Journals European Journal of Microbiolo...

European Journal of Microbiology & Immunology
Thomas Willer, Annette Kaiser, Adrian Smith, Silke Rautenschlein
Cell cultures are models in biological and medical research to understand physiological and pathological processes. Cell lines are not always available depending on cell type and required species. In addition, the immortalization process often affects cell biology. Primary cells generally maintain a greater degree of similarity in short-term culture to the cells in tissue. Goal of this study was to verify the suitability of chicken primary epithelial caecal cells (PECCs) for in vitro investigations of host‒pathogen interactions...
June 21, 2024: European Journal of Microbiology & Immunology
Ke Du, Soraya Mousavi, Minnja S Foote, Stefan Bereswill, Markus M Heimesaat
Serious risks to human health are posed by acute campylobacteriosis, an enteritis syndrome caused by oral infection with the food-borne bacterial enteropathogen Campylobacter jejuni. Since the risk for developing post-infectious autoimmune complications is intertwined with the severity of enteritis, the search of disease-mitigating compounds is highly demanded. Given that benzoic acid is an organic acid with well-studied health-promoting including anti-inflammatory effects we tested in our present study whether the compound might be a therapeutic option to alleviate acute murine campylobacteriosis...
May 27, 2024: European Journal of Microbiology & Immunology
Navid Dashti, Forough Golsaz-Shirazi, Haleh Soltanghoraee, Amir-Hassan Zarnani, Mehdi Mohammadi, Danyal Imani, Mahmood Jeddi-Tehrani, Mohammad Mehdi Amiri, Fazel Shokri
BACKGROUND: Waning immunity and emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), highlight the need for further research in vaccine development. METHODS: A recombinant fusion protein containing the receptor-binding domain (RBD) fused to the human IgG1 Fc (RBD-Fc) was produced in CHO-K1 cells. RBD-Fc was emulsified with four adjuvants to evaluate its immunogenicity. The RBD-specific humoral and cellular immune responses were assessed by ELISA...
May 16, 2024: European Journal of Microbiology & Immunology
A Teshon, R Reyes, D P Schammel, O Corso, C Schammel, P Kent, A M Devane
Acquired benign tracheoesophageal fistulas and bronchoesophageal fistulas (TEF) are typically associated with granulomatous mediastinal infections, 75% of which are iatrogenic. Candida albicans and Actinomyces are commonly occurring organisms, but are uncommon etiologies of TEF. Normal colonization and the slow growth characteristics of some species of these agents rarely result in infection, mycetoma, and broncholithiasis, and thus, delays in diagnosis and treatment are likely. Few reports describe C. albicans or Actinomyces spp...
May 13, 2024: European Journal of Microbiology & Immunology
Tanim Jabid Hossain
Infectious diseases pose a formidable global challenge, compounded by the emergence of antimicrobial resistance. Consequently, researchers are actively exploring novel antimicrobial compounds as potential solutions. This endeavor underscores the pivotal role of methods employed for screening and evaluating antimicrobial activity-a critical step in discovery and characterization of antimicrobial agents. While traditional techniques such as well-diffusion, disk-diffusion, and broth-dilution are commonly utilized in antimicrobial assays, they may encounter limitations concerning reproducibility and speed...
April 22, 2024: European Journal of Microbiology & Immunology
Cosme Alvarado-Esquivel, Sergio Estrada-Martínez, Agar Ramos-Nevarez, Ángel Osvaldo Alvarado-Félix, Sandra Margarita Cerrillo-Soto, Gustavo Alexis Alvarado-Félix, Carlos Alberto Guido-Arreola, Leandro Saenz-Soto
Abdominal pain has been rarely reported in individuals infected with Toxoplasma gondii (T. gondii). The aim of this study was to determine the association between T. gondii infection and abdominal pain. Two hundred and ninety-nine patients with abdominal pain (cases) and 299 age- and gender-matched people without abdominal pain (controls) were tested for anti-T. gondii IgG and IgM antibodies. Twenty-four (8.0%) of the 299 cases and 12 (4.0%) of the 299 controls were positive for anti-T. gondii IgG antibodies (OR: 2...
April 2, 2024: European Journal of Microbiology & Immunology
Bence Marosi, Béla Kádár, Anna Bruzsa, Laura Kocsis, Katalin Kamotsay, János Sinkó, Bálint Gergely Szabó, Botond Lakatos
INTRODUCTION: Over the past decade, enterococcal bloodstream infection (BSI) shows increasing incidence globally among the elderly and in patients with comorbidities. In this study, we aimed to assess microbiological and clinical characteristics and long-term outcomes of BSIs caused by Enterococcus spp. in adult patients with and without active onco-hematological malignancies hospitalized at a national referral institute. METHODS: A prospective analysis of consecutive enterococcal BSI cases was conducted in the National Institute of Hematology and Infectious Diseases (Budapest, Hungary) between December 2019 and April 2022...
