Sherry G Dodds, Carolina B Livi, Manish Parihar, Hang-Kai Hsu, Adriana D Benavides, Jay Morris, Martin Javors, Randy Strong, Barbara Christy, Paul Hasty, Zelton Dave Sharp
Rapamycin inhibits mechanistic (or mammalian) target of rapamycin (mTOR) that promotes protein production in cells by facilitating ribosome biogenesis (RiBi) and eIF4E-mediated 5'cap mRNA translation. Chronic treatment with encapsulated rapamycin (eRapa) extended health and life span for wild-type and cancer-prone mice. Yet, the long-term consequences of chronic eRapa treatment are not known at the organ level. Here, we report our observations of chronic eRapa treatment on mTORC1 signaling and RiBi in mouse colon and visceral adipose...
2016: Pathobiology of Aging & Age related Diseases