journal
https://read.qxmd.com/read/38883161/usefulness-of-the-heart-rate-variability-test-in-predicting-intradialytic-hypotension-in-patients-undergoing-chronic-haemodialysis
#1
JOURNAL ARTICLE
Yohan Park, Ji Won Lee, Se-Hee Yoon, Won Min Hwang, Sung-Ro Yun, Ji-Young Son, Byung Ha Chung, Jiwon Min
BACKGROUND: Intradialytic hypotension (IDH) is the primary complication of haemodialysis (HD); however, its diverse pathophysiology and inconsistent definitions complicate its prediction. Despite attempts using the heart rate variability (HRV) test for IDH prediction, studies on its usefulness for predicting IDH diagnosed per the nadir 90 criterion are lacking. We aimed to evaluate HRV test efficacy and reproducibility in predicting IDH based on the nadir 90 criterion. METHODS: Seventy patients undergoing HD participated in this multicentre prospective observational study...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38873576/association-of-calciprotein-particles-with-serum-phosphorus-among-patients-undergoing-conventional-and-extended-hours-haemodialysis
#2
JOURNAL ARTICLE
Nobuhiro Nishibori, Masaki Okazaki, Yutaka Miura, Manabu Hishida, Shimon Kurasawa, Takahiro Imaizumi, Noritoshi Kato, Tomoki Kosugi, Makoto Kuro-O, Hirotake Kasuga, Fumika Kaneda, Shoichi Maruyama
BACKGROUND AND HYPOTHESIS: Extended-hours haemodialysis (HD) is associated with better clinical outcomes than conventional HD. We investigated whether extended-hours HD and conventional HD have varying effects on blood levels of calciprotein particles (CPPs) and phosphorus, which have been identified as major pathogenic molecules for vascular calcification. METHODS: Patients who underwent conventional or extended in-centre daytime HD between January and March 2020 were included...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38873575/a-female-patient-with-dent-disease-due-to-skewed-x-chromosome-inactivation
#3
JOURNAL ARTICLE
Viola D'Ambrosio, Elizabeth R Wan, Keith Siew, Wesley Hayes, Stephen B Walsh
X-linked proximal tubulopathies are rare diseases that predominantly affect men. Women are generally carriers and clinical or biochemical manifestations are usually absent or mild. We present the case of a young woman who presented with a full phenotype of Dent disease type 1 due to a de novo mutation in the CLCN5 gene and a skewed X-chromosome inactivation. Although cases of overt Dent disease type 2 and Lowe syndrome in women have been described in the literature, to our knowledge this is the first case of overt Dent disease type 1...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38859934/consistency-of-metabolite-associations-with-measured-glomerular-filtration-rate-in-children-and-adults
#4
JOURNAL ARTICLE
Taibo Li, Morgan E Grams, Lesley A Inker, Jingsha Chen, Eugene P Rhee, Bradley A Warady, Andrew S Levey, Michelle R Denburg, Susan L Furth, Vasan S Ramachandran, Paul L Kimmel, Josef Coresh
BACKGROUND: There is interest in identifying novel filtration markers that lead to more accurate GFR estimates than current markers (creatinine and cystatin C) and are more consistent across demographic groups. We hypothesize that large-scale metabolomics can identify serum metabolites that are strongly influenced by glomerular filtration rate (GFR) and are more consistent across demographic variables than creatinine, which would be promising filtration markers for future investigation...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38854426/combined-evaluation-of-glomerular-phospholipase-a2-receptor-and-immunoglobulin-g-subclass-in-membranous-nephropathy
#5
JOURNAL ARTICLE
Kenji Ueki, Akihiro Tsuchimoto, Yuta Matsukuma, Eri Ataka, Hirofumi Okamoto, Shigeru Tanaka, Kosuke Masutani, Takanari Kitazono, Toshiaki Nakano
BACKGROUND: Phospholipase A2 receptor (PLA2R) is a major target antigen in idiopathic membranous nephropathy (MN). Anti-PLA2R antibodies are mainly of the immunoglobulin G (IgG) subclass IgG4, although other IgG subclass depositions in glomeruli may also be detected. However, the importance of the subclass of the IgG deposit has not been proven. Thus we investigated clinical findings from patients with idiopathic MN in relation to glomerular PLA2R deposition and IgG subclass. METHODS: We enrolled 132 Japanese patients with biopsy-proven idiopathic MN in a multicentre retrospective observational study...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38854425/the-efficacy-and-safety-of-rituximab-with-or-without-glucocorticoid-in-inducing-remission-of-mcd-with-different-clinical-presentations-in-adults-a-retrospective-study
