journal
https://read.qxmd.com/read/38314737/infrequent-transition-to-direct-oral-anticoagulants-in-patients-with-cancer
#1
JOURNAL ARTICLE
Nina Nouhravesh, Caroline Sindet-Pedersen, Maja Hellfritzsch, Ali Akil Al-Alak, Thomas Kümler, Erik L Grove, Morten Lamberts
INTRODUCTION: Pharmacokinetic drug-drug interactions (DDIs) are challenging aspects of direct oral anticoagulant (DOAC) therapy in patients with cancer. We evaluated the prevalence of potential DOAC/antineoplastic agent DDIs and the one-year cumulative incidence of switching from low-molecular-weight heparin (LMWH) to a DOAC in patients with cancer. METHODS: Patients with cancer and an indication of LMWH were included from Herlev and Gentofte Hospital, Denmark, in the 2014-2019 period...
January 25, 2024: Danish Medical Journal
https://read.qxmd.com/read/38314735/adherence-to-guidelines-prior-to-endoscopic-sinus-surgery-in-patients-with-chronic-rhinosinusitis-and-asthma
#2
JOURNAL ARTICLE
Lotte Buskbjerg Nøhr, Therese Ovesen, Kasra Zainali-Gill
INTRODUCTION: Optimal care for patients with simultaneous chronic rhinosinusitis (CRS) and asthma is often complicated due to interaction between these conditions. This study depicts the lack of attention to asthma within the otorhinolaryngological field, and the relationship between CRS and asthma, including the risk of revision surgery in such patients. METHODS: A retrospective cohort study was conducted on patients undergoing functional endoscopic sinus surgery (FESS) because of CRS with nasal polyps (CRSwNP) and without nasal polyps in a five-year period...
January 25, 2024: Danish Medical Journal
https://read.qxmd.com/read/38314734/diagnostic-flow-of-patients-in-a-national-fast-track-referral-system-for-malignant-melanoma
#3
JOURNAL ARTICLE
Silje Haukali Omland, Anna Harager, Peter Phillipsen, Katrine Karmisholt
Elderly people and patients with chronic lifestyle diseases are at risk of being hit harder by environmental influences. Environmental impacts increase the risk of various lifestyle diseases. Biomimetics gives us a unique opportunity to find new treatments for lifestyle diseases and counteract health effects of environmental threats. A biomimetic alliance for better health achieved through cross-disciplinal collaboration may not only contribute to better health but also to a better and more sustainable environment: What is good for the planet is good for our health...
January 25, 2024: Danish Medical Journal
https://read.qxmd.com/read/38314736/outpatient-pain-service-in-trauma-and-orthopaedic-surgery
#4
JOURNAL ARTICLE
Claus Bredahl, Simone Høstgaard, Jannie Bisgaard
INTRODUCTION: Chronic pain is a common complication after surgery and trauma. The incidence of chronic pain may potentially be reduced by effective management of severe acute pain, in hospital and during the subacute post-operative phase at home. METHODS: This was a cohort study from an outpatient follow-up service for patients with pain at discharge after orthopaedic surgery and trauma in a level 1 university hospital setting. The patients' charts were reviewed...
January 23, 2024: Danish Medical Journal
https://read.qxmd.com/read/38314733/the-therapeutic-potential-of-galanin-in-the-management-of-pain-a-review-article
#5
JOURNAL ARTICLE
Tomas Hökfelt, Zsuzsanna Wiesenfeld-Hallin
Neuropeptides represent the most diverse family of neurotransmitters counting numerous members and even more G protein-coupled receptors, all of which are potential targets for drug development. Here, we focus on galanin and its three receptors by describing their possible involvement in pain and regeneration. Although animal experiments indicate that galanin, together with other molecules, may act as an endogenous system protecting against pain and improving nerve growth, these results have so far not been translated into patient treatments...
