journal
Journals Journal of Trauma and Acute Ca...

Journal of Trauma and Acute Care Surgery

https://read.qxmd.com/read/38605437/direct-red-blood-cell-effect-on-thrombosis-is-dependent-on-the-interaction-of-tissue-factor-and-calcium-with-membrane-phosphatidylserine
#1
JOURNAL ARTICLE
Adam D Price, Ryan C Chae, Taylor E Wallen, Ellen R Becker, Matthew R Baucom, Rebecca Schuster, Lisa England, Timothy A Pritts, Michael D Goodman
BACKGROUND: Prior literature has implicated Red Blood Cells (RBCs) in the initiation of thrombosis and suggests that post-transfusion hypercoagulability may occur secondary to the effects of RBCs. Elevated serum tissue factor is a known sequelae of acute trauma. Phosphatidylserine is a pro-thrombotic phospholipid present within the RBC cell membrane. We hypothesized that RBC aggregation is dependent on the interaction between RBC membrane bound (exposed) PS, extracellular calcium, and tissue factor...
April 12, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595274/warfarin-not-direct-oral-anticoagulants-nor-antiplatelet-therapy-is-associated-with-increased-bleeding-risk-in-emergency-general-surgery-patients-implications-in-this-new-era-of-novel-anticoagulants-an-east-multicenter-study
#2
JOURNAL ARTICLE
Seema P Anandalwar, Lindsay O'Meara, Roumen Vesselinov, Ashling Zhang, Jeffrey N Baum, Amanda Cooper, Cassandra Decker, Thomas Schroeppel, Jenny Cai, Daniel Cullinane, Richard D Catalano, Nikolay Bugaev, Madison LeClair, Christina Feather, Katherine McBride, Valerie Sams, Pak Shan Leung, Samantha Olafson, Devon S Callahan, Joseph Posluszny, Simon Moradian, Jordan Estroff, Beth Hochman, Natasha Coleman, Anna Goldenberg-Sandau, Jeffry Nahmias, Kathryn Rosenbaum, Jason Pasley, Lindsay Boll, Leah Hustad, Jessica Reynolds, Michael Truitt, Mira Ghneim
INTRODUCTION: To assess perioperative bleeding complications & in-hospital mortality in patients requiring emergency general surgery (EGS) presenting with a history of antiplatelet (AP) vs. direct oral anticoagulant (DOAC) vs warfarin use. METHODS: Prospective observational study across 21 centers between 2019-2022. Inclusion criteria were age ≥ 18 years, & DOAC, warfarin or AP use within 24 hours of an EGSP. Outcomes included perioperative bleeding and in-hospital mortality...
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595271/comparison-of-law-enforcement-officer-versus-emergency-medical-services-placed-tourniquets
#3
JOURNAL ARTICLE
Dhara Shukla, Geoff Shapiro, E Reed Smith, Babak Sarani
INTRODUCTION: Tourniquet (TQ) use for hemorrhage control is a core skill for many law enforcement officers (LEO) and all emergency medical services (EMS) providers. However, LEO TQ training is not as intensive as EMS. Overuse of TQ can result in over triage. We hypothesize that LEO are more liberal than EMS with TQ placement. METHODS: A seven-year retrospective, single center study of adult patients who had a TQ placed in the field was conducted. Data were stratified by provider who placed the TQ...
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595266/plasma-proteomics-profile-based-comparison-of-torso-versus-brain-injury-a-prospective-cohort-study
#4
JOURNAL ARTICLE
Jotaro Tachino, Yuki Togami, Hisatake Matsumoto, Tsunehiro Matsubara, Shigeto Seno, Hiroshi Ogura, Jun Oda
INTRODUCTION: Trauma-related deaths and post-traumatic sequelae are a global health concern, necessitating a deeper understanding of the pathophysiology to advance trauma therapy. Proteomics offers insights into identifying and analyzing plasma proteins associated with trauma and inflammatory conditions; however, current proteomic methods have limitations in accurately measuring low-abundance plasma proteins. This study compared plasma proteomics profiles of patients from different acute trauma subgroups to identify new therapeutic targets and devise better strategies for personalized medicine...
