journal
Journals Human Vaccines & Immunotherape...

Human Vaccines & Immunotherapeutics

https://read.qxmd.com/read/38502342/attitudes-barriers-and-facilitators-to-adherent-completion-of-the-recombinant-zoster-vaccine-regimen-in-canada-qualitative-interviews-with-healthcare-providers-and-patients
#21
JOURNAL ARTICLE
Sydney George, Jessica Regan, Amnah Awan, Meaghan O'Connor, April Foster, Kimberly Raymond, Iris Gorfinkel, Shelly A McNeil
This qualitative, cross-sectional study aimed to understand the barriers and facilitators related to the adherence and completion of the recombinant zoster vaccine (RZV) two-dose series in Canada, as perceived by healthcare providers (HCPs) and patients. Data collection occurred via 60-minute concept elicitation interviews with 12 HCPs (4 physicians, 2 nurse practitioners, 6 pharmacists) who had prescribed and/or administered RZV in Canada, and 21 patients aged ≥50 years who had received ≥1 dose of RZV...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38502119/bidirectional-crosstalk-between-the-epithelial-mesenchymal-transition-and-immunotherapy-a-bibliometric-study
#22
JOURNAL ARTICLE
Wei Du, Zemin Tang, Ashuai Du, Qinglong Yang, Rong Xu
Immunotherapy has recently attracted considerable attention. However, currently, a thorough analysis of the trends associated with the epithelial-mesenchymal transition (EMT) and immunotherapy is lacking. In this study, we used bibliometric tools to provide a comprehensive overview of the progress in EMT-immunotherapy research. A total of 1,302 articles related to EMT and immunotherapy were retrieved from the Web of Science Core Collection (WOSCC). The analysis indicated that in terms of the volume of research, China was the most productive country (49...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38501434/politics-and-confidence-toward-the-covid-19-vaccination-points-to-be-considered
#23
JOURNAL ARTICLE
Somsri Wiwanitkit, Viroj Wiwanitkit
No abstract text is available yet for this article.
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38497584/mapping-the-intellectual-structure-and-landscape-of-colorectal-cancer-immunotherapy-a-bibliometric-analysis
#24
JOURNAL ARTICLE
Qin Ling Ou, Yong Long Chang, Jin Hui Liu, Hai Xia Yan, Lin Zi Chen, Duan Yang Guo, Si Fang Zhang
Immunotherapy, particularly immune checkpoint inhibitor (ICIs) therapy, stands as an innovative therapeutic approach currently garnering substantial attention in cancer treatment. It has become a focal point of numerous studies, showcasing significant potential in treating malignancies, including lung cancer and melanoma. The objective of this research is to analyze publications regarding immunotherapy for colorectal cancer (CRC), investigating their attributes and identifying the current areas of interest and cutting-edge advancements...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38497583/real-life-experience-on-covid-19-and-seasonal-influenza-vaccines-co-administration-in-the-vaccination-hub-of-the-university-hospital-of-palermo-italy
#25
JOURNAL ARTICLE
Claudio Costantino, Walter Mazzucco, Arianna Conforto, Livia Cimino, Alessia Pieri, Sara Rusignolo, Nicole Bonaccorso, Floriana Bravatà, Laura Pipitone, Martina Sciortino, Marcello Tocco, Elena Zarcone, Giorgio Graziano, Fabio Tramuto, Carmelo Massimo Maida, Alessandra Casuccio, Francesco Vitale
With the pandemic, there has been a global reduction in influenza virus circulation, with WHO reporting, during 2021/22 season, laboratory testing positivity rate for influenza of less than 3%. Influenza surveillance systems anticipated a peak of influenza cases in the Northern Hemisphere during 2022/2023 season and the Italian Ministry of Health recommended the routinary co-administration of influenza with bivalent COVID-19 vaccines for the 2022/2023 season. At the Vaccination Hub of the University Hospital (UH) of Palermo, more than 700 subjects received influenza and COVID-19 booster doses in co-administration, during the 2021/2022 season...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38497448/a-phase-3-single-arm-open-label-study-to-evaluate-the-safety-tolerability-and-immunogenicity-of-a-15-valent-pneumococcal-conjugate-vaccine-v114-in-a-3-1-regimen-in-healthy-infants-in-south-korea-pneu-ped-kor
#26
JOURNAL ARTICLE
