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JOURNAL ARTICLE
Hanna Bonnekoh, Monique Butze, Sebastian Spittler, Petra Staubach, Karsten Weller, Jörg Scheffel, Marcus Maurer, Karoline Krause
BACKGROUND: Cold urticaria (ColdU) is characterized by pruritic wheals following exposure of the skin to cold. Many patients show insufficient response to antihistamines, the first line treatment. Based on the high efficacy of interleukin-1(IL-1)-inhibition in cold-induced urticarial autoinflammatory diseases, we assessed the effects of rilonacept, an IL-1 inhibitor, in ColdU patients unresponsive to standard treatment. METHODS: In this randomized, double-blind, placebo-controlled two-center study, we included 20 patients with ColdU...
March 2023: Clinical and Translational Allergy
#22
JOURNAL ARTICLE
Ramón Gimeno, Clara Ribas-Llauradó, David Pesque, Evelyn Andrades, Bruno Cenni, Barbara Ambros, Ramon Pujol, Ana M Giménez-Arnau
BACKGROUND: Despite advances in the treatment of chronic urticaria, in a significant percentage of the patients symptoms are not fully controlled with conventional approaches. New strategies under development include blocking intracellular mediators of mast cell and basophil activation. OBJECTIVE: We aim to investigate the effects of the Bruton's tyrosine kinase (BTK) inhibitor remibrutinib on human blood basophils and CD34+ -derived mast cells activation induced by serum obtained from chronic urticaria patients...
March 2023: Clinical and Translational Allergy
#23
JOURNAL ARTICLE
Sophia Björkander, Susanna Klevebro, Natalia Hernandez-Pacheco, Maura Kere, Sandra Ekström, Maria Sparreman Mikus, Marianne van Hage, Anna James, Inger Kull, Anna Bergström, Jenny Mjösberg, Christopher Andrew Tibbitt, Erik Melén
BACKGROUND: Obese asthma is a complex phenotype and further characterization of the pathophysiology is needed. This study aimed to explore inflammation-related plasma biomarkers in lean and overweight/obese asthmatics. METHODS: We elucidated levels of inflammation-related plasma proteins in obese asthma phenotypes in the population-based cohort BAMSE (Swedish: Children, Allergy, Milieu, Stockholm, Epidemiology) using data from 2069 24-26-year-olds. Subjects were divided into lean asthma (n = 166), lean controls (n = 1440), overweight/obese asthma (n = 73) and overweight/obese controls (n = 390)...
March 2023: Clinical and Translational Allergy
#24
JOURNAL ARTICLE
Ewa Cichocka-Jarosz, Sabine Dölle-Bierke, Urszula Jedynak-Wąsowicz, Dominique Sabouraud-Leclerc, Alice Köhli, Lars Lange, Nikolaos G Papadopoulos, Jonathan Hourihane, Katja Nemat, Kathrin Scherer Hofmeier, Stephanie Hompes, Hagen Ott, Lucila Lopes de Oliveira, Thomas Spindler, Christian Vogelberg, Margitta Worm
BACKGROUND: Cow's milk (CM) and hen's egg (HE) are leading triggers of anaphylaxis in early childhood. The aim of this study was to identify clinical phenotypes and therapeutic measures for CM anaphylaxis (CMA) compared to HE anaphylaxis (HEA) in children up to 12 years of age, based on a large pan-European dataset from the European Anaphylaxis Registry. METHODS: Data from 2007 to 2020 on clinical phenotypes and treatment from 10 European countries, as well as Brazil, were analysed...
March 2023: Clinical and Translational Allergy
#25
JOURNAL ARTICLE
Ga-Young Ban, Eun-Mi Yang, Young-Min Ye, Hae-Sim Park
BACKGROUND: The long-term goals of asthma treatment are to achieve well control of symptoms and to minimize the future risk of asthma exacerbation. Identifying biomarkers for uncontrolled asthma is important for improving the asthma outcome. This study aimed to investigate the association of the levels of eosinophil-derived neurotoxin (EDN) with asthma control status in specific asthma phenotype, aspirin-exacerbated respiratory disease (AERD), and aspirin-tolerant asthma (ATA). METHODS: A total of 136 adult asthmatics, including 47 asthmatics with AERD and 89 asthmatics with ATA, were enrolled...
