journal
Journals International Journal for Para...

International Journal for Parasitology, Drugs and Drug Resistance

https://read.qxmd.com/read/38875756/lower-micromolar-activity-of-the-antifungal-imidazoles-on-the-bacterial-type-bifunctional-aldehyde-alcohol-dehydrogenase-adhe-in-cryptosporidium-parvum-and-in-vitro-efficacy-against-the-zoonotic-parasite
#1
JOURNAL ARTICLE
Haichuan Chen, Dongqiang Wang, Chenchen Wang, Peng Jiang, Mingxiao Liu, Jigang Yin, Yonglan Yu
Cryptosporidium parvum is a waterborne and foodborne zoonotic protozoan parasite, a causative agent of moderate to severe diarrheal diseases in humans and animals. However, fully effective treatments are unavailable for medical and veterinary uses. There is a need to explore new drug targets for potential development of new therapeutics. Because C. parvum relies on anaerobic metabolism to produce ATP, fermentative enzymes in this parasite are attractive targets for exploration. In this study, we investigated the ethanol-fermentation in the parasite and characterized the basic biochemical features of a bacterial-type bifunctional aldehyde/alcohol dehydrogenase, namely CpAdhE...
June 6, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38821038/ouabain-atpase-inhibitor-potentially-enhances-the-effect-of-polyhexamethylene-biguanide-on-acanthamoeba-castellanii
#2
JOURNAL ARTICLE
Kuang-Yi Shih, Yao-Tsung Chang, Yu-Jen Wang, Jian-Ming Huang
Acanthamoeba, a free-living amoeba, is commonly found in various natural environments, such as rivers and soil, as well as in public baths, swimming pools, and sewers. Acanthamoeba can cause severe illness such as granulomatous amoebic encephalitis and Acanthamoeba keratitis (AK) in humans. AK, the most recognized disease, can cause permanent visual impairment or blindness by affecting the cornea. AK commonly affects contact lens wearers who neglect proper cleaning habits. The symptoms of AK include epithelial and stromal destruction, corneal infiltrate, and intense ocular pain, occasionally necessitating surgical removal of the entire eyeball...
May 22, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38795510/first-case-of-macrocyclic-lactone-resistant-dirofilaria-immitis-in-europe-cause-for-concern
#3
JOURNAL ARTICLE
Donato Traversa, Anastasia Diakou, Mariasole Colombo, Sohini Kumar, Thavy Long, Serafeim C Chaintoutis, Luigi Venco, Gianluca Betti Miller, Roger Prichard
Heartworm disease caused by the nematode Dirofilaria immitis is one of the most important parasitoses of dogs. The treatment of the infection is long, complicated, risky and expensive. Conversely, prevention is easy, safe, and effective and it is achieved by the administration of macrocyclic lactones (MLs). In recent years, D. immitis strains resistant to MLs have been described in Southern USA, raising concerns for possible emergence, or spreading in other areas of the world. The present study describes the first case of ML-resistant D...
May 21, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38805932/repurposing-drugbank-compounds-as-potential-plasmodium-falciparum-class-1a-aminoacyl-trna-synthetase-multi-stage-pan-inhibitors-with-a-specific-focus-on-mitomycin
#4
JOURNAL ARTICLE
Fisayo Olotu, Mariscal Brice Tchatat Tali, Curtis Chepsiror, Olivier Sheik Amamuddy, Fabrice Fekam Boyom, Özlem Tastan Bishop
Plasmodium falciparum aminoacyl tRNA synthetases (PfaaRSs) are potent antimalarial targets essential for proteome fidelity and overall parasite survival in every stage of the parasite's life cycle. So far, some of these proteins have been singly targeted yielding inhibitor compounds that have been limited by incidences of resistance which can be overcome via pan-inhibition strategies. Hence, herein, for the first time, we report the identification and in vitro antiplasmodial validation of Mitomycin (MMC) as a probable pan-inhibitor of class 1a (arginyl(A)-, cysteinyl(C), isoleucyl(I)-, leucyl(L), methionyl(M), and valyl(V)-) PfaaRSs which hypothetically may underlie its previously reported activity on the ribosomal RNA to inhibit protein translation and biosynthesis...
May 20, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38718717/exploring-therapeutic-approaches-against-naegleria-fowleri-infections-through-the-covid-box
#5
JOURNAL ARTICLE
Javier Chao-Pellicer, Iñigo Arberas-Jiménez, Ines Sifaoui, José E Piñero, Jacob Lorenzo-Morales
Naegleria fowleri, known as the brain-eating amoeba, is the pathogen that causes the primary amoebic meningoencephalitis (PAM), a severe neurodegenerative disease with a fatality rate exceeding 95%. Moreover, PAM cases commonly involved previous activities in warm freshwater bodies that allow amoebae-containing water through the nasal passages. Hence, awareness among healthcare professionals and the general public are the key to contribute to a higher and faster number of diagnoses worldwide. Current treatment options for PAM, such as amphotericin B and miltefosine, are limited by potential cytotoxic effects...