January 23, 2024: Danish Medical Journal
https://read.qxmd.com/read/38314732/reduced-graft-survival-in-renal-transplant-patients-with-urinary-tract-infections-a-meta-analysis
#6
JOURNAL ARTICLE
Aimi Dm Hamilton, Helle A Prætorius
INTRODUCTION: Renal transplant patients are prone to developing urinary tract infections (UTIs). However, the potential effect of a UTI on renal graft loss remains unclear. METHODS: We systematically surveyed the literature for a potential association between UTI and graft loss. Articles were identified in online databases using a specific search string, followed by post selection for meta-analysis following four inclusion criteria: 1) a clear definition of UTI and recurrent UTI, 2) n > 200, 3) patient age > 16 years and 4) inclusion of data on graft loss...
January 15, 2024: Danish Medical Journal
https://read.qxmd.com/read/38314731/-pain-without-loosening-revisions-of-knee-arthroplasties-in-the-danish-knee-arthroplasty-register
#7
JOURNAL ARTICLE
Kristine Bollerup Arndt, Henrik Morville Schrøder, Anders Troelsen, Mikkel Rathsach Andersen, Lasse Enkebølle Rasmussen, Martin Lindberg-Larsen
INTRODUCTION: We aimed to investigate "pain without loosening" as an indication for knee arthroplasty revisions and to screen for other indications potentially hidden in this category to improve future registration and enhance data quality in the Danish Knee Arthroplasty Register. METHODS: We included 104 patients undergoing revision knee arthroplasty for the indication "pain without loosening" from 1 January 2016 to 31 December 2018 at five Danish centres. Medical records, radiographs and computed tomographies were reviewed...
January 15, 2024: Danish Medical Journal
https://read.qxmd.com/read/38235988/reply-to-correspondence-on-cover-letters-written-by-chatgpt-4-or-humans
#8
LETTER
Can Deniz Deveci, Jason Joe Baker, Binyamin Sikander, Jacob Rosenberg
This is a reply to the: "Correspondence on "cover letters written by ChatGPT-4 or humans"" Dan Med J 2024;71(1):A205177.
December 18, 2023: Danish Medical Journal
https://read.qxmd.com/read/38235987/correspondence-on-cover-letters-written-by-chatgpt-4-or-humans
#9
LETTER
Hinpetch Daungsupawong, Viroj Wiwanitkit
This is a letter to the editor on the article "A comparison of cover letters written by ChatGPT-4 or humans" Dan Med J 2023;70(12):A06230412.
December 18, 2023: Danish Medical Journal
https://read.qxmd.com/read/38235986/biomimetics-and-planetary-health-a-review-of-human-diseases-in-interaction-with-the-environment-and-ecosystem
#10
JOURNAL ARTICLE
Peter Stenvinkel
Elderly people and patients with chronic lifestyle diseases are at risk of being hit harder by environmental influences. Environmental impacts increase the risk of various lifestyle diseases. Biomimetics gives us a unique opportunity to find new treatments for lifestyle diseases and counteract health effects of environmental threats. A biomimetic alliance for better health achieved through cross-disciplinal collaboration may not only contribute to better health but also to a better and more sustainable environment: What is good for the planet is good for our health...
December 18, 2023: Danish Medical Journal
https://read.qxmd.com/read/38235984/complications-in-hepatic-vein-catheterisation-and-transjugular-liver-biopsy
#11
JOURNAL ARTICLE
Nanna Hansen, Annette Dam Fialla
INTRODUCTION: Portal pressure predicts the occurrence of decompensations in cirrhosis. Portal pressure is primarily measured via hepatic vein catheterisation (HVC), to which a transjugular liver biopsy (TJLB) may be added. Indications for HVC are mainly therapy control and prognosis. TJLB is performed when a percutaneous liver biopsy is contraindicated or for other diagnostic reasons. Both procedures have reported low complication rates. The aim of this study was to identify indications and 30-day postprocedural complications...
