journal
https://read.qxmd.com/read/24224095/improving-compliance-with-screening-of-diabetic-patients-for-microalbuminuria-in-primary-care-practice
#21
JOURNAL ARTICLE
Abeer Anabtawi, L Mary Mathew
Studies showed suboptimal compliance rate of primary care physicians with microalbuminuria screening. This study evaluated impact of electronic medical records (EMR) and computerized physicians reminders on compliance rate and showed small to modest improvement. Combining EMR with quality control monitoring has significantly improved compliance [OR 1.556, 95% CI 1.251-1.935, P = 0.006].
2013: ISRN Endocrinology
https://read.qxmd.com/read/24224094/risk-of-cancer-in-diabetes-the-effect-of-metformin
#22
REVIEW
Mojtaba Malek, Rokhsareh Aghili, Zahra Emami, Mohammad E Khamseh
Cancer is the second cause of death. Association of diabetes as a growing and costly disease with cancer is a major health concern. Meanwhile, preexisting diabetes is associated with an increased risk of all-cause and cancer-specific mortalities. Presence of diabetes related comorbidities, poorer response to cancer treatment, and excess mortality related to diabetes are among the most important explanations. Although diabetes appear to be a risk factor for cancer and is associated with the mortality risk in cancer patients, several factors such as diabetes duration, multiple drug therapy, and the presence of diabetes comorbidities make the assessment of the effect of diabetes treatment on cancer risk and mortality difficult...
2013: ISRN Endocrinology
https://read.qxmd.com/read/24171117/aryl-hydrocarbon-receptor-ligands-inhibit-igf-ii-and-adipokine-stimulated-breast-cancer-cell-proliferation
#23
JOURNAL ARTICLE
Travis B Salisbury, Gary Z Morris, Justin K Tomblin, Ateeq R Chaudhry, Carla R Cook, Nalini Santanam
Obesity increases human cancer risk and the risk for cancer recurrence. Adipocytes secrete paracrine factors termed adipokines that stimulate signaling in cancer cells that induce proliferation. The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that plays roles in tumorigenesis, is regulated by exogenous lipophilic chemicals, and has been explored as a therapeutic target for cancer therapy. Whether exogenous AHR ligands modulate adipokine stimulated breast cancer cell proliferation has not been investigated...
2013: ISRN Endocrinology
https://read.qxmd.com/read/24159393/diagnostic-value-of-the-combined-measurement-of-serum-hcy-serum-cys-c-and-urinary-microalbumin-in-type-2-diabetes-mellitus-with-early-complicating-diabetic-nephropathy
#24
JOURNAL ARTICLE
Tengkai Wang, Qian Wang, Zhimei Wang, Zuomin Xiao, Lunqin Liu
Diabetic nephropathy (DN) is a major cause of end-stage kidney disease, and therefore early diagnosis and intervention may help reverse renal damage. One hundred and sixty-eight patients with T2DM and 56 healthy volunteers (control group) were enrolled at Shandong University Qilu Hospital between April 2010 and October 2012. All subjects underwent blood sampling for sera homocysteine (Hcy) and cystatin C (Cys C) assays and a urine microalbumin test. The patients were divided into three groups according to the urine microalbumin excretion rate (UMAER): the simple DM group (SDM group, n = 51), the early-stage DN group (EDN group, n = 60), and the clinical DN and renal failure group (CDN group, n = 57)...
2013: ISRN Endocrinology
https://read.qxmd.com/read/24093064/gestational-diabetes-mellitus-screening-and-outcomes-in-southern-italian-pregnant-women
#25
JOURNAL ARTICLE
Carmelo Capula, Eusebio Chiefari, Anna Vero, Biagio Arcidiacono, Stefania Iiritano, Luigi Puccio, Vittorio Pullano, Daniela P Foti, Antonio Brunetti, Raffaella Vero
Recent Italian guidelines exclude women <35 years old, without risk factors for gestational diabetes mellitus (GDM), from screening for GDM. To determine the effectiveness of these measures with respect to the International Association of the Diabetes and Pregnancy Study Groups (IADPSG) criteria, we evaluated 2,448 pregnant women retrospectively enrolled in Calabria, southern Italy. GDM was diagnosed following the IADPSG 2010 criteria. Among 538 women <35 years old, without risk factors, who would have not been tested according to the Italian guidelines, we diagnosed GDM in 171 (31...
