journal
https://read.qxmd.com/read/37077042/adipokines-in-glucose-and-lipid-metabolism
#21
JOURNAL ARTICLE
Xueqing Wang, Siwen Zhang, Zhuo Li
Adipokines are proteins secreted by adipose tissue to regulate glucolipid metabolism and play vital roles in our body. Different adipokines have more than one endocrine function and be divided into several different categories according to their functions, including adipokines involved in glucolipid metabolism, the inflammatory response, insulin action, activation of brown adipose tissue (BAT) and appetite regulation. Multiple adipokines interact with each other to regulate metabolic processes. Based on the recent progress of adipokine research, this article discusses the role and mechanism of various adipokines in glucolipid metabolism, which may provide new ideas for understanding the pathogenesis and improving the treatment of various metabolic diseases...
December 2023: Adipocyte
https://read.qxmd.com/read/37005742/traf6-promotes-osteogenesis-in-adscs-through-raf-erk-merk-hif1-a-pathway
#22
JOURNAL ARTICLE
Xiang-Dong Liu, Jian Zheng, Shuang Song, Zi-Jun Chen, Yu-Xi Wang, Si-Jia Zhang, Guan-Hua Zhang, Qun Lu, Ying-Liang Song
Critical-size defects (CSDs) are challenging oral clinical issues that need to be solved. Adipose-derived mesenchymal stem cells (ADSCs) and gene therapy offer a new target to solve these issues. Consequently, ADSCs attract more and more attention because of advantages such as easy obtainability and no ethical concerns. TNF receptor-associated factor 6 (TRAF6) is a significant binding protein both of tumour necrosis factor superfamily and of the toll/interleukin-1 receptor superfamily. Evidence is accumulating that TRAF6 inhibited osteoclast formation and promoted the proliferation of multiple myeloma cell lines and bone resorption...
December 2023: Adipocyte
https://read.qxmd.com/read/36973648/-in-vitro-studies-of-the-renin-angiotensin-system-in-human-adipose-tissue-adipocytes-and-possible-relationship-to-sars-cov-2-a-scoping-review
#23
REVIEW
Ryan Ting, Heidi Dutton, Alexander Sorisky
The renin-angiotensin system (RAS) operates within adipose tissue. Obesity-related changes can affect adipose RAS, predisposing to hypertension, type 2 diabetes, and possibly severe COVID-19. We evaluated the in vitro research on human adipose RAS and identified gaps in the literature. Medline (Ovid), Embase (Ovid), Web of Science, Scopus, and 1findr were searched to identify relevant studies. Fifty primary studies met our inclusion criteria for analysis. Expression of RAS components ( n  = 14), role in differentiation ( n  = 14), association with inflammation ( n  = 15) or blood pressure ( n  = 7) were investigated...
December 2023: Adipocyte
https://read.qxmd.com/read/36961293/retraction
#24
(no author information available yet)
No abstract text is available yet for this article.
December 2023: Adipocyte
https://read.qxmd.com/read/36775902/highly-expressed-lncrna-foxd2-as1-in-adipose-mesenchymal-stem-cell-derived-exosomes-affects-hacat-cells-via-regulating-mir-185-5p-rock2-axis
#25
JOURNAL ARTICLE
Huanchao Chang, Junliang Chen, Kun Ding, Tianling Cheng, Shengjian Tang
The healing of skin wounds is a highly coordinated multi-step process that occurs after trauma including surgical incisions, thermal burns, and chronic ulcers. In this study, the authors investigated lncRNA FOXD2-AS1 function in adipose mesenchymal exosomes from ADMSCs that were successfully extracted. Highly expressed lncRNA FOXD2-AS1 in ADMSCs-exosomes accelerated HaCaT cell migration and proliferation. LncRNA FOXD2-AS1 negatively targeted miR-185-5p, and miR-185-5p negatively targeted ROCK2. Highly expressed lncRNA FOXD2-AS1 in ADMSCs-exosomes promoted HaCaT cell migration and proliferation via down-regulating miR-185-5p and further up-regulating ROCK2...
December 2023: Adipocyte
https://read.qxmd.com/read/36710425/mir-26a-5p-regulates-adipocyte-differentiation-via-directly-targeting-acsl3-in-adipocytes
#26
JOURNAL ARTICLE
Ning Ding, Wenwen Wang, Jun Teng, Yongqing Zeng, Qin Zhang, Licai Dong, Hui Tang
Preadipocytes become mature adipocytes after proliferation and differentiation, and although many genes and microRNAs have been identified in intramuscular fat, their physiological function and regulatory mechanisms remain largely unexplored. miR-26a-5p has been reported to be related to fat deposition, but its effect on porcine preadipocyte differentiation has not been explored. In this study, bioinformatics analysis and luciferase reporter assay identified that miR-26a-5p binds to the 3'UTR of Acyl-CoA synthetase long-chain family member 3 ( ACSL3 ) mRNA...
