journal
https://read.qxmd.com/read/27069689/serotonin-related-gene-polymorphisms-and-asymptomatic-neurocognitive-impairment-in-hiv-infected-alcohol-abusers
#21
JOURNAL ARTICLE
Karina Villalba, Jessy G Dévieux, Rhonda Rosenberg, Jean Lud Cadet
HIV-infected individuals continue to experience neurocognitive deterioration despite virologically successful treatments. While the cause remains unclear, evidence suggests that HIV-associated neurocognitive disorders (HAND) may be associated with neurobehavioral dysfunction. Genetic variants have been explored to identify risk markers to determine neuropathogenesis of neurocognitive deterioration. Memory deficits and executive dysfunction are highly prevalent among HIV-infected adults. These conditions can affect their quality of life and HIV risk-taking behaviors...
2016: Genetics Research International
https://read.qxmd.com/read/27042357/unique-agg-interruption-in-the-cgg-repeats-of-the-fmr1-gene-exclusively-found-in-asians-linked-to-a-specific-snp-haplotype
#22
JOURNAL ARTICLE
Pornprot Limprasert, Janpen Thanakitgosate, Kanoot Jaruthamsophon, Thanya Sripo
Fragile X syndrome (FXS) is the most common inherited intellectual disability. It is caused by the occurrence of more than 200 pure CGG repeats in the FMR1 gene. Normal individuals have 6-54 CGG repeats with two or more stabilizing AGG interruptions occurring once every 9- or 10-CGG-repeat blocks in various populations. However, the unique (CGG)6AGG pattern, designated as 6A, has been exclusively reported in Asians. To examine the genetic background of AGG interruptions in the CGG repeats of the FMR1 gene, we studied 8 SNPs near the CGG repeats in 176 unrelated Thai males with 19-56 CGG repeats...
2016: Genetics Research International
https://read.qxmd.com/read/27019752/induced-pluripotent-stem-cell-as-a-new-source-for-cancer-immunotherapy
#23
REVIEW
Farzaneh Rami, Halimeh Mollainezhad, Mansoor Salehi
The immune system consists of cells, proteins, and other molecules that beside each other have a protective function for the host against foreign pathogens. One of the most essential features of the immune system is distinguishability between self- and non-self-cells. This function has an important role in limiting development and progression of cancer cells. In this case, the immune system can detect tumor cell as a foreign pathogen; so, it can be effective in elimination of tumors in their early phases of development...
2016: Genetics Research International
https://read.qxmd.com/read/26885398/association-of-rbp4-genotype-with-phenotypic-reproductive-traits-of-sows
#24
JOURNAL ARTICLE
A Marantidis, G P Laliotis, M Avdi
PCR-RFLP was applied to a commercial crossbred pig population in order to investigate the association between polymorphism (SNP) of Retinol-binding protein 4 (RBP4) gene and reproductive performance. 400 sows were genotyped and 2000 records of reproductive traits were used in order to retrieve information about the allele frequencies and the association of the RBP4 gene with main reproductive characteristics of the population. A deviation from the Hardy-Weinberg equilibrium was observed as a result of the AB genotype excess...
2016: Genetics Research International
https://read.qxmd.com/read/26788372/de-novo-assembly-and-transcriptome-characterization-of-canine-retina-using-high-throughput-sequencing
#25
JOURNAL ARTICLE
Bhaskar Reddy, Amrutlal K Patel, Krishna M Singh, Deepak B Patil, Pinesh V Parikh, Divyesh N Kelawala, Prakash G Koringa, Vaibhav D Bhatt, Mandava V Rao, Chaitanya G Joshi
We performed transcriptome sequencing of canine retinal tissue by 454 GS-FLX and Ion Torrent PGM platforms. RNA-Seq analysis by CLC Genomics Workbench mapped expression of 10,360 genes. Gene ontology analysis of retinal transcriptome revealed abundance of transcripts known to be involved in vision associated processes. The de novo assembly of the sequences using CAP3 generated 29,683 contigs with mean length of 560.9 and N50 of 619 bases. Further analysis of contigs predicted 3,827 full-length cDNAs and 29,481 (99%) open reading frames (ORFs)...
