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Journals Multiple Sclerosis and related...

Multiple Sclerosis and related Disorders

https://read.qxmd.com/read/38901372/analysis-of-evusheld-safety-and-efficacy-in-multiple-sclerosis-patients
#1
JOURNAL ARTICLE
Emilie N Liu, Marcos Real, Jennifer H Yang, Ashley Fair, Natalie Whitmire, Allyssa Perez, Carolyn Wilder, Shauna Rosengren, Revere P Kinkel, Jennifer S Graves
BACKGROUND: In December 2021, the U.S. Food and Drug Administration issued emergency use authorization for the combination monoclonal antibodies tixagevimab and cilgavimab (Evusheld - AstraZeneca) for COVID-19 pre-exposure prophylaxis. While COVID-19 vaccination is recommended for multiple sclerosis (MS) patients, there is concern for insufficient antibody response in patients receiving B-cell depleting therapies. The literature is sparse regarding the safety and efficacy of Evusheld use in MS patients...
June 17, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38901370/fatigue-in-individuals-with-multiple-sclerosis-is-there-a-relationship-with-walking-speed-and-mobility
#2
JOURNAL ARTICLE
Vitória Eduarda Alves de Jesus, Mariana da Conceição Rodrigues Ribeiro, Sthéfany Garcia Azevedo, Flavia Cardoso Schaper, Juliana Machado Santiago Dos Santos Amaral, Janaine Cunha Polese, Raquel de Carvalho Lana, Larissa Tavares Aguiar
BACKGROUND: Fatigue is a common symptom in patients with multiple sclerosis and it can lead to activity limitations. Thus, it is important to analyze the relationship between fatigue and activity outcomes, such as walking speed and mobility. OBJECTIVES: To investigate the relationship between fatigue and walking speed and mobility in individuals with multiple sclerosis. METHODS: A cross-sectional study was performed. Adults with multiple sclerosis, without cognitive impairments and who were able to walk were recruited...
June 15, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38901371/longitudinal-change-of-serum-nfl-as-disease-activity-biomarker-candidate-in-mogad-a-descriptive-cohort-study
#3
JOURNAL ARTICLE
Patrick Schindler, Judith Bellmann-Strobl, Jens Kuhle, Brigitte Wildemann, Sven Jarius, Friedemann Paul, Klemens Ruprecht
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) is an autoinflammatory disease of the central nervous system. MOGAD often follows a relapsing course that can lead to severe disability, but monophasic disease is possible as well. Currently, there is an unmet clinical need for disease activity biomarkers in MOGAD. Serum neurofilament light chain (sNfL) is a sensitive biomarker for neuroaxonal damage. However, data on longitudinal change of sNfL as disease activity biomarker for MOGAD are scarce...
June 13, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38880029/disentangling-multiple-sclerosis-heterogeneity-in-the-french-territory-among-genetic-and-environmental-factors-via-bayesian-heritability-analysis
#4
JOURNAL ARTICLE
Andrea Nova, Sonia Bourguiba-Hachemi, Nicolas Vince, Pierre-Antoine Gourraud, Luisa Bernardinelli, Teresa Fazia
BACKGROUND: This study aimed to investigate the factors contributing to the variability of Multiple Sclerosis (MS) among individuals born and residing in France. Geographical variation in MS prevalence was observed in France, but the role of genetic and environmental factors in explaining this heterogeneity has not been yet elucidated. METHODS: We employed a heritability analysis on a cohort of 403 trios with an MS-affected proband in the French population. This sample was retrieved from REFGENSEP register of MS cases collected in 23 French hospital centers from 1992 to 2017...
June 13, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38889559/age-corrected-neurofilament-light-chain-ratio-decreases-but-does-not-predict-relapse-in-highly-active-multiple-sclerosis-patients-initiating-natalizumab-treatment
#5
JOURNAL ARTICLE
Helene Højsgaard Chow, Eva Rosa Petersen, Anna Olsson, Julie Hejgaard Laursen, Malene Bredahl Hansen, Annette Bang Oturai, Per Soelberg Sørensen, Helle Bach Søndergaard, Finn Sellebjerg
BACKGROUND: Neurofilament light chain (NFL) is a biomarker for monitoring disease activity and treatment response in multiple sclerosis (MS). However, while most agree that NFL levels predict disease activity and worsening, the predictive value of NFL on future relapse risk remains uncertain. OBJECTIVE: The primary aim was to evaluate the predictive value of age-corrected serum NFL (sNFL) ratio on relapse risk in highly active relapsing-remitting MS patients (RRMS) treated with natalizumab...
