journal
https://read.qxmd.com/read/38384203/guide-to-rho-d-immune-globulin-in-women-with-molecularly-defined-asian-type-del-c-1227g-a
#1
REVIEW
In Hwa Jeong, SooHo Yu, Tae Yeul Kim, Soo-Young Oh, Duck Cho
Rh hemolytic disease of the fetus and newborn is a potential risk for D-negative mothers who produce anti-D during pregnancy, which can lead to morbidity and mortality in subsequent pregnancies. To prevent this hemolytic disease, Rho(D) immune globulin (RhIG) is generally administered to D-negative mothers without anti-D at 28 weeks of gestation and shortly after delivery. However, current guidelines suggest that pregnant mothers with molecularly defined weak D types 1, 2, 3, 4.0, and 4.1 do not need RhIG as they are unlikely to produce alloanti-D when exposed to fetuses with D-positive red cells...
February 22, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38373793/usefulness-of-component-resolved-diagnosis-of-pollen-food-allergy-syndrome
#2
LETTER
Moon Won Lee, Hyun Ji Lee, Seulgi Moon, Kyung-Hwa Shin
No abstract text is available yet for this article.
February 20, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38373792/educational-outcomes-and-perception-changes-in-medical-students-after-visiting-a-blood-donation-center
#3
JOURNAL ARTICLE
Junseo Lee, Seryeong Kim, Sun Young Jeong, Seug Yun Yoon, Namsu Lee, Jong-Ho Won, Jeong Won Shin, Soon Hyo Kwon, Min-Young Lee, Kyoung Ha Kim
Educating primary care physicians about blood donation and transfusion is critical. The Division of Hematology and Oncology at Soonchunhyang University Seoul Hospital in Korea introduced an on-site educational program termed the Blood Donation Center Visiting Program in the clerkship education for final-year medical students. We evaluated the educational outcomes and changes in perception among medical students after the Blood Donation Center Visiting Program based on a survey. The program was implemented from 2021 to 2023...
February 20, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38373791/evaluating-the-taqman-jr-a-genotyping-method-for-rapidly-predicting-the-presence-of-anti-jr-a-antibodies
#4
JOURNAL ARTICLE
Yu-Kyung Koo, Soon Sung Kwon, Eun Jung Suh, Na Hyeong Kim, Hyun Kyung Kim, Youn Keong Cho, Seung Jun Choi, Sinyoung Kim, Kyung-A Lee
BACKGROUND: The Jra antigen is a high-prevalence red blood cell (RBC) antigen. Reports on cases of fatal hemolytic disease of the fetus and newborn and acute hemolytic transfusion reactions suggest that antibodies against Jra (anti-Jra ) have potential clinical significance. Identifying anti-Jra is challenging owing to a lack of commercially available antisera. We developed an alternative approach to rapidly predict the presence of anti-Jra using the TaqMan single-nucleotide polymorphism (SNP)-genotyping method...
February 20, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38361427/manufacturing-cell-and-gene-therapies-challenges-in-clinical-translation
#5
REVIEW
Na Kyung Lee, Jong Wook Chang
The safety and efficacy of both cell and gene therapies have been demonstrated in numerous preclinical and clinical trials. Chimeric antigen receptor T (CAR-T) cell therapy, which leverages the technologies of both cell and gene therapies, has also shown great promise for treating various cancers. Advancements in pertinent fields have also highlighted challenges faced while manufacturing cell and gene therapy products. Potential problems and obstacles must be addressed to ease the clinical translation of individual therapies...
February 16, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38237930/comparison-of-measurable-residual-disease-in-pediatric-b-lymphoblastic-leukemia-using-multiparametric-flow-cytometry-and-next-generation-sequencing
#6
JOURNAL ARTICLE
Sang Mee Hwang, Inseong Oh, Seok Ryun Kwon, Jee-Soo Lee, Moon-Woo Seong
Measurable residual disease (MRD) testing, a standard procedure in B-lymphoblastic leukemia (B-ALL) diagnostics, is assessed using multiparametric flow cytometry (MFC) and next-generation sequencing (NGS) analysis of immunoglobulin gene rearrangements. We evaluated the concordance between eight-color, two-tube MFC-MRD the LymphoTrack NGS-MRD assays using 139 follow-up samples from 54 pediatric patients with B-ALL. We also assessed the effect of hemodilution in MFC-MRD assays. The MRD-concordance rate was 79...
January 19, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38237929/comparative-analysis-of-ab-vs-abo-specific-plasma-for-desensitization-in-blood-group-o-recipients-an-in-vitro-study
#7
JOURNAL ARTICLE
Young Ae Lim
Neutralizing capacity measurement (NCM) of soluble ABH substances (SAS) in plasma was assessed to guide the selection of the appropriate ABO group of fresh-frozen plasma (FFP) for plasma exchange (PE) in blood group O recipients with ABO-incompatible transplantations. Neutralizing capacity was assessed by measuring anti-A and/or anti-B titers in samples comprising one unit of O FFP and 10 O EDTA plasma samples and subtracting the binary logarithm of the titer in each group with a saline dilution. Ten EDTA plasma samples with Lewis b (Leb ) antigen positivity and 10 sets of pooled FFP from each blood group were used as diluents...