2015: Genetics Research International
https://read.qxmd.com/read/26783467/study-of-cysteine-rich-protein-61-genetic-polymorphism-in-predisposition-to-fracture-nonunion-a-case-control
#26
JOURNAL ARTICLE
Sabir Ali, Syed Rizwan Hussain, Ajai Singh, Vineet Kumar, Shah Walliullah, Nazia Rizvi, Manish Yadav, Mohammad Kaleem Ahmad, Abbas Ali Mahdi
Background. Many factors are responsible for this impaired healing, especially in long bones, but a possible genetic predisposition for the development of this complication remains unknown till now. In the present study, we aim to examine the CYR61 gene polymorphism in fracture nonunion patients and the correlation with clinical findings. Materials and Methods. We performed SNP analysis of the CYR61 gene in 250 fracture nonunion patients and 250 healthy subjects were genotyped in this hospital-based case control study, and 56 cases were further evaluated for mRNA expression of CYR61 by real-time quantitative reverse-transcription PCR...
2015: Genetics Research International
https://read.qxmd.com/read/26693353/frequency-distribution-of-mannose-binding-lectin-2-and-vitamin-d-receptor-gene-variants-putative-markers-for-tuberculosis
#27
JOURNAL ARTICLE
Anuroopa Gupta, Harish Padh
Genetic polymorphism in Mannose Binding Lectin-2 (MBL-2) and Vitamin D Receptor (VDR) is known to influence the susceptibility to tuberculosis. The objective of the present study was to evaluate the frequency distribution of the MBL-2 promoter and structural polymorphism (-550 H/L, -221 Y/X, and +4 P/Q; R52C, G54D, and G57F) and VDR polymorphism (FokI, BsmI, TaqI, and ApaI) in healthy individuals of Indian population and comparative analysis with the global population. In Indian population, the frequency of VDR mutant alleles "f" for FokI, "b" for BsmI, "t" for TaqI, and "a" for ApaI was 25%, 54%, 30%, and 61%, respectively...
2015: Genetics Research International
https://read.qxmd.com/read/26688756/association-of-polymorphisms-of-phase-i-metabolizing-genes-with-sister-chromatid-exchanges-in-occupational-workers-exposed-to-toluene-used-in-paint-thinners
#28
JOURNAL ARTICLE
Kanu Priya, Anita Yadav, Neeraj Kumar, Sachin Gulati, Neeraj Aggarwal, Ranjan Gupta
This study investigated genetic damage in paint workers mainly exposed to toluene as it is a major solvent used in paint thinners. Sister chromatid exchange (SCE) assay was used as biomarker of genotoxicity. Blood samples were collected from 30 paint workers and 30 control subjects matched with respect to age and other confounding factors except for exposure to toluene. SCE frequency was found to be significantly higher in paint workers (4.81 ± 0.92) as compared to control individuals (1.73 ± 0.54) (p < 0...
2015: Genetics Research International
https://read.qxmd.com/read/26640714/identification-of-proximal-and-distal-22q11-2-microduplications-among-patients-with-cleft-lip-and-or-palate-a-novel-inherited-atypical-0-6%C3%A2-mb-duplication
#29
JOURNAL ARTICLE
Maryam Sedghi, Hossein Abdali, Mehrdad Memarzadeh, Mansoor Salehi, Narges Nouri, Majid Hosseinzadeh, Nayereh Nouri
Misalignments of low-copy repeats (LCRs) located in chromosome 22, particularly band 22q11.2, predispose to rearrangements. A variety of phenotypic features are associated with 22q11.2 microduplication syndrome which makes it challenging for the genetic counselors to recommend appropriate genetic assessment and counseling for the patients. In this study, multiplex ligation probe dependent amplification (MLPA) analysis was performed on 378 patients with cleft lip and/or palate to characterize rearrangements in patients suspected of 22q11...