June 12, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38880031/reconciling-lesions-relapses-and-smouldering-associated-worsening-a-unifying-model-for-multiple-sclerosis-pathogenesis
#6
REVIEW
Niraj Mistry, Jeremy Hobart, David Rog, Nils Muhlert, Joela Mathews, David Baker, Gavin Giovannoni
The failure of relapses and white matter lesions to properly explain long-term disability and progression in multiple sclerosis is compounded by its artificial separation into relapsing remitting, secondary progressive, and primary progressive pigeonholes. The well-known epidemiological disconnection between relapses and long-term disability progression has been rediscovered as "progression independent of relapse activity", i.e. smouldering multiple sclerosis. This smouldering associated worsening proceeds despite early and prolonged use of disease modification therapies, even those that are highly effective at preventing relapses and new/enhancing white matter lesions on MRI...
June 12, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38885599/using-machine-learning-algorithms-to-detect-fear-of-falling-in-people-with-multiple-sclerosis-in-standardized-gait-analysis
#7
JOURNAL ARTICLE
Paula Schumann, Katrin Trentzsch, Heidi Stölzer-Hutsch, Thurid Jochim, Maria Scholz, Hagen Malberg, Tjalf Ziemssen
INTRODUCTION: Multiple sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system. The progressive impairment of gait is one of the most important pathognomic symptoms which are associated with falls and fear of falling (FOF) in people with MS (pwMS). 60 % of pwMS show a FOF, which leads to restrictions in mobility as well as physical activity and reduces the quality of life in general. Therefore, early detection of FOF is crucial because it enables early implementation of rehabilitation strategies as well as clinical decision-making to reduce progression...
June 10, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38878624/improving-prospective-memory-in-persons-with-multiple-sclerosis-via-telehealth-a-randomized-feasibility-study
#8
JOURNAL ARTICLE
Elizabeth S Gromisch, Aaron P Turner, Lindsay O Neto, Jodie K Haselkorn, Sarah A Raskin
BACKGROUND: Persons with multiple sclerosis (PwMS) can experience deficits in prospective memory (PM) or "remembering to remember," which are associated with functional difficulties. However, no cognitive rehabilitation intervention has specifically addressed improving PM in PwMS. The Telehealth PM Intervention (TPMI) provides a novel combination of two strategies-visual imagery and implementation intentions-that have each been beneficial in other populations. This study aimed to evaluate the feasibility of TPMI and its preliminary efficacy, which could be used to inform future trials...
June 10, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38889558/validation-of-scores-from-a-telephone-administered-multiple-sclerosis-walking-scale-12-in-persons-with-multiple-sclerosis
#9
JOURNAL ARTICLE
Robert W Motl, Prudence Plummer, Deborah Backus, Jeffrey R Hebert, Whitney N Neal, Alexander Ng, John Lowman, Francois Bethoux, Hollie Schmidt, Robert McBurney, Kevin K McCully, Gary Cutter
BACKGROUND: The Multiple Sclerosis Walking Scale-12 (MSWS-12) has typically been delivered through paper-and-pencil or computer-based administration. PURPOSE: This study examined the validity of inferences from scores derived via a telephone administration of the MSWS-12 applied as part of screening of participants with walking dysfunction into a clinical trial of exercise training in MS. METHOD: The MSWS-12 was administered on two occasions separated by approximately 2 weeks through the telephone and then in-person (i...