May 7, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38761529/acaricide-resistance-status-of-livestock-ticks-from-east-and-west-africa-and-in-vivo-efficacy-of-acaricides-to-control-them
#6
JOURNAL ARTICLE
Alec Evans, Maxime Madder, Josephus Fourie, Lénaïg Halos, Bersissa Kumsa, Elikira Kimbita, Joseph Byaruhanga, Frank Norbert Mwiine, Dennis Muhanguzi, Safiou Bienvenu Adehan, Alassane Toure, Jahashi Nzalawahe, Fred Aboagye-Antwi, Ndudim Isaac Ogo, Leon Meyer, Frans Jongejan, Imad Bouzaidi Cheikhi, Maggie Fisher, Peter Holdsworth
Through a collaborative effort across six Sub-Saharan African countries, using recognized international assessment techniques, 23 stocks of three tick species (Rhipicephalus microplus, Rhipicephalus appendiculatus and Amblyomma variegatum) of economic importance for rural small holder farming communities from East and West Africa were collected from cattle, and evaluated in in vitro larval packet tests (LPT). The results demonstrated medium to high resistance to chlorfenvinphos and amitraz across species. Rhipicephalus microplus demonstrated high level alpha-cypermethrin and cypermethrin resistance...
May 6, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38733883/robenidine-derivatives-as-potential-antischistosomal-drug-candidates
#7
JOURNAL ARTICLE
Christian N Lotz, Alina Krollenbrock, Lea Imhof, Michael Riscoe, Jennifer Keiser
Schistosomiasis caused by Schistosoma spp. is a disease that causes a considerable health burden to millions of people worldwide. The limited availability of effective drugs on the market and the increased risk of resistance development due to extensive usage, highlight the urgent need for new antischistosomal drugs. Recent studies have shown that robenidine derivatives, containing an aminoguanidine core, exhibit promising activities against Plasmodium falciparum, motivating further investigation into their efficacy against Schistosoma mansoni, due to their similar habitat and the resulting related cellular mechanisms like the heme detoxification pathway...
May 5, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38733882/faecal-egg-count-reduction-tests-and-nemabiome-analysis-reveal-high-frequency-of-multi-resistant-parasites-on-sheep-farms-in-north-east-germany-involving-multiple-strongyle-parasite-species
#8
JOURNAL ARTICLE
Jürgen Krücken, Paula Ehnert, Stefan Fiedler, Fabian Horn, Christina S Helm, Sabrina Ramünke, Tanja Bartmann, Alexandra Kahl, Ann Neubert, Wiebke Weiher, Ricarda Daher, Werner Terhalle, Alexandra Klabunde-Negatsch, Stephan Steuber, Georg von Samson-Himmelstjerna
Anthelmintic resistance in sheep parasitic gastrointestinal nematodes is widespread and a severe health and economic issue but prevalence of resistance and involved parasite species are unknown in Germany. Here, the faecal egg count reduction test (FECRT) was performed on eight farms using fenbendazole, ivermectin and moxidectin and on four farms using only moxidectin. A questionnaire was used to obtain data on management practices to potentially identify risk factors for presence of resistance. All requirements of the recently revised WAAVP guideline for diagnosing anthelmintic resistance using the FECRT were applied...
May 5, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38703737/in-vitro-and-in-vivo-activities-of-a-trithiolato-diruthenium-complex-conjugated-with-sulfadoxine-against-the-apicomplexan-parasite-toxoplasma-gondii
#9
JOURNAL ARTICLE
Ghalia Boubaker, Alice Bernal, Anitha Vigneswaran, Dennis Imhof, Maria Cristina Ferreira de Sousa, Kai Pascal Alexander Hänggeli, Noé Haudenschild, Julien Furrer, Emilia Păunescu, Oksana Desiatkina, Andrew Hemphill
Organometallic compounds, including Ruthenium complexes, have been widely developed as anti-cancer chemotherapeutics, but have also attracted much interest as potential anti-parasitic drugs. Recently hybrid drugs composed of organometallic Ruthenium moieties that were complexed to different antimicrobial agents were synthesized. One of these compounds, a trithiolato-diRuthenium complex (RU) conjugated to sulfadoxine (SDX), inhibited proliferation of Toxoplasma gondii tachyzoites grown in human foreskin fibroblast (HFF) monolayers with an IC50  < 150 nM, while SDX and the non-modified RU complex applied either individually or as an equimolar mixture were much less potent...
