Read by QxMD icon Read

Journal of the American Heart Association

Jamie G Hijmans, Kelly A Stockelman, Vinicius Garcia, Ma'ayan V Levy, L Madden Brewster, Tyler D Bammert, Jared J Greiner, Brian L Stauffer, Elizabeth Connick, Christopher A DeSouza
Background Circulating microparticles have emerged as biomarkers and effectors of vascular disease. Elevated rates of cardiovascular disease are seen in HIV -1-seropositive individuals. The aims of this study were to determine: (1) if circulating microparticles are elevated in antiretroviral therapy-treated HIV -1-seropositive adults; and (2) the effects of microparticles isolated from antiretroviral therapy -treated HIV -1-seropositive adults on endothelial cell function, in vitro. Methods and Results Circulating levels of endothelial-, platelet-, monocyte-, and leukocyte-derived microparticles were determined by flow cytometry in plasma from 15 healthy and 15 antiretroviral therapy-treated, virologically suppressed HIV -1-seropositive men...
February 19, 2019: Journal of the American Heart Association
David Aguilar
See Article by Raghavan et al.
February 19, 2019: Journal of the American Heart Association
Sridharan Raghavan, Jason L Vassy, Yuk-Lam Ho, Rebecca J Song, David R Gagnon, Kelly Cho, Peter W F Wilson, Lawrence S Phillips
Background Diabetes mellitus is a risk factor for cardiovascular disease ( CVD ) and has been associated with 2- to 4-fold higher mortality. Diabetes mellitus-related mortality has not been reassessed in individuals receiving routine care in the United States in the contemporary era of CVD risk reduction. Methods and Results We retrospectively studied 963 648 adults receiving care in the US Veterans Affairs Healthcare System from 2002 to 2014; mean follow-up was 8 years. We estimated associations of diabetes mellitus status and hemoglobin A1c (HbA1c) with all-cause and CVD mortality using covariate-adjusted incidence rates and multivariable Cox proportional hazards regression...
February 19, 2019: Journal of the American Heart Association
Xiucui Ma, Kartik Mani, Haiyan Liu, Attila Kovacs, John T Murphy, Layla Foroughi, Brent A French, Carla J Weinheimer, Aldi Kraja, Ivor J Benjamin, Joseph A Hill, Ali Javaheri, Abhinav Diwan
Background Mutations in αB-crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting ( IF ) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autophagy-lysosomal pathway, in the myocardium. We tested whether TFEB activation can be harnessed to treat advanced proteotoxic cardiomyopathy. Methods and Results Mice overexpressing the R120G mutant of αB-crystallin in cardiomyocytes ( Myh6-Cry ABR 120G) were subjected to IF or ad-lib feeding, or transduced with adeno-associated virus- TFEB or adeno-associated virus-green fluorescent protein after development of advanced proteotoxic cardiomyopathy...
February 19, 2019: Journal of the American Heart Association
Lilian Mantziari, Charles Butcher, Rui Shi, Andrianos Kontogeorgis, Aaisha Opel, Zhong Chen, Shouvik Haldar, Sandeep Panikker, Wajid Hussain, David Gareth Jones, Michael A Gatzoulis, Vias Markides, Sabine Ernst, Tom Wong
Background Atrial tachycardia ( AT ) is common in patients with adult congenital heart disease and is challenging to map and ablate. We used ultra-high-density mapping to characterize the AT mechanism and investigate whether substrate characteristics are related to ablation outcomes. Methods and Results A total of 50 AT s were mapped with ultra-high-density mapping in 23 procedures. Patients were followed up for up to 12 months. Procedures were classified to group A if there was 1 single AT induced (n=12) and group B if there were ≥2 AT s induced (n=11 procedures)...
February 19, 2019: Journal of the American Heart Association
Angela Lowenstern, Tracy Y Wang
See Article by Gu et al.
February 19, 2019: Journal of the American Heart Association
Sophie Z Gu, Benjamin Beska, Danny Chan, Dermot Neely, Jonathan A Batty, Jennifer Adams-Hall, Helen Mossop, Weiliang Qiu, Vijay Kunadian
Background Dementia is a growing health burden of an aging population. This study aims to evaluate the prevalence of cognitive impairment and the predictors of cognitive decline at 1 year in older patients with non-ST-elevation acute coronary syndrome undergoing invasive care. Methods and Results Older patients with non-ST-elevation acute coronary syndrome were recruited into the ICON1 study. Cognition was evaluated using Montreal Cognitive Assessment. The composite major adverse cardiovascular events comprised death, myocardial infarction, unplanned revascularization, stroke, and significant bleeding at 1 year...