January 19, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38237928/direct-ldl-cholesterol-assay-vs-estimated-equations-in-patients-with-hypertriglyceridemia-or-low-ldl-cholesterol-levels
#8
LETTER
Jennifer Rodríguez-Domínguez, Álvaro Piedra-Aguilera, María Martínez-Bujidos, Susana Malumbres-Serrano, Cristian Morales-Indiano, Carla Fernández-Prendes
No abstract text is available yet for this article.
January 19, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38221747/clinical-practice-guideline-for-blood-based-circulating-tumor-dna-assays
#9
Jee-Soo Lee, Eun Hye Cho, Boram Kim, Jinyoung Hong, Young-Gon Kim, Yoonjung Kim, Ja-Hyun Jang, Seung-Tae Lee, Sun-Young Kong, Woochang Lee, Saeam Shin, Eun Young Song
Circulating tumor DNA (ctDNA) has emerged as a promising tool for various clinical applications, including early diagnosis, therapeutic target identification, treatment response monitoring, prognosis evaluation, and minimal residual disease detection. Consequently, ctDNA assays have been incorporated into clinical practice. In this review, we offer an in-depth exploration of the clinical implementation of ctDNA assays. Notably, we examined existing evidence related to pre-analytical procedures, analytical components in current technologies, and result interpretation and reporting processes...
January 15, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38205527/current-challenges-in-chimeric-antigen-receptor-t-cell-therapy-in-patients-with-b-cell-lymphoid-malignancies
#10
REVIEW
Seok Jin Kim, Sang Eun Yoon, Won Seog Kim
Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy based on genetically engineered T cells derived from patients. The introduction of CAR T-cell therapy has changed the treatment paradigm of patients with B-cell lymphoid malignancies. However, challenging issues including managing life-threatening toxicities related to CAR T-cell infusion and resistance to CAR T-cell therapy, leading to progression or relapse, remain. This review summarizes the issues with currently approved CAR T-cell therapies for patients with relapsed or refractory B-cell lymphoid malignancies, including lymphoma and myeloma...
January 11, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38205526/association-between-aortic-valve-sclerosis-and-clonal-hematopoiesis-of-indeterminate-potential
#11
JOURNAL ARTICLE
Minkwan Kim, Jin Ju Kim, Seung-Tae Lee, Yeeun Shim, Hyeonah Lee, SungA Bae, Nak-Hoon Son, Saeam Shin, In Hyun Jung
BACKGROUND: The mechanism and medical treatment target for degenerative aortic valve disease, including aortic stenosis, is not well studied. In this study, we investigated the effect of clonal hematopoiesis of indeterminate potential (CHIP) on the development of aortic valve sclerosis (AVS), a calcified aortic valve without significant stenosis. METHODS: Participants with AVS (valves ≥2 mm thick, high echogenicity, and a peak transaortic velocity of <2...
January 11, 2024: Annals of Laboratory Medicine
https://read.qxmd.com/read/38151855/twins-with-an-identical-novel-mutation-in-itgb3-a-case-report-of-glanzmann-thrombasthenia-like-syndrome
#12
LETTER
Jaewoong Lee, Jong-Mi Lee, Hoon Seok Kim, Jin Jung, Yonggoo Kim, Suk Young Park, Myungshin Kim, Eunhee Han
No abstract text is available yet for this article.
December 28, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38151854/optimization-of-a-protocol-for-isolating-cell-free-dna-from-cerebrospinal-fluid
#13
JOURNAL ARTICLE
Ho Hyun Song, Hyeran Park, Doohwan Cho, Hae In Bang, Hyuk-Jin Oh, Jieun Kim
A standardized protocol for the isolation of cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) is lacking. Therefore, we established a cfDNA isolation protocol optimized for clinical CSF specimens, integrating acceptable modifications and using artificial CSF generated from remnant CSF spiked with reference cell-free tumor DNA (ctDNA). We compared the isolation yields of in vitro diagnostic (IVD)-certified column-based (CB) and magnetic bead-based (MB) isolation. Furthermore, we modified both methods, including pre- and post-elution steps...
December 28, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38145894/toward-standardization-of-flow-cytometric-immunophenotyping-for-the-diagnosis-and-monitoring-of-hematologic-malignancies
#14
EDITORIAL
Seon Young Kim, Hee Jin Huh
No abstract text is available yet for this article.
