journal
https://read.qxmd.com/read/37730732/5-aminovaleric-acid-betaine-predicts-impaired-glucose-metabolism-and-diabetes
#21
JOURNAL ARTICLE
Linus Haberbosch, Sylwia Kierszniowska, Lothar Willmitzer, Knut Mai, Joachim Spranger, Lukas Maurer
BACKGROUND: 5-Aminovaleric acid betaine (5-AVAB) has recently been identified as a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a Western diet. Accumulating evidence suggests a role in metabolic dysfunction associated with obesity, diabetes, and fatty liver disease. However, whether 5-AVAB plays a role in human disease is unclear, and human data are sparse. METHODS: We measured circulating 5-AVAB serum levels in 143 individuals with overweight or obesity participating in a randomized intervention study (NCT00850629) investigating the long-term effect of a weight maintenance strategy after diet-induced weight reduction...
September 20, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37709770/adherence-to-ketogenic-diet-in-lifestyle-interventions-in-adults-with-overweight-or-obesity-and-type-2-diabetes-a-scoping-review
#22
REVIEW
Shiyu Li, Yan Du, Christiane Meireles, Kumar Sharma, Lu Qi, Alondra Castillo, Jing Wang
BACKGROUND/OBJECTIVES: Despite the evidence supporting the efficacy of the ketogenic diet (KD) on weight and type 2 diabetes (T2D) management, adherence to the KD is challenging. Additionally, no studies have reported changes in PA among individuals with overweight/obesity and T2D who have followed KD. We mapped out the methods used to assess adherence to the KD and level of physical activity (PA) in lifestyle interventions for weight and T2D management in individuals with overweight/obesity and T2D and compared levels of KD adherence and PA in these interventions...
September 14, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37689792/ethnicity-race-parent-educational-attainment-and-obesity-associated-with-prediabetes-in-children
#23
JOURNAL ARTICLE
Reem Ghaddar, Erin A Hudson, Matthew R Jeans, Sarvenaz Vandyousefi, Matthew J Landry, Jaimie N Davis
BACKGROUND/OBJECTIVES: Obesity and other predictors of type 2 diabetes disproportionally affect Hispanic and Black children in the US compared to non-Hispanic White (NHW) children. Yet, the prevalence of prediabetes in children remains unestablished, and guidelines for screening young children are lacking. This study examined the relationships between demographic factors and prediabetes in vulnerable youth in central Texas. SUBJECTS/METHODS: This is a cross-sectional analysis of baseline data from 976 3rd-5th graders (7-12 years) who participated in TX Sprouts, a school-based gardening, nutrition, and cooking trial in 16 elementary schools serving mainly children from minority backgrounds and lower-income households...
September 9, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37660118/the-mediating-role-of-obesity-on-the-prospective-association-between-urinary-sucrose-and-diabetes-incidence-in-a-sub-cohort-of-the-epic-norfolk
#24
JOURNAL ARTICLE
Alexander Lang, Oliver Kuss, Tim Filla, Gunter Kuhnle, Sabrina Schlesinger
BACKGROUND/OBJECTIVES: Findings from epidemiological studies showed controversial findings between dietary sugar intake and the development of diabetes. Most of these studies assessed dietary sugar intake by self-reports which might be prone to bias. Urinary sucrose, an objective biomarker of sucrose intake, might provide better insights into this association. Thus, the aim of this study was to investigate the associations between sucrose intake, measured via self-reports and urinary sucrose, with incident diabetes and to detect the impact of obesity on this association...
September 2, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37633959/a-web-based-low-carbohydrate-diet-intervention-significantly-improves-glycaemic-control-in-adults-with-type-2-diabetes-results-of-the-t2diet-study-randomised-controlled-trial
#25
RANDOMIZED CONTROLLED TRIAL
Jedha Dening, Mohammadreza Mohebbi, Gavin Abbott, Elena S George, Kylie Ball, Sheikh Mohammed Shariful Islam
BACKGROUND/OBJECTIVES: In people with type 2 diabetes mellitus (T2DM), low carbohydrate diets (LCD), defined as 10-<26% total energy intake from carbohydrate, have indicated improved glycaemic control and clinical outcomes. Web-based interventions can help overcome significant challenges of accessibility and availability of dietary education and support for T2DM. No previous study had evaluated a web-based LCD intervention using a randomised controlled trial (RCT) design. The objective of this study was to assess whether a web-based LCD programme provided in conjunction with standard care improves glycaemic control in adults with T2DM...