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595231/contemporary-diagnosis-and-management-of-colorectal-injuries-what-you-need-to-know
#5
JOURNAL ARTICLE
Adam Fields, Ali Salim
Colorectal injuries are commonly encountered by trauma surgeons. The management of colorectal injuries has evolved significantly over the past several decades, beginning with wartime experience and subsequently refining with prospective randomized studies. Colon injuries were initially nonoperative, evolved towards fecal diversion for all, then became anatomic based with resection and primary anastomosis with selective diversion, and now primary repair, resection with primary anastomosis, or delayed anastomosis after damage control laparotomy are all commonplace...
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595230/should-soldiers-take-oral-tranexamic-acid-before-going-into-battle
#6
JOURNAL ARTICLE
Nicolas Cazes, Simon-Pierre Corcostegui, Steven Lovi, Emeric Romary, Vincent Desrobert, Lionel Lidzborski, Clément Derkenne
Tranexamic acid is an inexpensive antifibrinolytic treatment that reduces morbidity and mortality in civilian and military trauma patients. It must be administered within 3 hours of the injury, and its efficacy is greater the earlier it is given. It is already used preventively in the civilian environment in a number of indications to reduce bleeding and bleeding-related mortality. We wondered about the potential benefits of preventive oral administration of tranexamic acid prior to an assault for military personnel with a potential risk of injury...
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595229/the-difficult-cholecystectomy-what-you-need-to-know
#7
JOURNAL ARTICLE
Anupamaa Seshadri, Andrew B Peitzman
This review discusses the grading of cholecystitis, the optimal timing of cholecystectomy, adopting a culture of safe cholecystectomy, understanding the common error traps that can lead to intraoperative complications and how to avoid them. The Tokyo Guidelines, AAST, Nassar and Parkland scoring systems are discussed. The patient factors, physiologic status and operative findings that predict a difficult cholecystectomy or conversion from laparoscopic to open cholecystectomy are reviewed. With laparoscopic expertise and patient conditions that are not prohibitive, early laparoscopic cholecystectomy is recommended...
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595222/response-to-the-letter-to-the-editor-for-our-article-entitled-a-pseudo-dilemma-are-we-over-diagnosing-and-over-treating-traumatic-splenic-intraparenchymal-pseudoaneurysms
#8
JOURNAL ARTICLE
Melike N Harfouche, Rishi Kundi, Thomas M Scalea
No abstract text is available yet for this article.
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38595220/is-barbed-better-evaluation-of-triclosan-coated-barbed-suture-on-wound-complications-following-emergency-laparotomy
#9
JOURNAL ARTICLE
Joshua Dilday, Patrick McGillen, Stephen Park, Shea Gallagher, Heewon Lee, Morgan Schellenberg, Kazuhide Matsushima, Kenji Inaba, Matthew J Martin
INTRODUCTION: Emergent laparotomy is associated with significant wound complications including surgical site infections (SSI) and fascial dehiscence (FD). Triclosan-coated barbed suture (TCB) for fascial closure has been shown to reduce local complications but primarily in elective settings. We sought to evaluate the effect of TCB emergency laparotomy fascial closure on major wound complications. METHODS: Adult patients undergoing emergency laparotomy were prospectively evaluated over 1-year...
April 10, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38587897/investigation-and-validation-of-the-teg6s-during-rotary-wing-aeromedical-flight
#10
JOURNAL ARTICLE
James Bardes, Daniel Grabo, Aaron Shmookler, Sijin Wen, Alison Wilson
INTRODUCTION: In order to improve rural and austere trauma care, hospital-based testing performed at the point of injury may shorten the time lapsed from injury to intervention. This study aimed to evaluate the use of the TEG6s® device in a rotary wing aircraft. Prior attempts suffered from limitation related to lack of vibration mitigation. METHODS: This was an investigator initiated, industry supported study. Haemonetics® provided a TEG6s® analyzer...
April 8, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38587892/i-would-not-change-a-thing
#11
JOURNAL ARTICLE
Amy J Goldberg
No abstract text is available yet for this article.