December 26, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38145893/the-first-case-of-congenital-nephrogenic-diabetes-insipidus-caused-by-avpr2-disruption-because-of-4q25-insertional-translocation
#15
LETTER
Boram Kim, Yo Han Ahn, Jae Hyeon Park, Han Sol Lim, Seung Won Chae, Jee-Soo Lee, Hee Gyung Kang, Man Jin Kim, Moon-Woo Seong
No abstract text is available yet for this article.
December 26, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38145892/-nup214-rearrangements-in-leukemia-patients-a-case-series-from-a-single-institution
#16
JOURNAL ARTICLE
Yu Jeong Choi, Young Kyu Min, Seung-Tae Lee, Jong Rak Choi, Saeam Shin
BACKGROUND: The three best-known NUP214 rearrangements found in leukemia ( SET:: NUP214 , NUP214 ::ABL1 , and DEK:: NUP214 ) are associated with treatment resistance and poor prognosis. Mouse experiments have shown that NUP214 rearrangements alone are insufficient for leukemogenesis; therefore, the identification of concurrent mutations is important for accurate assessment and tailored patient management. Here, we characterized the demographic characteristics and concurrent mutations in patients harboring NUP214 rearrangements...
December 26, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38145891/current-status-of-flow-cytometric-immunophenotyping-of-hematolymphoid-neoplasms-in-korea
#17
JOURNAL ARTICLE
Mikyoung Park, Jihyang Lim, Ari Ahn, Eun-Jee Oh, Jaewoo Song, Kyeong-Hee Kim, Jin-Yeong Han, Hyun-Woo Choi, Joo-Heon Park, Kyung-Hwa Shin, Hyerim Kim, Miyoung Kim, Sang-Hyun Hwang, Hyun-Young Kim, Duck Cho, Eun-Suk Kang
BACKGROUND: Flow cytometric immunophenotyping of hematolymphoid neoplasms (FCI-HLN) is essential for diagnosis, classification, and minimal residual disease (MRD) monitoring. FCI-HLN is typically performed using in-house protocols, raising the need for standardization. Therefore, we surveyed the current status of FCI-HLN in Korea to obtain fundamental data for quality improvement and standardization. METHODS: Eight university hospitals actively conducting FCI-HLN participated in our survey...
December 26, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38098301/performance-evaluation-of-the-roche-cobas-5800-hbv-and-hcv-tests-comparison-of-the-200-and-500-%C3%AE-l-protocols
#18
JOURNAL ARTICLE
Seri Jeong, Su Kyung Lee, Eun-Jung Cho, Han-Sung Kim, Young Kyung Lee, Jae-Seok Kim, Wonkeun Song, Hyun Soo Kim
BACKGROUND: Clinical management of patients infected with hepatitis B virus (HBV) or hepatitis C virus (HCV) relies on the viral load (VL). The Cobas 5800 system (Roche Diagnostics) can determine VLs in 200 and 500 μL samples, but the performance of each protocol has not been compared. We evaluated the performance of both protocols for the HBV and HCV tests. METHODS: Precision and linearity were verified using commercial panels. Probit analyses were used to determine limits of detection (LoDs)...
December 15, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38098300/optimizing-the-hospital-blood-bank-stock-in-korea-a-comparative-analysis-of-the-uniform-5-day-stock-index-and-a-novel-blood-stock-index
#19
JOURNAL ARTICLE
Seo-Jin Park, Young Ae Lim, Kyung-Hee Kim
BACKGROUND: Maintaining optimal blood inventory levels in hospitals is important to prevent blood shortage and wastage. We aimed to provide an efficient blood inventory management strategy for hospital blood banks nation-wide by comparing the current use of 5-day issuable stock (IS) with Lim's IS as a novel target IS. METHODS: The average and CV of daily usage (DU) were calculated from information entered into Korea's Blood Management System by 194 participating hospitals in 2019 and 2020...
December 15, 2023: Annals of Laboratory Medicine
https://read.qxmd.com/read/38087945/neutralization-testing-based-immunogenicity-analysis-of-recent-prevalent-severe-acute-respiratory-syndrome-coronavirus-2-omicron-sublineages
#20
JOURNAL ARTICLE
Eun Ju Lee, Hyeokjin Lee, Sang Won O, Jee Eun Rhee, Jeong-Min Kim, Dong Ju Kim, Il-Hwan Kim, Jin Sun No, Ae Kyung Park, Jeong-Ah Kim, Chae Young Lee, Young-Ki Choi, Eun-Jin Kim
Although WHO declared the end of the public health emergency for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), XBB lineages continue to evolve and emerge globally. In particular, XBB.1.5 and XBB.1.16 are raising concerns because of their high immune evasion, leading to apprehensions regarding vaccine efficacy reduction and potential reinfection. We aimed to investigate the COVID-19 outbreak in Korea and predict the likelihood of reinfection by testing neutralizing activity against live viruses from the S clade and 19 Omicron sublineages...
December 13, 2023: Annals of Laboratory Medicine
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