Journals European Journal of Microbiolo...

European Journal of Microbiology & Immunology
Zhao Yang, Hongchuan Zhang, Xiaohui Xia, Jiangwei Zhang
Identification of cytotoxic T lymphocyte (CTL) epitopes from tumor related antigens is a promising approach for malignant tumor immunotherapy. TC2N, a recently identified tumor associated antigen from human glioblastoma, is regarded as a promising target of tumor-specific immunotherapy. As one of the most widely used histocompatibility molecules in Chinese is HLA-A*0201, we were able to identify the TC2N peptides that are provided by this molecular type. A panel of antigenic peptides produced from TC2N were predicted by using a computer tool...
February 15, 2024: European Journal of Microbiology & Immunology
Yutaka Tatano, Toshiaki Shimizu, Chiaki Sano, Haruaki Tomioka
Autophagy is a cellular stress-induced intracellular process, through which damaged cellular components are decomposed via lysosomal degradation. This process plays important roles in host innate immunity, particularly the elimination of intracellular pathogens inside host macrophages. A more detailed understanding of the roles of autophagic events in the effective manifestation of macrophagic antimycobacterial activity is needed. Furthermore, the effects of medicinal plants on macrophagic autophagy response to mycobacterial infection need to be clarified...
February 13, 2024: European Journal of Microbiology & Immunology
Jamil Allen G Fortaleza, Christian Joseph N Ong, Rener De Jesus
Staphylococcus aureus infections have already presented a substantial public health challenge, encompassing different clinical manifestations, ranging from bacteremia to sepsis and multi-organ failures. Among these infections, methicillin-resistant S. aureus (MRSA) is particularly alarming due to its well-documented resistance to multiple classes of antibiotics, contributing significantly to global mortality rates. Consequently, the urgent need for effective treatment options has prompted a growing interest in exploring phage therapy as a potential non-antibiotic treatment against MRSA infections...
February 2, 2024: European Journal of Microbiology & Immunology
Andreas Hahn, Hagen Frickmann, Ulrike Loderstädt
BACKGROUND: Doxycycline-based prevention of bacterial sexually transmitted infections (STIs) has been assessed in various studies and has been recommended by the European AIDS Clinical Society to be proposed to persons with repeated STIs on a case-by-case basis. However, while good preventive effects could be shown for Chlamydia trachomatis and Treponema pallidum in Europe, no reliable prevention against doxycycline resistance-affected bacterial causes of STIs like Neisseria gonorrhoeae and Mycoplasma genitalium was confirmed...
January 30, 2024: European Journal of Microbiology & Immunology
Vincent A Eiselt, Stefan Bereswill, Markus M Heimesaat
Pulmonary infections of patients with cystic fibrosis (CF) or in intensive care units are frequently caused by the Gram-negative opportunistic pathogen Pseudomonas aeruginosa. Since these bacteria are commonly inherently multidrug-resistant (MDR) and hence, antibiotic treatment options are limited, bacteriophages may provide alternative therapeutic and prophylactic measures in the combat of pneumonia caused by P. aeruginosa. This prompted us to perform a comprehensive literature survey of current knowledge regarding effects of phages applied against pulmonary P...
January 23, 2024: European Journal of Microbiology & Immunology
Evgeni Dimitrov, Krasimira Halacheva, Georgi Minkov, Emil Enchev, Yovcho Yovtchev
AIM: The ability of neutrophil CD16 (nCD16) expression to predict outcome in complicated intra-abdominal infections (cIAIs) has not yet been studied; therefore we aimed to evaluate its potential prognostic value in such patients. METHODS: Between November 2018 and August 2021 a single-center prospective study was performed in the Department of Surgical Diseases at a University Hospital Stara Zagora. A flow cytometry was used to measure the levels of nCD16 before surgery and on the 3rd postoperative day (POD) in 62 patients with cIAIs...
January 17, 2024: European Journal of Microbiology & Immunology
Alma Rosa Pérez-Álamos, Marisela Aguilar-Durán, Sergio Estrada Martínez, Agar Ramos-Nevárez, Carlos Alberto Guido-Arreola, Antonio Sifuentes-Álvarez, Sandra Margarita Cerrillo-Soto, Raúl Graciano Ibarra, Cosme Alvarado-Esquivel
We aimed to determine the association between the seropositivity to Toxoplasma gondii and the ABO and Rh blood groups in 2,053 people. ABO and Rhesus blood groups and anti-T. gondii IgG and IgM antibodies were determined using commercially available assays. Of the 2,053 people studied, 171 (8.3%) were positive for anti-T. gondii IgG antibodies. Sixty-five (38.0%) and 36 (21.1%) of these 171 individuals had high anti-T. gondii IgG antibody levels (≥150 IU mL-1) and anti-T. gondii IgM antibodies, respectively...