April 27, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38810336/plasmodium-rna-triphosphatase-validation-as-antimalarial-target
#10
JOURNAL ARTICLE
Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G Gomez-Lorenzo
Target-based approaches have traditionally been used in the search for new anti-infective molecules. Target selection process, a critical step in Drug Discovery, identifies targets that are essential to establish or maintain the infection, tractable to be susceptible for inhibition, selective towards their human ortholog and amenable for large scale purification and high throughput screening. The work presented herein validates the Plasmodium falciparum mRNA 5' triphosphatase (PfPRT1), the first enzymatic step to cap parasite nuclear mRNAs, as a candidate target for the development of new antimalarial compounds...
April 26, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38685159/nourseothricin-as-a-novel-drug-for-selection-of-transgenic-giardia-lamblia
#11
JOURNAL ARTICLE
Corina D Wirdnam, Dawid Warmus, Carmen Faso
Functional gene and protein characterizations in parasitic protists are often limited by their genetic tractability. Despite the development of CRISPR-Cas9-derived or inspired approaches for a handful of protist parasites, the overall genetic tractability of these organisms remains limited. The intestinal parasite Giardia lamblia is one such species, with the added challenge of a paucity of reliable selection markers. To address this limitation, we tested the feasibility of using Nourseothricin as an effective selection agent in Giardia...
April 26, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38669849/treating-cryptosporidiosis-a-review-on-drug-discovery-strategies
#12
REVIEW
Anne-Charlotte Lenière, Alexis Vlandas, Jérôme Follet
Despite several decades of research on therapeutics, cryptosporidiosis remains a major concern for human and animal health. Even though this field of research to assess antiparasitic drug activity is highly active and competitive, only one molecule is authorized to be used in humans. However, this molecule was not efficacious in immunocompromised people and the lack of animal therapeutics remains a cause of concern. Indeed, the therapeutic arsenal needs to be developed for both humans and animals. Our work aims to clarify research strategies that historically were diffuse and poorly directed...
April 20, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38676995/evaluation-of-the-antiplasmodial-efficacy-of-synthetic-2-5-diphenyloxazole-analogs-of-compounds-naturally-derived-from-oxytropis-lanata
#13
JOURNAL ARTICLE
Nanang R Ariefta, Koichi Narita, Toshihiro Murata, Yoshifumi Nishikawa
The persistent prevalence and dissemination of drug-resistant malaria parasites continue to challenge the progress of malaria eradication efforts. As a result, there is an urgent need to search for and develop innovative therapies. In this study, we screened synthetic 2,5-diphenyloxazole analogs from Oxytropis lanata. Among 48 compounds, 14 potently inhibited the proliferation of P. falciparum strains 3D7 (chloroquine-sensitive) and K1 (multidrug-resistant) in vitro, exhibited IC50 values from 3.38 to 12.65 μM and 1...
April 18, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38669848/high-throughput-prioritization-of-target-proteins-for-development-of-new-antileishmanial-compounds
#14
JOURNAL ARTICLE
Lucas G Azevedo, Ezequiel Sosa, Artur T L de Queiroz, Aldina Barral, Richard J Wheeler, Marisa F Nicolás, Leonardo P Farias, Dario Fernández Do Porto, Pablo Ivan P Ramos
Leishmaniasis, a vector-borne disease, is caused by the infection of Leishmania spp., obligate intracellular protozoan parasites. Presently, human vaccines are unavailable, and the primary treatment relies heavily on systemic drugs, often presenting with suboptimal formulations and substantial toxicity, making new drugs a high priority for LMIC countries burdened by the disease, but a low priority in the agenda of most pharmaceutical companies due to unattractive profit margins. New ways to accelerate the discovery of new, or the repositioning of existing drugs, are needed...
April 16, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38621317/oral-administration-of-ipi549-protects-mice-from-neuropathology-and-an-overwhelming-inflammatory-response-during-experimental-cerebral-malaria
#15
JOURNAL ARTICLE
Zhuoru Jin, Wei Pang, Yan Zhao, Hui Min, Shijie Yao, Zhifang Bian, Yixin Wen, Chuanyang Peng, Yaming Cao, Li Zheng
Infection with Plasmodium falciparum is often deadly when it results in cerebral malaria, which is associated with neuropathology described as an overwhelming inflammatory response and mechanical obstruction of cerebral microvascular. PI3Kγ is a critical component of intracellular signal transduction and plays a central role in regulating cell chemotaxis, migration, and activation. The purpose of this study was to examine the relationship between inhibiting the PI3Kγ pathway and the outcome of experimental cerebral malaria (ECM) in C57BL/6J mice infected with the mouse malaria parasite, Plasmodium berghei ANKA...