February 19, 2019: Journal of the American Heart Association
Julie Kelman, Lindsay R Pool, Penny Gordon-Larsen, J Jeffrey Carr, James G Terry, Jamal S Rana, Kiarri N Kershaw
Background While prior studies have linked the neighborhood environment and development of subclinical atherosclerosis, it is unknown whether living in neighborhoods with greater availability of "unhealthy" food outlets (fast-food chain restaurants and convenience stores) is associated with risk of developing coronary artery calcification ( CAC ). Methods and Results We included 2706 CARDIA study (Coronary Artery Risk Development in Young Adults) participants who underwent CAC measurement during follow-up years 15 (2000-2001), 20 (2005-2006), and 25 (2010-2011)...
February 19, 2019: Journal of the American Heart Association
Risa Mukai, Daniela Zablocki, Junichi Sadoshima
See Article by Ma et al.
February 19, 2019: Journal of the American Heart Association
Ashvin N Pande, Alice K Jacobs
See Editorial by Cenko et al.
February 19, 2019: Journal of the American Heart Association
Hyungjoo Cho, June-Goo Lee, Soo-Jin Kang, Won-Jang Kim, So-Yeon Choi, Jiyuon Ko, Hyun-Seok Min, Gun-Ho Choi, Do-Yoon Kang, Pil Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Background An angiography-based supervised machine learning ( ML ) algorithm was developed to classify lesions as having fractional flow reserve ≤0.80 versus >0.80. Methods and Results With a 4:1 ratio, 1501 patients with 1501 intermediate lesions were randomized into training versus test sets. Between the ostium and 10 mm distal to the target lesion, a series of angiographic lumen diameter measurements along the centerline was plotted. The 24 computed angiographic features based on the diameter plot and 4 clinical features (age, sex, body surface area, and involve segment) were used for ML by XGBoost...
February 19, 2019: Journal of the American Heart Association
Gabriela S S Chaves, Gabriela Lima de Melo Ghisi, Raquel R Britto, Sherry L Grace
Background Despite the epidemic of cardiovascular diseases in middle-income countries, few trials are testing the benefits of cardiac rehabilitation ( CR ). This trial assessed (1) maintenance of functional capacity, risk factor control, knowledge, and heart-health behaviors and (2) mortality and morbidity at 6 months following CR in a middle-income country. Methods and Results Eligible Brazilian coronary patients were initially randomized (1:1:1 concealed) to 1 of 3 parallel arms (comprehensive CR [exercise plus education], exercise-only CR , or wait-list control)...
February 19, 2019: Journal of the American Heart Association
Julio A Chirinos, Priyanka Bhattacharya, Anupam Kumar, Elizabeth Proto, Prasad Konda, Patrick Segers, Scott R Akers, Raymond R Townsend, Payman Zamani
Background Heterogeneity in the underlying processes that contribute to heart failure with preserved ejection fraction ( HF p EF ) is increasingly recognized. Diabetes mellitus is a frequent comorbidity in HF p EF , but its impact on left ventricular and arterial structure and function in HF p EF is unknown. Methods and Results We assessed the impact of diabetes mellitus on left ventricular cellular and interstitial hypertrophy (assessed with cardiac magnetic resonance imaging, including T1 mapping pregadolinium and postgadolinium administration), arterial stiffness (assessed with arterial tonometry), and pulsatile arterial hemodynamics (assessed with in-office pressure-flow analyses and 24-hour ambulatory monitoring) among 53 subjects with HF p EF (32 diabetic and 21 nondiabetic subjects)...
February 19, 2019: Journal of the American Heart Association
Marcela Herrera, Ting Yang, Matthew A Sparks, Michael W Manning, Beverly H Koller, Thomas M Coffman
Background Prostaglandin E2 ( PGE 2 ) is a major prostanoid with multiple actions that potentially affect blood pressure ( BP ). PGE 2 acts through 4 distinct E-prostanoid ( EP ) receptor isoforms: EP 1 to EP 4. The EP 4 receptor ( EP 4R) promotes PGE 2 -dependent vasodilation, but its role in the pathogenesis of hypertension is not clear. Methods and Results To address this issue, we studied mice after temporal- and cell-specific deletion of EP 4R. First, using a mouse line with loss of EP 4 expression induced universally after birth, we confirm that EP 4R mediates a major portion of the acute vasodilatory effects of infused PGE 2 ...
February 19, 2019: Journal of the American Heart Association
Tracey L Weissgerber, Oscar Garcia-Valencia, Natasa M Milic, Elizabeth Codsi, Hajrunisa Cubro, Meryl C Nath, Wendy M White, Karl A Nath, Vesna D Garovic
Background The endothelial glycocalyx is a vasoprotective barrier between the blood and endothelium. We hypothesized that glycocalyx degradation is present in preeclampsia, a pregnancy-specific hypertensive disorder characterized by endothelial dysfunction and activation. Methods and Results We examined the sublingual glycocalyx noninvasively using sidestream dark field imaging in the third trimester among women with normotensive pregnancies (n=73), early (n=14) or late (n=29) onset preeclampsia, or gestational diabetes mellitus (n=21)...