Alvino Maestri, Su Eun Park, Fiona Fernandes, Zhongyi Lucy Li, Yae-Jean Kim, Yun-Kyung Kim, Jin Lee, Ji Young Park, Dong Hyun Kim, GyongSeon Yang, Hyunjung Lim, Jin Oh Kim, Robert Lupinacci, Tina M Sterling, Marissa Wilck, Alejandra Esteves-Jaramillo, Natalie Banniettis
There is an ongoing burden of pneumococcal disease in children despite the use of pneumococcal conjugate vaccines (PCVs). This phase 3, open-label, single-arm, multisite, descriptive study was designed to evaluate the safety and immunogenicity of a 3 + 1 regimen of V114 (VAXNEUVANCE™), a 15-valent PCV, in South Korean infants and toddlers. Adverse events (AEs) were reported for 14 d following any vaccination, and throughout the study period for serious AEs. Serotype-specific immunoglobulin G (IgG) response rates (proportion of participants meeting an IgG threshold value of ≥0...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38497413/formulation-development-of-a-stable-influenza-recombinant-neuraminidase-vaccine-candidate
#27
JOURNAL ARTICLE
Bing Li, Irina V Ustyugova, Lisa Szymkowicz, Shaolong Zhu, Marin Ming, Karen Y Y Fung, Guadalupe Cortés, D Andrew James, Michael Hrynyk, Nausheen Rahman, Roger H Brookes, Salvador F Ausar
Current influenza vaccines could be augmented by including recombinant neuraminidase (rNA) protein antigen to broaden protective immunity and improve efficacy. Toward this goal, we investigated formulation conditions to optimize rNA physicochemical stability. When rNA in sodium phosphate saline buffer (NaPBS) was frozen and thawed (F/T), the tetrameric structure transitioned from a "closed" to an "open" conformation, negatively impacting functional activity. Hydrogen deuterium exchange experiments identified differences in anchorage binding sites at the base of the open tetramer, offering a structural mechanistic explanation for the change in conformation and decreased functional activity...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38497273/community-based-participatory-research-as-a-promising-practice-for-addressing-vaccine-hesitancy-rebuilding-trust-and-addressing-health-disparities-among-racial-and-ethnic-minority-communities
#28
JOURNAL ARTICLE
Sophie E O'Bryan, Fatima Muñoz, David Smith, Adriana Bearse, Blanca Melendrez, Biren Kamdar, Cynthia James-Price, Daniel Ramirez, Argentina E Servin
The COVID-19 pandemic disproportionately affected racial and ethnic minority communities across the United States (U.S.). Despite the disproportionate burden of COVID-19 faced by communities of color, Black and Hispanic communities are less likely to be fully vaccinated than White non-Hispanic Persons. Health inequity and vaccine hesitancy are complex phenomena that require multilevel responses tailored to the unique needs of each community, a process that inherently necessitates a high level of community engagement in order to develop the most effective health interventions...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38489031/editorial-to-special-issue-the-power-of-immunoprofiling-supported-by-computational-data-integration-and-machine-learning
#29
EDITORIAL
Elke Bergmann-Leitner
No abstract text is available yet for this article.
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38488143/real-world-effectiveness-of-recombinant-zoster-vaccine-in-self-identified-chinese-individuals-aged-%C3%A2-50-years-in-the-united-states
#30
JOURNAL ARTICLE
Ana Florea, Lina Sy, Lei Qian, Bradley Ackerson, Yi Luo, Jun Wu, Yanjun Cheng, Jennifer Ku, Leticia Vega Daily, Harpreet Takhar, Jeannie Song, Elizabeth Chmielewski-Yee, O'Mareen Spence, Harry Seifert, Driss Oraichi, Hung Fu Tseng
We evaluated the vaccine effectiveness (VE) of two doses of recombinant zoster vaccine (RZV) against herpes zoster (HZ) and postherpetic neuralgia (PHN) in Chinese adults at Kaiser Permanente Southern California (KPSC). Chinese KPSC members were identified based on self-reported ethnicity or self-reported preferred spoken/written language. Those aged ≥50 years who received two doses of RZV 4 weeks to ≤ 6 months apart were matched 1:4 to RZV unvaccinated Chinese members and followed through June 2022; second doses were accrued 6/1/2018-12/31/2020...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38478989/human-vaccines-and-immunotherapeutics-news-february-2024
#31
EDITORIAL
Ronald Ellis, Adam Weiss
No abstract text is available yet for this article.