December 2023: Adipocyte
https://read.qxmd.com/read/36654490/identification-of-major-hub-genes-involved-in-high-fat-diet-induced-obese-visceral-adipose-tissue-based-on-bioinformatics-approach
#27
JOURNAL ARTICLE
Yu Jiang, Rui Zhang, Jia-Qi Guo, Ling-Lin Qian, Jing-Jing Ji, Ya Wu, Zhen-Jun Ji, Zi-Wei Yang, Yao Zhang, Xi Chen, Gen-Shan Ma, Yu-Yu Yao
High-fat diet (HFD) can cause obesity, inducing dysregulation of the visceral adipose tissue (VAT). This study aimed to explore potential biological pathways and hub genes involved in obese VAT, and for that, bioinformatic analysis of multiple datasets was performed. The expression profiles (GSE30247, GSE167311 and GSE79434) were downloaded from Gene Expression Omnibus. Overlapping differentially expressed genes (ODEGs) between normal diet and HFD groups in GSE30247 and GSE167311 were selected to run protein-protein interaction network, GO and KEGG analysis...
December 2023: Adipocyte
https://read.qxmd.com/read/37982546/adipogenic-characterization-of-immortalized-cd55-progenitor-cells-from-human-white-adipose-tissue
#28
JOURNAL ARTICLE
Morgane Couchet, Hui Gao, Felix Klingelhuber, Jutta Jalkanen, Thais De Castro Barbosa, Muhmmad Omar-Hmeadi, Lucas Massier, Natalie Krahmer, Niklas Mejhert, Mikael Rydén
BACKGROUND: Mature adipocytes are notoriously difficult to study ex vivo and alternative cell culture systems have therefore been developed. One of the most common models are human adipose progenitor cells (hAPCs). Unfortunately, these display replicative senescence after prolonged culture conditions, which limits their use in mechanistic studies. METHODS: Herein, we knocked in human telomerase reverse transcriptase (TERT) into the AAVS1 locus of CD55+ hAPCs derived from abdominal subcutaneous adipose tissue and characterized the cells before and after differentiation into adipocytes...
November 20, 2023: Adipocyte
https://read.qxmd.com/read/37942520/bioactive-peptides-pdbsn-improve-mitochondrial-function-and-suppression-the-oxidative-stress-in-human-adiposity-cells
#29
JOURNAL ARTICLE
Huiping Shen, Yong Lei, Wen Xie, Tieliang Ma, Li Bao, Qin Gao, Bingyu Chen, Biao Dai, Dani Qin
Introduction : Mitochondria are essential for generating cellular energy and are significant in the pathogenesis of obesity. Peptide PDBSN has been demonstrated to inhibit the adipogenic differentiation of adipocytes in vitro and improves metabolic homoeostasis in vivo. Therefore, in this study, we further investigated the effects of PDBSN on the morphology, synthesis, and function of adipocyte mitochondria. Methods : Human visceral and subcutaneous primary preadipocytes (HPA-v and HPA-s) were cultured into mature adipocytes...
November 9, 2023: Adipocyte
https://read.qxmd.com/read/37042512/mri-measured-periprostatic-adipose-tissue-volume-as-a-prognostic-predictor-in-prostate-cancer-patients-undergoing-laparoscopic-radical-prostatectomy
#30
JOURNAL ARTICLE
Tianyu Xiong, Fang Cao, Guangyi Zhu, Xiaobo Ye, Yun Cui, Nianzeng Xing, Huibo Zhang, Yinong Niu
Periprostatic adipose tissue (PPAT) has been reported to play an important role in prostate cancer (PCa) progression, however, the association between PPAT amount and prognosis of patients who underwent laparoscopic radical prostatectomy (LRP) still remains unclear. In this cross-sectional study, we evaluated the association between the PPAT volume and the prognosis of PCa patients after LRP. We retrospectively analyzed data of 189 PCa patients who underwent LRP in Beijing Chaoyang Hospital from July 2010 to August 2021...
