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Journals International Journal of Surgi...

International Journal of Surgical Oncology

https://read.qxmd.com/read/33381312/critical-analysis-of-stage-iv-epithelial-ovarian-cancer-patients-after-treatment-with-neoadjuvant-chemotherapy-followed-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs-hipec
#21
JOURNAL ARTICLE
Carlos A Munoz-Zuluaga, Armando Sardi, Michelle Sittig, Vadim Gushchin, Mary C King, Carol Nieroda, Felipe Lopez-Ramirez, Teresa P Diaz-Montes
Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) after neoadjuvant chemotherapy (NACT) showed promise as initial treatment for stage IIIC (SIII) epithelial ovarian cancer (EOC); however, stage IV (SIV) outcomes are rarely reported. We assessed our experience and outcomes treating newly diagnosed SIV EOC with NACT plus CRS/HIPEC compared to SIII patients. Methods: Advanced EOC from 2015-2018 managed with NACT (carboplatin/paclitaxel) due to unresectable disease or poor performance status followed by interval CRS/HIPEC were reviewed...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32953172/enabling-microparticle-imprinting-to-achieve-penetration-and-local-endurance-in-the-peritoneum-via-high-intensity-ultrasound-hius-for-the-treatment-of-peritoneal-metastasis
#22
JOURNAL ARTICLE
Agata Mikolajczyk, Tanja Khosrawipour, Alice Martino, Joanna Kulas, Marek Pieczka, Maciej Zacharski, Jakub Nicpon, Veria Khosrawipour
Introduction: Micro- and nanoparticles, with their submicron size, the versatility of physical and chemical properties, and easily modifiable surface, are uniquely positioned to bypass the body's clearing systems. Nonetheless, two main problems with micro- and nanoparticles arise which limit the intraperitoneal application. The study was performed to evaluate whether HIUS enables the imprinting of microparticles and, therefore, enhances penetration and local endurance in the peritoneum...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32733704/the-management-of-desmoid-tumors-a-retrospective-study-of-30-cases
#23
JOURNAL ARTICLE
Yosr Zenzri, Yosra Yahyaoui, Lamia Charfi, Zahra Ghodhbani, Feryel Letaief, Mouna Ayadi, Amel Mezlini
OBJECTIVES: Desmoid tumor also called aggressive fibromatosis is a rare type of benign tumor. It is a mesenchymal malignancy without metastatic potential. The standard management is resection, but other options including observation may be discussed. Desmoid-type fibromatosis may occur throughout the body, but the abdominal wall is the most common site. The aim of our study was to assess the clinicoepidemiological profile, prognostic factors, and treatment outcome of desmoid tumors. METHODS: A monocentric retrospective study was conducted over a period of 19 years between February 2000 and November 2019 at the oncology department of Salah Azaïz Institute...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32695508/aldh1-cancer-stem-cell-marker-as-a-prognostic-factor-in-triple-negative-breast-cancer
#24
JOURNAL ARTICLE
Sonar Soni Panigoro, Dian Kurnia, Ahmad Kurnia, Samuel Johny Haryono, Zafiral Azdi Albar
Breast cancer is the most common cancer with an increasing incidence in Asia. About 20% of all breast cancers are triple-negative breast cancers (TNBCs). BCSC is a subset of tumor cells that has stem cell-like characteristics, such as a high capacity for self-renewal and tumor initiation, which implies that BCSC may cause aggressiveness of TNBC. ALDH1 has a role in early stem cell differentiation through its function in the oxidation of retinol to retinoic acid, proposed to be a strong candidate for breast cancer stem cells...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32685211/predictive-factors-of-positive-circumferential-and-longitudinal-margins-in-early-t3-colorectal-cancer-resection
#25
JOURNAL ARTICLE
M Ashraf Balbaa, Noha Elkady, Emad M Abdelrahman
