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Journal of Parkinson's Disease

Nguyen-Vi Mohamed, Frédérique Larroquette, Lenore K Beitel, Edward A Fon, Thomas M Durcan
Studying Parkinson's disease (PD) in the laboratory presents many challenges, the main one being the limited availability of human cells and tissue from affected individuals. As PD is characterized by a loss of dopaminergic (DA) neurons in the brain, it is nearly impossible for researchers to access and extract these cells from living patients. Thus, in the past PD research has focused on the use of patients' post-mortem tissues, animal models, or immortalized cell lines to dissect cellular pathways of interest...
February 4, 2019: Journal of Parkinson's Disease
Ioanna Markaki, Stefanos Klironomos, Per Svenningsson
Cerebral small vessel disease (SVD), often manifesting as white matter lesions (WMLs), and Parkinson's disease (PD) are common disorders whose prevalence increases with age. Vascular risk factors contribute to SVD, but their role in PD is less clear. The study objective was to investigate the frequency and grade of WMLs in PD, and their association with clinical and biochemical parameters. In 100 consecutive patients, we found that increasing WML severity was independently associated with increased age and lower cerebrospinal fluid amyloid-β1-42...
January 28, 2019: Journal of Parkinson's Disease
Timothy Grover, Dejan Georgiev, Rania Kaliola, Philipp Mahlknecht, André Zacharia, Joseph Candelario, Jonathan Hyam, Ludvic Zrinzo, Marwan Hariz, Thomas Foltynie, Patricia Limousin, Marjan Jahanshahi, Elina Tripoliti
BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) is an established treatment for late stage Parkinson's disease (PD). Speech intelligibility (SI) and verbal fluency (VF) have been shown to deteriorate following chronic STN-DBS. It has been suggested that speech might respond favourably to low frequency stimulation (LFS). OBJECTIVE: We examined how speech intelligibility, perceptual speech characteristics, phonemic and semantic VF and processes underlying it (clustering and switching) respond to LFS of 60 and 80 Hz in comparison to high frequency stimulation (HFS) (110, 130 and 200 Hz)...
December 28, 2018: Journal of Parkinson's Disease
Per Petersson, Pär Halje, M Angela Cenci
The mechanisms and significance of basal ganglia oscillations is a fundamental research question engaging both clinical and basic investigators. In Parkinson's disease (PD), neural activity in basal ganglia nuclei is characterized by oscillatory patterns that are believed to disrupt the dynamic processing of movement-related information and thus generate motor symptoms. Beta-band oscillations associated with hypokinetic states have been reviewed in several excellent previous articles. Here we focus on faster oscillatory phenomena that have been reported in association with a diverse range of motor states...
December 26, 2018: Journal of Parkinson's Disease
Kristina Rosqvist, Per Odin, Peter Hagell, Susanne Iwarsson, Maria H Nilsson, Alexander Storch
No abstract text is available yet for this article.
December 21, 2018: Journal of Parkinson's Disease
Deborah Sturm, Ann-Kristin Folkerts, Elke Kalbe
BACKGROUND: Despite a growing research literature on caregiver burden in progressive diseases (e.g., dementia), the experiences and needs of family members of patients with Parkinson's disease (PD), especially of those who are not caring primarily, are underinvestigated. Furthermore, there is only limited evidence for interventions for PD relatives. OBJECTIVE: The aim of this cross-sectional study was to assess the intervention needs of PD family members. METHODS: 133 relatives of PD patients were asked about the essential topics and the appropriate format of a psychoeducational group intervention by means of a standardized questionnaire...
December 19, 2018: Journal of Parkinson's Disease
Ignacio Regidor, Diego Santos-García, Mar Ia José Catalán, Vıctor Puente, Francesc Valldeoriola, Francisco Grandas, Pablo Mir, Juan Carlos Parra, José Matías Arbelo
BACKGROUND: Levodopa-carbidopa intestinal gel (LCIG) is effective in the treatment of advanced Parkinson's disease (PD). However, the patients' profile that might benefit from treatment with LCIG has not been characterized. OBJECTIVE: This retrospective study explored the influence of disease duration (DD) on the effectiveness of LCIG and identified factors associated with treatment discontinuation in a cohort of advanced PD patients. METHODS: Patients initiating LCIG therapy between Jan-2006 and Dec-2011 in 18 Spanish centers were included...
December 14, 2018: Journal of Parkinson's Disease
John R Younce, Albert A Davis, Kevin J Black
 The atypical antipsychotic ziprasidone has been considered inappropriate for use in patients with Parkinson's disease (PD), as most atypical antipsychotics worsen parkinsonism. However, the current evidence for safety and efficacy of ziprasidone in PDP has not been evaluated in a systematic fashion. We review published experience with ziprasidone for treating psychosis in PD via systematic search of MEDLINE, Embase, Cochrane CENTRAL, and with terms related to "ziprasidone" and "Parkinson's disease", inclusive of case reports and prospective studies...
November 21, 2018: Journal of Parkinson's Disease
Kevin McFarthing, Tanya Simuni
No abstract text is available yet for this article.
2019: Journal of Parkinson's Disease
Kevin McFarthing, Tanya Simuni
No abstract text is available yet for this article.
2019: Journal of Parkinson's Disease
Kevin McFarthing
No abstract text is available yet for this article.