January 12, 2024: European Journal of Microbiology & Immunology
Markus M Heimesaat, Niklas Schabbel, Luis Q Langfeld, Nizar W Shayya, Soraya Mousavi, Stefan Bereswill
Human infections with the food-borne zoonotic enteropathogen Campylobacter jejuni are increasing globally. Since multi-drug resistant bacterial strains are further on the rise, antibiotic-independent measures are needed to fight campylobacteriosis. Given its anti-microbial and anti-inflammatory properties the polyphenolic compound resveratrol constitutes such a promising candidate molecule. In our present placebo-controlled intervention trial, synthetic resveratrol was applied perorally to human gut microbiota-associated (hma) IL-10-/- mice starting a week before oral C...
December 15, 2023: European Journal of Microbiology & Immunology
Ellis Kobina Paintsil, Wycliffe O Masanta, Annika Dreyer, Leonid Ushanov, Stella I Smith, Hagen Frickmann, Andreas E Zautner
Campylobacter infections and campylobacteriosis-associated post-infectious sequelae are a significant global health burden that needs to be addressed from a specific African perspective. We conducted a comprehensive literature search on NCBI PubMed to compile a comprehensive narrative review article on Campylobacter infections in Africa, focusing on key aspects in human and veterinary medicine as well as food hygiene. We specifically focused on the epidemiology of enteropathogenic Campylobacter spp. in sub-Saharan and North Africa considering antimicrobial susceptibility...
December 5, 2023: European Journal of Microbiology & Immunology
Zsanett Kövér, Ágnes Bán, Márió Gajdács, Beáta Polgár, Edit Urbán
Medication-related osteonecrosis of the jaw (MRONJ) is an increasingly common consequence of antiresorptive treatment, which often leads to the development of necrotic exposed bone surfaces with inflammatory processes affecting the jawbone. Although the development of MRONJ is often associated with the inflammatory response or infections caused by the colonizing members of the oral microbiota, the exact pathogenesis of MRONJ is still not fully understood. In the present paper, we aimed to provide additional, microbiological culture-supported evidence, supporting the "infection hypothesis" that Actinomyces spp...
December 1, 2023: European Journal of Microbiology & Immunology
Soraya Mousavi, Lia V Busmann, Rasmus Bandick, Nizar W Shayya, Stefan Bereswill, Markus M Heimesaat
BACKGROUND: Acute campylobacteriosis caused by oral infections with the enteropathogen Campylobacter jejuni represent serious threats to global human health. Since novel treatment options with safe and antibiotics-independent compounds would be highly appreciable, we here investigated the anti-bacterial and disease-alleviating effects of carvacrol, butyrate, ellagic acid, and 2'-fucosyl-lactose in acute murine campylobacteriosis. To address this, secondary abiotic IL-10-/- mice were perorally infected with C...
November 21, 2023: European Journal of Microbiology & Immunology
Laura Alejandra Mendoza-Larios, Fernando García-Dolores, Luis Francisco Sánchez-Anguiano, Elizabeth Irasema Antuna-Salcido, Jesús Hernández-Tinoco, Adriana Rocha-Salais, Marcela Araceli Segoviano-Mendoza, Antonio Sifuentes-Álvarez, Cosme Alvarado-Esquivel
We sought to determine the association between Toxoplasma gondii (T. gondii) infection of the central nervous system and suicide in a sample of decedents in Mexico City. One hundred and forty-seven decedents (87 who committed suicide and 60 who did not commit suicide) were studied. Brain tissues (amygdala and prefrontal cortex) of decedents were examined for the detection of T. gondii using immunohistochemistry. Detection of T. gondii was positive in 7 (8.0%) of the 87 cases (6 found in prefrontal cortex and one in amygdala), and in one (1...
November 20, 2023: European Journal of Microbiology & Immunology
Vishwa A Khatri, Sambuddha Paul, Niraj Jatin Patel, Sahaja Thippani, Janhavi Y Sawant, Katie L Durkee, Cassandra L Murphy, Geneve Ortiz Aleman, Justine A Valentino, Jasmine Jathan, Anthony Melillo, Eva Sapi
The bacterial spirochete Borrelia burgdorferi, the causative agent of Lyme Disease, can disseminate and colonize various tissues and organs, orchestrating severe clinical symptoms including arthritis, carditis, and neuroborreliosis. Previous research has demonstrated that breast cancer tissues could provide an ideal habitat for diverse populations of bacteria, including B. burgdorferi, which is associated with a poor prognosis. Recently, we demonstrated that infection with B. burgdorferi enhances the invasion and migration of triple-negative MDA-MB-231 cells which represent a type of breast tumor with more aggressive cancer traits...
October 19, 2023: European Journal of Microbiology & Immunology
Anna Goc, Waldemar Sumera, Matthias Rath, Aleksandra Niedzwiecki
Infections caused by Staphylococcus aureus are currently a worldwide threat affecting millions of individuals. The pathogenicity of S. aureus is associated with numerous virulence factors, including cell surface proteins, polysaccharides, and secreted toxins. The pore-forming α-hemolysin, known as α-toxin, is produced by nearly all virulent strains of S. aureus and is implicated in several diseases including skin and soft tissue infections, atopic dermatitis, and pneumonia. There are currently no vaccines available for the prevention of S...