March 2023: Clinical and Translational Allergy
#26
JOURNAL ARTICLE
Subhabrata Moitra, Marzia Simoni, Sandra Baldacci, Sara Maio, Anna Angino, Patrizia Silvi, Giovanni Viegi, Stefania La Grutta, Franco Ruggiero, Gianni Bedini, Francesca Natali, Lorenzo Cecchi, Uwe Berger, Maria Prentovic, Amir Gamil, Nour Baïz, Michel Thibaudon, Samuel Monnier, Davide Caimmi, Luciana K Tanno, Pascal Demoly, Simone Orlandini, Isabella Annesi-Maesano
BACKGROUND: Allergic rhinitis (AR) is a major non-communicable disease that affects the health-related quality of life (HRQoL) of patients. However, data on HRQoL and symptom control in AR patients with comorbid asthma (AR + asthma) are lacking. METHODS: In this multicentre, cross-sectional study, patients with AR were screened and administered questionnaires of demographic characteristics and health conditions (symptoms/diagnosis of AR and asthma, disease severity level, and allergic conditions)...
February 2023: Clinical and Translational Allergy
#27
JOURNAL ARTICLE
Tobias Gureczny, Benjamin Heindl, Livia Klug, Felix Wantke, Wolfgang Hemmer, Stefan Wöhrl
BACKGROUND: As extract-based skin testing as well as in vitro tests for major allergens have their own advantages, both procedures are usually performed in routine settings. In times of shortages in medical staff and supplies, we asked ourselves, how many patients would be underdiagnosed, if only one test could be used. METHODS: In a retrospective analysis, we investigated a cohort of 2646 patients seen by a single physician in a large Austrian outpatient allergy clinic in 2018...
February 2023: Clinical and Translational Allergy
#28
JOURNAL ARTICLE
Afonso Cachim, Ana Margarida Pereira, Rute Almeida, Rita Amaral, Magna Alves-Correia, Pedro Vieira-Marques, Claudia Chaves-Loureiro, Carmelita Ribeiro, Francisca Cardia, Joana Gomes, Carmen Vidal, Eurico Silva, Sara Rocha, Diana Rocha, Maria Luís Marques, Rosália Páscoa, Daniela Morais, Ana Margarida Cruz, Marta Santalha, José Augusto Simões, Sofia da Silva, Diana Silva, Rita Gerardo, Filipa Todo Bom, Ana Morete, Inês Vieira, Pedro Vieira, Rosário Monteiro, Maria Rosário Raimundo, Luís Monteiro, Ângela Neves, Carlos Santos, Ana Margarida Penas, Rita Regadas, José Varanda Marques, Inês Rosendo, Margarida Abreu Aguiar, Sara Fernandes, Carlos Seiça Cardoso, Filipa Pimenta, Patrícia Meireles, Mariana Gonçalves, João Almeida Fonseca, Cristina Jácome
BACKGROUND: Previous studies have demonstrated the feasibility of using an asthma app to support medication management and adherence but failed to compare with other measures currently used in clinical practice. However, in a clinical setting, any additional adherence measurement must be evaluated in the context of both the patient and physician perspectives so that it can also help improve the process of shared decision making. Thus, we aimed to compare different measures of adherence to asthma control inhalers in clinical practice, namely through an app, patient self-report and physician assessment...
February 2023: Clinical and Translational Allergy
#29
JOURNAL ARTICLE
Carolin Steinert, Sherezade Moñino-Romero, Monique Butze, Jörg Scheffel, Sabine Dölle-Bierke, Josefine Dobbertin-Welsch, Kirsten Beyer, Marcus Maurer, Sabine Altrichter
BACKGROUND: IgE-mediated food allergy is the result of an aberrant immune response involving the interaction of a food allergen with its specific IgE bound to FcɛRI, the high affinity IgE receptor, on mast cells. Allergen-specific IgE also binds to soluble binding factors, but, their expression and role in food allergy is not well characterized. Here, we assess the prevalence and relevance of soluble IgE binding factors in food allergy and tolerance. METHODS: We measured serum levels of four IgE binding factors, that is, galectin-3, galectin-9, soluble FcɛRI (sFcεRI) and soluble CD23 (sCD23) in 67 adults sensitized to peanut or hazelnut and sFcɛRI in 29 children sensitized to hen's egg...
February 2023: Clinical and Translational Allergy
#30
LETTER
Dong Liu, Jingyun Li, Yunbo Gao, Feifei Cao, Wei Xiong, Chengshuo Wang, Yuan Zhang, Luo Zhang
No abstract text is available yet for this article.