April 14, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38663046/discovery-of-antiplasmodial-pyridine-carboxamides-and-thiocarboxamides
#16
JOURNAL ARTICLE
Alexa Redway, Christina Spry, Ainka Brown, Ursula Wiedemann, Imam Fathoni, Larnelle F Garnie, Deyun Qiu, Timothy J Egan, Adele M Lehane, Yvette Jackson, Kevin J Saliba, Nadale Downer-Riley
Malaria continues to be a significant burden, particularly in Africa, which accounts for 95% of malaria deaths worldwide. Despite advances in malaria treatments, malaria eradication is hampered by insecticide and antimalarial drug resistance. Consequently, the need to discover new antimalarial lead compounds remains urgent. To help address this need, we evaluated the antiplasmodial activity of twenty-two amides and thioamides with pyridine cores and their non-pyridine analogues. Twelve of these compounds showed in vitro anti-proliferative activity against the intraerythrocytic stage of Plasmodium falciparum, the most virulent species of Plasmodium infecting humans...
April 3, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38555795/drug-resistance-in-animal-trypanosomiases-epidemiology-mechanisms-and-control-strategies
#17
REVIEW
Marzuq A Ungogo, Harry P de Koning
Animal trypanosomiasis (AT) is a complex of veterinary diseases known under various names such as nagana, surra, dourine and mal de caderas, depending on the country, the infecting trypanosome species and the host. AT is caused by parasites of the genus Trypanosoma, and the main species infecting domesticated animals are T. brucei brucei, T. b. rhodesiense, T. congolense, T. simiae, T. vivax, T. evansi and T. equiperdum. AT transmission, again depending on species, is through tsetse flies or common Stomoxys and tabanid flies or through copulation...
March 30, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38554597/comparative-structure-activity-and-target-exploration-of-1-2-diphenylethynes-in-haemonchus-contortus-and-caenorhabditis-elegans
#18
JOURNAL ARTICLE
Harrison T Shanley, Aya C Taki, Nghi Nguyen, Tao Wang, Joseph J Byrne, Ching-Seng Ang, Michael G Leeming, Nicholas Williamson, Bill C H Chang, Abdul Jabbar, Brad E Sleebs, Robin B Gasser
Infections and diseases caused by parasitic nematodes have a major adverse impact on the health and productivity of animals and humans worldwide. The control of these parasites often relies heavily on the treatment with commercially available chemical compounds (anthelmintics). However, the excessive or uncontrolled use of these compounds in livestock animals has led to major challenges linked to drug resistance in nematodes. Therefore, there is a need to develop new anthelmintics with novel mechanism(s) of action...
March 19, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38520842/absence-of-association-between-pfnfs1-mutation-and-in-vitro-susceptibility-to-lumefantrine-in-plasmodium-falciparum
#19
JOURNAL ARTICLE
Weilin Zeng, Wei Zhao, Hao Wei, Yucheng Qin, Zheng Xiang, Yanrui Wu, Xi Chen, Yanmei Zhang, Hui Zhao, Mengxi Duan, Wenya Zhu, Kemin Sun, Yiman Wu, Tao Liang, Ye Mou, Cheng Liu, Xiuya Tang, Yaming Huang, Liwang Cui, Zhaoqing Yang
Artemether-lumefantrine (AL) is the most widely used antimalarial drug for treating uncomplicated falciparum malaria. This study evaluated whether the K65Q mutation in the Plasmodium falciparum cysteine desulfurase IscS (Pfnfs1) gene was associated with alternated susceptibility to lumefantrine using clinical parasite samples from Ghana and the China-Myanmar border area. Parasite isolates from the China-Myanmar border had significantly higher IC50 values to lumefantrine than parasites from Ghana. In addition, the K65 allele was significantly more prevalent in the Ghanaian parasites (34...
March 19, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38484645/acrylonitrile-derivatives-in-vitro-activity-and-mechanism-of-cell-death-induction-against-trypanosoma-cruzi-and-leishmania-amazonensis
#20
JOURNAL ARTICLE
Carlos J Bethencourt-Estrella, Samuel Delgado-Hernández, Atteneri López-Arencibia, Desirée San Nicolás-Hernández, Lizbeth Salazar-Villatoro, Maritza Omaña-Molina, David Tejedor, Fernando García-Tellado, Jacob Lorenzo-Morales, José E Piñero
Leishmaniasis and Chagas disease are parasitic infections that affect millions of people worldwide, producing thousands of deaths per year. The current treatments against these pathologies are not totally effective and produce some side effects in the patients. Acrylonitrile derivatives are a group of compounds that have shown activity against these two diseases. In this work, four novels synthetic acrylonitriles were evaluated against the intracellular form and extracellular forms of L. amazonensis and T. cruzi...
March 6, 2024: International Journal for Parasitology, Drugs and Drug Resistance
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