April 12, 2023: Adipocyte
https://read.qxmd.com/read/36779587/an-optimized-method-for-oil-red-o-staining-with-the-salicylic-acid-ethanol-solution
#31
JOURNAL ARTICLE
Junbao Du, Li Zhao, Quan Kang, Yun He, Yang Bi
Oil Red O (ORO) staining is a commonly used experimental technique to detect lipid content in cells or tissues. Freshly prepared ORO in 60% isopropanol is the most widely used method at present. However, isopropanol is volatile and harmful to the human body. It will also affect the interpretation of the results due to the formation of crystals and non-specific diffuse staining. In this paper, by screening and validation, we report a salicylic acid ethanol solution (containing 50% ethanol, 5%-10% salicylic acid) for the preparation of ORO solution, which has a better staining effect on lipid staining in cells and tissues, with a clean background and short dyeing time...
February 13, 2023: Adipocyte
https://read.qxmd.com/read/36763512/an-optimised-protocol-for-the-investigation-of-insulin-signalling-in-a-human-cell-culture-model-of-adipogenesis
#32
JOURNAL ARTICLE
Jonathan M Gamwell, Keanu Paphiti, Leanne Hodson, Fredrik Karpe, Katherine E Pinnick, Marijana Todorčević
While there is no standardised protocol for the differentiation of human adipocytes in culture, common themes exist in the use of supra-physiological glucose and hormone concentrations, and an absence of exogenous fatty acids. These factors can have detrimental effects on some aspects of adipogenesis and adipocyte function. Here, we present methods for modifying the adipogenic differentiation protocol to overcome impaired glucose uptake and insulin signalling in human adipose-derived stem cell lines derived from the stromovascular fraction of abdominal and gluteal subcutaneous adipose tissue...
February 10, 2023: Adipocyte
https://read.qxmd.com/read/36722834/mir136-regulates-proliferation-and-differentiation-of-small-tail-han-sheep-preadipocytes
#33
JOURNAL ARTICLE
Man Luo, Lin Wang, Cheng Xiao, Mengsi Zhou, Minghui Li, Hongjuan Li
Low meat performance is the defect of Small Tail Han sheep. Intramuscular fat affects meat quality and largely determined by adipogenesis. In previous study, miR136 was showed one of differentially expressed microRNAs between preadipocytes and mature adipocytes of Small Tail Han sheep but its role in adipogenesis is still not elucidated. Here, we investigated the effect of miR136 on adipogenesis and the underlying mechanism. qPCR data showed that miR136 level increased with preadipocytes proliferation while declined with preadipocytes differentiation...
February 1, 2023: Adipocyte
https://read.qxmd.com/read/36457256/lumican-modulates-adipocyte-function-in-obesity-associated-type-2-diabetes
#34
JOURNAL ARTICLE
Strieder-Barboza, Carmen G Flesher, Lynn M Geletka, Tad Eichler, Olukemi Akinleye, Alexander Ky, Anne P Ehlers, Carey N Lumeng, Robert W O'Rourke
Obesity-associated type 2 diabetes (DM) leads to adipose tissue dysfunction. Lumican is a proteoglycan implicated in obesity, insulin resistance (IR), and adipocyte dysfunction. Using human visceral adipose tissue (VAT) from subjects with and without DM, we studied lumican effects on adipocyte function. Lumican was increased in VAT and adipocytes in DM. Lumican knockdown in adipocytes decreased lipolysis and improved adipogenesis and insulin sensitivity in VAT adipocytes in DM, while treatment with human recombinant lumican increased lipolysis and impaired insulin-sensitivity in an ERK-dependent manner...
December 2022: Adipocyte
https://read.qxmd.com/read/36415995/mri-measured-adipose-features-as-predictive-factors-for-detection-of-prostate-cancer-in-males-undergoing-systematic-prostate-biopsy-a-retrospective-study-based-on-a-chinese-population
#35
JOURNAL ARTICLE
Tianyu Xiong, Fang Cao, Guangyi Zhu, Xiaobo Ye, Yun Cui, Huibo Zhang, Yinong Niu
In this study, we retrospectively evaluated the data of 901 men undergoing ultrasonography-guided systematic prostate biopsy between March 2013 and May 2022. Adipose features, including periprostatic adipose tissue (PPAT) thickness and subcutaneous fat thickness, were measured using MRI before biopsy. Prediction models of all PCa and clinically significant PCa (csPCa) (Gleason score higher than 6) were established based on variables selected by multivariate logistic regression and prediction nomograms were constructed...