Background: Malignant involvement of circumferential resection margin (CRM) and longitudinal resection margin (LRM) after surgical resection of colorectal cancer (CRC) are associated with higher rates of recurrence and development of distant metastasis. This can influence the overall patient's prognosis. The aim of the current study was to identify pathological factors as predictors for the involvement of resection margins in early T3 CRC. Patients and Methods. Fifty patients radiologically diagnosed to have cT3a/b (CRC) were included in the study...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32550023/parosteal-osteosarcoma-a-benign-looking-tumour-amenable-to-a-variety-of-surgical-reconstruction
#26
JOURNAL ARTICLE
Yogi Prabowo, Achmad Fauzi Kamal, Evelina Kodrat, Marcel Prasetyo, Samuel Maruanaya, Toto Suryo Efar
Osteosarcoma arising from cortical surface is classified into parosteal, periosteal and high-grade surface osteosarcoma. Along the spectrum, parosteal osteosarcoma occupies the well-differentiated end. It is a relatively rare disease entity, comprised only 4% of all osteosarcomas and barely reported in the literature. The objective of this study is to describe cases of parosteal osteosarcoma as well as a variety of treatment options amenable to such entity. Six cases of parosteal osteosarcoma were identified based on histopathological reports in a tertiary referral hospital in Jakarta, Indonesia between January 2001 and December 2019...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32455011/clinicopathologic-features-and-outcome-of-adenocarcinoma-of-the-anal-canal-a-population-based-study
#27
JOURNAL ARTICLE
Shekhar Gogna, Roberto Bergamaschi, Agon Kajmolli, Mahir Gachabayov, Aram Rojas, David Samson, Rifat Latifi, Xiang Da Dong
Background: Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States. Methods: The data on anal canal adenocarcinoma from SEER Program, between 1973-2015, were extracted. We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival. Results: The incidence of AA increased initially by 4...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32351736/the-effect-of-lymph-nodes-histologic-response-on-survival-outcomes-in-moroccan-patients-with-rectal-cancer
#28
JOURNAL ARTICLE
Ihsane El Otmani, Fatima El Agy, Mohammed El Abkari, Karim Ibn Majdoub Hassani, Khalid Mazaz, El Bachir Benjelloun, Khalid Ait Taleb, Touria Bouhafa, Zineb Benbrahim, Sidi Adil Ibrahimi, Laila Chbani
Prognosis for patients with locally advanced rectal cancer remains controversial. The purpose of this study was to elucidate possible association between therapeutic effect on lymph nodes (LNs) and patient prognosis. Overall, 149 patients with rectal cancer received preoperative radiotherapy in concomitance with chemotherapy or exclusive radiotherapy before rectal excision. Microscopic examination of formalin-fixed lymph nodes was assessed for therapeutic effect. The establishment of groups combined reaction tissue types of fibrosis, colloid, and necrosis after neoadjuvant treatment was assigned...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/32181017/saving-the-breast-saves-the-lives-of-breast-cancer-patients
#29
JOURNAL ARTICLE
Mohammad Esmaeil Akbari, Maryam Khayamzadeh, Hamid Reza Mirzaei, Afshin Moradi, Atieh Akbari, Farid Moradian, Neda Khalili
Introduction . Surgery has been known as the procedure of choice for breast cancer management since 1700 years before Christ. Nowadays, breast-conserving surgery and mastectomy are performed in selected cases with specific clinical criteria. Here, we compare these two procedures for breast cancer patients with variable features in Cancer Research Center, Tehran, as a single institution experience. Methods: In this 25-year follow-up retrospective cohort study, we identified breast cancer patients who had undergone breast-conserving therapy or mastectomy...
