Shushmita Chand, Alok Shiomurti Tripathi, Tabinda Hasan, Kavitha Ganesh, Mary Anne W Cordero, Mohammad Yasir, Magdi E A Zaki, Pankaj Tripathi, Lucy Mohapatra, Rahul Kumar Maurya
OBJECTIVES: Present report evaluates the protective effect of geraniol on high fat diet (HFD) induced obesity in rats and also determines the molecular mechanism of it. METHODS: Rats were induced with obesity with administration of HFD for four weeks and geraniol 200 and 400 mg/kg p.o. was administered for the next four week in the respective groups. Blood glucose and oral glucose tolerance test (OGTT), lipid profile was estimated in the geraniol treated HFD induced obesity in rats...
December 5, 2023: Nutrition & Diabetes
Xiaofei Liu, Yangrui Zheng, Da Li, Yali Zhao, Houchen Lv, Lixun Guan, Shihui Fu
PURPOSE: This prospective study with 10-year follow-up aimed to analyze potential impact of body mass index (BMI) and gamma gap on heart failure and mortality rate in older patients with coronary artery disease (CAD). METHODS: There were 987 consecutive older patients with CAD included and divided into four groups according to BMI and gamma gap levels. RESULTS: Median age was 86 years. The highest proportion of heart failure (46.2%) and the highest mortality rate (84...
December 5, 2023: Nutrition & Diabetes
Cheng Luo, Can Hou, Danyi Yang, Tingting Tan, Chen Chao
AIMS: Type 1 diabetes (T1D) is an autoimmune disorder that destroys insulin-generating pancreatic β-cells. Preserving pancreatic β-cell function is important for treating T1D. Our study aims to explore the mechanism underlying urolithin C (UC)-mediated regulation of β-cell function. METHODS: Non-obese diabetic (NOD) mice were administrated with UC to evaluate UC-mediated protection of T1D. The inflammation of the pancreas islets was examined by hematoxylin and eosin staining...
December 1, 2023: Nutrition & Diabetes
Na Liu, Chunni Heng, Yi Cui, Di Wu, Ling Li, Mengge Bai, Yanxue Guo, Wen Wang, Yinling Zhang
BACKGROUND: Dietary management has been recommended as the cornerstone of type 2 diabetes mellitus (T2DM) management. However, low adherence to dietary recommendations has been identified in both developed and developing countries. Previous research suggests that inhibitory control influences eating behavior, but few studies have been conducted in patients with T2DM. Thus, we aimed to explore the relationship between inhibitory control and dietary adherence among patients with T2DM. METHODS: A total of 393 patients with T2DM from the endocrinology departments of three tertiary hospitals in China were enrolled by the convenience sampling method...
November 22, 2023: Nutrition & Diabetes
Swetha Sampathkumar, Durga Parkhi, Yonas Ghebremichael-Weldeselassie, Nithya Sukumar, Ponnusamy Saravanan
BACKGROUND: Gestational Diabetes Mellitus (GDM) is hyperglycaemia first detected during pregnancy. Globally, GDM affects around 1 in 6 live births (up to 1 in 4 in low- and middle-income countries- LMICs), thus, urgent measures are needed to prevent this public health threat. OBJECTIVE: To determine the effectiveness of pre-pregnancy lifestyle in preventing GDM. METHODS: We searched MEDLINE, Web of science, Embase and Cochrane central register of controlled trials...
November 16, 2023: Nutrition & Diabetes
Qianwen Zhao, Yifan Yin, Yunlei Deng
BACKGROUND AND AIMS: Sarcopenia is associated with worse prognosis for non-alcoholic fatty liver disease (NAFLD). However, disease progression in the MAFLD-related sarcopenia is largely unknown. We aimed to clarify the relationship between MAFLD and/or sarcopenia with mortality and liver fibrosis in the real world. METHODS: A total of 13,692 individuals were selected from the third National Health and Nutrition Examination Surveys and linked mortality until December 2019...
November 15, 2023: Nutrition & Diabetes
Osvaldo F Morera, Mosi I Dane'el, Brandt A Smith, Alisha H Redelfs, Sarah L Ruiz, Kristopher J Preacher, Leah D Whigham
BACKGROUND/OBJECTIVES: Nutrition and obesity researchers often dichotomize or discretize continuous independent variables to conduct an analysis of variance to examine group differences. We describe consequences associated with dichotomizing and discretizing continuous variables using two cross-sectional studies related to nutrition. SUBJECTS/METHODS: Study 1 investigated the effects of health literacy and nutrition knowledge on nutrition label accuracy (n = 612)...