December 18, 2023: Danish Medical Journal
https://read.qxmd.com/read/38235985/randomised-controlled-trial-of-in-versus-out-patient-management-of-benign-hemithyroidectomy
#12
JOURNAL ARTICLE
Carl Frederik Haugaard, Preben Homøe, Alexander Nygren, Ole Mathiesen, Lise Nørrekjær Hansen, Gitte Bjørn Hvilsom
INTRODUCTION: Outpatient (OPT) thyroid surgery is increasing, with patient selection being pivotal for safety. While numerous studies exist, most are retrospective and encompass both benign and malignant cases. METHODS: We conducted a randomised clinical trial on patients undergoing hemithyroidectomy for benign thyroid disease. Participants were assigned to OPT or inpatient groups. We collected data on complications, failure to discharge on surgery day, post-operative pain, nausea, sleep quality and patient satisfaction...
December 6, 2023: Danish Medical Journal
https://read.qxmd.com/read/38235983/intramedullary-nailing-versus-external-ring-fixator-for-treatment-of-tibial-fractures-a-study-protocol-for-a-randomised-clinical-trial
#13
JOURNAL ARTICLE
Rasmus Stokholm, Peter Larsen, Jan Duedal Rölfing, Juozas Petruskevicius, Morten K Rasmussen, Steffen Skov, Rasmus Elsoe
INTRODUCTION: Tibial shaft fractures are among the most common lower extremity fractures. Treatment of tibial shaft fractures with intramedullary nailing has become the treatment of choice in adults. However, commonly reported outcomes include knee pain, limitations in activities of daily living and reduction in quality of life (QOL). The literature lacks high-quality studies to document superiority of intramedullary nailing versus other surgical treatment methods. The present study aims to compare the 12-month Knee Injury and Osteoarthritis Outcome Score (KOOS) - sport and recreation activities (sport/rec) after standard intramedullary nailing with external ring fixation for adult patients with isolated tibial shaft fractures...
December 6, 2023: Danish Medical Journal
https://read.qxmd.com/read/38018708/a-comparison-of-cover-letters-written-by-chatgpt-4-or-humans
#14
JOURNAL ARTICLE
Can Deniz Deveci, Jason Joe Baker, Binyamin Sikander, Jacob Rosenberg
INTRODUCTION: Artificial intelligence has started to become a part of scientific studies and may help researchers with a wide range of tasks. However, no scientific studies have been published on its ussefulness in writing cover letters for scientific articles. This study aimed to determine whether Generative Pre-Trained Transformer (GPT)-4 is as good as humans in writing cover letters for scientific papers. METHODS: In this randomised non-inferiority study, we included two parallel arms consisting of cover letters written by humans and by GPT-4...
November 23, 2023: Danish Medical Journal
https://read.qxmd.com/read/38018707/cold-steel-versus-impedance-dependent-tissue-sealer-tonsillectomy-a-study-protocol-for-a-randomised-controlled-trial
#15
JOURNAL ARTICLE
Line Schiøtt Nissen, Jannik Bertelsen, Nina Munk Lyhne, Susanne Holm Nielsen, Pernille Hahn, Jesper Holm, Therese Ovesen
INTRODUCTION: Approximately 7,000 tonsillectomies are performed annually in Denmark on a benign basis. The cold steel surgical technique is the gold standard. The risk of post tonsillectomy bleeding (PTH) in a centre in Jutland is 7.9%. A new impedance-dependent tissue sealer (IDTS) device has been developed, with preliminary results showing a reduction in operation time, perioperative bleeding and post-operative risk of bleeding of 4.5%. METHODS: A randomised, controlled, double-blinded multicentre trial of cold steel tonsillectomy versus IDTS will be performed on 1,250 patients...