June 9, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38885600/cognitive-performance-and-magnetic-resonance-imaging-in-people-with-multiple-sclerosis-a-systematic-review-and-meta-analysis
#10
REVIEW
Omid Mirmosayyeb, Fardin Nabizadeh, Elham Moases Ghaffary, Mohammad Yazdan Panah, Robert Zivadinov, Bianca Weinstock-Guttman, Ralph H B Benedict, Dejan Jakimovski
BACKGROUND: Several studies have shown the different relationships between cognitive functions and structural magnetic resonance imaging (MRI) measurements in people with multiple sclerosis (pwMS). However, there is an ongoing debate regarding the magnitude of correlation between MRI measurements and specific cognitive function tests. This systematic review and meta-analysis aimed to synthesize the most consistent correlations between MRI measurements and cognitive function in pwMS. METHODS: PubMed/MEDLINE, Embase, Scopus, and Web of Science databases were systematically searched up to February 2023, to find relevant data...
June 8, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38880030/perspectives-on-fatigue-management-among-veterans-living-with-multiple-sclerosis
#11
JOURNAL ARTICLE
Lindsey M Knowles, Bishan Yang, Felicia Mata-Greve, Aaron P Turner
BACKGROUND: Chronic fatigue is one of the most common, disabling, and least understood symptoms of many chronic health conditions including multiple sclerosis (MS). A multidisciplinary rehabilitative treatment approach is recommended for MS-related fatigue, but few people with MS have access to such treatment. In-person and telehealth cognitive behavioral therapy (CBT) for fatigue is an emerging acceptable and effective treatment for MS-related fatigue in civilians that has not been studied in Veterans with MS, a population that is more likely to be older, male, unemployed, and disabled...
June 8, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38878625/real-world-therapy-management-of-patients-with-multiple-sclerosis-receiving-cladribine-tablets-beyond-year-4-results-from-a-german-cladribine-cohort
#12
JOURNAL ARTICLE
Markus C Kowarik, Michael Ernst, Lara Woitschach, Lukas Cepek, Daniela Rau, Benedicta Kühnler, Sylke Schlemilch-Paschen, Christoph Grothe, Matthias Schwab, Petra Jöstingmeyer, Christoph Kleinschnitz, Refik Pul
BACKGROUND: The current approval of oral cladribine covers four years, with two treatment courses in the first two years, followed by two treatment-free years. For decision-making in year 5, experts recommend three scenarios: Extending the treatment-free period, retreatment with cladribine, or therapy switch. OBJECTIVE: To assess the implementation of the three year-5-scenarios in clinical practice in a large multicentric real-world cohort in Germany. METHODS: Data from adult patients diagnosed with highly active RMS (first dose between 8/2017 and 8/2018) were included...
June 7, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38880028/neuropsychological-outcomes-following-hsct-in-ms-a-systematic-review
#13
REVIEW
Laura Davenport, Mathew McCauley, Erin Breheny, Liam Smyth, Maria Gaughan, Niall Tubridy, Chris McGuigan, Fiadhnait O'Keeffe
BACKGROUND: Autologous haematopoietic stem cell transplant (HSCT) is considered an effective treatment for highly active multiple sclerosis (MS). To date, most research has focused primarily on disease outcome measures, despite the significant impact of neuropsychological symptoms on MS patients' quality of life. The current systematic review aimed to examine whether HSCT for MS impacts neuropsychological outcome measures such as cognition, fatigue, mood, and quality of life. METHODS: The review was registered with the International Prospective Register of Systematic Reviews (PROSPERO, ID: CRD42023474214)...
June 4, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38880027/covid-19-and-retinal-layer-thickness-a-bidirectional-mendelian-randomization-study
#14
JOURNAL ARTICLE
Kun Zhao, Xiqiao Xiang, Ziwei Zheng, Qingwei Zhang, Bingxin Gu, Yanyan Zhang, Zhen Tang, Yuanhao Wei, Lin Yuan, Shaoling Yang, Lili Lang
BACKGROUND: Observational studies have reported that COVID-19 is associated with alterations in retinal layer thickness, including changes in the ganglion cell inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL). However, the causal relationships remain unknown. Therefore, we assessed the direction and strength of the causal relationship between COVID-19 and GCIPL and RNFL thicknesses using a bidirectional two-sample Mendelian randomization (MR) design. METHODS: Data were obtained from a large-scale COVID-19 Host Genetics Initiative (Nsample = 6,512,887), GCIPL dataset (Ncase = 31,434), and RNFL dataset (Ncase = 31,434)...
