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Annals of Laboratory Medicine

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https://read.qxmd.com/read/30623629/comparison-of-method-group-precision-in-proficiency-testing-of-clinical-chemistry-tests-before-and-after-two-major-changes-reorganization-of-proficiency-testing-and-implementation-of-the-differential-benefit-for-the-quality-of-laboratory-tests
#1
https://read.qxmd.com/read/30623628/septicemia-caused-by-herbaspirillum-huttiense-secondary-to-pneumonia
#2
Changseung Liu, Mi Jeong Kwon, Myungsook Kim, Jung Hyun Byun, Dongeun Yong, Kyungwon Lee
No abstract text is available yet for this article.
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623627/association-between-prolonged-closure-time-on-the-platelet-function-analyzer-200-and-risk-of-perioperative-blood-transfusion
#3
Kibum Jeon, Jiwon Lee, Eunyup Lee, Jeesoo Lee, Miyoung Kim, Han Sung Kim, Hee Jung Kang, Young Kyung Lee
No abstract text is available yet for this article.
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623626/-flt3-internal-tandem-duplication-in-patients-with-acute-myeloid-leukemia-is-readily-detectable-in-a-single-next-generation-sequencing-assay-using-the-pindel-algorithm
#4
Borahm Kim, SooJeong Kim, Seung Tae Lee, Yoo Hong Min, Jong Rak Choi
No abstract text is available yet for this article.
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623625/age-specific-cutoffs-of-the-sysmex-uf-1000i-automated-urine-analyzer-for-rapid-screening-of-urinary-tract-infections-in-outpatients
#5
Hyunji Kim, Hye Ryoun Kim, Tae Hyoung Kim, Mi Kyung Lee
We investigated the usefulness of age-specific cutoffs for screening of urinary tract infections (UTIs) in Korean outpatients, using the automated urine analyzer UF-1000i (Sysmex, Kobe, Japan). We retrospectively reviewed outpatient medical records. Urine samples of 7,443 outpatients from January 2010 to December 2017 were analyzed using urine culture and UF-1000i. ROC curves were calculated for each UF-1000i parameter based on the culture results. There were 1,398 culture positive samples, 5,774 culture negative samples, and 271 contaminated samples...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623624/laboratory-diagnosis-of-clostridium-difficile-infection-in-korea-the-first-national-survey
#6
Hae Sun Chung, Jeong Su Park, Bo Moon Shin
In May 2015, we conducted a voluntary online survey on laboratory diagnostic assays for Clostridium difficile infection (CDI) across clinical microbiology laboratories in Korea. Responses were obtained from 66 laboratories, including 61 hospitals and five commercial laboratories. Among them, nine laboratories reported having not conducted CDI assays. The toxin AB enzyme immunoassay (toxin AB EIA), nucleic acid amplification test (NAAT), and C. difficile culture, alone or in combination with other assays, were used in 51 (89...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623623/reclassification-of-acute-myeloid-leukemia-according-to-the-2016-who-classification
#7
Jin Jung, Byung Sik Cho, Hee Je Kim, Eunhee Han, Woori Jang, Kyungja Han, Jae Wook Lee, Nack Gyun Chung, Bin Cho, Myungshin Kim, Yonggoo Kim
We reviewed our leukemia database to reclassify 610 patients previously diagnosed as having acute myeloid leukemia (AML) according to the updated 2016 WHO classification. Nine patients were categorized as having myelodysplastic syndrome and myeloid neoplasms with germline predisposition. AML with recurrent genetic abnormalities accounted for 57.4% (345/601) of the patients under the 2016 WHO classification. AML with mutated NPM1 was the most common form (16.5%), with the majority associated with monocytic differentiation (63...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623622/chromosomal-microarray-analysis-as-a-first-tier-clinical-diagnostic-test-in-patients-with-developmental-delay-intellectual-disability-autism-spectrum-disorders-and-multiple-congenital-anomalies-a-prospective-multicenter-study-in-korea
#8
Woori Jang, Yonggoo Kim, Eunhee Han, Joonhong Park, Hyojin Chae, Ahlm Kwon, Hayoung Choi, Jiyeon Kim, Jung Ok Son, Sang Jee Lee, Bo Young Hong, Dae Hyun Jang, Ji Yoon Han, Jung Hyun Lee, So Young Kim, In Goo Lee, In Kyung Sung, Yeonsook Moon, Myungshin Kim, Joo Hyun Park