March 27, 2024: European Journal of Microbiology & Immunology
Carolin B Menikheim, Soraya Mousavi, Stefan Bereswill, Markus M Heimesaat
In recent years, the incidence of food-borne bacterial enteric diseases has increased worldwide causing significant health care and socioeconomic burdens. According to the World Health Organization, there are an estimated 600 million cases of foodborne illnesses worldwide each year, resulting in 420,000 deaths. Despite intensive efforts to tackle this problem, foodborne pathogenic microorganisms continue to be spread further. Therefore, there is an urgent need to find novel anti-microbial non-toxic compounds for food preservation...
March 25, 2024: European Journal of Microbiology & Immunology
Elena Ponzo, Angelina Midiri, Andrea Manno, Martina Pastorello, Carmelo Biondo, Giuseppe Mancuso
Schistosomiasis is a neglected tropical disease that is prevalent in low- and middle-income countries. There are five human pathogenic species, of which Schistosoma haematobium, Schistosoma mansoni and Schistosoma japonicum are the most prevalent worldwide and cause the greatest burden of disease in terms of mortality and morbidity. In addition, hybrid schistosomes have been identified through molecular analysis. Human infection occurs when cercariae, the larval form of the parasite, penetrate the skin of people while bathing in contaminated waters such as lakes and rivers...
March 18, 2024: European Journal of Microbiology & Immunology
Ignasi Roca, Kathya Espinoza, Cinthia Irigoin-Lovera, Maria Piquet, Luciano A Palomino-Kobayashi, Angie K Castillo, Diego D Gonzales-DelCarpio, Joaquim Viñes, Laura Muñoz, Barbara Ymaña, Rosario Oporto, Carlos Zavalaga, Maria J Pons, Joaquim Ruiz
Acinetobacter spp. are often isolated from natural sources, but knowledge about their presence in wild animals is fragmented and uncomplete. The present study aimed to characterize a series of Acinetobacter radioresistens isolated from Humboldt penguins (Spheniscus humboldti). Fifteen Humboldt penguins from an inhabited northern Peruvian island were sampled. Microorganisms were identified by MALDI-TOF MS. Antibiotic susceptibility to 12 antimicrobial agents was established, and clonal relationships were determined...
March 14, 2024: European Journal of Microbiology & Immunology
Arefeh Zabeti Touchaei, Sogand Vahidi, Ali Akbar Samadani
INTRODUCTION: APC and TP53 are the two most regularly mutated genes in colon adenocarcinoma (COAD), especially in progressive malignancies and antitumoral immune response. The current bioinformatics analysis investigates the APC and TP53 gene expression profile in colon adenocarcinoma as a prognostic characteristic for survival, particularly concentrating on the correlated immune microenvironment. METHODS: Clinical and genetic data of colon cancer and normal tissue samples were obtained from The Cancer Genome Atlas (TCGA)-COAD and Genotype-Tissue Expression (GTEx) online databases, respectively...
March 12, 2024: European Journal of Microbiology & Immunology
Markus M Heimesaat, Luis Q Langfeld, Niklas Schabbel, Soraya Mousavi, Stefan Bereswill
Incidence rates of human Campylobacter jejuni infections are progressively increasing globally. Since the risk for the development of post-infectious autoimmune diseases correlates with the severity of the preceding enteritis and campylobacteriosis treatment usually involves symptomatic measures, it is desirable to apply antibiotic-independent compounds to treat or even prevent disease. Given its health-promoting including anti-inflammatory properties carvacrol constitutes a promising candidate. This prompted us to test the disease-alleviating including immune-modulatory effects of carvacrol prophylaxis in acute murine campylobacteriosis...
March 11, 2024: European Journal of Microbiology & Immunology
Niraj Jatin Patel, Sahaja Thippani, Jasmine Jathan, Gauri Gaur, Janhavi Y Sawant, Jay M Pandya, Eva Sapi
Borrelia burgdorferi, the causative agent of Lyme disease, has recently been demonstrated to infect and enhance the invasive properties of breast cancer cells, while also influencing the expression of inflammatory chemokines (CXCL8 and CXCL10). This study investigates the presence of B. burgdorferi in invasive breast cancer tissues using commercially available, FDA-approved breast cancer tissue microarrays consisting of 350 ductal, 32 lobular, and 22 intraductal invasive breast carcinomas, alongside 29 normal breast tissues...