June 3, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38838424/alterations-of-brain-structural-and-functional-connectivity-networks-topology-and-decoupling-in-pediatric-myelin-oligodendrocyte-glycoprotein-antibody-associated-disease
#15
JOURNAL ARTICLE
Shuang Ding, Xiujuan Li, Zhongxin Huang, Longlun Wang, Zhuowei Shi, Jinhua Cai, Helin Zheng
OBJECTIVE: To investigate the alteration in structural and functional connectivity networks (SCN and FCN) as well as their coupling in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), and determine if these properties could serve as potential biomarkers for the disease. MATERIALS AND METHODS: In total of 32 children with MOGAD and 30 age- and sex-matched healthy controls (HC) were employed to construct the SCN and FCN, respectively...
June 2, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38850685/can-placebo-controlled-phase-2-disease-modifying-therapy-trials-in-ms-still-be-justified
#16
EDITORIAL
Gavin Giovannoni, Christopher H Hawkes, Jeannette Lechner-Scott, Michael Levy, E Ann Yeh, George Pepper, Klaus Schmierer
No abstract text is available yet for this article.
May 31, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38833975/comparison-of-the-effects-of-mechanical-hippotherapy-and-cawthorne-cooksey-exercises-in-patients-with-multiple-sclerosis-randomized-trial
#17
JOURNAL ARTICLE
Alesta Kabuk, Ömer Şevgin
BACKGROUND: Patients diagnosed with multiple sclerosis (MS) commonly encounter heightened postural instability and challenges in aligning their eyes, head, and bodily motions while engaging in specific tasks. This study aims to compare the effects of Cawthorne-Cooksey and mechanical hippotherapy exercises on fatigue, balance, gait, dizziness, and life quality in patients with MS. METHODS: The MS patients were randomly divided into Cawthorne-Cooksey (n:25) and mechanical hippotherapy exercise (n:25) groups...
May 30, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38850796/exploring-the-relationship-between-manual-dexterity-and-cognition-in-people-with-multiple-sclerosis-9-hole-peg-and-multiple-cognitive-functions
#18
JOURNAL ARTICLE
Rinu Abraham, Amiya Waldman-Levi, Marissa A Barrera, Hans Bogaardt, Daniel Golan, Catherine Bergmann, Cynthia Sullivan, Jeffrey Wilken, Myassar Zarif, Barbara Bumstead, MariJean Buhse, Thomas J Covey, Glen M Doniger, Iris-Katharina Penner, Laura M Hancock, Sarah A Morrow, Erin Giroux, Mark Gudesblatt
AIM AND RATIONALE: Problems with manual dexterity and cognition impact the everyday performance of people with multiple sclerosis (PwMS). Accumulated findings point to the relationship between deficits in manual dexterity and auditory domains of cognition with a lack of evidence on visuospatial and verbal aspects of cognitive functioning. Therefore, this study explores the relationship between manual dexterity and cognition in a cohort of PwMS. METHOD: This cross-sectional study collected data from 63 PwMS aged 22 to 55 through a convenient sampling method...
May 27, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38820699/why-i-created-the-rachel-horne-prize-for-women-s-research-in-multiple-sclerosis
#19
JOURNAL ARTICLE
Rachel Horne
No abstract text is available yet for this article.
May 24, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38820697/results-of-a-feasibility-and-initial-efficacy-clinical-trial-of-a-high-intensity-interval-training-program-using-adaptive-equipment-in-persons-with-multiple-sclerosis-who-have-walking-disability
#20
JOURNAL ARTICLE
Stephanie L Silveira, Robert W Motl, David J Elmer, Trey Botkin, Tania Ontiveros, Sydney Williams, Elizabeth A Hubbard
BACKGROUND: High intensity interval training (HIIT) has been identified as potential stimulus for eliciting health-promoting physical activity in an efficient manner among persons with multiple sclerosis (MS). The current study aimed to examine the feasibility and initial efficacy of a 12-week HIIT program using a recumbent stepper (RSTEP) in persons with MS who have walking disability. Feasibility outcomes of interest included process (i.e., recruitment, adherence, and retention rates), resource (i...
May 24, 2024: Multiple Sclerosis and related Disorders
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