BACKGROUND: To validate the clinical application of chromosomal microarray analysis (CMA) as a first-tier clinical diagnostic test and to determine the impact of CMA results on patient clinical management, we conducted a multicenter prospective study in Korean patients diagnosed as having developmental delay/intellectual disability (DD/ID), autism spectrum disorders (ASD), and multiple congenital anomalies (MCA). METHODS: We performed both CMA and G-banding cytogenetics as the first-tier tests in 617 patients...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623621/detection-of-autoantibodies-against-nucleoporin-p62-in-sera-of-patients-with-primary-biliary-cholangitis
#9
Alicja Bauer, Andrzej Habior
BACKGROUND: Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by specific autoantibodies. We evaluated the prevalence of autoantibodies against nucleoporin p62 (anti-p62) in PBC patients' sera to determine whether it can be a marker for PBC, in comparison with other immunological and biochemical parameters. We validated the performance of our in-house ELISA technique. METHODS: Serum samples were collected from 135 PBC patients. Thirty patients with primary sclerosing cholangitis (PSC) and 30 with autoimmune hepatitis (AIH) were included as pathological controls, and 40 healthy blood donors served as healthy controls...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623620/neopterin-levels-and-indoleamine-2-3-dioxygenase-activity-as-biomarkers-of-immune-system-activation-and-childhood-allergic-diseases
#10
Songül Ünüvar, Duygu Erge, Bilge Kılıçarslan, Harika Gözde Gözükara Bağ, Ferhat Çatal, Gözde Girgin, Terken Baydar
BACKGROUND: Although Th2 immune activation is predominant in allergic diseases, neopterinlevels and indoleamine 2,3-dioxygenase (IDO)-1 activity (kynurenine:tryptophan ratio), which reflect Th1 immune activity, increase with interferon-gamma (IFN-γ) stimulation. We investigated neopterin, tryptophan, and kynurenine levels as biomarkersof the Th1 immune system activation and changes in IDO-1 activityin children with asthma, allergic rhinitis, and atopic dermatitis, as well as the relationship between these biomarkers and the total IgE level, age, and disease severity...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623619/small-red-blood-cell-fraction-on-the-uf-1000i-urine-analyzer-as-a-screening-tool-to-detect-dysmorphic-red-blood-cells-for-diagnosing-glomerulonephritis
#11
Hyunjung Kim, Young Ok Kim, Yonggoo Kim, Jin Soon Suh, Eun Jung Cho, Hae Kyung Lee
BACKGROUND: Dysmorphic red blood cells (dRBCs) are first-line biomarkers for detecting glomerulonephritis (GN) in patients with hematuria. The UF-1000i system (Sysmex, Kobe, Japan), based on flow cytometry, provides small red blood cell (RBC) values (UF-1000i [UF]-%sRBCs). We evaluated the clinical application of UF-%sRBCs for detecting %dRBCs and GN. METHODS: Urine samples of 103 patients (47 with GN; 56 without GN [NGN]) were analyzed using UF-1000i urinalysis, phase-contrast microscopy (PCM), and urine chemistry...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623618/dried-blood-spot-multiplexed-steroid-profiling-using-liquid-chromatography-tandem-mass-spectrometry-in-korean-neonates
#12
Rihwa Choi, Hyung Doo Park, Hyeon Ju Oh, Kyounghoon Lee, Junghan Song, Soo Youn Lee
BACKGROUND: Screening for congenital adrenal hyperplasia (CAH) using immunoassays for 17α-hydroxyprogesterone generates many false-positive results. We developed and validated a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous quantification of nine steroid hormones in dried blood spot (DBS) samples, and established reference intervals for these hormones. METHODS: We examined our method for linearity, precision, accuracy, extraction recovery, and matrix effects and determined the reference intervals of cortisol, 17α-hydroxyproges-terone, 11-deoxycortisol, 21-deoxycortisol, androstenedione, corticosterone, 11-deoxycorticosterone, testosterone, and progesterone in 1,146 DBS samples (from 272 preterm and 874 full-term neonates)...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623617/diagnostic-accuracy-of-the-risk-of-ovarian-malignancy-algorithm-in-clinical-practice-at-a-single-hospital-in-korea