March 7, 2024: European Journal of Microbiology & Immunology
Varun Sasidharan Nair, Jochen Huehn
Vitamin C plays a multifaceted role in various biological processes and is well-known to facilitate pleiotropic activities in both innate and adaptive immune responses, where the antioxidant capacity of vitamin C is most likely highly relevant since immune responses mainly occur in reducing environments. Beyond its antioxidant properties, vitamin C can enhance the transcription potential of genes by promoting DNA demethylation through ten-eleven-translocation (Tet) methylcytosine dioxygenases, which have been recently demonstrated to be critical for the development and differentiation of T cells...
March 6, 2024: European Journal of Microbiology & Immunology
Márió Gajdács, Mária Matuz, Benkő Ria, Zoltán Pető, Edit Hajdú
Extensive use of carbapenems may lead to selection pressure for Stenotrophomonas maltophilia (SM) in hospital environments. The aim of our study was to assess the possible association between systemic antibiotic use and the incidence of SM. A retrospective, observational study was carried out in a tertiary-care hospital in Hungary, between January 1st 2010 and December 31st 2019. Incidence-density for SM and SM resistant to trimethoprim-sulfamethoxazole (SXT) was standardized for 1000 patient-days, while systemic antibiotic use was expressed as defined daily doses (DDDs) per 100 patient-days...
March 5, 2024: European Journal of Microbiology & Immunology
Péter Pallós, Márió Gajdács, Edit Urbán, Yvett Szabados, Klaudia Szalai, Lívia Hevesi, Anna Horváth, Anna Kuklis, Devina Morjaria, Wajiha Iffat, Helal F Hetta, Nicola Piredda, Matthew Gavino Donadu
The clinical role of Acinetobacter baumannii has been highlighted in numerous infectious syndromes with a high mortality rate, due to the high prevalence of multidrug-resistant (MDR) isolates. The treatment and eradication of this pathogen is hindered by biofilm-formation, providing protection from noxious environmental factors and antimicrobials. The aim of this study was to assess the antibiotic susceptibility, antiseptic susceptibility and biofilm-forming capacity using phenotypic methods in environmental A...
March 5, 2024: European Journal of Microbiology & Immunology
Vincent A Eiselt, Stefan Bereswill, Markus M Heimesaat
Prosthetic joint infections (PJIs) are dreaded arthroplasty complications often caused by Staphylococcus aureus. Due to methicillin-resistant S. aureus (MRSA) strains or biofilm formation, successful treatment remains difficult. Currently, two-stage revision surgery constitutes the gold standard therapy of PJIs, sometimes replaced or supplemented by debridement, antibiotics, and implant retention (DAIR). Given the dire consequences of therapeutic failure, bacteriophage therapy might be another treatment option...
March 4, 2024: European Journal of Microbiology & Immunology
Kantima Choosang, Siriphan Boonsilp, Kanyanan Kritsiriwuthinan, Palin Chumchuang, Nanthawan Thanacharoensakun, Aminoh Saai, Sawanya Pongparit
Plasmodium vivax is the most prevalent cause of malaria in Thailand and is predominant in malarial endemic areas worldwide. P. vivax infection is characterized by low parasitemia, latent liver-stage parasites, or asymptomatic infections leading to underreported P. vivax cases. These are significant challenges for controlling and eliminating P. vivax from endemic countries. This study developed and evaluated a dot-blot enzyme-linked immunosorbent assay (ELISA) using PvMSP1-42 recombinant antigen for serological diagnosis based on the detection of antibodies against P...
March 1, 2024: European Journal of Microbiology & Immunology
Verner N Orish, Sylvester Y Lokpo, Precious K Kwadzokpui, Rufai Safianu, Aleksandra Marinkovic, Stephanie Prakash, Chuku Okorie, Ricardo Izurieta, Rajashree Pandit, Adekunle Sanyaolu
BACKGROUND: Although, several studies have reported abnormal Mean Corpuscular Volume (MCV) values and anaemia associated with malaria infections with a focus on Plasmodium falciparum among patients with complicated and uncomplicated malaria, none has looked at the association with asymptomatic malaria. This study aimed to assess this association. METHODS: We conducted a cross-sectional study using 3 mL of blood samples from 549 children aged 5-17 years attending 5 schools selected in the Volta Region...
February 26, 2024: European Journal of Microbiology & Immunology
Zhao Yang, Hongchuan Zhang, Xiaohui Xia, Jiangwei Zhang
Identification of cytotoxic T lymphocyte (CTL) epitopes from tumor related antigens is a promising approach for malignant tumor immunotherapy. TC2N, a recently identified tumor associated antigen from human glioblastoma, is regarded as a promising target of tumor-specific immunotherapy. As one of the most widely used histocompatibility molecules in Chinese is HLA-A*0201, we were able to identify the TC2N peptides that are provided by this molecular type. A panel of antigenic peptides produced from TC2N were predicted by using a computer tool...
February 15, 2024: European Journal of Microbiology & Immunology
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