journal
Journals International Journal of Hepat...

International Journal of Hepatology

https://read.qxmd.com/read/35411218/clinical-characteristics-of-patients-with-hepatocellular-carcinoma-a-single-center-3-year-experience-from-somalia
#21
JOURNAL ARTICLE
Mohamed A Hassan-Kadle, Marian Muse Osman, Esra Keles, Hasan Huseyin Eker, Kursad Nuri Baydili, Hussein Mahdi Ahmed, Abdirahman Abdikadir Osman
Background: To evaluate the relationship between prognosticators representing tumor aggressiveness and socio-demographic, laboratory, and imaging findings in patients with hepatocellular carcinoma (HCC). Methods: We retrospectively searched patients with HCC between January 2017 and December 2019 in our tertiary referral hospital. The tumor-related factors and liver damage indicators and their relationship to indicate the value of prognosis were analyzed. Results: A total of 268 HCC patients, with a male-to-female ratio of 2...
2022: International Journal of Hepatology
https://read.qxmd.com/read/35402050/urinary-ba-indices-as-prognostic-biomarkers-for-complications-associated-with-liver-diseases
#22
JOURNAL ARTICLE
Wenkuan Li, Jawaher Abdullah Alamoudi, Nagsen Gautam, Devendra Kumar, Macro Olivera, Yeongjin Gwon, Sandeep Mukgerjee, Yazen Alnouti
Hepatobiliary diseases and their complications cause the accumulation of toxic bile acids (BA) in the liver, blood, and other tissues, which may exacerbate the underlying condition and lead to unfavorable prognosis. To develop and validate prognostic biomarkers for the prediction of complications of cholestatic liver disease based on urinary BA indices, liquid chromatography-tandem mass spectrometry was used to analyze urine samples from 257 patients with cholestatic liver diseases during a 7-year follow-up period...
2022: International Journal of Hepatology
https://read.qxmd.com/read/35070455/disproportionate-distribution-of-hbv-genotypes-a-and-d-and-the-recombinant-genotype-d-e-in-the-high-and-low-hbv-endemic-regions-of-uganda-a-wake-up-call-for-regional-specific-hbv-management
#23
JOURNAL ARTICLE
Hussein Mukasa Kafeero, Dorothy Ndagire, Ponsiano Ocama, Charles Drago Kato, Eddie Wampande, Henry Kajumbula, David Kateete, Abdul Walusansa, Ali Kudamba, Kigozi Edgar, Fred Ashaba Katabazi, Maria Magdalene Namaganda, Jamilu E Ssenku, Hakim Sendagire
Background: Hepatitis B virus (HBV) is the leading cause of liver-related diseases. In Uganda, there is a regional disparity in the HBV burden. Our study was aimed at establishing the circulating genotypes in a low and a high endemic region to give plausible explanations for the differences in regional burden and guide the future management of the disease. Methods: A total of 200 HBsAg-seropositive subjects were recruited into the study by convenience sampling. The HBsAg Rapid Test Strip (Healgen Scientific Limited Liability Company, Houston, TX77047- USA) was used to screen for HBsAg while the Roche machine (Roche, Basel Switzerland/Abbot Technologies (USA)) was used to determine the viral load...
2022: International Journal of Hepatology
https://read.qxmd.com/read/34976412/role-of-high-density-lipoprotein-cholesterol-hdl-c-as-a-clinical-predictor-of-decompensation-in-patients-with-chronic-liver-disease-cld
#24
JOURNAL ARTICLE
Harshavardhan Rao B, Priya Nair, Anoop K Koshy, S Krishnapriya, C R Greeshma, Rama P Venu
Introduction: Systemic inflammation triggered by bacterial products like lipopolysaccharides (LPS) in the circulation is an important factor leading to decompensation in patients with chronic liver disease (CLD). High-density lipoprotein cholesterol (HDL-C) has a significant role in innate immune response to LPS in the circulation and could therefore increase the risk for decompensation in patients with CLD. In this study, we have explored the role of HDL-C as a prognostic marker for decompensation...
2021: International Journal of Hepatology
https://read.qxmd.com/read/34900353/diastolic-dysfunction-is-a-predictor-of-poor-survival-in-patients-with-decompensated-cirrhosis
#25
JOURNAL ARTICLE
Manas Kumar Behera, Surendra Nath Swain, Manoj Kumar Sahu, Gaurav Kumar Behera, Debakanta Mishra, Jimmy Narayan, Ayaskant Singh, Shobhit Agarwal, Pradeep Kumar Mallick
BACKGROUND: Left ventricular diastolic dysfunction (LVDD) appears to be the earliest cardiac disturbance in cirrhosis patients. There are many previous reports reporting the significance of severity of LVDD on the outcome of liver transplantation or TIPS insertion, a few Indian studies have addressed the role of LVDD on survival in decompensated cirrhosis. The objective of this study is to assess the effect of LVDD on the survival of decompensated cirrhotic patients. METHODS: We prospectively evaluated 92 decompensated cirrhotic patients from April 2015 to March 2017 at IMS and SUM Hospital, Bhubaneswar, India...