April 8, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38587878/impact-of-hypocalcemia-on-mortality-in-pediatric-trauma-patients-who-require-transfusion
#12
JOURNAL ARTICLE
Elissa Abou Khalil, Erin Feeney, Katrina M Morgan, Philip C Spinella, Barbara A Gaines, Christine M Leeper
INTRODUCTION: Admission hypocalcemia has been associated with poor outcomes in injured adults. The impact of hypocalcemia on mortality has not been widely studied in pediatric trauma. METHODS: A pediatric trauma center database was queried retrospectively (2013-2022) for children age < 18 years who received blood transfusion within 24 hours of injury and had ionized calcium (iCal) level on admission. Children who received massive transfusion (>40 mL/kg) prior to hospital arrival or calcium prior to laboratory testing were excluded...
April 8, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38569049/irregular-warfare-must-combine-good-medicine-with-both-good-tactics-and-good-strategies-position-paper-by-the-french-special-operations-forces-medical-command
#13
JOURNAL ARTICLE
Pierre Pasquier, Mathieu David, Ludovic Petit, Morgan Chery, Sébastien Habas, Edouard Patey, Sébastien Conort, Nicolas Zeller, Marc-Olivier Gelmann, Sébastien Peyrefitte, Fabrice Castel, Stéphane Travers, Pierre Mahé
INTRODUCTION: Military operations are no longer limited to the application of counterterrorism and counterinsurgency strategies; they are now characterized by hybrid, irregular, and unconventional features. While some authors have indicated the need for medical support to adapt to these new modes of military operations, they have focused mainly on the tactical level of care on the battlefield. As Sun Tzu states, "Strategy without tactics is the slowest route to victory. Tactics without strategy is the noise before defeat," further proposals are still needed on the application of both medical tactics and medical strategies in irregular warfare...
April 1, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38556639/systemic-acylcarnitine-levels-are-affected-in-response-to-multiple-injuries-and-hemorrhagic-shock-an-analysis-of-lipidomic-changes-in-a-standardized-porcine-model
#14
JOURNAL ARTICLE
Yannik Kalbas, Yohei Kumabe, Felix Karl Ludwig Klingebiel, Sascha Halvachizadeh, Michel Paul Johan Teuben, Miriam Weisskopf, Nikola Cesarovic, Andreas J Hülsmeier, Sonja Märsmann, Christian Hierholzer, Frank Hildebrand, Thorsten Hornemann, Roman Pfeifer, Paolo Cinelli, Hans-Christoph Pape
INTRODUCTION: Along with recent advances in analytical technologies, TCA-cycle intermediates are increasingly identified as promising makers for cellular ischemia and mitochondrial dysfunction during hemorrhagic shock (HS). For traumatized patients, the knowledge of the role of lipid oxidation substrates is sparse. In this study, we aimed to analyze the dynamics of systemic acylcarnitine (AcCa) release in a standardized polytrauma model with HS. METHODS: 52 male pigs (50 ± 5 kg) were randomized into two groups: Group IF (isolated fracture) was subject to a standardized femur shaft fracture...
March 29, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38548736/prognostic-factors-associated-with-venous-thromboembolism-following-traumatic-injury-a-systematic-review-and-meta-analysis
#15
JOURNAL ARTICLE
Alexandre Tran, Shannon M Fernando, Bram Rochwerg, Morad S Hameed, Phillip Dawe, Harvey Hawes, Elliott Haut, Kenji Inaba, Paul T Engels, Ryan Zarychanski, Deborah M Siegal, Marc Carrier
INTRODUCTION: Trauma patients are at increased risk of venous thromboembolism (VTE), including deep venous thrombosis (DVT) and/or pulmonary embolism (PE). We conducted a systematic review and meta-analysis summarizing the association between prognostic factors and the occurrence of VTE following traumatic injury. METHODS: We searched the EMBASE and MEDLINE databases from inception to August 2023. We identified studies reporting confounding adjusted associations between patient, injury or post-injury care factors and risk of VTE...
March 29, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38548709/contemporary-management-of-patients-with-multiple-rib-fractures-what-you-need-to-know
#16
JOURNAL ARTICLE
Babak Sarani, Fredric Pieracci
10% of all injured patients and 55% of patients with blunt chest trauma experience rib fractures. The incidence of death due to rib fractures is related to the number of fractured ribs, severity of fractured ribs, and patient age and co-morbid conditions. Death due to rib fracture is mostly caused by pneumonia due to inability to expectorate and take deep breaths. Over the last 25-30 years, there has been renewed interest in surgical stabilization of rib fractures, known colloquially as "rib plating". This review will present what you need to know in regards to triage decisions on whether or not to admit a patient to the hospital, the location to which they should be admitted, criteria and evidentiary support for SSRF, timing to SSRF, and operative technique...
