Read by QxMD icon Read

Human Vaccines & Immunotherapeutics

Sharad Agarkhedkar, Jugesh Chhatwal, Rajeev Zachariah Kompithra, Sanjay K Lalwani, Arun Narayan, Vinay Muninarayanaswam, Nithya Gogtay, Kristin Stempa, Viviane Gresset-Bourgeois
A quadrivalent split-virion inactivated influenza vaccine (IIV4; Fluzone® Quadrivalent, Sanofi Pasteur) has been available in the US since 2013 for individuals aged ≥ 6 months. Here, we describe the results of an open-label, multicenter trial (WHO Universal Trial Number U1111-1143-8370) evaluating the immunogenicity and safety of IIV4 in Indian children aged 6-35 months and 3-8 years, adolescents aged 9-17 years, and adults aged ≥ 18 years (n = 100 per group). Post-vaccination hemagglutination inhibition titers for all strains in all age groups were ≥ 8 fold higher than at baseline (range, 8-51)...
February 14, 2019: Human Vaccines & Immunotherapeutics
Jing Wang, Dandan Tang, Jialu Wang, Zhaoxia Zhang, Yanxia Chen, Kai Wang, Xueliang Zhang, Cailing Ma
BACKGROUND: Genotype distribution and prevalence of human papillomavirus (HPV) among women vary from different regions and crowds, prophylactic HPV vaccin could prevent some diseases related to HPV, which include cervical precancerous lesions and cancer. Baseline surveys prior to mass HPV vaccination are critical to determine vaccine efficacy and detect changes in HPV type after vaccination. OBJECTIVE: The aim of this study is to study the HPV type-specific prevalence in 698 women with cytological abnormalities, aging from 18 to 77 years old...
February 8, 2019: Human Vaccines & Immunotherapeutics
Stacey B Griner, Erika L Thompson, Cheryl A Vamos, Anil K Chaturvedi, Coralia Vazquez-Otero, Laura K Merrell, Nolan S Kline, Ellen M Daley
Evidence suggests a causal connection between the Human Papillomavirus (HPV) and oropharyngeal cancers. HPV-related oropharyngeal cancers are increasing and are the most common HPV-associated cancer. Previous research suggests that dental professionals recognize a role in the prevention of HPV and oropharyngeal cancers. As an initial step to investigating effective mechanisms of incorporating HPV prevention into dental practices, including the HPV vaccine, this qualitative study explored dental opinion leaders' perspectives on barriers and facilitators to HPV-related prevention in the dental profession...
February 8, 2019: Human Vaccines & Immunotherapeutics
Rachel M Cunningham, G Brady Kerr, Jessica Orobio, Flor M Munoz, Armando Correa, Natalie Villafranco, Ana C Monterrey, Douglas J Opel, Julie A Boom
The Parent Attitudes about Childhood Vaccines (PACV) survey is a validated instrument for identifying vaccine-hesitant parents; however, a Spanish version is not available. Utilizing the WHO framework for translating survey instruments, we used an iterative process for developing the Spanish PACV that included forward translation, expert panel review, back translation and pre-testing that utilized cognitive interviewing. We made revisions to the Spanish PACV at each step, focusing on addressing inclusivity, readability, clarity and conceptual equivalence...
February 8, 2019: Human Vaccines & Immunotherapeutics
Edouard Ledent, Giovanni Gabutti, Esther W De Bekker-Grob, Juan Luis Alcázar, Magda Campins, María Teresa Del Hierro Gurruchaga, María José Fernández Cruz, Giuseppe Ferrera, Francesca Fortunato, Pierfederico Torchio, Giorgio Zoppi, Christian Agboton, Walid Kandeil, Federico Marchetti
Pertussis vaccination of parents and household contacts ('cocooning') to protect newborn infants is an established strategy in many countries, although uptake may be low. Many aspects may influence such decision-making. We conducted a cross-sectional survey (NCT01890447) of households and other close contacts of newborns aged ≤6 months (or of expectant mothers in their last trimester) in Spain and Italy, using an adaptive discrete-choice experiment questionnaire. Aims were to assess the relative importance of attributes influencing vaccine adoption, and to estimate variation in vaccine adoption rates and the impact of cost on vaccination rates...
February 8, 2019: Human Vaccines & Immunotherapeutics
Kristin Oliver, Colleen McCorkell, Ilana Pister, Noora Majid, Denise H Benkel, Jane R Zucker
OBJECTIVE: To identify characteristics associated with human papilloma virus (HPV) vaccination rates, describe barriers and facilitators to vaccine uptake and the potential role for clinician-to-clinician Assessment, Feedback, Incentives, and eXchange (AFIX) visits in school-based health centers (SBHCs). METHODS: We conducted clinician-to-clinician AFIX visits at 24 New York City (NYC) high-school and middle-school SBHCs with up-to-date adolescent vaccination rates below 40%...