November 8, 2023: Nutrition & Diabetes
Jungu Lee, Suyeon Jeon, Mijeong Lee, Michung Yoon
BACKGROUND: Fenofibrate is a hypolipidemic peroxisome proliferator-activated receptor α (PPARα) agonist used clinically to reduce hypercholesterolemia and hypertriglyceridemia. OBJECTIVE: We investigated the effects of fenofibrate on insulin resistance and tissue inflammation in a high-fat diet (HFD)-fed ovariectomized (OVX) C57BL/6J mice, a mouse model of obese postmenopausal women. METHODS: Female OVX mice were randomly divided into 3 groups and received a low-fat diet, an HFD, or an HFD supplemented with 0...
November 7, 2023: Nutrition & Diabetes
Yanjun Song, Zhen'ge Chang, Chenxi Song, Kongyong Cui, Boqun Shi, Rui Zhang, Qiuting Dong, Kefei Dou
BACKGROUND/OBJECTIVES: To date, evidence regarding the protective roles of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet in patients with type 2 diabetes mellitus (T2DM) is scarce. This study aims to estimate the impact of adhering to the MIND diet on the mortality in patients with and without T2DM. SUBJECTS/METHODS: In this cohort study, 6887 participants (1021 patients with T2DM) from the NHANES dataset were analyzed...
October 10, 2023: Nutrition & Diabetes
Linus Haberbosch, Sylwia Kierszniowska, Lothar Willmitzer, Knut Mai, Joachim Spranger, Lukas Maurer
BACKGROUND: 5-Aminovaleric acid betaine (5-AVAB) has recently been identified as a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a Western diet. Accumulating evidence suggests a role in metabolic dysfunction associated with obesity, diabetes, and fatty liver disease. However, whether 5-AVAB plays a role in human disease is unclear, and human data are sparse. METHODS: We measured circulating 5-AVAB serum levels in 143 individuals with overweight or obesity participating in a randomized intervention study (NCT00850629) investigating the long-term effect of a weight maintenance strategy after diet-induced weight reduction...
September 20, 2023: Nutrition & Diabetes
Shiyu Li, Yan Du, Christiane Meireles, Kumar Sharma, Lu Qi, Alondra Castillo, Jing Wang
BACKGROUND/OBJECTIVES: Despite the evidence supporting the efficacy of the ketogenic diet (KD) on weight and type 2 diabetes (T2D) management, adherence to the KD is challenging. Additionally, no studies have reported changes in PA among individuals with overweight/obesity and T2D who have followed KD. We mapped out the methods used to assess adherence to the KD and level of physical activity (PA) in lifestyle interventions for weight and T2D management in individuals with overweight/obesity and T2D and compared levels of KD adherence and PA in these interventions...
September 14, 2023: Nutrition & Diabetes
Reem Ghaddar, Erin A Hudson, Matthew R Jeans, Sarvenaz Vandyousefi, Matthew J Landry, Jaimie N Davis
BACKGROUND/OBJECTIVES: Obesity and other predictors of type 2 diabetes disproportionally affect Hispanic and Black children in the US compared to non-Hispanic White (NHW) children. Yet, the prevalence of prediabetes in children remains unestablished, and guidelines for screening young children are lacking. This study examined the relationships between demographic factors and prediabetes in vulnerable youth in central Texas. SUBJECTS/METHODS: This is a cross-sectional analysis of baseline data from 976 3rd-5th graders (7-12 years) who participated in TX Sprouts, a school-based gardening, nutrition, and cooking trial in 16 elementary schools serving mainly children from minority backgrounds and lower-income households...
September 9, 2023: Nutrition & Diabetes
Alexander Lang, Oliver Kuss, Tim Filla, Gunter Kuhnle, Sabrina Schlesinger
BACKGROUND/OBJECTIVES: Findings from epidemiological studies showed controversial findings between dietary sugar intake and the development of diabetes. Most of these studies assessed dietary sugar intake by self-reports which might be prone to bias. Urinary sucrose, an objective biomarker of sucrose intake, might provide better insights into this association. Thus, the aim of this study was to investigate the associations between sucrose intake, measured via self-reports and urinary sucrose, with incident diabetes and to detect the impact of obesity on this association...
September 2, 2023: Nutrition & Diabetes
Jedha Dening, Mohammadreza Mohebbi, Gavin Abbott, Elena S George, Kylie Ball, Sheikh Mohammed Shariful Islam
BACKGROUND/OBJECTIVES: In people with type 2 diabetes mellitus (T2DM), low carbohydrate diets (LCD), defined as 10-<26% total energy intake from carbohydrate, have indicated improved glycaemic control and clinical outcomes. Web-based interventions can help overcome significant challenges of accessibility and availability of dietary education and support for T2DM. No previous study had evaluated a web-based LCD intervention using a randomised controlled trial (RCT) design. The objective of this study was to assess whether a web-based LCD programme provided in conjunction with standard care improves glycaemic control in adults with T2DM...
