Tze-Hoong Chua, Connie Y H Leung, H E Fang, Chun-Kin Chow, Siu-Kit Ma, Sin-Fun Sia, Iris H Y Ng, Stanley G Fenwick, Cassandra M James, Sin Bin Chua, Siang Thai Chew, Jimmy Kwang, J S M Peiris, Trevor M Ellis
The protective efficacy of a subunit avian influenza virus H5 vaccine based on recombinant baculovirus expressed H5 haemagglutinin antigen and an inactivated H5N2 avian influenza vaccine combined with a marker antigen (tetanus toxoid) was compared with commercially available inactivated H5N2 avian influenza vaccine in young ducks. Antibody responses, morbidity, mortality, and virus shedding were evaluated after challenge with a Vietnamese clade 1 H5N1 HPAI virus [A/VN/1203/04 (H5N1)] that was known to cause a high mortality rate in ducks...
2010: Influenza Research and Treatment