August 27, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37573386/e4orf1-improves-adipose-tissue-specific-metabolic-risk-factors-and-indicators-of-cognition-function-in-a-mouse-model-of-alzheimer-s-disease
#26
JOURNAL ARTICLE
Md Shahjalal Hossain Khan, Marleigh Hefner, Arubala Reddy, Nikhil V Dhurandhar, Vijay Hegde
OBJECTIVE: Obesity, impaired glycemic control, and hepatic steatosis often coexist and are risk factors for developing dementia, and Alzheimer's disease (AD). We hypothesized that a therapeutic agent that improves glycemic control and steatosis may attenuate obesity-associated progression of dementia. We previously identified that adenoviral protein E4orf1 improves glycemic control and reduces hepatic steatosis despite obesity in mice. Here, we determined if this metabolic improvement by E4orf1 will ameliorate cognitive decline in a transgenic mouse model of AD...
August 12, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37460458/severe-covid-19-associated-hyperglycemia-is-caused-by-beta-cell-dysfunction-a-prospective-cohort-study
#27
JOURNAL ARTICLE
Jan Gojda, Kateřina Koudelková, Anna Ouřadová, Alexander Lang, Magdaléna Krbcová, Alexandra Gvozdeva, Viktor Šebo, Lotte Slagmolen, Jana Potočková, Petr Tůma, Lenka Rossmeislová, Michal Anděl, Fredrik Karpe, Sabrina Schlesinger
BACKGROUND: COVID-19, an infectious disease caused by SARS-CoV-2, was shown to be associated with an increased risk of new-onset diabetes. Mechanisms contributing to the development of hyperglycemia are still unclear. We aimed to study whether hyperglycemia is related to insulin resistance and/or beta cell dysfunction. MATERIALS AND METHODS: Survivors of severe COVID-19 but without a known history of diabetes were examined at baseline (T0) and after 3 (T3) and 6 (T6) months: corticosteroids use, indirect calorimetry, and OGTT...
July 17, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37402708/the-heterogeneous-associations-between-gestational-weight-gain-and-adverse-pregnancy-outcomes-in-gestational-diabetes-mellitus-according-to-abnormal-glucose-metabolism
#28
JOURNAL ARTICLE
Qi Wu, Yunyan Chen, Hao Ma, Tao Zhou, Ying Hu, Zhaoxia Liang, Danqing Chen
OBJECTIVES: The gestational weight gain (GWG) and hyperglycemia are two key factors affecting adverse pregnancy outcomes among women with gestational diabetes mellitus (GDM). We aimed to investigate the combinatorial effect of abnormal glucose metabolism and GWG on adverse outcomes in GDM. METHODS: This retrospective cohort study included 2611 pregnant women with GDM in Women's Hospital School of Medicine Zhejiang University. Bases on the OGTT glucose levels, we categorized the GDM cohort into three subgroups: impaired fasting glucose (IFG) group, impaired glucose tolerance (IGT) group, and combined impaired glucose (IFG&IGT) group...
July 4, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37391399/vitamin-d-deficiency-contributes-to-the-diabetic-kidney-disease-progression-via-increase-zeb1-zeb2-expressions
#29
JOURNAL ARTICLE
Cláudia Silva Souza, Amanda Lima Deluque, Beatriz Magalhães Oliveira, Ana Lívia Dias Maciel, Cleonice Giovanini, Patrícia Aline Boer, Francisco José Albuquerque de Paula, Roberto Silva Costa, Heloísa Della Colleta Franscecato, Lucas Ferreira de Almeida, Terezila Machado Coimbra
BACKGROUND: Diabetic kidney disease (DKD) remains one of the main causes of end-stage renal disease (ESRD) and mortality in diabetic patients worldwide. Vitamin D deficiency (VitDD) is one of the main consequences of different chronic kidney disease (CKD) types and is associated with rapid progression to ESRD. Nevertheless, the mechanisms that lead to this process are poorly understood. This study aimed to characterize a model of diabetic nephropathy progression in VitDD and the epithelial-mesenchymal-transition (EMT) role in these processes...
July 1, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37127641/association-between-fatty-acids-and-the-risk-of-impaired-glucose-tolerance-and-type-2-diabetes-mellitus-in-american-adults-nhanes-2005-2016
#30
JOURNAL ARTICLE
Xiaoqiong Zhu, Liu Chen, Jiansheng Lin, Mingqin Ba, Junqiu Liao, Ping Zhang, Cunxi Zhao
BACKGROUND: Fatty acids (FAs) play a major role in regulating insulin sensitivity. However, owing to dietary quantitative tools, it has been challenging to study the dietary FAs in previous studies. There is a lack of knowledge regarding the associations between dietary FAs and the risk of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). METHODS: Dietary FAs, adjustment of variables including age, sex, race, educational level, poverty to income ratio, body mass index, smoking, hypertension, physical activity, and diabetes data were extracted from the National Health and Nutrition Examination Survey 2005-2016...