August 27, 2023: Nutrition & Diabetes
Md Shahjalal Hossain Khan, Marleigh Hefner, Arubala Reddy, Nikhil V Dhurandhar, Vijay Hegde
OBJECTIVE: Obesity, impaired glycemic control, and hepatic steatosis often coexist and are risk factors for developing dementia, and Alzheimer's disease (AD). We hypothesized that a therapeutic agent that improves glycemic control and steatosis may attenuate obesity-associated progression of dementia. We previously identified that adenoviral protein E4orf1 improves glycemic control and reduces hepatic steatosis despite obesity in mice. Here, we determined if this metabolic improvement by E4orf1 will ameliorate cognitive decline in a transgenic mouse model of AD...
August 12, 2023: Nutrition & Diabetes
Jan Gojda, Kateřina Koudelková, Anna Ouřadová, Alexander Lang, Magdaléna Krbcová, Alexandra Gvozdeva, Viktor Šebo, Lotte Slagmolen, Jana Potočková, Petr Tůma, Lenka Rossmeislová, Michal Anděl, Fredrik Karpe, Sabrina Schlesinger
BACKGROUND: COVID-19, an infectious disease caused by SARS-CoV-2, was shown to be associated with an increased risk of new-onset diabetes. Mechanisms contributing to the development of hyperglycemia are still unclear. We aimed to study whether hyperglycemia is related to insulin resistance and/or beta cell dysfunction. MATERIALS AND METHODS: Survivors of severe COVID-19 but without a known history of diabetes were examined at baseline (T0) and after 3 (T3) and 6 (T6) months: corticosteroids use, indirect calorimetry, and OGTT...
July 17, 2023: Nutrition & Diabetes
Qi Wu, Yunyan Chen, Hao Ma, Tao Zhou, Ying Hu, Zhaoxia Liang, Danqing Chen
OBJECTIVES: The gestational weight gain (GWG) and hyperglycemia are two key factors affecting adverse pregnancy outcomes among women with gestational diabetes mellitus (GDM). We aimed to investigate the combinatorial effect of abnormal glucose metabolism and GWG on adverse outcomes in GDM. METHODS: This retrospective cohort study included 2611 pregnant women with GDM in Women's Hospital School of Medicine Zhejiang University. Bases on the OGTT glucose levels, we categorized the GDM cohort into three subgroups: impaired fasting glucose (IFG) group, impaired glucose tolerance (IGT) group, and combined impaired glucose (IFG&IGT) group...
July 4, 2023: Nutrition & Diabetes
Cláudia Silva Souza, Amanda Lima Deluque, Beatriz Magalhães Oliveira, Ana Lívia Dias Maciel, Cleonice Giovanini, Patrícia Aline Boer, Francisco José Albuquerque de Paula, Roberto Silva Costa, Heloísa Della Colleta Franscecato, Lucas Ferreira de Almeida, Terezila Machado Coimbra
BACKGROUND: Diabetic kidney disease (DKD) remains one of the main causes of end-stage renal disease (ESRD) and mortality in diabetic patients worldwide. Vitamin D deficiency (VitDD) is one of the main consequences of different chronic kidney disease (CKD) types and is associated with rapid progression to ESRD. Nevertheless, the mechanisms that lead to this process are poorly understood. This study aimed to characterize a model of diabetic nephropathy progression in VitDD and the epithelial-mesenchymal-transition (EMT) role in these processes...
July 1, 2023: Nutrition & Diabetes
Xiaoqiong Zhu, Liu Chen, Jiansheng Lin, Mingqin Ba, Junqiu Liao, Ping Zhang, Cunxi Zhao
BACKGROUND: Fatty acids (FAs) play a major role in regulating insulin sensitivity. However, owing to dietary quantitative tools, it has been challenging to study the dietary FAs in previous studies. There is a lack of knowledge regarding the associations between dietary FAs and the risk of impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM). METHODS: Dietary FAs, adjustment of variables including age, sex, race, educational level, poverty to income ratio, body mass index, smoking, hypertension, physical activity, and diabetes data were extracted from the National Health and Nutrition Examination Survey 2005-2016...
May 1, 2023: Nutrition & Diabetes
N Ďásková, I Modos, M Krbcová, M Kuzma, H Pelantová, J Hradecký, M Heczková, M Bratová, P Videňská, P Šplíchalová, M Králová, M Heniková, J Potočková, A Ouřadová, R Landberg, T Kühn, M Cahová, J Gojda
AIM: The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ across metabolic spectra (lean-obese-diabetes); (2) that specific MIME patterns could explain the differential responses to dietary inulin; and (3) that the response can be predicted based on baseline MIME signature and clinical characteristics...
April 21, 2023: Nutrition & Diabetes
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