Michael Thrull, Khaled Atasi, Lennart-Maximilian Boese, Mahmut Cakar, Ullrich Heller, Nils Jansen, Leoni-Christine Menzel, Hassan Omaimen, Katharina Theis, Damir Karacic, Diyan Dimov, Roland Coras, Randolf Klingebiel
We report the rare occurrence of a temporal glioblastoma multiforme (GBM) showing transdural tumor extension into adjacent mastoid cells. As the dura mater provides a barrier to intraaxial tumors, GBM seldom penetrates into the skull base, even though it is a high-grade astrocytoma with a tendency to spread. Yet, some mechanisms of GBM-induced skull invasion have been identified, making this entity a very rare but nonetheless relevant differential diagnosis in otherwise ambiguous cases of an intracerebral tumor extending into the skull base...
2023: Case Reports in Otolaryngology