May 1, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37085526/multi-omics-signatures-in-new-onset-diabetes-predict-metabolic-response-to-dietary-inulin-findings-from-an-observational-study-followed-by-an-interventional-trial
#31
JOURNAL ARTICLE
N Ďásková, I Modos, M Krbcová, M Kuzma, H Pelantová, J Hradecký, M Heczková, M Bratová, P Videňská, P Šplíchalová, M Králová, M Heniková, J Potočková, A Ouřadová, R Landberg, T Kühn, M Cahová, J Gojda
AIM: The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ across metabolic spectra (lean-obese-diabetes); (2) that specific MIME patterns could explain the differential responses to dietary inulin; and (3) that the response can be predicted based on baseline MIME signature and clinical characteristics...
April 21, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37085478/sugar-sweetened-beverages-low-no-calorie-beverages-fruit-juice-and-non-alcoholic-fatty-liver-disease-defined-by-fatty-liver-index-the-sweet-project
#32
JOURNAL ARTICLE
Novita D Naomi, Joy Ngo, Elske M Brouwer-Brolsma, Marion E C Buso, Sabita S Soedamah-Muthu, Carmen Pérez-Rodrigo, Joanne A Harrold, Jason C G Halford, Anne Raben, Johanna M Geleijnse, Lluis Serra-Majem, Edith J M Feskens
BACKGROUND: Sweetened beverage intake may play a role in non-alcoholic fatty liver disease (NAFLD) development, but scientific evidence on their role is limited. This study examined associations between sugar-sweetened beverages (SSB), low/no-calorie beverages (LNCB) and fruit juice (FJ) intakes and NAFLD in four European studies. METHODS: Data for 42,024 participants of Lifelines Cohort, NQPlus, PREDIMED-Plus and Alpha Omega Cohort were cross-sectionally analysed...
April 21, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37076479/trends-in-dietary-patterns-over-the-last-decade-and-their-association-with-long-term-mortality-in-general-us-populations-with-undiagnosed-and-diagnosed-diabetes
#33
JOURNAL ARTICLE
Sheng Yuan, Jining He, Shaoyu Wu, Rui Zhang, Zheng Qiao, Xiaohui Bian, Hongjian Wang, Kefei Dou
BACKGROUND: Dietary management plays an important role in diabetes care, while the trends in dietary patterns over the last decade in US adults with diagnosed and undiagnosed diabetes remain unknown. This study aims to estimate the dietary patterns over the last decade by baseline diabetes diagnoses and explore their association with long-term prognosis. METHODS: Participants' data were extracted from the National Health and Nutrition Examination Survey (NHANES) 2007-2018, which were divided into three groups according to the diabetes diagnosis: without diabetes, undiagnosed diabetes, and diagnosed diabetes...
April 19, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37031163/lentinan-confers-protection-against-type-1-diabetes-by-inducing-regulatory-t-cell-in-spontaneous-non-obese-diabetic-mice
#34
JOURNAL ARTICLE
Tijun Wu, Zhi Cai, Fandi Niu, Bin Qian, Peng Sun, Nan Yang, Jing Pang, Hongliang Mei, Xiaoai Chang, Fang Chen, Yunxia Zhu, Yating Li, Fu-Gen Wu, Yaqin Zhang, Ting Lei, Xiao Han
BACKGROUND: Lentinan (LNT) is a complex fungal component that possesses effective antitumor and immunostimulating properties. However, there is a paucity of studies regarding the effects and mechanisms of LNT on type 1 diabetes. OBJECTIVE: In the current study, we investigated whether an intraperitoneal injection of LNT can diminish the risk of developing type 1 diabetes (T1D) in non-obese diabetic (NOD) mice and further examined possible mechanisms of LNT's effects...
April 8, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/37024467/a-scalable-virtual-weight-management-program-tailored-for-adults-with-type-2-diabetes-effects-on-glycemic-control
#35
JOURNAL ARTICLE
John W Apolzan, Jessica Gokee LaRose, Stephen D Anton, Robbie A Beyl, Frank L Greenway, Edmond P Wickham, Autumn Lanoye, Melissa N Harris, Corby K Martin, Tiffany Bullard, Gary D Foster, Michelle I Cardel
BACKGROUND: The objective was to test the efficacy of a scalable, virtually delivered, diabetes-tailored weight management program on glycemic control in adults with type 2 diabetes (T2D). METHODS: This was a single arm, three-site clinical trial. Participants had baseline HbA1c between 7-11% and BMI between 27-50 kg/m2 . Primary outcome was change in HbA1c at 24 weeks. Secondary outcomes were changes in body weight, waist circumference, the Diabetes Distress Scale (DDS), quality of life (IWQOL-L), and hunger (VAS)...