2021: International Journal of Hepatology
https://read.qxmd.com/read/34712496/supplementation-with-branched-chain-amino-acids-induces-unexpected-deleterious-effects-on-astrocyte-survival-and-intracellular-metabolism-with-or-without-hyperammonemia-a-preliminary-in-vitro-study
#26
JOURNAL ARTICLE
Ting Wang, Kazuyuki Suzuki, Toshimi Chiba, Keisuke Kakisaka, Yasuhiro Takikawa
Introduction: Ammonia is a key component in the pathogenesis of hepatic encephalopathy. Branched-chain amino acids (BCAA) have been reported to improve the symptoms of HE induced by hyperammonemia; however, we recently reported that ammonia increases intracellular levels of BCAA and exerts toxic effects on astrocytes. Objectives: This follow-up study was designed to confirm the direct effects of BCAA on human astrocytes and clarify their underlying mechanisms using metabolome analysis and evaluation of associated signaling...
2021: International Journal of Hepatology
https://read.qxmd.com/read/34484836/infrahepatic-inferior-vena-cava-clamping-reduces-blood-loss-during-liver-transection-for-cholangiocarcinoma
#27
JOURNAL ARTICLE
Natwutpong Leeratanakachorn, Vor Luvira, Theerawee Tipwaratorn, Suapa Theeragul, Apiwat Jarearnrat, Attapol Titapun, Tharatip Srisuk, Supot Kamsa-Ard, Ake Pugkhem, Narong Khuntikeo, Chawalit Pairojkul, Vajarabhongsa Bhudhisawasdi
BACKGROUND: Major hepatectomy is the mainstay of the treatment for cholangiocarcinoma. Infrahepatic inferior vena cava (IVC) clamping is an effective maneuver for reducing blood loss during liver transection. The impact of this procedure on major hepatectomy for cholangiocarcinoma is unknown. This study evaluated the effect of infrahepatic IVC clamping on blood loss during liver transection. METHODS: Clinical and pathological data were collected retrospectively for 116 cholangiocarcinoma patients who underwent major hepatectomy between January 2015 and December 2016, to investigate the benefit of infrahepatic IVC clamping...
2021: International Journal of Hepatology
https://read.qxmd.com/read/34211786/prevalence-of-hepatic-encephalopathy-from-a-commercial-medical-claims-database-in-the-united-states
#28
JOURNAL ARTICLE
Aniruddha Potnis, Susan VanMeter, Jan Stange
INTRODUCTION: Hepatic encephalopathy (HE), a complication of cirrhosis, is associated with increased healthcare resource utilization and mortality, and impaired quality of life. Information on the prevalence of HE in the US general population is limited. METHODS: Prevalence of HE was estimated by sequential stepwise data analysis of the Symphony Health anonymized patient-level data (APLD) claims database. First, patients ≥ 18 years with International Classification of Diseases ninth/tenth edition, clinical modification (ICD-9/10-CM), and codes for cirrhosis from 2018 medical and hospital claims were used to estimate prevalence of cirrhosis within the data set and number of patients with cirrhosis in the US general population...
2021: International Journal of Hepatology
https://read.qxmd.com/read/34123432/the-influence-of-donor-and-recipient-complement-c3-polymorphisms-on-liver-transplant-outcome
#29
JOURNAL ARTICLE
Maria Pires, James Underhill, Abdel Douiri, Alberto Quaglia, Wayel Jassem, William Bernal, Nigel Heaton, Phillip Morgan, Richard Thompson, J Michael Tredger
Despite early reports of an impact of complement C3 polymorphism on liver transplant patient and graft survival, subsequent evidence has been conflicting. Our aim was to clarify the contributions of donor and recipient C3 genotype, separately and together, on patient and graft outcomes and acute rejection incidence in liver transplant recipients. Eight donor/recipient groups were analyzed according to their genotype and presence or absence of C3 F allele (FFFS, FFSS, FSFF, FSFS, FSSS, SSFF, SSFS, and SSSS) and correlated with clinical outcomes of patient survival, graft survival, and rejection...