February 2023: Clinical and Translational Allergy
#31
LETTER
Maria Ödling, Ann-Charlotte Sundqvist, Josef Brandström, Anna Nopp, Niklas Andersson, Caroline Nilsson, Inger Kull
No abstract text is available yet for this article.
February 2023: Clinical and Translational Allergy
#32
LETTER
Lotte S Spekhorst, Marlies de Graaf, Lisa P van der Rijst, Nicolaas P A Zuithoff, René C Schweizer, Marijke Kamsteeg, Inge Haeck, Anneke M T van Lynden-van Nes, Paula van Lumig, Geertruida L E Romeijn, Marie-Louise Schuttelaar, Marjolein S de Bruin-Weller
No abstract text is available yet for this article.
January 2023: Clinical and Translational Allergy
#33
JOURNAL ARTICLE
Roselie Achten, Judith Thijs, Marlot van der Wal, Chantal van Luijk, Matthijs van Luin, Mohsin El Amrani, Edward Knol, Eveline Delemarre, Constance den Hartog Jager, Marlies de Graaf, Daphne Bakker, Joke de Boer, Femke van Wijk, Marjolein de Bruin-Weller
BACKGROUND: The patho-mechanism of ocular surface disease (OSD) in dupilumab-treated atopic dermatitis (AD) patients remains unclear. The aim of this study is to measure dupilumab levels in tear fluid and serum, and relate these findings to the severity of OSD during dupilumab treatment in AD patients. METHODS: This prospective study included dupilumab-treated moderate-to-severe AD patients who were seen by a dermatologist and an ophthalmologist before the start of dupilumab (baseline), and after 4 and 28 weeks of dupilumab treatment...
January 2023: Clinical and Translational Allergy
#34
JOURNAL ARTICLE
Jean Bousquet, Josep M Anto, Bernardo Sousa-Pinto, Wienczyslawa Czarlewski, Anna Bedbrook, Tari Haahtela, Ludger Klimek, Oliver Pfaar, Piotr Kuna, Maciej Kupczyk, Frederico S Regateiro, Boleslaw Samolinski, Arunas Valiulis, Arzu Yorgancioglu, Sylvie Arnavielhe, Xavier Basagaña, Karl C Bergmann, Sinthia Bosnic-Anticevich, Luisa Brussino, G Walter Canonica, Victoria Cardona, Lorenzo Cecchi, Claudia Chaves-Loureiro, Elisio Costa, Alvaro A Cruz, Bilun Gemicioglu, Wytske J Fokkens, Juan Carlos Ivancevich, Helga Kraxner, Violeta Kvedariene, Désirée E Larenas-Linnemann, Daniel Laune, Renaud Louis, Michael Makris, Marcus Maurer, Erik Melén, Yann Micheli, Mario Morais-Almeida, Joaquim Mullol, Marek Niedoszytko, Yoshitaka Okamoto, Nikolaos G Papadopoulos, Vincenzo Patella, Nhân Pham-Thi, Philip W Rouadi, Joaquin Sastre, Nicola Scichilone, Aziz Sheikh, Mikhail Sofiev, Luis Taborda-Barata, Sanna Toppila-Salmi, Ioanna Tsiligianni, Erkka Valovirta, Maria Teresa Ventura, Rafael José Vieira, Mihaela Zidarn, Rita Amaral, Ignacio J Ansotegui, Annabelle Bédard, Samuel Benveniste, Michael Bewick, Carsten Bindslev-Jensen, Hubert Blain, Matteo Bonini, Rodolphe Bourret, Fulvio Braido, Pedro Carreiro-Martins, Denis Charpin, Ivan Cherrez-Ojeda, Tomas Chivato, Derek K Chu, Cemal Cingi, Stefano Del Giacco, Frédéric de Blay, Philippe Devillier, Govert De Vries, Maria Doulaptsi, Virginie Doyen, Gérard Dray, Jean-François Fontaine, R Maximiliano Gomez, Jan Hagemann, Enrico Heffler, Maja Hofmann, Ewa Jassem, Marek Jutel, Thomas Keil, Vicky Kritikos, Inger Kull, Marek Kulus, Olga Lourenço, Eve Mathieu-Dupas, Enrica Menditto, Ralph Mösges, Ruth Murray, Rachel Nadif, Hugo Neffen, Stefania Nicola, Robyn O'Hehir, Heidi Olze, Yuliia Palamarchuk, Jean-Louis Pépin, Benoit Pétré, Robert Picard, Constantinos Pitsios, Francesca Puggioni, Santiago Quirce, Filip Raciborski, Sietze Reitsma, Nicolas Roche, Monica Rodriguez-Gonzalez, Jan Romantowski, Ana Sá-Sousa, Faradiba S Serpa, Marine Savouré, Mohamed H Shamji, Milan Sova, Annette Sperl, Cristiana Stellato, Ana Todo-Bom, Peter Valentin Tomazic, Olivier Vandenplas, Michiel Van Eerd, Tuula Vasankari, Frédéric Viart, Susan Waserman, Joao A Fonseca, Torsten Zuberbier
MASK-air® , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK-air® is a Good Practice of DG Santé on digitally-enabled, patient-centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co-operation and Development). MASK-air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis...