October 18, 2023: European Journal of Microbiology & Immunology
Kirsten Alexandra Eberhardt, Luzia Veletzky, Felix Weinreich, Richard Odame Phillips, Fred Stephen Sarfo, Torsten Feldt, Albert Dompreh, Shadrack Osei Asibey, Richard Boateng, Hagen Frickmann
BACKGROUND: Mansonellosis is a widely neglected helminth disease which is predominantly observed in tropical regions. This study was conducted to assess potential associations of the prevalence of circulating Mansonella perstans-specific cell-free DNA in human serum and HIV infection in Ghanaian individuals. METHODS: For this purpose, serum samples obtained from Ghanaian HIV-patients (n = 989) and non-HIV-infected Ghanaian control individuals (n = 91) were subjected to real-time PCR targeting the ITS-(internal transcribed spacer-)2 sequence of M...
September 26, 2023: European Journal of Microbiology & Immunology
Bianca Kelly Neves Izidro da Silva, Ana Cláudia Alves Cortez, Luciana Aires Oliveira, Juan Diego Ribeiro de Almeida, Érica Simplício de Souza, Katia Santana Cruz, Ani Beatriz Jackisch Matsuura, Mauricio Morishi Ogusku, Karolina Jeaneth Solórzano Chavarría, Djane Baía-da-Silva, Quique Bassat, Marcus Vinícius Guimarães Lacerda, Hagen Frickmann, João Vicente Braga de Souza
BACKGROUND: This study aimed at improving a real-time polymerase-chain-reaction (qPCR) assay for the detection of Histoplasma capsulatum, a fungal pathogen that can cause severe respiratory infections in humans, in clinical and soil samples. METHODS: Primer and probes were in-silico designed, in-silico and in-vitro evaluated including clinical biopsy materials and finally subjected to a real-world application with collected soil samples. RESULTS: Applying the qPCR assay with liver and lung biopsies from 71 patients each, including 59 patients infected with human immunodeficiency virus (HIV), as well as with Sabouraud (SAB) agar culture as the diagnostic reference standard, diagnostic accuracy of the qPCR assay of 100% (5/5) sensitivity and 96% (63/66) specificity for liver samples and 100% (4/4) sensitivity and 94% (63/67) specificity for the lung samples was recorded...
September 21, 2023: European Journal of Microbiology & Immunology
Jurij D Brockhoff, Stefan Bereswill, Markus M Heimesaat
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by inflammation and neurodegeneration. Current research suggests that diet may influence disease course, severity of symptoms, and quality of life in MS patients. The ketogenic diet (KD) has been used for more than a century as a therapeutic approach for various medical conditions. It was originally developed in the 1920s as a treatment option for epilepsy, and especially in the last 30 years, has gained popularity for its potential benefits in a variety of neurological conditions other than epilepsy...
September 4, 2023: European Journal of Microbiology & Immunology
Markus M Heimesaat, Soraya Mousavi, Dennis Weschka, Stefan Bereswill
The prevalence of Campylobacter jejuni infections is increasing worldwide and responsible for significant morbidities and socioeconomic expenses. The rise in antimicrobial resistance of C. jejuni underscores the urge for evaluating antibiotics-independent compounds as therapeutic and preventive treatment options of human campylobacteriosis. Given its well-known anti-microbial and immune-modulatory properties we here surveyed the disease-modifying effects of trans-cinnamaldehyde pretreatment in experimental campylobacteriosis...
September 1, 2023: European Journal of Microbiology & Immunology
Niklas Klein, Lioba Bürvenich, Christian Büchler
We report on a 38-year-old male patient with disseminated gonococcal infection. Preceding the discharge diagnosis, the patient was treated regarding rheumatoid arthritis, which resulted in the deterioration of the patient's medical condition due to the immunomodulatory nature of the applied medication. The causative agent was identified by culturing joint puncture fluid inoculated into blood culture vials. Primary infection with the pathogen could not be pinpointed in terms of time, but on further questioning, the patient reported intimate contacts with a number of different male partners, which may be assumed to have included the infection source...
July 7, 2023: European Journal of Microbiology & Immunology
Fatimah AlMutawa, Ana Cabrera, Feifei Chen, Johan Delport
BACKGROUND: Early identification of COVID-19 (coronavirus disease of 2019) by diagnostic tests played an important role in the isolation of infectious patients and management of this pandemic. Various methodologies and diagnostic platforms are available. The current "gold standard" for SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) diagnosis is real-time reverse transcriptase-polymerase chain reaction (RT-PCR). To overcome the limitations posed by the short supply experienced early during the pandemic and to increase our capacity, we assessed the performance of the MassARRAY System (Agena Bioscience)...
June 15, 2023: European Journal of Microbiology & Immunology
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