February 8, 2019: Human Vaccines & Immunotherapeutics
Ilaria Loperto, Simonetti Andrea, Nardone Antonio, Maria Triassi
Seasonal influenza is a very common disease. Yearly vaccination of at-risk population groups is a well-recognized cost-effective/cost-saving preventive measure. It is, however, unclear which available alternative has the most favorable economic profile. Some available options are: trivalent (TIV) and quadrivalent (QIV) inactivated vaccines, adjuvanted TIV (aTIV). Because of immunosenescence, aTIV has been specifically developed for elderly. The present study aimed at assessing the available evidence of aTIV use in elderly from the economic perspective...
February 8, 2019: Human Vaccines & Immunotherapeutics
January Salas-Mckee, Weimin Kong, Whitney L Gladney, Julie K Jadlowsky, Gabriela Plesa, Megan M Davis, Joseph A Fraietta
The advent of engineered T cells as a form of immunotherapy marks the beginning of a new era in medicine, providing a transformative way to combat complex diseases such as cancer. Following FDA approval of CAR T cells directed against the CD19 protein for the treatment of acute lymphoblastic leukemia and diffuse large B cell lymphoma, CAR T cells are poised to enter mainstream oncology. Despite this success, a number of patients are unable to receive this therapy due to inadequate T cell numbers or rapid disease progression...
February 8, 2019: Human Vaccines & Immunotherapeutics
Catherine A Panozzo, Melissa B Gilkey, Melanie L Kornides, J Frank Wharam
BACKGROUND: Health insurers are well-positioned to address low HPV vaccination coverage in the US through initiatives such as provider assessment and feedback. However, little is known about the feasibility of using administrative claims data to assess provider performance on vaccine delivery. METHODS: We used administrative claims data from a regional health plan to estimate provider performance on the 2013-2015 Healthcare Effectiveness Data and Information Set (HEDIS) measure for HPV vaccine...
February 8, 2019: Human Vaccines & Immunotherapeutics
Ruixiao Du, Qunying Mao, Yalin Hu, Shuhui Lang, Shiyang Sun, Kelei Li, Fan Gao, Lianlian Bian, Ce Yang, Bopei Cui, Longfa Xu, Tong Cheng, Zhenglun Liang
Coxsackievirus A16 (CA16) has caused worldwide epidemics of hand, foot and mouth disease (HFMD), particularly in infants and pre-school children. Currently, there are no vaccines or antiviral drugs available for CA16-associated disease. In this study, a CA16-specific monoclonal antibody (MAb) NA11F12 was derived with an epidemic CA16 strain (GenBank no. JX127258). NA11F12 was found to have high cross-neutralization activity against different CA16 subgenotypes but not EV71 using RD cells. The neutralizing titers of NA11F12 ranged from 1:1024 to 1:12288 against A, B1, B2 and C subgenotypes of CA16 and was less than 8 against EV71 strain...
February 8, 2019: Human Vaccines & Immunotherapeutics
H J Larson, K Hartigan-Go, A DeFigueiredo
No abstract text is available yet for this article.
February 8, 2019: Human Vaccines & Immunotherapeutics
Manami Bhattacharya, Paul L Reiter, Annie-Laurie McRee
Over 43 million immigrants live in the United States (U.S.). Foreign-born populations experience multiple disparities related to human papillomavirus (HPV), including higher cervical cancer mortality rates, yet little research has examined the prevalence of genital HPV infection among this population. We used data from 1,822 women and 1,622 men ages 20-59 in the U.S. who participated in the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Participants reported their nativity status (foreign- vs...
February 8, 2019: Human Vaccines & Immunotherapeutics
Alvaro J Idrovo, Gabriel D Pinilla-Monsalve, Edgar F Manrique-Hernández
The interesting article by Simas et. al. describes an outbreak case with over 600 individuals who exhibited neurological symptoms and which occurred in a town located at the northern region of Colombia in 2014. The community associated this event to the second-dose vaccination campaign against the Human Papillomavirus (HPV) and scientists defined it as a mass psychogenic illness.1,2 Unfortunately, the authors did not include in their article important findings related to a case-control study (with n = 137 and n = 437, respectively), conducted by the Colombian government...