2021: International Journal of Hepatology
https://read.qxmd.com/read/34113467/patients-with-hepatitis-c-infection-and-normal-liver-function-a-neuropsychological-and-neurophysiological-assessment-of-cognitive-functions
#30
JOURNAL ARTICLE
Jefferson Abrantes, Daniel Simplicio Torres, Carlos Eduardo Brandão-Mello
Several studies have proposed a link between chronic hepatitis C virus (HCV) infection and the development of cognitive disorders. However, the inclusion of confounding factors in their samples significantly limits the interpretation of the results. Therefore, here, we aimed to compare the neurophysiological and cognitive performance between patients with HCV infection and a control group after excluding other factors that may cause cognitive impairment. This cross-sectional, group-control, observational study was performed from September 12, 2014, to October 20, 2017...
2021: International Journal of Hepatology
https://read.qxmd.com/read/34007489/the-application-of-selective-hepatic-inflow-vascular-occlusion-with-anterior-approach-in-liver-resection-effectiveness-in-managing-major-complications-and-long-term-survival
#31
JOURNAL ARTICLE
Khai Viet Ninh, Nghia Quang Nguyen, Son Hong Trinh, Anh Gia Pham, Thi-Ngoc-Ha Doan
Background: Hepatectomy is always a challenge to surgeons and requires an appropriate approach for specific tumors to achieve effective complication management. Selective hepatic pedicle clamping is more considerable strategy when comparing with total hepatic pedicle clamping in the balance between reducing blood loss and transfusion with causing the hepatic parenchyma damages (two main complications affecting liver resection result). Objectives: In this study, we aim to describe the application of selective hepatic inflow vascular occlusion (SHIVO) and anatomical anterior approach in liver resection and evaluate the results, focusing on intraoperative and postoperative complications...
2021: International Journal of Hepatology
https://read.qxmd.com/read/33976943/emerging-roles-of-impaired-autophagy-in-fatty-liver-disease-and-hepatocellular-carcinoma
#32
REVIEW
Suryakant Niture, Minghui Lin, Leslimar Rios-Colon, Qi Qi, John T Moore, Deepak Kumar
Autophagy is a conserved catabolic process that eliminates dysfunctional cytosolic biomolecules through vacuole-mediated sequestration and lysosomal degradation. Although the molecular mechanisms that regulate autophagy are not fully understood, recent work indicates that dysfunctional/impaired autophagic functions are associated with the development and progression of nonalcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), and hepatocellular carcinoma (HCC). Autophagy prevents NAFLD and AFLD progression through enhanced lipid catabolism and decreasing hepatic steatosis, which is characterized by the accumulation of triglycerides and increased inflammation...
2021: International Journal of Hepatology
https://read.qxmd.com/read/33628512/low-serum-25-hydroxy-vitamin-d-25-ohd-and-hepatic-encephalopathy-in-hcv-related-liver-cirrhosis
#33
JOURNAL ARTICLE
Mohamed Abd Ellatif Afifi, Ahmed Mohamed Hussein, Mahmoud Rizk
BACKGROUND: Patients with liver cirrhosis experience a large variety of metabolic disorders associated with more hepatic decompensation. Hepatic encephalopathy (HE) is a significant complication in liver cirrhosis patients, presenting a wide spectrum of neuropsychological symptoms. A deficiency of 25-hydroxy vitamin D (25-OHD) in the general population is associated with a loss of cognitive function, dementia, and Alzheimer's disease. Aim of the Study . Our study aims to check the relationship between low serum 25-OHD and HE in patients with HCV-related liver cirrhosis and assess its link with patient mortality...
2021: International Journal of Hepatology
https://read.qxmd.com/read/33457017/antioxidant-effects-of-eugenol-on-oxidative-stress-induced-by-hydrogen-peroxide-in-islets-of-langerhans-isolated-from-male-mouse
#34
JOURNAL ARTICLE
Ali Akbar Oroojan, Narges Chenani, Marzieh An'aam
Background: The antioxidant system in islets of Langerhans is weak, which can lead to diabetes. Meanwhile, the main component of cloves that produce antioxidant effects is eugenol. Accordingly, the present study was conducted to investigate the antioxidant effect of eugenol on oxidative stress induced by hydrogen peroxide (H2 O2 ) in islets of Langerhans isolated from the male mice. Materials and Methods: In this experimental study, adult Naval Medical Research Institute (NMRI) mice (20-25 g) were prepared...
2020: International Journal of Hepatology
https://read.qxmd.com/read/33381321/prognostic-factors-of-radiofrequency-ablation-plus-systemic-chemotherapy-for-unresectable-colorectal-cancer-with-liver-metastasis
#35
JOURNAL ARTICLE
Ky Thai Doan, Long Nguyễn Việt, Thinh Nguyen Tien, Binh Nguyen Canh, Hoai Ngo Thi, Ngoc Nguyen Thanh, Bieu Bui Quang, Quang Le Van, Hyun Woong Lee, Bang Mai Hong
Introduction: Survival outcomes in patients with unresectable colorectal cancer (CRC) liver metastasis treated by radiofrequency ablation (RFA) combined with systemic chemotherapy and correlation with potential prognostic factors were investigated. Material and Methods . A retrospective cohort study was conducted on 61 CRC patients with unresectable liver metastasis who underwent liver tumor-directed percutaneous RFA combined with conventional systemic chemotherapy between October 2013 and September 2018...