January 2023: Clinical and Translational Allergy
#35
LETTER
Luis Taborda-Barata, Maria Teresa Ventura, Hubert Blain, Luisa Brussino, Violeta Kvedariene, Désirée E Larenas-Linneman, Nhân Pham-Thi, Boleslaw Samolinski, Joao A Fonseca, Jean Bousquet, Bernardo Sousa-Pinto
No abstract text is available yet for this article.
January 2023: Clinical and Translational Allergy
#36
LETTER
Charlotte G Mortz, Henrik F Kjaer, Torbjørn Kabel Georgsen, Trine H Rasmussen, Helene M Rasmussen, Sigurd Broesby-Olsen, Carsten Bindslev-Jensen
No abstract text is available yet for this article.
January 2023: Clinical and Translational Allergy
#37
JOURNAL ARTICLE
Nicolas Migueres, Christina Delmas, Julie Petit Thomas, Hélène Kuntz, Elisabeth Peri-Fontaa, Philippe Schultz, Michel Velten, Frédéric de Blay
BACKGROUND: Dysphonia is a frequent comorbidity of asthma and has been suggested to be a local side effect of inhaled corticosteroids due to laryngeal candidiasis. We hypothesized that dysphonia in asthmatics was not due to laryngeal organic lesions but to laryngeal dysfunction during phonation (LDP). OBJECTIVE: We compared the frequency of LDP in female asthmatic patients treated with inhaled corticosteroids to female controls. METHODS: We compared 68 asthmatic female patients to 53 female control subjects...
December 2022: Clinical and Translational Allergy
#38
JOURNAL ARTICLE
Audrey Dunn Galvin, Andrea Vereda, Pablo Rodríguez Del Río, Antonella Muraro, Carla Jones, Robert Ryan, David Norval, Jennifer Jobrack, Aikaterini Anagnostou, Julie Wang
BACKGROUND: Health-related quality of life (HRQoL) is significantly and substantially reduced in individuals with peanut allergy due to many factors associated with unanticipated or potentially fatal reactions. Further insight on the impact of peanut oral immunotherapy in managing peanut allergy on HRQoL is needed. The aim of this analysis was to assess effects of peanut (Arachis hypogaea) allergen powder-dnfp (PTAH), a biologic drug for peanut oral immunotherapy, on HRQoL from three phase 3 and two follow-on trials of PTAH...
December 2022: Clinical and Translational Allergy
#39
LETTER
Juliette Caron, Sahara Graf, Christine Delebarre-Sauvage
Among 74 patients with an immediate hypersensitivity reaction (IHR) to iodinated contrast media (ICM), the rate of allergic patients confirmed by positive prick test or diluted intradermal test (IDT) was 8.1%. 12.5% of re-exposed patients had a recurrent IHR despite negative skin tests. Investigations on pure IDT to ICM and development of drug provocation test may provide additional safety nets to uncover recurrent ICM reactors. Agreements among allergists are needed to unify practices.
December 2022: Clinical and Translational Allergy
#40
REVIEW
Heidi Mikkelsen, Eskild Morten Landt, Marianne Benn, Børge Grønne Nordestgaard, Morten Dahl
BACKGROUND: Several risk factors for asthma have been proposed; however, the causality of these associations is sometimes unclear. Mendelian randomization is a powerful epidemiological approach that can help elucidate the causality of risk factors. The aim of the present study was to identify causal risk factors for asthma through Mendelian Randomization studies. METHODS: A systematic search of PubMed and EMBASE was conducted, to identify studies investigating risk factors for asthma or respiratory allergies through Mendelian Randomization...
November 2022: Clinical and Translational Allergy
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