journal
https://read.qxmd.com/read/38444750/making-the-invisible-visible-imaging-techniques-for-assessing-muscle-mass-and-muscle-quality-in-chronic-kidney-disease
#21
REVIEW
Alice Sabatino, Kristoffer Huitfeldt Sola, Torkel B Brismar, Bengt Lindholm, Peter Stenvinkel, Carla Maria Avesani
Muscle wasting and low muscle mass are prominent features of protein energy wasting (PEW), sarcopenia and sarcopenic obesity in patients with chronic kidney disease (CKD). In addition, muscle wasting is associated with low muscle strength, impaired muscle function and adverse clinical outcomes such as low quality of life, hospitalizations and increased mortality. While assessment of muscle mass is well justified, the assessment of skeletal muscle should go beyond quantity. Imaging techniques provide the means for non-invasive, comprehensive, in-depth assessment of the quality of the muscle such as the infiltration of ectopic fat...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38435351/risk-of-incident-chronic-kidney-disease-among-patients-with-urolithiasis-a-nationwide-longitudinal-cohort-study
#22
JOURNAL ARTICLE
Jae Young Kim, Jae Kwang Lee, Jung Tak Park, Tae Ik Chang
BACKGROUND: Urolithiasis has been infrequently implicated to have a causal association with chronic kidney disease (CKD). Recently, several studies have demonstrated the relationship between urolithiasis and CKD. However, the generalizability of their results is limited. This study aimed to investigate the association between urolithiasis and the risk of incident CKD. METHODS: This longitudinal cohort study used the National Health Insurance Service data, including 219 570 Korean adults with incident urolithiasis requiring procedural interventions and without prior kidney disease and 219 570 age- and sex-matched controls without urolithiasis between 1 January 2002 and 31 December 2020...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38435350/renal-function-alters-the-association-of-lipoprotein-a-with-cardiovascular-outcomes-in-patients-undergoing-percutaneous-coronary-intervention-a-prospective-cohort-study
#23
JOURNAL ARTICLE
Guyu Zeng, Pei Zhu, Deshan Yuan, Peizhi Wang, Tianyu Li, Qinxue Li, Jingjing Xu, Xiaofang Tang, Ying Song, Yan Chen, Ce Zhang, Sida Jia, Ru Liu, Lin Jiang, Lei Song, Runlin Gao, Yuejin Yang, Xueyan Zhao, Jinqing Yuan
BACKGROUND AND HYPOTHESIS: Lipoprotein(a) [Lp(a)] and renal dysfunction are both independent risk factors for cardiovascular disease. However, it remains unclear whether renal function mediates the association between Lp(a) and cardiovascular outcomes in patients undergoing percutaneous coronary intervention (PCI). METHODS: From a large prospective cohort study, 10 435 eligible patients undergoing PCI from January 2013 to December 2013 were included in our analysis...
March 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38425707/actioning-the-findings-of-hard-endpoint-clinical-trials-as-they-emerge-in-the-realm-of-chronic-kidney-disease-care-a-review-and-a-call-to-action
#24
REVIEW
Giovanni F M Strippoli, Suetonia C Green
Fewer than half of patients treated with hemodialysis survive 5 years. Multiple therapeutics are used to address the complications of advanced chronic kidney disease but most have not been found to improve clinical outcomes. Clinical trials of treatment innovations for chronic kidney diseases and dialysis care have been suboptimal in number and quality. Recent trials are changing this trend. Practice and policy change when new evidence emerges remains frequently impeded by resource and organizational constraints and accordingly, clinical practice guidelines are updated years or decades after definitive evidence is produced...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38425706/anticoagulation-in-patients-with-end-stage-kidney-disease-and-atrial-fibrillation-a-national-population-based-study
#25
JOURNAL ARTICLE
Deok-Gie Kim, Sung Hwa Kim, Sung Yong Park, Byoung Geun Han, Jae Seok Kim, Jae Won Yang, Young Jun Park, Jun Young Lee
BACKGROUND: The prevalence of atrial fibrillation (AF) in patients with end-stage kidney disease (ESKD) is high and increasing. However, evidence regarding oral anticoagulant (OAC) use in these patients is insufficient and conflicting. METHODS: This retrospective cohort study included patients in the Korea National Health Insurance System diagnosed with AF after ESKD onset from January 2007 to December 2017. The primary outcome was all-cause death. Secondary outcomes were ischaemic stroke, hospitalization for major bleeding and major adverse cardiovascular events (MACE)...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38410686/testing-the-waters-on-home-based-albuminuria-screening-to-enhance-the-detection-and-management-of-ckd
#26
Lauren Floyd, Pierre Delanaye
No abstract text is available yet for this article.