2020: International Journal of Hepatology
https://read.qxmd.com/read/33133698/the-high-prevalence-of-negative-hepatitis-b-surface-antibody-anti-hbs-among-pregnant-women-in-bandung-indonesia-a-community-based-study
#36
JOURNAL ARTICLE
Dolvy Girawan, Raden T D Judistiani, Nelly A Risan, Muhammad B Bestari, Eka S Nugraha, Yudith S Ermaya, Dwi Prasetyo
Background: Hepatitis B virus (HBV) infection is a disease that creates a high global burden by affecting approximately 3.5% of the total world population. The main transmission of this disease is from mother to child (MTCT). HBV vaccination program was already initiated in Indonesia in 1987. However, after three decades, the HBV infection prevalence stays stagnant. This study aimed to explore the seroprevalence of HBV markers and the attributable risk factors of pregnant women at risk of transmitting HBV to their offspring...
2020: International Journal of Hepatology
https://read.qxmd.com/read/33123384/hepatocyte-and-islet-cell-cotransplantation-on-poly-l-lactide-matrix-for-the-treatment-of-liver-cirrhosis
#37
JOURNAL ARTICLE
Siufui Hendrawan, Jennifer Lheman, Nuraeni, Ursula Weber, Hans Ulrich Baer
The human autologous hepatocyte matrix implant is a promising alternative procedure to counter liver damage. We assessed the outcome of human hepatocytes isolation from cirrhotic liver compared to the clinical and histological scores of disease severity. A total of 11 patients with various clinical scores (CTP and MELD) and histological score (Metavir, fibrosis) of liver cirrhosis were included in the hepatocyte matrix implant clinical phase I study. The liver segment and pancreatic tissue were harvested from each patient, and hepatocytes and cells of islets of Langerhans were isolated...
2020: International Journal of Hepatology
https://read.qxmd.com/read/32724678/endothelial-dysfunction-a-marker-of-atherosclerosis-is-independent-of-metabolic-syndrome-in-nafld-patients
#38
JOURNAL ARTICLE
Jimmy Narayan, Haribhakti Seba Das, Preetam Nath, Ayaskanta Singh, Debakanta Mishra, Pradeep Kumar Padhi, Shivaram Prasad Singh
Background: The study was designed to assess cardiovascular risk factors flow-mediated dilatation % (FMD%) and carotid intima-media thickness (CIMT) in NAFLD. Methods: 126 NAFLD subjects and 31 chronic hepatitis B (CHB) controls were studied. Measuring carotid intima-media thickness (CIMT) and the flow-mediated dilatation % (FMD%) by brachial artery Doppler ultrasound were used to assess atherosclerosis. The risk of cardiac events at 10 years (ROCE 10) was estimated by the Prospective Cardiovascular Munster Study (PROCAM) score...
2020: International Journal of Hepatology
https://read.qxmd.com/read/32607257/hepatocellular-expression-of-sirt1-and-its-effect-on-hepatocellular-carcinoma-progression-a-future-therapeutic-perspective
#39
REVIEW
Meseret Derbew Molla, Gashaw Dessie, Yonas Akalu, Birhanu Ayelign
Hepatocellular carcinoma (HCC) is an aggressive primary hepatic malignancy with a significant morbidity and mortality rate. Although chemotherapy along with surgical incision is believed to be an effective therapeutic approach, to date recurrence is being lifted a major concern. Thus, identifying another best therapeutic approach is becoming the main aim of physicians and scholars. In support of this, recently, several studies reported a significant observation of Sirtuin1 (SIRT1) overexpression in the malignant tumor cells, including HCC...
2020: International Journal of Hepatology
https://read.qxmd.com/read/32550025/drug-treatment-of-patients-with-liver-cirrhosis-in-a-tertiary-hospital-in-northern-ghana-does-it-comply-with-recommended-guidelines
#40
JOURNAL ARTICLE
Baba Sulemana Mohammed, Matthew Aidoo
The diverse influence of liver function on drug disposition can lead health-care practitioners to inappropriate drug selection, inappropriate drug dosing, or some level of therapeutic negativism. The aim of this study was to assess how drug prescribing in patients with liver cirrhosis at the Tamale Teaching Hospital comply with recommendations of pharmacotherapy and safety guidelines. A prospective cross-sectional study was conducted from February to July, 2019, at the medical ward of the Tamale Teaching Hospital...
2020: International Journal of Hepatology
journal
journal
43672
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.