journal
Journals Human Vaccines & Immunotherape...

Human Vaccines & Immunotherapeutics

https://read.qxmd.com/read/38724010/association-between-combination-covid-19-influenza-vaccination-and-long-covid-in-middle-aged-and-older-europeans-a-cross-sectional-study
#21
JOURNAL ARTICLE
Wenyan Wu, Xiaowei Zheng, Huan Ding, Tongtong Miao, Yuhan Zang, Suwen Shen, Yumeng Gao
The potential impact of combined COVID-19 and influenza vaccination on long COVID remains uncertain. In the present cross-sectional study, we aimed to investigate the plausible association between them in middle-aged and older Europeans based on the Survey of Health, Ageing, and Retirement in Europe (SHARE). A total of 1910 participants were recruited in the analyses. The study outcome was long COVID. Participants were divided into 4 groups through the self-reported status of COVID-19 and influenza vaccination...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38723789/reduced-risk-of-cin2-recurrence-in-women-immunized-with-a-9-valent-hpv-vaccine-post-excision-retrospective-cohort-study
#22
JOURNAL ARTICLE
Vladimír Dvořák, Marek Petráš, Vladimír Dvořák, Danuše Lomozová, Pavel Dlouhý, Ivana Králová Lesná, Radovan Pilka
The main aim of our study was to investigate the specific contribution of a 9-valent human papillomavirus vaccine (9vHPV) to the recurrence risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) in women vaccinated post-excision. Therefore, we conducted a retrospective monocentric cohort study in women aged 22-49 years undergoing conization between 2014 and 2023. The 9vHPV-vaccinated women were matched to unvaccinated women for age and follow-up duration in a 1:2 ratio to eliminate allocation bias...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38723786/exploring-parental-perspectives-maternal-rsv-vaccination-versus-infant-rsv-monoclonal-antibody
#23
JOURNAL ARTICLE
Bryony Treston, Sarah Geoghegan
Respiratory Syncytial Virus poses a significant global public health threat, particularly affecting infants aged less than one year of age. Recently, two forms of passive immunization against infant RSV have been developed and brought to market; nirsevimab a long-acting monoclonal antibody (mAb) and RSV-PreF, a maternal RSV vaccine. The acceptability and uptake of these products will play a pivotal role in determining the success of any national immunization strategy aimed at safeguarding infants from RSV. It is crucial at this time to reflect on the factors that influence parental decisions surrounding immunization to facilitate more informed discussions, enhance healthcare communication, and contribute to the design of effective RSV prevention strategies that resonate with the concerns and aspirations of parents worldwide...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38714332/cost-effectiveness-of-the-adjuvanted-quadrivalent-influenza-vaccine-for-older-adults-in-south-korea
#24
JOURNAL ARTICLE
Youngji Song, Eunha Shim
South Korea's National Immunization Program administers the quadrivalent influenza vaccine (QIV) to manage seasonal influenza, with a particular focus on the elderly. After reviewing the safety and immune response triggered by the adjuvanted QIV (aQIV) in individuals aged 65 and older, the Ministry of Food and Drug Safety in Korea approved its use. However, the extensive impact of aQIV on public health is yet to be fully understood. This study assessed the cost-effectiveness of replacing QIV with aQIV in South Korean adults aged 65 years and older...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38714327/long-term-stability-and-immunogenicity-of-lipid-nanoparticle-covid-19-mrna-vaccine-is-affected-by-particle-size
#25
JOURNAL ARTICLE
Ruimeng Shi, Xueli Liu, Yajuan Wang, Meilu Pan, Shaoqin Wang, Lin Shi, Beibei Ni
Messenger ribonucleic acid (mRNA) technology has been rapidly applied for the development of the COVID-19 vaccine. However, naked mRNA itself is inherently unstable. Lipid nanoparticles (LNPs) protect mRNAs from extracellular ribonucleases and facilitate mRNA trafficking. For mRNA vaccines, antigen-presenting cells utilize LNPs through uptake to elicit antigen-specific immunity. There are reports on the impact of various physical characteristics of LNPs, particularly those with sizes less than 200 nm, especially 50 to 150 nm, on the overall stability and protective efficacy of mRNA vaccines...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38714324/exosome-may-be-the-next-generation-of-promising-cell-free-vaccines
#26
REVIEW
Zelan Dai, Ruiru Cai, Hong Zeng, Hailian Zhu, Youwei Dou, Shibo Sun