February 8, 2019: Human Vaccines & Immunotherapeutics
Yi-Hua Zhou, Hongyu Huang, Mingzhe Ning, Jingli Liu, Jie Chen, Jing Feng, Yimin Dai, Yali Hu
Hepatitis B e antigen (HBeAg) has been considered to cause immunotolerance to hepatitis B virus (HBV) in newborn infants after fetal HBeAg exposure. This study compared anti-HBs responses to hepatitis B vaccination in infants who were born to HBeAg-positive and -negative mothers respectively, to investigate whether fetal HBeAg exposure may induce immunotolerance to HBV. Totally 265 infants who received recommended neonatal immunoprophylaxis against hepatitis B and had no HBV infection were included. Anti-HBs levels were compared between 124 infants with cord blood positive HBeAg and 141 infants with cord blood negative HBeAg at 7-12 months of age...
February 8, 2019: Human Vaccines & Immunotherapeutics
Wei Duan, Li Zhang, Shuangsheng Wu, Chunna Ma, Ying Sun, Man Zhang, Yi Zhang, Xingxing Zhang, Quanyi Wang, Peng Yang
Background Little is known about the vaccine effectiveness (VE) in attenuating the influenza-associated symptoms in children during the 2014-2015 influenza season in Beijing, China, in which there was a mismatch between the vaccine and circulating strain. Methods This study included 210 laboratory-confirmed influenza cases among children, who were enrolled in 2014, from November 1 to December 31. Standard demographic information and clinical symptoms were recorded. Influenza vaccination was confirmed via a vaccination registry...
February 8, 2019: Human Vaccines & Immunotherapeutics
Arturo Reyes-Sandoval
Chikungunya fever (CHIKF) is a mosquito-borne disease caused by Chikungunya virus (CHIKV). This virus is considered a priority pathogen to the UK government, the US National Institute of Allergy and Infectious Diseases (NIAID) and the US military personnel, due to the potential of CHIKV to cause major outbreaks. Nearly all CHIKV infections are symptomatic, often incapacitating and patients experience severe joint pain and inflammation that can last for more than one year with 0.4-0.5% fatality rates. Mother-to-child transmission has also been described...
February 8, 2019: Human Vaccines & Immunotherapeutics
Ovidiu Tatar, Gilla K Shapiro, Samara Perez, Kristina Wade, Zeev Rosberger
BACKGROUND: Achieving optimal human papillomavirus (HPV) vaccine uptake can be delayed by parents' HPV vaccine hesitancy, which is as a multi-stage intention process rather than a dichotomous (vaccinated/not vaccinated) outcome. Our objective was to longitudinally explore HPV related attitudes, beliefs and knowledge and to estimate the effect of psychosocial factors on HPV vaccine acceptability in HPV vaccine hesitant parents of boys and girls. METHODS: We used an online survey to collect data from a nationally representative sample of Canadian parents of 9-16 years old boys and girls in September 2016 and July 2017...
February 8, 2019: Human Vaccines & Immunotherapeutics
Rachel Herman, Louise-Anne McNutt, Mehek Mehta, Daniel A Salmon, Robert A Bednarczyk, Jana Shaw
BACKGROUND: To assess the knowledge and attitudes of middle school students toward vaccination, we measured their understanding of vaccine safety and effectiveness, expectations for communication with heath care providers, and their desired role in the vaccination decision-making process. METHODS: A cross-sectional, self-administered survey was conducted among seventh and eighth grade students in a middle school in Upstate New York. Bivariate analyses were conducted to identify differences in perspective by gender, grade, and attitudes toward vaccination...
February 8, 2019: Human Vaccines & Immunotherapeutics
Melahat Melek Oguz
Children are at higher risk of influenza complications. The goals of this article are, estimating influenza vaccination coverage of Health Care Workers (HCWs) in tertiary children hospital, evaluating attitudes and practices of HCWs and evaluating whether HCWs vaccination uptake improved with onsite vaccination campaign. This was a before-after trial, which was carried out in a tertiary children hospital at 2017-2018 influenza season. The vaccination team visited all participants and collected information about previous vaccination uptake, attitudes and beliefs of HCWs by means of an anonymous questionnaire...
February 8, 2019: Human Vaccines & Immunotherapeutics
A D Steele, J C Victor, M E Carey, J E Tate, D E Atherly, C Pecenka, Z Diaz, U D Parashar, C D Kirkwood
Rotavirus vaccines have been introduced into over 95 countries globally and demonstrate substantial impact in reducing diarrheal mortality and diarrheal hospitalizations in young children. The vaccines are also considered by WHO as "very cost effective" interventions for young children, particularly in countries with high diarrheal disease burden. Yet the full potential impact of rotavirus immunization is yet to be realized. Large countries with big birth cohorts and where disease burden is high in Africa and Asia have not yet implemented rotavirus vaccines at all or at scale...
February 8, 2019: Human Vaccines & Immunotherapeutics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"