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38478958/changes-in-vaccine-coverage-and-incidence-of-acute-gastroenteritis-and-severe-rotavirus-gastroenteritis-in-children-5-years-in-shibata-city-niigata-prefecture-japan
#32
JOURNAL ARTICLE
Tomohiro Oishi, Satoshi Hasegawa, Tokushi Nakano, Shoji Sudo, Hiroaki Kuwajima, Shuko Tokuriki, Tsutomu Tamura
Rotavirus (RV) vaccines were first introduced in 2011 and adopted for universal vaccination in 2020 in Japan. However, the effectiveness of RV vaccines after being adopted for universal vaccination in 2020 has not been reported. Because of the easy accessibility of clinics in Japan, many children are not usually hospitalized for RV gastroenteritis (RVGE). Therefore, in order to evaluate the impact of the RV vaccine since 2008, we investigated the incidence of hospitalization for RVGE as well as the frequency of children aged < 5 years who received medical treatment for severe RVGE at clinics in Shibata City, Japan...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38468184/unraveling-the-copper-death-connection-decoding-covid-19-s-immune-landscape-through-advanced-bioinformatics-and-machine-learning-approaches
#33
JOURNAL ARTICLE
Qi Wang, Zhenzhong Su, Jing Zhang, He Yan, Jie Zhang
This study aims to analyze Coronavirus Disease 2019 (COVID-19)-associated copper-death genes using the Gene Expression Omnibus (GEO) dataset and machine learning, exploring their immune microenvironment correlation and underlying mechanisms. Utilizing GEO, we analyzed the GSE217948 dataset with control samples. Differential expression analysis identified 16 differentially expressed copper-death genes, and Cell type Identification By Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) quantified immune cell infiltration...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38466961/protective-doses-of-tetanus-toxoid-immunization-and-its-associated-factors-among-mothers-in-southern-ethiopia
#34
JOURNAL ARTICLE
Maycas Gembe, Teklu Wosenyeleh, Wubishet Gezimu
The World Health Organization recommends tetanus toxoid immunization before or during pregnancy for all women of childbearing age. The goal is to reduce maternal and neonatal mortality due to tetanus. According to the 2016 Ethiopia Demographic and Health Survey (EDHS) report, more than half (51%) of women did not receive protective doses of tetanus immunization. To the best of our knowledge, this study uniquely tried to assess the level of protective doses of tetanus toxoid immunization in southern Ethiopia...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38466197/immunogenicity-of-covid-19-vaccines-in-patients-with-cirrhosis-a-meta-analysis
#35
JOURNAL ARTICLE
Lichen Ouyang, Gang Lei, Yeli Gong
The immunogenicity of COVID-19 vaccines in patients with liver cirrhosis remains largely unknown. The purpose of this meta-analysis was to investigate the immunogenicity of COVID-19 vaccines in patients with cirrhosis and compare the humoral and cellular immune responses following complete COVID-19 vaccination between cirrhosis patients and healthy controls. A systematic literature search was conducted in PubMed, EMBASE, and Web of Science from 1 January 2020 to 22 August 2023. Sixteen studies with 2127 cirrhosis patients were included...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38465886/using-an-extended-information-motivation-behavioral-skills-model-to-explain-hpv-vaccination-intention-among-men-who-have-sex-with-men-only-and-men-who-have-sex-with-men-and-women
#36
JOURNAL ARTICLE
Guiqian Shi, Bing Lin, Haiying Pan, Wei He, Xiaoni Zhong
Men who have sex with men and women (MSMW) have been reported to differ in psychosocial and sexual behavior patterns from men who have sex with men only (MSMO). However, results regarding the differences in HPV vaccination intention/behavior were inconclusive. We compared HPV vaccination intention between MSMO and MSMW and analyzed the differences in potentially associated factors in China. MSM participants were recruited online using a snowball sampling method. Cross-sectional data were collected via a questionnaire based on the extended information-motivation-behavioral skills model...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38465707/seroprevalence-of-tetanus-and-pertussis-antibodies-among-health-care-workers-in-wuhu-china