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38410685/management-of-de-novo-nephrolithiasis-after-kidney-transplantation-a-comprehensive-review-from-the-european-renal-association-ckd-mbd-working-group
#27
REVIEW
Mehmet Kanbay, Sidar Copur, Cicek N Bakir, Alper Hatipoglu, Smeeta Sinha, Mathias Haarhaus
The lifetime incidence of kidney stones is 6%-12% in the general population. Nephrolithiasis is a known cause of acute and chronic kidney injury, mediated via obstructive uropathy or crystal-induced nephropathy, and several modifiable and non-modifiable genetic and lifestyle causes have been described. Evidence for epidemiology and management of nephrolithiasis after kidney transplantation is limited by a low number of publications, small study sizes and short observational periods. Denervation of the kidney and ureter graft greatly reduces symptomatology of kidney stones in transplant recipients, which may contribute to a considerable underdiagnosis...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38410684/safety-and-efficacy-of-glucagon-like-peptide-1-receptor-agonists-among-kidney-transplant-recipients-a-systematic-review-and-meta-analysis
#28
JOURNAL ARTICLE
Pajaree Krisanapan, Supawadee Suppadungsuk, Kanokporn Sanpawithayakul, Charat Thongprayoon, Pattharawin Pattharanitima, Supawit Tangpanithandee, Michael A Mao, Jing Miao, Wisit Cheungpasitporn
BACKGROUND: Evidence supporting glucagon-like peptide-1 receptor agonists (GLP-1RAs) in kidney transplant recipients (KTRs) remains scarce. This systematic review and meta-analysis aims to evaluate the safety and efficacy of GLP-1RAs in this population. METHODS: A comprehensive literature search was conducted in the MEDLINE, Embase and Cochrane databases from inception through May 2023. Clinical trials and observational studies that reported on the safety or efficacy outcomes of GLP-1RAs in adult KTRs were included...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38404365/mortality-and-hyperkalaemia-associated-hospitalisation-in-patients-with-chronic-kidney-disease-comparison-of-sodium-zirconium-cyclosilicate-and-sodium-calcium-polystyrene-sulfonate
#29
JOURNAL ARTICLE
Chikao Onogi, Yu Watanabe, Akihito Tanaka, Kazuhiro Furuhashi, Shoichi Maruyama
BACKGROUND: Sodium zirconium cyclosilicate (SZC), a novel drug used for treating hyperkalaemia, is effective in reducing serum potassium levels. The effects of potassium adsorbents on the mortality and hyperkalaemia-associated hospitalisation rates remain unclear. We aimed to examine how mortality and hyperkalaemia-associated hospitalisation rates vary with usage of various potassium adsorbents. METHODS: This retrospective study used patients' data between April 2008 and August 2021 obtained from a large-scale Japanese medical claims database...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38404364/incremental-dialysis-two-complementary-views
#30
JOURNAL ARTICLE
Debaters Francesco Gaetano Casino, Mariana Murea, Moderators Jürgen Floege, Carmine Zoccali
Franco Casino and Mariana Murea discuss today's knowledge about the 'incremental dialysis' concept. Franco Casino frames the problem by saying that, in the presence of substantial residual kidney function, kidney replacement therapy can begin with low doses and/or frequencies, to be gradually increased to compensate for any subsequent losses of residual kidney function, keeping the total clearance above the minimum levels of adequacy. He remarks that studies so far have documented that this approach is safe...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38404363/monoallelic-pathogenic-ift140-variants-are-a-common-cause-of-autosomal-dominant-polycystic-kidney-disease-spectrum-phenotype
#31
JOURNAL ARTICLE
Chiara Dordoni, Letizia Zeni, Diego Toso, Cinzia Mazza, Federica Mescia, Roberta Cortinovis, Laura Econimo, Gianfranco Savoldi, Federico Alberici, Francesco Scolari, Claudia Izzi
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder, characterized by development and enlargement of kidney cysts, eventually leading to end-stage kidney disease (ESKD). Pathogenic variants in the PKD1 and PKD2 genes are the major cause of ADPKD; additional rare variants in the GANAB, DNAJB11, ALG5 and ALG9 genes have been found in a minority of ADPKD patients. More recently, a significant number of ADPKD families have been linked to monoallelic variants in the IFT140 gene...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38389710/dapagliflozin-in-chronic-kidney-disease-cost-effectiveness-beyond-the-dapa-ckd-trial
#32
JOURNAL ARTICLE
Phil McEwan, Jason A Davis, Peter D Gabb, David C Wheeler, Peter Rossing, Glenn M Chertow, Ricardo Correa-Rotter, Kouichi Tamura, Salvatore Barone, Juan Jose Garcia Sanchez
BACKGROUND: The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial enrolled patients with estimated glomerular filtration rate 25-75 mL/min/1.73 m2 and urine albumin-to-creatinine ratio >200 mg/g. The Dapagliflozin Effect on CardiovascuLAR Events-Thrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) trial enrolled patients with type 2 diabetes, a higher range of kidney function and no albuminuria criterion. The study objective was to estimate the cost-effectiveness of dapagliflozin in a broad chronic kidney disease population based on these two trials in the UK, Spain, Italy and Japan...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38370430/membranous-nephropathy-in-primary-antiphospholipid-syndrome
#33
JOURNAL ARTICLE
Romain Stammler, Camille Rapoport, Jean Paul Duong Van Huyen, Stéphane Zuily, Moranne Olivier, Eric Daugas, Emmanuel Esteve, Mathilde de Menthon, Helene Perrochia, Charlotte Mussini, Aurélie Sannier, Marion Rabant, David Buob, Alexandre Karras
No abstract text is available yet for this article.
