Tazeen Khan, Shilpa Naagar, Parvathy R Nair, Damarla Haritha, Preeti Yadav, Sudip Kumar Datta, Sulagna Bhattacharjee, Yashdeep Gupta, Dalim Kumar Baidya, Rahul Kumar Anand, Bikash Ranjan Ray, Shiba Ansari, Rajeshwari Subramaniam, Souvik Maitra
BACKGROUND: Insulin resistance is often implicated as a risk factor of cell-mediated immune dysfunction in sepsis patients and results in poor clinical outcome. However, it is unclear whether early insulin resistance is contributory to T-cell dysfunction and poor clinical outcome in coronavirus disease 2019 (COVID-19) patients. METHODS: Adult patients with moderate-to-severe or critically ill COVID-19 infection were included in this study. Serum samples were collected at the time of diagnosis for fasting plasma glucose, serum insulin, serum cortisol, and serum glucagon measurements, and the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) score was calculated...
2024: International Journal of Critical Illness and Injury Science