Traditional vaccines have limits against some persistent infections and pathogens. The development of novel vaccine technologies is particularly critical for the future. Exosomes play an important role in physiological and pathological processes. Exosomes present many advantages, such as inherent capacity being biocompatible, non-toxic, which make them a more desirable candidate for vaccines. However, research on exosomes are in their infancy and the barriers of low yield, low purity, and weak targeting of exosomes limit their applications in vaccines...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38709953/reply-to-the-enhancing-the-accuracy-of-seroprevalence-studies-reassessing-pertussis-infection-rates-in-eastern-china-during-the-covid-19-pandemic
#27
LETTER
Xiang Sun, Wen Wang
No abstract text is available yet for this article.
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38708779/benefits-challenges-and-strategies-related-to-using-presumptive-recommendations-for-hpv-vaccination-a-qualitative-study-with-rural-and-non-rural-serving-primary-care-professionals
#28
JOURNAL ARTICLE
Olufeyisayo O Odebunmi, Lisa P Spees, Caitlin B Biddell, Tatenda Yemeke, Juan Yanguela, Colleen Higgins, Melissa Gilkey, Sachiko Ozawa, Stephanie B Wheeler
HPV vaccination coverage remains far below the national target of 80% among US adolescents, particularly in rural areas, which have vaccine uptake rates that are 10% points lower than non-rural areas on average. Primary care professionals (PCPs) can increase coverage by using presumptive recommendations to introduce HPV vaccination in a way that assumes parents want to vaccinate. Through semi-structured interviews, we explored PCPs' experiences and perceptions of using presumptive recommendations in rural- and non-rural-serving primary care clinics in North Carolina...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38708549/driving-consistency-cepi-centralized-laboratory-network-s-conversion-factor-initiative-for-sars-cov-2-clinical-assays-used-for-efficacy-assessment-of-covid-vaccines
#29
JOURNAL ARTICLE
Ali Azizi, Gathoni Kamuyu, Deborah Ogbeni, Philipa Levesque-Damphousse, Daniel Knott, Luc Gagnon, Steven Phay-Tran, Bethan Hussey, Pamela Proud, Sue Charlton, Carolyn Clark, Valentina Bernasconi
To date, thousands of SARS-CoV-2 samples from many vaccine developers have been tested within the CEPI-Centralized Laboratory Network. To convert data from each clinical assay to international standard units, the WHO international standard and the CEPI standard generated by the Medicines and Healthcare products Regulatory Agency were run in multiple facilities to determine the conversion factor for each assay. Reporting results in international units advances global understanding of SARS-CoV-2 immunity and vaccine efficacy, enhancing the quality, reliability, and utility of clinical assay data...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38698759/herpes-zoster-in-older-adults-impact-on-carbon-footprint-in-the-united-states
#30
JOURNAL ARTICLE
Desmond Curran, Jacopo Bitetti, Imogen Catterall, Stephen Wincott
We provide estimates for (I) annual herpes zoster (HZ) cases, (II) carbon costs related to healthcare utilization, and (III) annual carbon emissions due to HZ among ≥50 years of age (YOA) United States (US) population. We estimated the annual number of HZ cases in the US based on available incidence data and demographic data of individuals ≥50 YOA. Both the healthcare resource utilization (HCRU) associated with HZ cases and the unit carbon dioxide equivalent (i.e. CO2 e) costs associated with each type of HCRU in the US were estimated based on literature and studies available online...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38698555/global-research-trends-in-car-t-cell-therapy-for-solid-tumors-a-comprehensive-visualization-and-bibliometric-study-2012-2023
#31
JOURNAL ARTICLE
Lele Miao, Juan Zhang, Wei Xu, Qian Qian, Guochao Zhang, Quan Yuan, Yuetao Lv, Haiguo Zhang, Chaoyan Shen, Wei Wang
CAR-T cell therapy has emerged as a significant approach for the management of hematological malignancies. Over the past few years, the utilization of CAR-T cells in the investigation and treatment of solid tumors has gained momentum, thereby establishing itself as a prominent area of research. This descriptive study involved the retrieval of articles about CAR-T cell therapy for solid tumors from the Web of Science Core Collection (WoSCC) database. Subsequently, bibliometric analysis and knowledge map analysis were conducted on these articles...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38696268/deceptive-tactics-misappropriation-of-scientific-literature-by-gazeta-do-povo-in-undermining-covid-19-vaccination-efforts
#32
JOURNAL ARTICLE
Heslley Machado Silva
No abstract text is available yet for this article.