#6
JOURNAL ARTICLE
Yujiao Sun, Zhuo Li, Jing Sun, Shasha Zhang, Rong Wang, Bing Chen
BACKGROUND: To investigate the efficacy and safety of rituximab (RTX) with or without glucocorticoid (GC) in inducing remission of minimal change disease (MCD) in adults. METHODS: Twenty-one adult MCD patients were included in the study. The patients were assigned to the following three groups according to their background before RTX treatment: an RTX single drug direct induction treatment group (Group A; n  = 9), a short-term, low-dose GC combined with RTX induction treatment group (Group B; n  = 4), and a short-term, adequate-dose GC-induced remission and RTX maintenance treatment group (Group C; n  = 8)...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846105/acute-kidney-tubular-injury-after-ingestion-of-red-yeast-rice-supplement
#7
JOURNAL ARTICLE
Reina Miyazaki, Yasuhito Takahashi, Tetsuya Kawamura, Hiroyuki Ueda, Nobuo Tsuboi, Takashi Yokoo
A 47-year-old woman developed severe kidney dysfunction after taking a lipid-lowering supplement, Red Yeast Rice Cholestehelp, for approximately 7 months. The patient developed sudden nausea and had an elevated serum creatinine level of 4.26 mg/dL. A kidney biopsy showed findings consistent with acute tubular necrosis. Kidney dysfunction improved with discontinuation of supplementation, and corticosteroid therapy. Similar kidney involvement has been reported, raising concerns regarding supplements in Japan...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846104/pulse-pressure-modifies-the-association-between-diastolic-blood-pressure-and-decrease-in-kidney-function-the-japan-specific-health-checkups-study
#8
JOURNAL ARTICLE
Hiroyuki Tamaki, Masahiro Eriguchi, Hisako Yoshida, Takayuki Uemura, Hikari Tasaki, Masatoshi Nishimoto, Takaaki Kosugi, Ken-Ichi Samejima, Kunitoshi Iseki, Shouichi Fujimoto, Tsuneo Konta, Toshiki Moriyama, Kunihiro Yamagata, Ichiei Narita, Masato Kasahara, Yugo Shibagaki, Masahide Kondo, Koichi Asahi, Tsuyoshi Watanabe, Kazuhiko Tsuruya
BACKGROUND: Unlike systolic blood pressure (SBP), the prognostic value of diastolic blood pressure (DBP) in kidney function has not been established. We hypothesized that pulse pressure (PP), which is associated with arteriosclerosis, would affect the prognostic value of DBP. METHODS: This longitudinal study used data from the Japan Specific Health Checkups Study was conducted between 2008 and 2014. The participants were stratified into three PP subgroups (low PP ≤39, normal PP 40-59 and high PP ≥60 mmHg)...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38835512/congestion-as-a-crucial-factor-determining-albuminuria-in-patients-with-cardiorenal-disease
#9
JOURNAL ARTICLE
Pau Llàcer, Marta Cobo Marcos, Rafael de la Espriella, Jara Gayán Ordás, Isabel Zegri, Aleix Fort, Adriana Rodríguez Chavarri, Ana Méndez, Zorba Blázquez, Pedro Caravaca Pérez, Jorge Rubio Gracia, Cristina Fernández, Alejandro Recio-Mayoral, Antonia Pomares, Jose Manuel García Pinilla, Jorge Vazquez López-Ibor, Almudena Castro, Maria Jose Soler, Jose Luis Górriz, Ramón Bascompte Claret, Paula Fluvià, Luis Manzano, Julio Núñez
BACKGROUND: Albuminuria could potentially emerge as a novel marker of congestion in acute heart failure. However, the current evidence linking albuminuria and congestion in patients with congestive heart failure (CHF) remains somewhat scarce. This study aimed to evaluate the prevalence of albuminuria in a cohort of patients with CHF, identify the independent factors associated with albuminuria and analyse the correlation with different congestion parameters. METHODS: This is a subanalysis of the Spanish Cardiorenal Registry, in which we enrolled 864 outpatients with heart failure and a value of urinary albumin:creatinine ratio (UACR) at the first visit...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38835511/risk-factors-for-acute-kidney-injury-and-kidney-relapse-in-patients-with-lupus-podocytopathy