2019: Journal of Parkinson's Disease
Bastiaan R Bloem, Rick C Helmich, Tiane Tilanus, Bart P van de Warrenburg
No abstract text is available yet for this article.
2019: Journal of Parkinson's Disease
Anders Björklund, Stephen B Dunnett
Rats and mice with unilateral damage to the nigrostriatal dopamine system-induced by neurotoxins, such as 6-hydroxydopamine, overexpression of α-synuclein, or injections of toxic synuclein protofibrils-are widely used as experimental models to mimic the loss of dopamine neurons seen in Parkinson's disease. The amphetamine rotation test is commonly used to monitor the extent of motor impairment induced by the lesion, and this test has also become the standard tool to demonstrate transplant-induced functional recovery or the efficacy of neuroprotective interventions aimed to preserve or restore DA neuron function...
2019: Journal of Parkinson's Disease
Seok Jong Chung, Han Soo Yoo, Hye Sun Lee, Phil Hyu Lee, Young H Sohn
BACKGROUND: Aberrant plasticity is closely linked to the development of levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). OBJECTIVE: This study investigated whether dominant-side patients with PD exhibit a shorter time to LID development, based on the hypothesis that the dominant hemisphere may have greater plasticity than non-dominant-side patients. METHODS: We analyzed data from 387 right-handed patients with PD who exhibited asymmetric motor deficits and received PD medications for ≥2 years (191 dominant-side and 196 non-dominant-side patients)...
2019: Journal of Parkinson's Disease
Liping Zhang, LingYu Zhang, Lin Li, Christian Hölscher
Parkinson's disease (PD) is a progressive neurological motor control disorder. A key feature is the loss of midbrain dopaminergic neurons and the accumulation of aggregated alpha-synuclein (α-syn). No current treatment is on the market that slows or halts disease progression. Previous studies have shown that glucagon-like peptide-1 (GLP-1) receptor agonists have neuroprotective effects in animal models of PD. In addition, in a phase II clinical trial, the GLP-1 receptor agonist exendin-4 has shown good protective effects in PD patients...
2019: Journal of Parkinson's Disease
Tim Stuckenschneider, Christopher D Askew, Annelise L Menêses, Ricarda Baake, Jan Weber, Stefan Schneider
BACKGROUND: Supervised exercise training alleviates motor symptoms in people with Parkinson's disease (PD). However, the efficacy of exercise to improve nonmotor symptoms such as cognitive function is less well known. OBJECTIVE: To systematically review evidence on the efficacy of different exercise modes (coordination exercise, resistance exercise, aerobic exercise) on domain-specific cognitive function in patients with PD. METHODS: Parallel-group randomized controlled trials published before March 2018 were included...
2019: Journal of Parkinson's Disease
Dario Arnaldi, Sanne K Meles, Alessandro Giuliani, Silvia Morbelli, Remco J Renken, Annette Janzen, Geert Mayer, Cathrine Jonsson, Wolfgang H Oertel, Flavio Nobili, Klaus L Leenders, Marco Pagani
BACKGROUND/OBJECTIVE: Idiopathic REM sleep behavior disorder (iRBD) often precedes Parkinson's disease (PD) and other alpha-synucleinopathies. The aim of the study is to investigate brain glucose metabolism of patients with RBD and PD by means of a multidimensional scaling approach, using18F-FDG-PET as a biomarker of synaptic function. METHODS: Thirty-six iRBD patients (64.1±6.5 y, 32 M), 72 PD patients, and 79 controls (65.6±9.4 y, 53 M) underwent brain 18F-FDG-PET...
2019: Journal of Parkinson's Disease
Anastasiia Bohush, Grażyna Niewiadomska, Serge Weis, Anna Filipek
BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the presence of inclusions known as Lewy bodies in some brain regions. Lewy bodies consist of α-synuclein and many other proteins including chaperones. OBJECTIVE: To learn more about the role of chaperone complexes in PD and a related disorder, i.e., dementia with Lewy bodies (DLB), in this work we analyzed the expression of HSP90 and its two quite recently identified co-chaperones, SGT1 and CHP-1, in selected brain regions from patients suffering from these diseases...
2019: Journal of Parkinson's Disease
Anna Schildt, Matthew D Walker, Katherine Dinelle, Qing Miao, Michael Schulzer, John O'Kusky, Matthew J Farrer, Doris J Doudet, Vesna Sossi
BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic risk factor for Parkinson's disease (PD). While the corresponding pathogenic mechanisms remain largely unknown, LRRK2 has been implicated in the immune system. OBJECTIVE: To assess whether LRRK2 mutations alter the sensitivity to a single peripheral inflammatory trigger, with ultimate impact on dopaminergic integrity, using a longitudinal imaging-based study design. METHODS: Rats carrying LRRK2 p...
November 12, 2018: Journal of Parkinson's Disease
Anthony Santiago, James W Langston, Rita Gandhy, Rohit Dhall, Salima Brillman, Linda Rees, Carolee Barlow
BACKGROUND: Wearable-sensors provide accurate, continuous objective measurements, quantifying the variable motor states of patients with Parkinson's disease (PD) in real time. OBJECTIVES: To evaluate the impact of using continuous objective measurement using the Personal KinetiGraph™ (PKG™) Movement Recording System in the routine clinical care of patients with PD (PwP). METHODS: Physicians employed the use of the PKG in patients for whom they were seeking objective measurement...
November 8, 2018: Journal of Parkinson's Disease
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