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38695296/seroprevalence-of-igg-antibodies-against-pertussis-toxin-in-the-chinese-population-a-systematic-review-and-meta-analysis
#33
REVIEW
Yao Zhu, Wanting Zhang, Jie Hu, Shuying Luo, Yang Zhou, Xuewen Tang, Rui Yan, Xuan Deng, Hanqing He
Pertussis is a vaccine-preventable infectious disease; however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool the seropositivity rates of IgG antibodies against pertussis toxin (PT-IgG) across the country. We systematically searched PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure Database for studies published between January 1, 2010, and June 30, 2023. Studies reporting the seroprevalence of PT-IgG among a healthy Chinese population were included...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38691025/nucleic-acid-vaccine-candidates-encapsulated-with-mesoporous-silica-nanoparticles-against-mers-cov
#34
JOURNAL ARTICLE
Iman Almansour, B Rabindran Jermy
Middle East respiratory coronavirus (MERS-CoV) is a newly emergent, highly pathogenic coronavirus that is associated with 34% mortality rate. MERS-CoV remains listed as priority pathogen by the WHO. Since its discovery in 2012 and despite the efforts to develop coronaviruses vaccines to fight against SARS-CoV-2, there are currently no MERS-CoV vaccine that has been approved. Therefore, there is high demand to continue on the development of prophylactic vaccines against MERS-CoV. Current advancements in vaccine developments can be adapted for the development of improved MERS-CoV vaccines candidates...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38687024/disparate-kinetics-in-immune-response-of-two-different-haemophilus-influenzae-type-b-conjugate-vaccines-immunogenicity-and-safety-observations-from-a-randomized-controlled-phase-iv-study-in-healthy-infants-and-toddlers-using-a-2-1-schedule
#35
RANDOMIZED CONTROLLED TRIAL
Federico Martinón-Torres, Ignacio Salamanca de la Cueva, Michael Horn, Soeren Westerholt, Samantha Bosis, Nadia Meyer, Brigitte Cheuvart, Navpreet Virk, Rupert W Jakes, Maurine Duchenne, Peter Van den Steen
Since the introduction of Haemophilus Influenzae type b (Hib) conjugate vaccines, invasive Hib disease has strongly declined worldwide, yet continued control of Hib disease remains important. In Europe, currently three different hexavalent combination vaccines containing Hib conjugates are marketed. In this phase IV, single-blind, randomized, controlled, multi-country study (NCT04535037), we aimed to compare, in a 2 + 1 vaccination schedule, the immunogenicity and safety and show non-inferiority, as well as superiority, of DTPa-HBV-IPV/Hib (Ih group) versus DTaP5-HB-IPV-Hib (Va group) in terms of anti-polyribosylribitol phosphate (PRP) antibody geometric mean concentrations (GMCs) and proportion of participants reaching anti-PRP antibody concentrations greater than or equal to a threshold of 5 µg/mL...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38682698/association-between-friends-hesitancy-and-personal-covid-19-vaccine-hesitancy-among-chinese-medical-staff
#36
JOURNAL ARTICLE
Lili Huang, Weiwei Hu, Yanhong Jiang, Weiwen Hong
COVID-19 vaccine hesitancy remains problematic among healthcare workers. Social network influences may shape vaccine decision-making, but few studies have examined this in this critical workforce. We assessed the relationship between friends' COVID-19 vaccination attitudes and personal hesitancy among Chinese healthcare personnel. In December 2022-January 2023, a cross-sectional online survey was conducted at a tertiary hospital in China using WeChat. Of the 1832 healthcare personnel who were invited to answer the structured questionnaire, 613 (33...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38669088/addressing-vaccine-hesitancy-rebuilding-trust-and-addressing-health-disparities-among-racial-and-ethnic-minority-communities-comment
#37
JOURNAL ARTICLE
Amnuay Kleebayoon, Viroj Wiwanitkit
No abstract text is available yet for this article.