#10
JOURNAL ARTICLE
Wen Xia, Jiayi Deng, Lulu Zhuang, Feng Xu, Ying Jin, Houan Zhou, Ti Zhang, Zhengzhao Liu, Haitao Zhang, Caihong Zeng, Zhihong Liu, Weixin Hu
BACKGROUND: Patients with lupus podocytopathy show a high incidence of acute kidney injury (AKI) and relapse, but the risk factors and mechanisms were unclear. This study analysed the clinicopathological features and risk factors for AKI and relapse in lupus podocytopathy patients. METHODS: The cohort of lupus podocytopathy was generated by screening the biopsies of patients with lupus nephritis (LN) from 2002 to 2022 and was divided into the mild glomerular lesion (MGL) and focal segmental glomerulosclerosis (FSGS) groups based on glomerular morphological characteristics...
June 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846418/towards-a-better-uptake-of-home-dialysis-in-europe-understanding-the-present-and-looking-to-the-future
#11
JOURNAL ARTICLE
Edwina A Brown, Giulia Boni Brivio, Wim Van Biesen
Use of peritoneal dialysis and home haemodialysis remains low in Europe, with the highest use in Scandinavian countries and the lowest in Eastern and Central Europe despite the advantages for people on dialysis and economic advantages for healthcare systems. This is partly due to the impact of the haemodialysis industry resulting in proliferation of haemodialysis units and nephrologist reimbursement related to use of haemodialysis. Equally important is the bias against home dialysis at both clinician and healthcare system levels...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846417/personalized-peritoneal-dialysis-prescription-beyond-clinical-or-analytical-values
#12
JOURNAL ARTICLE
María Fernanda Slon-Roblero, J Emilio Sanchez-Alvarez, Maria Auxiliadora Bajo-Rubio
Traditionally, dialysis adequacy has been assessed primarily by determining the clearance of a single small solute, urea. Nevertheless, it has become increasingly evident that numerous other factors play a crucial role in the overall well-being, outcomes and quality of life of dialysis patients. Consequently, in recent years, there has been a notable paradigm shift in guidelines and recommendations regarding dialysis adequacy. This shift represents a departure from a narrow focus only on the removal of specific toxins, embracing a more holistic, person-centered approach...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846416/integrated-home-dialysis-model-facilitating-home-to-home-transition
#13
JOURNAL ARTICLE
Louis-Charles Desbiens, Joanne M Bargman, Christopher T Chan, Annie-Claire Nadeau-Fredette
Peritoneal dialysis (PD) and home hemodialysis (HHD) are the two home dialysis modalities offered to patients. They promote patient autonomy, enhance independence, and are generally associated with better quality of life compared to facility hemodialysis. PD offers some advantages (enhanced flexibility, ability to travel, preservation of residual kidney function, and vascular access sites) but few patients remain on PD indefinitely due to peritonitis and other complications. By contrast, HHD incurs longer and more intensive training combined with increased upfront health costs compared to PD, but is easier to sustain in the long term...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846415/assisted-peritoneal-dialysis-in-europe-a-strategy-to-increase-and-maintain-home-dialysis
#14
JOURNAL ARTICLE
Margot Reyskens, Alferso C Abrahams, Karlien François, Anita van Eck van der Sluijs
Peritoneal dialysis (PD) is a form of kidney replacement therapy with the major advantage that it can be performed at home. This has a positive impact on patients' autonomy and quality of life. However, the dialysis population is ageing and physical and/or cognitive impairments are common. These limitations often form a barrier to PD and contribute to the low incidence and prevalence of PD in Europe. Assisted PD can be a solution to this problem. Assisted PD refers to a patient being assisted by a person or device in performing all or part of their dialysis-related tasks, thereby making PD more accessible to elderly but also younger frail patients...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846414/use-of-ehealth-and-remote-patient-monitoring-a-tool-to-support-home-dialysis-patients-with-an-emphasis-on-peritoneal-dialysis