2013: ISRN Endocrinology
https://read.qxmd.com/read/24066237/impact-of-neonatal-manipulation-of-androgen-receptor-function-on-endocrine-metabolic-programming-in-the-juvenile-female-rat
#26
JOURNAL ARTICLE
Luisina Ongaro, Andres Giovambattista, Eduardo Spinedi
The impact of neonatal androgen receptor (AR) stimulation/blockage, due to testosterone propionate (TP)/AR antagonist treatment, on individual anthropometry and neuroendocrine-metabolic function was evaluated in the juvenile female rat. Pups (age 5 days) were s.c. injected with TP (1.25 mg), flutamide (F; 1.75 mg), and TP + F or vehicle (control, CT) and studied on day 30 of age. Body weight (BW), parametrial adipose tissue (PMAT) mass, food intake, adipoinsular axis, and steroidogenic functions were examined...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23997963/liraglutide-suppresses-the-plasma-levels-of-active-and-des-acyl-ghrelin-independently-of-active-glucagon-like-peptide-1-levels-in-mice
#27
JOURNAL ARTICLE
Katsunori Nonogaki, Marina Suzuki
Glucagon-like peptide-1 (GLP-1), an insulinotropic gastrointestinal peptide that is primarily produced by intestinal endocrine L-cells, stimulates satiety. Ghrelin, a hormone that is produced predominantly by the stomach stimulates hunger. There are two forms of ghrelin: active ghrelin and inactive des-acyl ghrelin. After depriving mice of food for 24 h, we demonstrated that the systemic administration of liraglutide (100  μ g/kg), a human GLP-1 analog that binds to the GLP-1 receptor, increased (1.4-fold) the plasma levels of active GLP-1 and suppressed the plasma levels of active and des-acyl ghrelin after 1 h...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23956870/predictors-of-postpartum-glucose-tolerance-testing-in-italian-women-with-gestational-diabetes-mellitus
#28
JOURNAL ARTICLE
Carmelo Capula, Eusebio Chiefari, Anna Vero, Stefania Iiritano, Biagio Arcidiacono, Luigi Puccio, Vittorio Pullano, Daniela Foti, Antonio Brunetti, Raffaella Vero
Postpartum screening is critical for early identification of type 2 diabetes in women previously diagnosed with gestational diabetes mellitus (GDM). Nevertheless, its rate remains disappointingly low. Thus, we plan to examine the rate of postpartum glucose tolerance test (ppOGTT) for Italian women with GDM, before and after counseling, and identify demographic, clinical, and/or biochemical predictors of adherence. With these aims, we retrospectively enrolled 1159 women with GDM, in Calabria, Southern Italy, between 2004 and 2011...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23936666/paradoxically-low-levels-of-total-and-hmw-adiponectin-in-relation-to-metabolic-parameters-in-a-tongan-population
#29
JOURNAL ARTICLE
Philip Peake, Stephen Colagiuri, Lesley V Campbell, Yvonne Shen
Aim. Adiponectin has demonstrated anti-inflammatory and insulin sensitising properties, and low circulating levels may be an important risk factor for diabetes. We examined levels of adiponectin and its insulin-sensitising HMW isoform and their relationship with metabolic parameters in Tongans, a population prone to type II diabetes. Methods. Adiponectin and its HMW isoform were quantitated by Elisa in specimens from a randomly recruited, multistage cluster population survey of Tongans and from a group of Caucasians...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23936665/estrogen-signaling-and-the-aging-brain-context-dependent-considerations-for-postmenopausal-hormone-therapy
#30
JOURNAL ARTICLE
Natasha N Mott, Toni R Pak
Recent clinical studies have spurred rigorous debate about the benefits of hormone therapy (HT) for postmenopausal women. Controversy first emerged based on a sharp increase in the risk of cardiovascular disease in participants of the Women's Health Initiative (WHI) studies, suggesting that decades of empirical research in animal models was not necessarily applicable to humans. However, a reexamination of the data from the WHI studies suggests that the timing of HT might be a critical factor and that advanced age and/or length of estrogen deprivation might alter the body's ability to respond to estrogens...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23936664/four-hour-temporal-relation-of-5-htp-and-l-dopa-induces-inhibitory-responses-in-recrudescing-gonad-of-indian-palm-squirrel-funambulus-pennantii