2020: International Journal of Surgical Oncology
https://read.qxmd.com/read/31915549/early-lymph-node-metastasis-may-predict-poor-prognosis-in-soft-tissue-sarcoma
#30
JOURNAL ARTICLE
Makoto Emori, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Tomoko Sonoda, Arihiko Tsukamoto, Junya Shimizu, Yasutaka Murahashi, Emi Mizushima, Kohichi Takada, Kazuyuki Murase, Kotoe Iesato, Keita Igarashi, Tsukasa Hori, Masaki Yamamoto, Shintaro Sugita, Naohisa Miyakoshi, Tadashi Hasegawa, Yoichi Shimada, Toshihiko Yamashita
Background: Lymph node metastasis (LNM) is a relatively rare event in soft tissue sarcoma. An association between the timing of LNM detection and patient prognosis is presently unknown. Patients and Methods: We retrospectively analyzed the clinicopathological features of 33 patients with LNM between 2001 and 2015. Analysis of the timing of LNM diagnosis was grouped according to patients presenting LNM in either <8 months (the median time from primary tumor diagnosis to LNM) or ≥8 months after primary tumor diagnosis...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/31915548/increased-tissue-penetration-of-doxorubicin-in-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-after-high-intensity-ultrasound-hius
#31
JOURNAL ARTICLE
Veria Khosrawipour, Sören Reinhard, Alice Martino, Tanja Khosrawipour, Mohamed Arafkas, Agata Mikolajczyk
Background: High-intensity ultrasound (HIUS) has been studied for the past two decades as a new therapeutic option for solid tumor direct treatment and a method for better chemotherapy delivery and perfusion. This treatment approach has not been tested to our knowledge in peritoneal metastatic therapy, where limited tissue penetration of intraperitoneal chemotherapy has been a main problem. Both liquid instillations and pressurized aerosols are affected by this limitation. This study was performed to evaluate whether HIUS improves chemotherapy penetration rates...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/31737363/thyroidectomy-as-treatment-of-choice-for-differentiated-thyroid-cancer
#32
JOURNAL ARTICLE
Dario Giuffrida, Raffaella Giuffrida, Ivana Puliafito, Veronica Vella, Lorenzo Memeo, Caterina Puglisi, Concetto Regalbuto, Gabriella Pellegriti, Stefano Forte, Antonino Belfiore
BACKGROUND: Despite a large amount of data, the optimal surgical management of differentiated thyroid cancer remains controversial. Current guidelines recommend total thyroidectomy if primary thyroid cancer is >4 cm, while for tumors that are between 1 and 4 cm in size, either a bilateral or a unilateral thyroidectomy may be appropriate as surgical treatment. In general, total thyroidectomy would seem to be preferable because subtotal resection can be correlated with a higher risk of local recurrences and cervical lymph node metastases; on the other hand, total thyroidectomy is associated with more complications...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/31316828/postsurgical-ultrasound-evaluation-of-patients-with-prosthesis-in-acellular-dermal-matrix-results-from-monocentric-experience
#33
JOURNAL ARTICLE
Ballesio Laura, Casinelli Alice, Gigli Silvia, Boldrini Cristiana, Di Taranto Giuseppe, Albano Antonio, Onesti Maria Giuseppina
Mastectomy and breast prosthetic reconstruction is the most common surgical treatment for women diagnosed with breast cancer. In the last few years, breast prosthetic augmentation in acellular dermal matrix (ADM) has been introduced. The aim of this study is to present our single-center experience in evaluating the outcome of patients who underwent breast reconstruction in ADM, using ultrasound (US) examination. US follow-up allows evaluating both normal postoperative findings and changes and potential local complications, demonstrating that ADM is a safe option for women candidates for mastectomy...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/31186956/prognostic-factors-and-survival-time-in-patients-with-small-bowel-tumors-a-retrospective-observational-study
#34
JOURNAL ARTICLE
Shokouh Taghipour Zahir, Zahra Heidarymeybodi, Sogol AleSaeidi
This study examines survival time in patients with small bowel tumors and determines its contributing factors. In this retrospective analytical study, the medical records of 106 patients with small bowel cancer (from 2006 to 2011) were investigated. The patients' data were extracted, including age, gender, clinical presentation, location of tumor, histological type, grade of tumor, site of metastasis, and type of treatment. The Kaplan-Meier test was used to estimate the overall survival time and the Log-rank test to compare the survival curves...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/31139467/a-concise-review-of-pelvic-radiation-therapy-rt-for-rectal-cancer-with-synchronous-liver-metastases
#35
REVIEW
Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Bora Uysal, Hakan Gamsiz, Bahar Dirican, Murat Beyzadeoglu
Background and Objective: Colorectal cancer is a major health concern as a very common cancer and a leading cause of cancer-related mortality worldwide. The liver is a very common site of metastatic spread for colorectal cancers, and, while nearly half of the patients develop metastases during the course of their disease, synchronous liver metastases are detected in 15% to 25% of cases. There is no standardized treatment in this setting and no consensus exists on optimal sequencing of multimodality management for rectal cancer with synchronous liver metastases...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/31057961/oral-submucous-fibrosis-in-pediatric-patients-a-systematic-review-and-protocol-for-management
#36
REVIEW
Anuj Jain, Saumya Taneja
Aim: To conduct a systematic review evaluating the cases of oral submucous fibrosis in pediatric patients. Material and Method: Systematic review was conducted using PRISMA guidelines. The article focused on oral submucous fibrosis in pediatric patients were included. A total of five manuscripts were included in our systematic review. The prevalence of OSMF in pediatric patients, gender distribution, causes, and clinical presentation were reviewed. Results: On systematically reviewing, a total of 10 cases of OSMF in pediatric patients were found...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/30956820/soft-tissue-sarcomas-of-the-thoracic-wall-more-prone-to-higher-mortality-and-local-recurrence-a-single-institution-long-term-follow-up-study
#37
JOURNAL ARTICLE
Tine Rytter Soerensen, Mathias Raedkjaer, Peter Holmberg Jørgensen, Anette Hoejsgaard, Akmal Safwat, Thomas Baad-Hansen
Objectives: This study aims to assess the impact of surgical margin and malignancy grade on overall survival (OS) and local recurrence free rate (LRFR) for soft tissue sarcomas (STS) of the thoracic wall. Methods: This retrospective cohort study identified 88 patients, diagnosed and treated surgically for a nonmetastatic STS located in the thoracic wall between 1995 and 2013, using the population based and validated Aarhus Sarcoma Registry and Danish Sarcoma Registry...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/30941211/outcome-of-cervical-lymph-nodes-dissection-for-thyroid-cancer-with-nodal-metastases-a-southeast-asian-3-year-experience
#38
JOURNAL ARTICLE
Raymond Z M Lim, Juin Y Ooi, Jih H Tan, Henry C L Tan, Seniyah M Sikin
Introduction: Therapeutic nodal dissection is still the mainstay of treatment for patients with lymph node metastases in many centres. The local data, however, on the outcome of therapeutic LND remains limited. Hence, this study aims to inform practice by presenting the outcomes of LND for thyroid cancer patients and our experience in a tertiary referral centre. Methods: This is a single-centre retrospective observational study in a Malaysian tertiary endocrine surgery referral centre...
2019: International Journal of Surgical Oncology
https://read.qxmd.com/read/30643644/comparison-of-survival-in-patients-with-isolated-peritoneal-carcinomatosis-from-colorectal-cancer-treated-with-cytoreduction-and-melphalan-or-mitomycin-c-as-hyperthermic-intraperitoneal-chemotherapy-agent
#39
COMPARATIVE STUDY
Arkadii Sipok, Armando Sardi, Carol Nieroda, Mary Caitlin King, Michelle Sittig, Vadim Gushchin
Background: The role of hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is debated. Melphalan as a perfusion agent has also demonstrated survival benefit in other recurrent and chemoresistant malignancies. Thus, we hypothesize that melphalan as a HIPEC agent may improve overall survival (OS) and progression-free survival (PFS) in patients with PC from CRC. Methods: A retrospective review of a prospective database of 48 patients who underwent optimal CRS (CC-0/1) and HIPEC from 2001-2016 was performed...
2018: International Journal of Surgical Oncology
https://read.qxmd.com/read/30155294/early-cervical-cancer-predictive-relevance-of-preoperative-3-tesla-multiparametric-magnetic-resonance-imaging
#40
JOURNAL ARTICLE
Hyun Jin Roh, Kyung Bin Kim, Jong Hwa Lee, Hwa Jung Kim, Yong-Soon Kwon, Sang Hun Lee
OBJECTIVE: We assess the predictive significance of preoperative 3-Tesla multiparametric MRI findings. METHODS: A total of 260 patients with FIGO IA2-IIA cervical cancer underwent primary surgical treatment between 2007 and 2016. Univariable and multivariable logistic regression analyses were used to assess the incremental prognostic significance. RESULTS: The clinical predictive factors associated with pT2b disease were MRI parametrial invasion (PMI) (adjusted odds ratio (AOR) 3...
2018: International Journal of Surgical Oncology
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