360/clinical-significance-of-coronary-arterial-dominance-a-review-of-the-literature
#19
REVIEW
Bovey Wu, Ahmed Kheiwa, Pooja Swamy, Mamas A Mamas, Ryan J Tedford, Mirvat Alasnag, Purvi Parwani, Dmitry Abramov
Coronary dominance describes the anatomic variation of coronary arterial supply, notably as it relates to perfusion of the inferior cardiac territories. Differences in the development and outcome in select disease states between coronary dominance patterns are increasingly recognized. In particular, observational studies have identified higher prevalence of poor outcomes in left coronary dominance in the setting of ischemic, conduction, and valvular disease. In this qualitative literature review, we summarize anatomic, physiologic, and clinical implications of differences in coronary dominance to highlight current understanding and gaps in the literature that should warrant further studies...
April 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38639359/design-rationale-and-initial-findings-from-hera-fib-on-10%C3%A2-222-patients-with-atrial-fibrillation-presenting-to-an-emergency-department-over-an-11-year-period
#20
JOURNAL ARTICLE
Christian Salbach, Mustafa Yildirim, Hauke Hund, Moritz Biener, Matthias Müller-Hennessen, Norbert Frey, Hugo A Katus, Evangelos Giannitsis, Barbara Ruth Milles
BACKGROUND: For the majority of patients with atrial fibrillation (AF), disease management has improved in recent years. However, there are still populations underrepresented or excluded in current registries and randomized controlled trials. HERA-FIB (Heidelberg Registry of Atrial Fibrillation) was planned to assess real-world evidence for the prevalence, demographic characteristics and management of patients with the diagnosis of AF presenting consecutively to a chest pain unit. METHODS AND RESULTS: HERA-FIB is a retrospective, observational, single-center study on patients with a diagnosis of AF presenting to a chest pain unit from June 2009 until March 2020...
April 19, 2024: Journal of the American Heart Association
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