#31
JOURNAL ARTICLE
Ranjana Jaiwal, C M Chaturvedi
Daily injections of L-dihydroxyphenylalanine (L-DOPA, dopamine precursor) given 4 h after 5-hydroxytryptophan (5-HTP, serotonin precursor) induced inhibitory responses in recrudescing gonad (in the first week of December) of Indian palm squirrel, a seasonally breeding subtropical animal. Other temporal relations (L-DOPA given at 0, 8, 12, 16, and 20 h after 5-HTP administration) did not show any effect on the recrudescing gonad. This inhibitory effect of 4 h was evident under short day length (6 : 18) group but was masked by the increasing day length of nature (NDL, late December onwards) and increased photoperiod of long day group (16 : 8)...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23878745/autoimmune-thyroid-disorders
#32
JOURNAL ARTICLE
M A Iddah, B N Macharia
Purpose of Review. Studies have been published in the field of autoimmune thyroid diseases since January 2005. The review is organized into areas of etiology, autoimmune features, autoantibodies, mechanism of thyroid cell injury, B-cell responses, and T-cell responses. Also it reviews the diagnosis and the relationship between autoimmune thyroid disease, neoplasm, and kidney disorders. Recent Findings. Autoimmune thyroid diseases have been reported in people living in different parts of the world including North America, Europe, Baalkans, Asia, Middle East, South America, and Africa though the reported figures do not fully reflect the number of people infected per year...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23862071/human-serum-pcsk9-is-elevated-at-parturition-in-comparison-to-nonpregnant-subjects-while-serum-pcsk9-from-umbilical-cord-blood-is-lower-compared-to-maternal-blood
#33
JOURNAL ARTICLE
Patricia Peticca, Angela Raymond, Andrée Gruslin, Marion Cousins, Ejibunmi Adetola, Hussein Abujrad, Janice Mayne, Teik Chye Ooi
Background. Serum lipids including total cholesterol (TC), triglycerides (TG), and low density lipoprotein cholesterol (LDL-C) are increased in pregnancy. Serum proprotein convertase subtilisin kexin 9 (PCSK9) is a significant player in lipoprotein metabolism. Circulating PCSK9 downregulates the LDL receptor on the surface of the liver, inhibiting clearance of LDL-C. Therefore, our study assessed serum PCSK9 concentrations at parturition (Maternal) compared to a nonpregnant (Control) cohort, as well as between mother and newborn (Maternal and Newborn)...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23853726/vitamin-d-receptor-gene-bsmi-polymorphism-in-polish-patients-with-systemic-lupus-erythematosus
#34
JOURNAL ARTICLE
Beata Kaleta, Jarosław Bogaczewicz, Ewa Robak, Anna Sysa-Jędrzejowska, Małgorzata Wrzosek, Weronika Szubierajska, Piotr Mróz, Jacek Lukaszkiewicz, Anna Woźniacka
The hormonally active form of vitamin D3, 1,25(OH)2D3 (calcitriol), exerts actions through VDR receptor, which acts as a transcriptional factor. Calcitriol is an immunomodulator that affects various immune cells, and several studies link it to many autoimmune diseases. BsmI polymorphism affects the level of VDR gene transcription, transcript stability, and posttranscriptional modifications. It seems to be related to the systemic lupus erythematosus (SLE). Our study examined the characteristics of VDR gene BsmI polymorphism in Polish SLE patients and their relationship with clinical manifestations of the disease...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23840961/routine-screening-for-cushing-s-syndrome-is-not-required-in-patients-presenting-with-obesity
#35
JOURNAL ARTICLE
Serap Baydur Sahin, Hacer Sezgin, Teslime Ayaz, Emine Uslu Gur, Kadir Ilkkilic
Background. Cushing's syndrome (CS) is a relatively unusual condition that resembles many of the phenotypic features of obesity. Our aim was to evaluate the frequency of CS in obese patients. Materials and Methods. This study included 354 consecutive patients (87.9% female, age 37.8 ± 13.4 years) who presented with simple obesity. All the patients were evaluated for the clinical signs of CS. Lipid parameters, fasting glucose (FPG) and insulin, 75 gr oral glucose tolerance test, basal cortisol and ACTH were measured...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23840960/mouse-models-and-techniques-for-the-isolation-of-the-diabetic-endothelium