March 29, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38548696/using-machine-learning-to-predict-outcomes-of-patients-with-blunt-traumatic-aortic-injuries
#17
JOURNAL ARTICLE
Eileen Lu, Joseph Dubose, Mythreye Venkatesan, Zhiping Paul Wang, Benjamin W Starnes, Naveed U Saqib, Charles C Miller, Ali Azizzadeh, Elizabeth L Chou
INTRODUCTION: The optimal management of blunt thoracic aortic injury (BTAI) remains controversial, with experienced centers offering therapy ranging from medical management to TEVAR. We investigated the utility of a machine learning (ML) algorithm to develop a prognostic model of risk factors on mortality in patients with BTAI. METHODS: The Aortic Trauma Foundation registry was utilized to examine demographics, injury characteristics, management and outcomes of patients with BTAI...
March 29, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38548690/smoking-primes-the-metabolomic-response-in-trauma
#18
JOURNAL ARTICLE
Lauren T Gallagher, Christopher Erickson, Angelo D'Alessandro, Terry Schaid, Otto Thielen, William Hallas, Sanchayita Mitra, Preston Stafford, Ernest E Moore, Christopher C Silliman, Carolyn S Calfee, Mitchell J Cohen
INTRODUCTION: Smoking is a public health threat due to its well described link to increased oxidative stress-related diseases including peripheral vascular disease and coronary artery disease. Tobacco use has been linked to risk of inpatient trauma morbidity including acute respiratory distress syndrome, however its mechanistic effect on comprehensive metabolic heterogeneity has yet to be examined. METHODS: Plasma was obtained on arrival from injured patients at a Level 1 Trauma Center and analyzed with modern mass spectrometry-based metabolomics...
March 29, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38548689/timing-of-venous-thromboembolism-prophylaxis-initiation-and-complications-in-polytrauma-patients-with-high-risk-bleeding-orthopedic-interventions-a-nationwide-analysis
#19
JOURNAL ARTICLE
Anna J Kobzeva-Herzog, Sophia M Smith, Daniel R Counihan, Michael S Kain, Aaron P Richman, Dane Scantling, Noelle N Saillant, Sabrina E Sanchez, Crisanto M Torres
INTRODUCTION: There are no clear recommendations for the perioperative timing and initiation of venous thromboembolism pharmacologic prophylaxis (VTEp) among polytrauma patients undergoing high-risk bleeding orthopedic operative intervention, leading to variations in VTEp administration. Our study examined the association between the timing of VTEp and VTE complications in polytrauma patients undergoing high-risk operative orthopedic interventions nationwide. METHODS: A retrospective cohort study of trauma patients ≥18 years who underwent high-risk bleeding operative orthopedic interventions for pelvic, hip, and femur fractures within 24 hours of admission at American College of Surgeons (ACS) verified trauma centers using the 2019-2020 ACS-TQIP databank...
March 29, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38531825/whole-blood-storage-duration-alters-fibrinogen-levels-and-thrombin-formation
#20
JOURNAL ARTICLE
Ryan Chae, Christopher Nguyen, Chad Archdeacon, Lindsey Wattley, Stephanie Sisak, Adam Price, Emma Perez, Rebecca Schuster, Alex Lentsch, Charles Caldwell, Michael Goodman, Timothy Pritts
INTRODUCTION: Whole blood resuscitation for hemorrhagic shock in trauma represents an opportunity to correct coagulopathy in trauma while also supplying red blood cells. The production of microvesicles in stored whole blood and their effect on its hemostatic parameters have not been described in previous literature. We hypothesized that microvesicles in aged stored whole blood are procoagulant and increase thrombin production via phosphatidylserine. METHODS: Whole blood was obtained from male C57BL/6 male mice and stored in anticoagulant solution for up to 10 days...
March 27, 2024: Journal of Trauma and Acute Care Surgery
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