Purnima Singh, Disheet A Shah, Mariam Jouni, Romina B Cejas, David K Crossman, Tarek Magdy, Shaowei Qiu, Xuexia Wang, Liting Zhou, Noha Sharafeldin, Lindsey Hageman, Donald E McKenna, Saro H Armenian, Frank M Balis, Douglas S Hawkins, Frank G Keller, Melissa M Hudson, Joseph P Neglia, A Kim Ritchey, Jill P Ginsberg, Wendy Landier, Ravi Bhatia, Paul W Burridge, Smita Bhatia
Background Anthracycline-induced cardiomyopathy is a leading cause of premature death in childhood cancer survivors, presenting a need to understand the underlying pathogenesis. We sought to examine differential blood-based mRNA expression profiles in anthracycline-exposed childhood cancer survivors with and without cardiomyopathy. Methods and Results We designed a matched case-control study (Children's Oncology Group-ALTE03N1) with mRNA sequencing on total RNA from peripheral blood in 40 anthracycline-exposed survivors with cardiomyopathy (cases) and 64 matched survivors without (controls)...
September 26, 2023: Journal of the American Heart Association