February 19, 2019: Journal of the American Heart Association
Yunhui Du, Shihan Zhang, Haicun Yu, Ye Wu, Ning Cao, Wen Wang, Wenli Xu, Yuming Li, Huirong Liu
Background Autoantibodies against the second extracellular loop of the β1 -adrenoceptor (β1 - AA ) act similarly to agonist of β1 -adrenergic receptor, which plays an important role in the pathophysiological characteristics of ventricular remodeling. Recently, considerable lines of evidence have suggested that CTRP9 (C1q tumor necrosis factor-related protein 9) is a potent cardioprotective cardiokine and protects the heart from ventricular remodeling. The aim of this study was to determine the role of CTRP 9 in ventricular remodeling induced by β1 - AA ...
February 19, 2019: Journal of the American Heart Association
Xi Zhang, Wanzhu Tu, JoAnn E Manson, Lesley Tinker, Simin Liu, Jane A Cauley, Lihong Qi, Charles Mouton, Lisa W Martin, Lifang Hou, Yiqing Song
Background Recent evidence suggests that racial/ethnic differences in circulating levels of free or bioavailable 25-hydroxy vitamin D (25[ OH ]D) rather than total 25( OH )D may explain apparent racial disparities in cardiovascular disease ( CVD ). We prospectively examined black-white differences in the associations of total, free, and bioavailable 25( OH )D, vitamin D-binding protein, and parathyroid hormone levels at baseline with incident CVD (including nonfatal myocardial infarction, nonfatal stroke, and CVD death) in postmenopausal women...
February 19, 2019: Journal of the American Heart Association
Jie Li, Brandon A Kemp, Nancy L Howell, James Massey, Krzysztof Mińczuk, Qiao Huang, Mahendra D Chordia, R Jack Roy, James T Patrie, Giovanni E Davogustto, Christopher M Kramer, Frederick H Epstein, Robert M Carey, Heinrich Taegtmeyer, Susanna R Keller, Bijoy K Kundu
Background Sustained pressure overload leads to changes in cardiac metabolism, function, and structure. Both time course and causal relationships between these changes are not fully understood. Therefore, we studied spontaneously hypertensive rats (SHR) during early hypertension development and compared them to control Wistar Kyoto rats. Methods and Results We serially evaluated myocardial glucose uptake rates (Ki) with dynamic 2-[18 F] fluoro-2-deoxy-D-glucose positron emission tomography, and ejection fraction and left ventricular mass to body weight ratios with cardiac magnetic resonance imaging in vivo, determined glucose uptake and oxidation rates in isolated perfused hearts, and analyzed metabolites, mammalian target of rapamycin activity and endoplasmic reticulum stress in dissected hearts...
February 19, 2019: Journal of the American Heart Association
Sophie M Holder, Áine Brislane, Ellen A Dawson, Nicola D Hopkins, Maria T E Hopman, N Timothy Cable, Helen Jones, Tim H A Schreuder, Victoria S Sprung, Louise Naylor, Andrew Maiorana, Andrew Thompson, Dick H J Thijssen, Daniel J Green
Background Premenopausal women have a lower incidence of cardiovascular disease, which may partly be due to a protective effect of estrogen on endothelial function. Animal studies suggest that estrogen may also improve the relationship between shear rate ( SR ) and endothelial function. We aimed to explore the relationship between endothelial function (ie, flow-mediated dilation [ FMD ]) and SR (ie, SR area under the curve [ SRAUC ]) in women versus men, and between pre- versus postmenopausal women. Methods and Results Brachial artery FMD and SRAUC were measured in accordance with expert-consensus guidelines in 932 healthy participants who were stratified into young adults (18-40 years, 389 men, 144 women) and older adults (>40 years, 260 men, 139 women)...
February 19, 2019: Journal of the American Heart Association
Edina Cenko, Mihaela van der Schaar, Jinsung Yoon, Sasko Kedev, Marija Valvukis, Zorana Vasiljevic, Milika Ašanin, Davor Miličić, Olivia Manfrini, Lina Badimon, Raffaele Bugiardini
Background We hypothesized that female sex is a treatment effect modifier of blood flow and related 30-day mortality after primary percutaneous coronary intervention ( PCI ) for ST -segment-elevation myocardial infarction and that the magnitude of the effect on outcomes differs depending on delay to hospital presentation. Methods and Results We identified 2596 patients enrolled in the ISACS - TC (International Survey of Acute Coronary Syndromes in Transitional Countries) registry from 2010 to 2016. Primary outcome was the occurrence of 30-day mortality...
February 19, 2019: Journal of the American Heart Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"