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38659106/medical-students-knowledge-about-human-papillomavirus-hpv-hpv-vaccine-and-head-and-neck-cancer
#38
JOURNAL ARTICLE
Norangelys Solis-Torres, Isardo Braverman-Diaz, Luis A Rivera-Morales, Jose J Perez-Sanchez, Valeria S Perez-Bravo, Angel J Neris-Sanchez, Alexis Vera, Yaritza Diaz-Algorri
The Human Papillomavirus (HPV) is a sexually transmitted infection that significantly affects the population worldwide. HPV preventive methods include vaccination, prophylactics, and education. Different types of cancers associated with HPV usually take years or decades to develop after infections, such as Head and Neck Cancer(HNC). Therefore, HPV prevention can be considered cancer prevention. A sample of medical students in Puerto Rico was evaluated to assess their knowledge about HPV, HPV vaccine, and HNC through two previously validated online questionnaires composed of 38 dichotomized questions, we measured HPV, HPV vaccination(HPVK), and HNC knowledge (HNCK)...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38659098/long-survival-after-neoadjuvant-and-adjuvant-camrelizumab-plus-chemotherapy-and-surgery-in-a-patient-with-hepatoid-adenocarcinoma-of-the-lung-a-case-report
#39
JOURNAL ARTICLE
Xuhua Huang, Linhai Zhu, Weifeng Pan, Jian Hu
Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive subtype of lung cancer. The prognosis for patients with HAL is generally poor and currently, there are only limited treatment options. Here, we present a case of a 47-year-old male diagnosed with locally advanced-stage HAL who achieved a remarkably long disease-free survival after receiving neoadjuvant and adjuvant camrelizumab plus chemotherapy and surgery. This case highlights the potential of immunochemotherapy plus surgery in improving outcomes for patients with HAL...
December 31, 2024: Human Vaccines & Immunotherapeutics
https://read.qxmd.com/read/38658178/modeling-outbreaks-of-covid-19-in-china-the-impact-of-vaccination-and-other-control-measures-on-curbing-the-epidemic
#40
JOURNAL ARTICLE
Wenting Zha, Han Ni, Yuxi He, Wentao Kuang, Jin Zhao, Liuyi Fu, Haoyun Dai, Yuan Lv, Nan Zhou, Xuewen Yang
This study aims to examine the development trend of COVID-19 in China and propose a model to assess the impacts of various prevention and control measures in combating the COVID-19 pandemic. Using COVID-19 cases reported by the National Health Commission of China from January 2, 2020, to January 2, 2022, we established a Susceptible-Exposed-Infected-Asymptomatic-Quarantined-Vaccinated-Hospitalized-Removed (SEIAQVHR) model to calculate the COVID-19 transmission rate and Rt effective reproduction number, and assess prevention and control measures...
December 31, 2024: Human Vaccines & Immunotherapeutics
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