#37
JOURNAL ARTICLE
Wei Shi, Bingsong Wang, Qinghong Meng, Xianlai Zhang, Zhen Li, Fang He, Fei Ying, Linyan Cong, Kaihu Yao
This study aimed to elucidate the seroprevalence of antibodies to tetanus and pertussis among Chinese health care workers. Blood specimens from health care workers were collected during the 2021 annual medical examination at the First People's Hospital of Wuhu. Commercial ELISA kits were employed to quantify serum IgG antibodies against tetanus toxin (anti-TT IgG) and both IgG and IgA antibodies against pertussis toxin (anti-PT IgG, anti-PT IgA). A concentration of anti-TT IgG exceeding 0.1 IU/ml was deemed seroprotective against tetanus, while concentrations of anti-PT IgG ≥ 50 IU/ml or anti-PT IgA ≥ 15 IU/ml were indicative of a prior pertussis infection...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38465660/using-big-data-to-analyze-the-vaccination-status-of-children-with-congenital-heart-disease-in-yinzhou-district-china
#38
JOURNAL ARTICLE
Lin Zhang, Ziliang Yang, Yueqi Yin, Wenzan Huang, Tianfei Yi, Jianming Ping, Liya Liu, Peng Shen, Yexiang Sun, Hongbo Lin
Congenital heart disease (CHD) represents a significant population warranting particular attention concerning vaccination coverage. To comprehend the vaccination status of CHD within Yinzhou District, Ningbo City, China, and to facilitate the formulation of preventive, control, and immunization strategies against vaccine-preventable diseases in children with congenital heart conditions. Using the China Yinzhou Electronic Health Record Study (CHERRY) database, we analyzed the vaccination coverage of children with CHD born between January 1, 2016 and September 20, 2021, and analyzed the influencing factors associated with the level of vaccination coverage...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38448394/enhanced-passive-safety-surveillance-of-high-dose-and-standard-dose-quadrivalent-inactivated-split-virion-influenza-vaccines-in-germany-and-finland-during-the-2022-23-influenza-season
#39
JOURNAL ARTICLE
Marina Amaral de Avila Machado, Sonja Gandhi-Banga, Sophie Gallo, Tathyana Giannotti Cousseau, Reddappa Maniganahally Byrareddy, Markku Nissilä, Jörg Schelling, Celine Monfredo
Enhanced Passive Safety Surveillance (EPSS) was conducted for quadrivalent inactivated split-virion influenza vaccines (IIV4) in Germany (high dose [HD]) and Finland (standard dose [SD]) for the northern hemisphere (NH) 2022/23 influenza season. The primary objective was to assess adverse events following immunization (AEFI) occurring ≤7 days post-vaccination. In each country, the EPSS was conducted at the beginning of the NH influenza season. Exposure information was documented using vaccination cards (VC), and AEFI were reported via an electronic data collection system or telephone...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38445666/factors-influencing-adverse-events-following-covid-19-vaccination
#40
JOURNAL ARTICLE
Paola Villanueva, Ellie McDonald, Julio Croda, Mariana Garcia Croda, Margareth Dalcolmo, Glauce Dos Santos, Bruno Jardim, Marcus Lacerda, David J Lynn, Helen Marshall, Roberto D Oliveira, Jorge Rocha, Alice Sawka, Fernando Val, Laure F Pittet, Nicole L Messina, Nigel Curtis
Various novel platform technologies have been used for the development of COVID-19 vaccines. In this nested cohort study among healthcare workers in Australia and Brazil who received three different COVID-19-specific vaccines, we (a) evaluated the incidence of adverse events following immunization (AEFI); (b) compared AEFI by vaccine type, dose and country; (c) identified factors influencing the incidence of AEFI; and (d) assessed the association between reactogenicity and vaccine anti-spike IgG antibody responses...
December 31, 2024: Human Vaccines & Immunotherapeutics
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