Christine Hum, Usama Tahir, Shirley H J Mei, Josee Champagne, Dean A Fergusson, Manoj Lalu, Duncan J Stewart, Keith Walley, John Marshall, Claudia C Dos Santos, Brent W Winston, Asher A Mendelson, Chintan Dave, Lauralyn McIntyre
BACKGROUND: In preclinical studies, mesenchymal stromal cells (MSCs), including umbilical cord-derived MSCs (UC-MSCs), demonstrate the ability to modulate numerous pathophysiological processes related to sepsis; however, a systematic synthesis of the literature is needed to assess the efficacy of UC-MSCs for treating sepsis. OBJECTIVE: To examine the effects of UC-MSCs on overall mortality (primary outcome) as well as on organ dysfunction, coagulopathy, endothelial permeability, pathogen clearance, and systemic inflammation (secondary outcomes) at prespecified time intervals in preclinical models of sepsis...
February 21, 2024: Stem Cells Translational Medicine