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38370429/recognition-of-intraglomerular-histological-features-with-deep-learning-in-protocol-transplant-biopsies-and-their-association-with-kidney-function-and-prognosis
#34
JOURNAL ARTICLE
Imane Farhat, Elise Maréchal, Doris Calmo, Manon Ansart, Michel Paindavoine, Patrick Bard, Georges Tarris, Didier Ducloux, Sophie Adrian Felix, Laurent Martin, Claire Tinel, Jean-Baptiste Gibier, Mathilde Funes de la Vega, Jean-Michel Rebibou, Jamal Bamoulid, Mathieu Legendre
BACKGROUND: The Banff Classification may not adequately address protocol transplant biopsies categorized as normal in patients experiencing unexplained graft function deterioration. This study seeks to employ convolutional neural networks to automate the segmentation of glomerular cells and capillaries and assess their correlation with transplant function. METHODS: A total of 215 patients were categorized into three groups. In the Training cohort, glomerular cells and capillaries from 37 patients were manually annotated to train the networks...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38370428/moderator-s-view-after-sglt2i-and-mra-antagonists-where-do-we-go
#35
REVIEW
Carmine Zoccali, Jürgen Floege
No abstract text is available yet for this article.
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38344682/genetic-and-clinical-characterization-of-familial-renal-glucosuria
#36
JOURNAL ARTICLE
Lubin Xu, Ruohuan Zhao, Yumo Zhao, Xueqing Tang, Nuo Si, Xiuzhi Guo, Cai Yue, Min Nie, Limeng Chen
BACKGROUND: Familial renal glucosuria (FRG) is a hereditary disorder caused by variants in SLC5A2 encoding sodium-glucose cotransporter 2 (SGLT2). In this study, we aimed to characterize proximal tubule solute transport, glucagon secretion and the genotype-phenotype relationship in FRG patients. METHODS: We sequenced SLC5A2 and PDZK1IP1 in 21 FRG patients and measured the renal threshold of glucose (RTG ) in 15 patients. We built an open-source online calculator of RTG , evaluated the proximal tubule transport of amino acid, uric acid and phosphate, and explored glucagon secretion after glucose ingestion in FRG patients...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38333627/microangiopathy-associated-with-poor-outcome-of-immunoglobulin-a-nephropathy-a-cohort-study-and-meta-analysis
#37
JOURNAL ARTICLE
Lei Dong, Yuncan Hu, Dan Yang, Liu Liu, Yueqiang Li, Shuwang Ge, Ying Yao
BACKGROUND: Microangiopathy (MA) lesions are not rare in immunoglobulin A nephropathy (IgAN) and have been suggested to have a potential role in increasing risk in renal function decline. However, this suggestion has not been universally accepted. We aimed to investigate its role in our cohort and in multiple studies through a systematic meta-analysis. METHODS: This cohort study included 450 IgAN patients, confirmed by renal biopsy, at Tongji Hospital, China, from January 2012 to December 2016...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38327283/the-utility-of-surveillance-peritoneal-dialysis-effluent-cultures-following-completion-of-pd-peritonitis-treatment-a-quality-improvement-report
#38
JOURNAL ARTICLE
Ana Sanchez-Escuredo, Mina Kashani, Jeffrey Perl
No abstract text is available yet for this article.
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38327282/kidney-failure-risk-equation-in-vascular-access-planning-a-population-based-study-supporting-value-in-decision-making
#39
JOURNAL ARTICLE
Mohammad Atiquzzaman, Bingyue Zhu, Alexandra Romann, Lee Er, Ognjenka Djurdjev, Micheli Bevilacqua, Michelle M Y Wong, Peter Birks, Tae Won Yi, Anurag Singh, Navdeep Tangri, Adeera Levin
BACKGROUND: The Kidney Failure Risk Equation (KFRE) can play a better role in vascular access (VA) planning in patients with chronic kidney disease (CKD) requiring hemodialysis (HD). We described the VA creation and utilization pattern under existing estimated glomerular filtration rate (eGFR)-based referral, and investigated the utility of KFRE score as an adjunct variable in VA planning. METHODS: Patients with CKD aged ≥18 years with eGFR <20 mL/min/1...
February 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38327281/morphometric-analysis-of-chronicity-on-kidney-biopsy-a-useful-prognostic-exercise
#40
REVIEW
Muhammad S Asghar, Aleksandar Denic, Andrew D Rule
Chronic changes on kidney biopsy specimens include increasing amounts of arteriosclerosis, glomerulosclerosis, interstitial fibrosis and tubular atrophy, enlarged nephron size, and reduced nephron number. These chronic changes are difficult to accurately assess by visual inspection but are reasonably quantified using morphometry. This review describes the various patient populations that have undergone morphometric analysis of kidney biopsies. The common approaches to morphometric analysis are described. The chronic kidney disease outcomes associated with various chronic changes by morphometry are also summarized...
February 2024: Clinical Kidney Journal
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