2015: Genetics Research International
https://read.qxmd.com/read/26380113/association-study-between-idiopathic-scoliosis-and-polymorphic-variants-of-vdr-igf-1-and-ampd1-genes
#30
JOURNAL ARTICLE
Svetla Nikolova, Vasil Yablanski, Evgeni Vlaev, Luben Stokov, Alexey Slavkov Savov, Ivo Marinov Kremensky
Idiopathic scoliosis (IS) is a complex genetic disorder of the musculoskeletal system, characterized by three-dimensional rotation of the spine with unknown etiology. For the aims of the current study we selected 3 single nucleotide polymorphisms with a low incidence of the polymorphic allele in Bulgarian population, AMPD1 (rs17602729), VDR (rs2228670), and IGF-1 (rs5742612), trying to investigate the association between these genetic polymorphisms and susceptibility to and progression of IS. The polymorphic regions of the genes were amplified by polymerase chain reaction (PCR)...
2015: Genetics Research International
https://read.qxmd.com/read/26090231/genome-wide-gene-expression-in-relation-to-age-in-large-laboratory-cohorts-of-drosophila-melanogaster
#31
JOURNAL ARTICLE
Kimberly A Carlson, Kylee Gardner, Anjeza Pashaj, Darby J Carlson, Fang Yu, James D Eudy, Chi Zhang, Lawrence G Harshman
Aging is a complex process characterized by a steady decline in an organism's ability to perform life-sustaining tasks. In the present study, two cages of approximately 12,000 mated Drosophila melanogaster females were used as a source of RNA from individuals sampled frequently as a function of age. A linear model for microarray data method was used for the microarray analysis to adjust for the box effect; it identified 1,581 candidate aging genes. Cluster analyses using a self-organizing map algorithm on the 1,581 significant genes identified gene expression patterns across different ages...
2015: Genetics Research International
https://read.qxmd.com/read/25883807/genetics-in-genomic-era
#32
JOURNAL ARTICLE
Eugenia Poliakov, David N Cooper, Elena I Stepchenkova, Igor B Rogozin
No abstract text is available yet for this article.
2015: Genetics Research International
https://read.qxmd.com/read/25874133/unlimited-thirst-for-genome-sequencing-data-interpretation-and-database-usage-in-genomic-era-the-road-towards-fast-track-crop-plant-improvement
#33
REVIEW
Arun Prabhu Dhanapal, Mahalingam Govindaraj
The number of sequenced crop genomes and associated genomic resources is growing rapidly with the advent of inexpensive next generation sequencing methods. Databases have become an integral part of all aspects of science research, including basic and applied plant and animal sciences. The importance of databases keeps increasing as the volume of datasets from direct and indirect genomics, as well as other omics approaches, keeps expanding in recent years. The databases and associated web portals provide at a minimum a uniform set of tools and automated analysis across a wide range of crop plant genomes...
2015: Genetics Research International
https://read.qxmd.com/read/25874132/importance-of-genetic-diversity-assessment-in-crop-plants-and-its-recent-advances-an-overview-of-its-analytical-perspectives
#34
REVIEW
M Govindaraj, M Vetriventhan, M Srinivasan
The importance of plant genetic diversity (PGD) is now being recognized as a specific area since exploding population with urbanization and decreasing cultivable lands are the critical factors contributing to food insecurity in developing world. Agricultural scientists realized that PGD can be captured and stored in the form of plant genetic resources (PGR) such as gene bank, DNA library, and so forth, in the biorepository which preserve genetic material for long period. However, conserved PGR must be utilized for crop improvement in order to meet future global challenges in relation to food and nutritional security...
2015: Genetics Research International
https://read.qxmd.com/read/25866679/caspase-activation-and-aberrant-cell-growth-in-a-p53-cell-line-from-a-li-fraumeni-syndrome-family
#35
JOURNAL ARTICLE
Zaki A Sherif
Wild-type p53 is well known to induce cell cycle arrest and apoptosis to block aberrant cell growth. However, p53's unique role in apoptosis and cell proliferation in Li-Fraumeni Syndrome (LFS) has not been well elucidated. The aim of this study is to characterize the activity of wild-type p53 protein in LFS family dominated by a germline negative mutant p53. As expected, etoposide-treated wild-type p53-containing cell lines, LFS 2852 and control Jurkat, showed a greater rate of caspase- and annexin V-induced apoptotic cell death compared to the p53-mutant LFS 2673 cell line although mitochondrial and nuclear assays could not detect apoptosis in these organelles...