#15
JOURNAL ARTICLE
Susie Q Lew, Claudio Ronco
Implementing eHealth requires technological advancement, universal broadband and internet access, and devices to conduct telemedicine and remote patient monitoring in end-stage kidney disease patients receiving home dialysis. Although eHealth was beginning to make inroads in this patient population, the COVID-19 pandemic spurred telemedicine usage when many regulations were waived during the Public Health Emergency to limit the spread of infection by endorsing social distancing. At the same time, two-way communication automatic peritoneal dialysis cyclers were introduced to advance remote patient monitoring...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846413/the-integrated-care-model-facilitating-initiation-of-or-transition-to-home-dialysis
#16
JOURNAL ARTICLE
Krishna Poinen, Sandip Mitra, Robert R Quinn
A proportion of end-stage kidney disease (ESKD) patients require kidney replacement therapy to maintain clinical stability. Home dialysis therapies offer convenience, autonomy and potential quality of life improvements, all of which were heightened during the COVID-19 pandemic. While the superiority of specific modalities remains uncertain, patient choice and informed decision-making remain crucial. Missed opportunities for home therapies arise from systemic, programmatic and patient-level barriers. This paper introduces the integrated care model which prioritizes the safe and effective uptake of home therapies while also emphasizing patient-centered care, informed decision-making, and comprehensive support...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38846412/fostering-a-future-of-home-dialysis-transforming-kidney-care-in-europe
#17
JOURNAL ARTICLE
María Fernanda Slon-Roblero
No abstract text is available yet for this article.
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38817914/ten-tips-on-how-to-assess-bone-health-in-patients-with-chronic-kidney-disease
#18
JOURNAL ARTICLE
Hanne Skou Jørgensen, Maria Jesús Lloret, Alexander D Lalayiannis, Rukshana Shroff, Pieter Evenepoel
Patients with chronic kidney disease (CKD) experience a several-fold increased risk of fracture. Despite the high incidence and the associated excess morbidity and premature mortality, bone fragility in CKD, or CKD-associated osteoporosis, remains a blind spot in nephrology with an immense treatment gap. Defining the bone phenotype is a prerequisite for the appropriate therapy of CKD-associated osteoporosis at the patient level. In the present review, we suggest 10 practical 'tips and tricks' for the assessment of bone health in patients with CKD...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38812910/the-association-between-hydrochlorothiazide-use-and-non-melanoma-skin-cancer-in-kidney-transplant-recipients
#19
JOURNAL ARTICLE
Ruth Rahamimov, Shay Telem, Batia Davidovichi, Dana Bielopolski, Tali Steinmetz, Eviatar Nesher, Shelly Lichtenberg, Benaya Rozen-Zvi
BACKGROUND: hydrochlorothiazide (HCTZ) diuretics were correlated with an increased risk of non-melanoma skin cancer (NMSC) and melanoma in the general population. Information is a scarce regarding this effect in kidney transplant recipients who are at increased risk of skin malignancies under immunosuppression. METHODS: Single-center retrospective analysis of adult kidney transplant recipients between 1 January 2010 and 31 December 2015. The primary outcome of the study was the first diagnosis of skin cancer that was removed and pathologically analyzed...
May 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38807969/can-exercise-improve-outcomes-for-frail-haemodialysis-patients
#20
EDITORIAL
Alice Radley, Amaryllis H Van Craenenbroeck, Kate I Stevens
No abstract text is available yet for this article.
May 2024: Clinical Kidney Journal
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