#13
Haeil Park, Jae Eun Shin, Dae Woo Lee, Min Jeong Kim, Hae Nam Lee
BACKGROUND: The risk of ovarian malignancy algorithm (ROMA) is used for assessing ovarian cancer risk in women with a pelvic mass. Its diagnostic accuracy is variable. We investigated whether the clinically acceptable minimal sensitivity of >80.0% could be obtained with the suggested cutoff of 7.4%/25.3% for pre/postmenopausal women and with adjusted cutoffs set to a specificity of ≥75.0% or a sensitivity of 95.0%, in a hospital with a lower ovarian cancer (OC) prevalence than previously reported...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623616/analytical-and-clinical-performance-of-the-nanopia-krebs-von-den-lungen-6-assay-in-korean-patients-with-interstitial-lung-diseases
#14
Eun Jung Cho, Kyoung Jin Park, Dae Hyun Ko, Hyun Jung Koo, Sang Min Lee, Jin Woo Song, Woochang Lee, Hae Kyung Lee, Kyung Hyun Do, Sail Chun, Won Ki Min
BACKGROUND: Krebs von den Lungen 6 (KL-6) is a sensitive marker for diagnosing, monitoring, and predicting the prognoses of interstitial lung diseases (ILDs). This study aimed to evaluate the performance of the Nanopia KL-6 assay (Sekisui Medical, Tokyo, Japan) and to test the relationship between KL-6 concentrations and clinical results. METHODS: In total, 230 patients diagnosed as having ILDs were enrolled. All underwent high-resolution computed tomography (HRCT) followed by the pulmonary function test (PFT)...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623615/accurate-and-rapid-measurement-of-glycated-hemoglobin-using-hlc-723-g11-variant-mode
#15
Min Seung Park, Kyunghoon Lee, Kyunghoon Lee, Junghan Song, Hyung Doo Park
BACKGROUND: Type II diabetes mellitus causes many complications, and its prevalence continues to increase in Korea. Accurate measurement of glycated Hb (HbA1c) is important because of its usefulness in diagnosis, follow-up, and prediction of prognosis. We tested the analytical performance of the HLC-723 G11 Variant Mode (G11vr; Tosoh Bioscience, Inc., Tokyo, Japan), recently introduced to Korea, in detecting HbA1c. METHODS: We evaluated precision, linearity, carry-over, and turnaround time...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30623614/comparison-of-clinical-performance-between-bact-alert-virtuo-and-bact-alert-3d-blood-culture-systems
#16
Seong Chun Kim, Seungjun Lee, Sunjoo Kim, Oh Hyun Cho, Hyunwoong Park, Seong Mi Yu
BACKGROUND: BacT/Alert Virtuo (BioMérieux, Durham, NC, USA) is a recently developed blood culture system that includes functions of automatic registration, loading, and unloading of the blood culture bottles, as well as measurement of blood volume. We compared the performances between the BacT/Alert Virtuo and 3D (BioMérieux) blood culture systems. METHODS: A total of 952 patients (1,904 sets) visiting an university-affiliated hospital in Korea for blood cultures were enrolled...
May 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30430792/erratum-novel-4-bp-intronic-deletion-c-1560-3_1560-6del-in-lemd3-in-a-korean-patient-with-osteopoikilosis
#17
(no author information available yet)
This corrects the article on p. 540 in vol. 37, PMID: 28840995.
March 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30430791/advantages-of-array-comparative-genomic-hybridization-using-buccal-swab-dna-for-detecting-pallister-killian-syndrome
#18
LETTER
Veronica Bertini, Simone Gana, Alessandro Orsini, Alice Bonuccelli, Diego Peroni, Valetto Angelo
No abstract text is available yet for this article.
March 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30430790/the-first-case-of-congenital-prekallikrein-deficiency-in-korea-with-a-novel-pathogenic-variant-c-1198g-t
#19
LETTER
Sohee Ryu, Ja Yoon Gu, Kyung Taek Hong, Doo Hee Han, Hyun Kyung Kim
No abstract text is available yet for this article.
March 2019: Annals of Laboratory Medicine
https://read.qxmd.com/read/30430789/centromere-protein-f-like-pattern-in-a-patient-with-rheumatoid-arthritis
#20
LETTER
Kyuhwa Hur, La He Jearn, Think You Kim
No abstract text is available yet for this article.
March 2019: Annals of Laboratory Medicine
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