December 2022: Adipocyte
https://read.qxmd.com/read/36260113/identification-and-characterization-of-novel-abdominal-and-pelvic-brown-adipose-depots-in-mice
#36
JOURNAL ARTICLE
Ana M Mesa, Theresa I Medrano, Vijay K Sirohi, William H Walker, Richard D Johnson, Sergei G Tevosian, Angie M Adkin, Paul S Cooke
Brown adipose tissue (BAT) generates heat through non-shivering thermogenesis, and increasing BAT amounts or activity could facilitate obesity treatment and provide metabolic benefits. In mice, BAT has been reported in perirenal, thoracic and cranial sites. Here, we describe new pelvic and lower abdominal BAT depots located around the urethra, internal reproductive and urinary tract organs and major lower pelvic blood vessels, as well as between adjacent muscles where the upper hind leg meets the abdominal cavity...
December 2022: Adipocyte
https://read.qxmd.com/read/36168895/dipeptidyl-peptidase-4-cell-surface-expression-marks-an-abundant-adipose-stem-progenitor-cell-population-with-high-stemness-in-human-white-adipose-tissue
#37
JOURNAL ARTICLE
Florian M Hatzmann, Sonja Großmann, Petra Waldegger, G Jan Wiegers, Markus Mandl, Tina Rauchenwald, Gerhard Pierer, Werner Zwerschke
The capacity of adipose stem/progenitor cells (ASCs) to undergo self-renewal and differentiation is crucial for adipose tissue homoeostasis, regeneration and expansion. However, the heterogeneous ASC populations of the adipose lineage constituting adipose tissue are not precisely known. In the present study, we demonstrate that cell surface expression of dipeptidyl peptidase-4 (DPP4)/cluster of differentiation 26 (CD26) subdivides the DLK1- /CD34+ /CD45- /CD31- ASC pool of human white adipose tissues (WATs) into two large populations...
December 2022: Adipocyte
https://read.qxmd.com/read/36093813/adipose-derived-mesenchymal-stem-cell-secreted-extracellular-vesicles-alleviate-non-alcoholic-fatty-liver-disease-via-delivering-mir-223-3p
#38
JOURNAL ARTICLE
Qinghui Niu, Ting Wang, Zhiqiang Wang, Feng Wang, Deyu Huang, Huali Sun, Hanyun Liu
Increasing studies have identified the potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) in non-alcoholic fatty liver disease (NAFLD) treatment. Hence, we further focused on the potential of adipose-derived MSC (ADSC)-EVs in NAFLD by delivering miR-223-3p. The uptake of isolated ADSC-EVs by hepatocytes was assessed, and the expression of miR-223-3p in ADSC-EVs and hepatocytes was characterized. It was established that miR-223-3p, enriched in ADSC-EVs, could be delivered by ADSC-EVs into hepatocytes...
December 2022: Adipocyte
https://read.qxmd.com/read/36053001/salvianolic-acid-a-promotes-mitochondrial-biogenesis-and-mitochondrial-function-in-3t3-l1-adipocytes-through-regulation-of-the-ampk-pgc1%C3%AE-signalling-pathway
#39
JOURNAL ARTICLE
Jialin Sun, Ping Leng, Xiao Li, Qie Guo, Jun Zhao, Yu Liang, Xiaolei Zhang, Xue Yang, Jing Li
Mitochondrial dysfunction is associated with insulin resistance and type 2 diabetes (T2DM). Decreased mitochondrial abundance and function were found in white adipose tissue (WAT) of T2DM patients. Therefore, promoting WAT mitochondrial biogenesis and improving adipocyte metabolism may be strategies to prevent and reverse T2DM. Salvianolic acid A (SAA) has been found to exert anti-diabetic and lipid disorder-improving effects. However whether SAA benefits mitochondrial biogenesis and function in adipose tissue is unclear...
December 2022: Adipocyte
https://read.qxmd.com/read/36036283/bioinformatics-analysis-to-obtain-critical-genes-regulated-in-subcutaneous-adipose-tissue-after-bariatric-surgery
#40
JOURNAL ARTICLE
Shuai Chen, Yicheng Jiang, Xiaoyang Qi, Peng Song, Liming Tang, Hanyang Liu
Bariatric surgery (BS) is a dependable method for managing obesity and metabolic diseases, however, the regulatory processes of lipid metabolism are still not well elucidated. Differentially expressed genes (DEGs) were analysed through three transcriptomic datasets of GSE29409, GSE59034 and GSE72158 from the GEO database regarding subcutaneous adipose tissue (SAT) after BS, and 37 DEGs were identified. The weighted gene co-expression network analysis (WGCNA), last absolute shrinkage and selection operator (LASSO) logistic regression and support vector machine-recursive feature elimination (SVM-RFE) algorithms further screened four key genes involved in the regulation of STMN2, SFRP4, APOE and MXRA5...
December 2022: Adipocyte
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