November 23, 2023: Danish Medical Journal
https://read.qxmd.com/read/38018705/a-survey-of-preoperative-diagnosis-and-management-of-complicated-appendicitis
#16
JOURNAL ARTICLE
Binyamin Sikander, Kristoffer Andresen, Hagar Al Fartoussi, Niklas Nygaard Baastrup, Camilla Al Fartoussi, Jacob Rosenberg, Siv Fonnes
INTRODUCTION: Complicated appendicitis is a severe condition, requiring early diagnosis and intervention to prevent complications. We aimed to investigate how resident surgeons distinguish and manage complicated appendicitis and their perspectives on preoperative diagnostic markers. METHODS: The electronic survey was face validated. It contained questions about demographics, resident surgeons' considerations on the preoperative diagnosis of complicated appendicitis, and views on the need for and relevance of preoperative diagnostic markers...
November 23, 2023: Danish Medical Journal
https://read.qxmd.com/read/38018706/genetics-of-metabolic-traits-in-greenlanders
#17
JOURNAL ARTICLE
Anne Cathrine Baun Thuesen, Mette K Andersen, Torben Hansen
The history of the Greenlandic population has contributed to a unique genetic composition in which high-impact and often novel genetic variants segregate at a high frequency. As a result, research in smaller populations like the Greenlandic has the potential to reveal genetic variation and associations that are not present or discoverable in other populations. In this review, we provide a summary of our research in Greenlanders and our findings of genetic variants with high impact on metabolic health, and outline the implications that this research has for the equitable distribution of genomic precision medicine...
November 16, 2023: Danish Medical Journal
https://read.qxmd.com/read/38018709/time-to-treat-the-climate-and-nature-crisis-as-one-indivisible-global-health-emergency
#18
JOURNAL ARTICLE
Kamran Abbasi, Parveen Ali, Virginia Barbour, Thomas Benfield, Kirsten Bibbins-Domingo, Stephen Hancocks, Richard Horton, Laurie Laybourn-Langton, Robert Mash, Peush Sahni, Wadeia Mohammad Sharief, Paul Yonga, Chris Zielinski
No abstract text is available yet for this article.
November 13, 2023: Danish Medical Journal
https://read.qxmd.com/read/38018704/prevalence-and-severity-of-freezing-of-gait-in-a-danish-cohort-of-people-with-parkinson-s-disease
#19
JOURNAL ARTICLE
Victor Schwartz Hvingelby, Miriam Höjholt Terkelsen, Rikke Nan Valdemarsen, Anne Sofie Møller Andersen, Erik H Danielsen, Mette Møller, Nicola Pavse, Erik Johnsen
INTRODUCTION: Parkinson's disease (PD) is a widespread neurodegenerative disorder characterised by wide range of symptoms. Freezing of gait (FoG), a transient feeling that the patient's feet are nailed to the floor, resulting in an inability to move, is a particularly distressful symptom. The assessment of FoG can be challenging. Often, clinicians are reliant on patients' subjective experiences and patient questionnaires such as the Freezing of Gait Questionnaire (FOGQ) and its updated version, the New FOGQ (NFOGQ)...
November 9, 2023: Danish Medical Journal
https://read.qxmd.com/read/37897374/characteristics-of-patients-with-subacute-thyroiditis
#20
JOURNAL ARTICLE
Caroline Rebbe Kjellerup, Marco Juul Thomsen, Nanna Marie Uldall Torp, Jesper Karmisholt, Stine Linding Andersen
INTRODUCTION: The diagnosis and management of subacute thyroiditis (SAT) may be challenging, and more evidence on patient and disease characteristics is warranted. METHODS: This was a retrospective cohort study of all patients in the North Denmark Region with a SAT diagnosis in the Danish National Patient Registry, 2016-2018. The medical records and biochemical results prior to the diagnosis and during a two-year follow-up period were reviewed. RESULTS: A total of 71 patients with a SAT diagnosis were identified, and the diagnosis was verified in 44 (62...
October 24, 2023: Danish Medical Journal
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