#36
JOURNAL ARTICLE
April L Darrow, J Gregory Maresh, Ralph V Shohet
Understanding the molecular mechanisms underlying diabetic endothelial dysfunction is necessary in order to improve the cardiovascular health of diabetic patients. Previously, we described an in vivo, murine model of insulin resistance induced by feeding a high-fat diet (HFD) whereby the endothelium may be isolated by fluorescence-activated cell sorting (FACS) based on Tie2-GFP expression and cell-surface staining. Here, we apply this model to two new strains of mice, ScN/Tie2-GFP and ApoE(-/-)/Tie2-GFP, and describe their metabolic responses and endothelial isolation...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23781346/placental-hsd2-expression-and-activity-is-unaffected-by-maternal-protein-consumption-or-gender-in-c57bl-6-mice
#37
JOURNAL ARTICLE
Mark R Garbrecht, Fred S Lamb
The placenta acts as a physiological barrier, preventing the transfer of maternal glucocorticoids to the developing fetus. This is accomplished via the oxidation, and subsequent inactivation, of endogenous glucocorticoids by the 11- β hydroxysteroid dehydrogenase type 2 enzyme (HSD2). Maternal protein restriction during pregnancy has been shown to result in a decrease in placental HSD2 expression and fetal glucocorticoid overexposure, especially late in gestation, resulting in low birth weight and "fetal programming" of the offspring...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23762597/the-effect-of-pioglitazone-on-antioxidant-levels-and-renal-histopathology-in-streptozotocin-induced-diabetic-rats
#38
JOURNAL ARTICLE
Munire Kuru Karabas, Mediha Ayhan, Engin Guney, Mukadder Serter, Ibrahim Meteoglu
Objective. Diabetic nephropathy is the most commonly seen cause of chronic renal failure, and oxidative stress is important in etiology. In the present study, favorable effects (if any) of the treatment with a thiazolidinedione group drug, pioglitazone, on antioxidant enzyme levels in the renal tissue, renal histopathology, and inflammatory cytokine levels have been investigated. Method. Forty male Wistar rats were divided into 4 groups as the control, diabetic control, and 10 and 30 mg pioglitazone-administered diabetic groups...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23762596/risk-factors-associated-with-benign-and-malignant-thyroid-nodules-in-autoimmune-thyroid-diseases
#39
JOURNAL ARTICLE
Priscila Carneiro Moreira Lima, Arnaldo Moura Neto, Marcos Antonio Tambascia, Denise Engelbrecht Zantut Wittmann
Objectives. Assess the prevalence of thyroid nodules and predictors of malignant origin in patients with autoimmune thyroid diseases. Patients and Methods. Retrospective study including 275 patients, 198 with Graves' disease and 77 with Hashimoto's thyroiditis. Clinical and demographical data, ultrasonographical nodule characteristics, total thyroid volume and histological characteristics were recorded. Results. Graves' disease: the prevalence of thyroid nodules and thyroid carcinoma were 27.78% and 5.05%, respectively...
2013: ISRN Endocrinology
https://read.qxmd.com/read/23691349/effect-of-polyherbal-mixtures-on-the-treatment-of-diabetes
#40
JOURNAL ARTICLE
Aparajeya Panda, Somanatha Jena, Pramod Kumar Sahu, Sanghamitra Nayak, Payodhar Padhi
The study focuses on polyherbal antidiabetic formulations of different plants used in the treatment of diabetes mixed in different concentrations. In the present study eleven medicinal plants with proven antidiabetic and related beneficial effects were selected for the preparation of five mixtures. The efficacy of prepared mixtures has been tested on streptozotocin- (STZ-) induced diabetic rats and compared with a commercially available drug glibenclamide. The mixtures at the dose levels of 400 mg/kg b.w...
2013: ISRN Endocrinology
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