April 6, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/36854678/daily-phytate-intake-increases-adiponectin-levels-among-patients-with-diabetes-type-2-a-randomized-crossover-trial
#36
RANDOMIZED CONTROLLED TRIAL
Pilar Sanchis, Paula Calvo, Antelm Pujol, Rosmeri Rivera, Francisco Berga, Regina Fortuny, Antonia Costa-Bauza, Felix Grases, Luis Masmiquel
AIM: Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2. METHODS: We performed a randomized crossover trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39)...
February 28, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/36604407/the-intestinal-permeability-marker-fitc-dextran-4kda-should-be-dosed-according-to-lean-body-mass-in-obese-mice
#37
JOURNAL ARTICLE
Louise M Voetmann, Bidda Rolin, Rikke K Kirk, Charles Pyke, Axel K Hansen
AIMS: To investigate the influence of the dose in the FITC-Dextran 4kDa (FD-4) permeability test in an obese mouse model, we tested the bodyweight dose regimen and a lean body mass-based dose regimen in high fat diet (HFD) mice and low fat diet (LFD) mice. We hypothesized that the FD-4 permeation result would be dose-dependent. METHODS: The two dose regimens were compared in HFD and LFD mice. Furthermore, we conducted a dose-response study to test the effect of a low or high dose of FD-4 in weight-stratified lean mice...
January 5, 2023: Nutrition & Diabetes
https://read.qxmd.com/read/36564376/the-effect-of-aging-on-glucose-metabolism-improvement-after-roux-en-y-gastric-bypass-in-type-2-diabetes-rats
#38
JOURNAL ARTICLE
Weijie Chen, Haixin Yin, Jianchun Xiao, Wei Liu, Qiang Qu, Fengying Gong, Xiaodong He
BACKGROUND: This study aimed to investigate the effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass (RYGB) in rat models with type 2 diabetes mellitus (T2DM). METHODS: Twenty aged Goto-Kakizaki rats were randomly assigned into RYGB-A group and sham RYGB (SR-A) group, and 10 adult Goto-Kakizaki rats also accept RYGB procedures (RYGB-Y). Glucose metabolism, resting energy expenditure (REE), glucagon-like peptide-1 (GLP-1) and total bile acid level were measured...
December 23, 2022: Nutrition & Diabetes
https://read.qxmd.com/read/36535927/dna-methylation-and-gene-expression-analysis-in-adipose-tissue-to-identify-new-loci-associated-with-t2d-development-in-obesity
#39
JOURNAL ARTICLE
Paulina Baca, Francisco Barajas-Olmos, Elaheh Mirzaeicheshmeh, Carlos Zerrweck, Lizbeth Guilbert, Ernesto Carlos Sánchez, Marlen Flores-Huacuja, Rafael Villafán, Angélica Martínez-Hernández, Humberto García-Ortiz, Cecilia Contreras-Cubas, Federico Centeno-Cruz, Lorena Orozco
BACKGROUND: Obesity is accompanied by excess adipose fat storage, which may lead to adipose dysfunction, insulin resistance, and type 2 diabetes (T2D). Currently, the tendency to develop T2D in obesity cannot be explained by genetic variation alone-epigenetic mechanisms, such as DNA methylation, might be involved. Here, we aimed to identify changes in DNA methylation and gene expression in visceral adipose tissue (VAT) that might underlie T2D susceptibility in patients with obesity. METHODS: We investigated DNA methylation and gene expression in VAT biopsies from 19 women with obesity, without (OND = 9) or with T2D (OD = 10)...
December 19, 2022: Nutrition & Diabetes
https://read.qxmd.com/read/36494332/the-association-of-maternal-fat-soluble-antioxidants-in-early-pregnancy-with-gestational-diabetes-mellitus-a-prospective-cohort-study
#40
JOURNAL ARTICLE
Yanyu Lyu, Guiyun Wang, Zhenfeng Sun, Xiaodai Cui, Qingyong Xiu, Lijun Wu
INTRODUCTION: Oxidative stress is linked to the development of gestational diabetes mellitus (GDM). Maternal antioxidant vitamins in early pregnancy may play a role in GDM occurrence. We aimed to investigate the associations of vitamins A and E in early pregnancy with the risk of GDM and to explore whether these antioxidant vitamins can be biomarkers for the early prediction of GDM. METHODS: We carried out a prospective cohort study conducted in Beijing and enrolled pregnant women (n = 667) with vitamins A and E measurements at 9 weeks (IQR 8-10) of gestation and having one-step GDM screened with a 75-g oral glucose tolerance test between 24 and 28 weeks of gestation...
December 9, 2022: Nutrition & Diabetes
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