2015: Genetics Research International
https://read.qxmd.com/read/25861479/genetic-variant-in-the-cyp19a1-gene-associated-with-coronary-artery-disease
#36
JOURNAL ARTICLE
Konstantina Bampali, Charalampos Grassos, Angeliki Mouzarou, Charalampos Liakos, Georgios Mertzanos, Klea Lamnissou, Dimitrios Babalis
The CYP19A1 gene encodes the enzyme aromatase, which is responsible for the biosynthesis of estrogens. The rs10046 polymorphism of CYP19A1 gene has been investigated in two studies on the occurrence of hypertension, but there are no studies on its correlation with coronary artery disease (CAD). We investigated 189 subjects who were hospitalized at "KAT" General Hospital of Athens and underwent coronary angiography. Of these, 123 were found with CAD with an average age of 60 years and constituted the patients group and 66 subjects with an average age of 58 years without damage in the coronary vessels and constituted the control group (healthy)...
2015: Genetics Research International
https://read.qxmd.com/read/25861478/inheritance-pattern-of-temephos-resistance-an-organophosphate-insecticide-in-aedes-aegypti-l
#37
JOURNAL ARTICLE
Vinaya Shetty, Deepak Sanil, N J Shetty
The present paper reports the mode of inheritance of resistance in laboratory induced temephos resistant and susceptible strains of Ae. aegypti. Homozygous resistant and susceptible strains of Ae. aegypti were generated by selective inbreeding at a diagnostic dose of 0.02 mg/L of temephos. Genetic crosses were carried out between these strains to determine the inheritance pattern of temephos resistance. The log-dosage probit mortality relationships and degree of dominance (D) were calculated. The dosage-mortality (d-m) line of the F 1 generation was nearer to the resistant parent than the susceptible one...
2015: Genetics Research International
https://read.qxmd.com/read/25548681/an-introspective-update-on-the-influence-of-mirnas-in-breast-carcinoma-and-neuroblastoma-chemoresistance
#38
REVIEW
Alessia Carta, Rachel Chetcuti, Duncan Ayers
Chemoresistance to conventional cytotoxic drugs may occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence genes. At abnormal levels, miRNAs can either gain ability to silence tumour suppressor genes or else lose ability to silence oncogenes. miRNAs can also affect pathways that are involved in drug metabolism, such as drug efflux pumps, resulting in a resistant phenotype...
2014: Genetics Research International
https://read.qxmd.com/read/25535590/molecular-characterization-of-sudanese-and-southern-sudanese-chicken-breeds-using-mtdna-d-loop
#39
JOURNAL ARTICLE
Charles E Wani, Ibrahim A Yousif, Muntasir E Ibrahim, Hassan H Musa
The objective of this study was to assess the genetic relationships and diversity and to estimate the amount of gene flow among the five chicken populations from Sudan and South Sudan and commercial strain of egg line White Leghorn chickens. The chicken populations were genotyped using mtDNA D-loop as a molecular marker. PCR product of the mtDNA D-loop segment was 600 bp and 14 haplotypes were identified. The neighbor-joining phylogenetic tree indicated that the indigenous Sudanese chickens can be grouped into two clades, IV and IIIa only...
2014: Genetics Research International
https://read.qxmd.com/read/25431675/mthfr-gene-c677t-polymorphism-in-autism-spectrum-disorders
#40
JOURNAL ARTICLE
Elif Funda Sener, Didem Behice Oztop, Yusuf Ozkul
Aim. Autism is a subgroup of autism spectrum disorders, classified as a heterogeneous neurodevelopmental disorder and symptoms occur in the first three years of life. The etiology of autism is largely unknown, but it has been accepted that genetic and environmental factors may both be responsible for the disease. Recent studies have revealed that the genes involved in the folate/homocysteine pathway may be risk factors for autistic children. In particular, C677T polymorphism in the MTHFR gene as a possible risk factor for autism is still controversial...
2014: Genetics Research International
journal
journal
43800
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.