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Journals International Journal of Hepat...

International Journal of Hepatology

https://read.qxmd.com/read/38550614/knowledge-gaps-and-determination-of-attitude-and-practice-among-medical-students-toward-hepatitis-b-infection-a-nationwide-cross-sectional-study
#1
JOURNAL ARTICLE
Nader Alaridah, Raba'a F Jarrar, Rayan M Joudeh, Haneen Al-Abdallat, Layan Ismail, Zaina Alnajjar, Mohammad Jum'ah, Anas Haidar Abu-Humaidan
INTRODUCTION: As reported by the World Health Organization (WHO), annually, there are 1.5 million new infections, with more than 290 million people living with chronic hepatitis B diseases in 2019. Medical students (MSs), a subgroup of health care workers (HCWs), are at high occupational risk for HBV infection since HCWs have a 2-10 times greater risk of getting the virus than the general population. Therefore, they must have a broad understanding of hepatitis B infection. In this study, we aimed to assess the level of knowledge, attitude, and practices among MSs, and to explore its predictors...
2024: International Journal of Hepatology
https://read.qxmd.com/read/38510786/the-efficacy-of-on-site-integration-screening-and-microelimination-programs-for-chronic-hepatitis-c-in-a-detection-center-a-comparison-of-the-treatment-outcomes-and-characteristics-of-incarcerated-patients-and-outpatients
#2
JOURNAL ARTICLE
Hsuan-Yuan Chang, Su-Hung Wang, Hsing-Tao Kuo, Ming-Jen Sheu, I-Che Feng, Chung-Han Ho, Jui-Yi Chen, Chi-Shu Sun, Chi-Hsing Chen, Cheng-Yi Lin, Chun-Chi Yang
We aimed to analyze the different patient characteristics and treatment outcomes (such as sustained viral response, SVR) between incarcerated patients with chronic hepatitis C (CHC) and those with CHC from the outpatient department through an on-site integrated screening and microelimination program in a detection center. In this retrospective study, which ran from May 2021 to April 2022, we included 32 consenting male prisoners aged at least 20 years who were willing to participate in the study. Members of the control group (who received DAAs in an outpatient setting) were selected from the treated CHC patient databank of individuals who received DAA regimens at Chi Mei Hospital between January 2021 and December 2022...
2024: International Journal of Hepatology
https://read.qxmd.com/read/38288080/severe-hepatotoxicity-in-mushroom-poisoning-by-lepiota-brunneoincarnata-from-complete-recovery-to-liver-transplantation-a-case-series-with-review-on-liver-function-tests-and-liver-histopathology
#3
JOURNAL ARTICLE
Mohammad Hossein Anbardar, Neda Soleimani, Kourosh Kazemi, Zahra Jafarpour, Mahsa Hasani, Sahand Mohammadzadeh, Parnia Torfehnezhad, Sedighe Jafarian, Mahsa Farhadi, Mina Salari Sardari
BACKGROUND: In spite of the scientific evidence supporting health advantages of mushrooms, some of them are seriously poisonous. The clinical picture of mushroom intoxication ranges from minor gastrointestinal symptoms to organ failure, such as liver failure and death. METHOD: We provided demographics, clinicopathological characteristics, applied treatments, and outcomes of mushroom poisoning by Lepiota species in a series of 18 cases that were referred from Kermanshah and Lorestan provinces to Abu-Ali-Sina Hospital, Shiraz, Iran...
2024: International Journal of Hepatology
https://read.qxmd.com/read/38274398/the-use-of-noninvasive-velacur%C3%A2-for-discriminating-between-volunteers-and-patients-with-chronic-liver-disease-a-feasibility-study
#4
JOURNAL ARTICLE
Michael P Curry, Edward Tam, Caitlin Schneider, Noha Abdelgelil, Tarek Hassanien, Nezam H Afdhal
BACKGROUND AND AIMS: Nonalcoholic fatty liver disease is the leading cause of chronic liver disease globally and can progress to cirrhosis, liver failure, and liver cancer. Current AASLD, AGA, and ADA guidelines recommend assessment for liver fibrosis in all patients with NAFLD. Serum biomarkers for fibrosis, while widely available, have notable limitations. Imaging-based noninvasive testing for liver fibrosis/cirrhosis is more accurate and is becoming more widespread. METHODS: We evaluated the feasibility of a novel shear wave absolute vibroelastography (S-WAVE) modality called Velacur® for assessing liver stiffness measurement (LSM) for fibrosis and attenuation coefficient estimation (ACE) in differentiating patients with chronic liver disease from normal healthy controls...
2024: International Journal of Hepatology
https://read.qxmd.com/read/38027071/hepatitis-c-prevalence-on-the-rise-but-screening-at-safety-net-institutions-lagging-behind
#5
JOURNAL ARTICLE
Jarin Prasa, Syed S Karim, Bobby Jacob, Paul Mustacchia
INTRODUCTION: In the United States, the hepatitis C virus (HCV) is a leading contributor to liver-related illnesses and fatalities. Despite effective antiviral medications, acute infections have increased in recent years, likely due to IV drug use and the opioid epidemic. Previous guidelines recommended one-time screening for individuals born between 1945 and 1965. The CDC now recommends screening all adults over 18 unless there is a low prevalence in the area. Accurate measurement of HCV prevalence is essential for targeted prevention...
2023: International Journal of Hepatology
https://read.qxmd.com/read/37593089/pathology-of-hepatocellular-carcinoma-and-tumor-bearing-liver-tissue-in-association-with-htert-promoter-mutation
#6
JOURNAL ARTICLE
Anne Kristin Fischer, Alexander Semaan, Anna-Lena Wulf, Christian Vokuhl, Diane Goltz, Hans-Peter Fischer
BACKGROUND: The hTERT promoter mutation represents a common and early event in hepatocarcinogenesis, but its linkage to the morphological status of the underlying liver tissue is poorly understood. We analyzed the connection between the histopathological changes in tumor-bearing liver tissue and the occurrence of the hTERT promoter mutation in hepatocellular carcinoma (HCC), correlated with clinical data. METHODS: The study cohort comprised 160 histologically confirmed HCC in patients with or without cirrhosis that were investigated for the hTERT promoter mutation...
2023: International Journal of Hepatology
https://read.qxmd.com/read/37520499/progressive-familial-intrahepatic-cholestasis-a-descriptive-study-in-a-tertiary-care-center
#7
JOURNAL ARTICLE
Fahad I Alsohaibani, Musthafa C Peedikayil, Abdulaziz F Alfadley, Mohamed K Aboueissa, Faisal A Abaalkhail, Saleh A Alqahtani
BACKGROUND: Progressive familial intrahepatic cholestasis (PFIC) is a rare genetic disorder that results from defective mechanisms of bile secretion. We aim to describe different types of PFIC and their clinical features, treatment modalities, and outcomes in Saudi Arabia. Patients and Methods . This is a retrospective study of all patients diagnosed with PFIC at King Faisal Specialist Hospital and Research Center in Riyadh from January 1, 2002, to December 31, 2021. All relevant information was collected from patient charts and transferred into the REDcap® database for statistical analysis...
2023: International Journal of Hepatology
https://read.qxmd.com/read/37292454/liver-segment-disposition-of-hepatocellular-carcinoma-predicts-microvascular-invasion
#8
JOURNAL ARTICLE
Arnold Nongmoh Forlemu, Raissa Nana Sede Mbakop, Praneeth Bandaru, Vijay Gayam, Hamsika Moparty, Tomoki Sempokuya, Faruq Pradhan, Madhavi Reddy, Marco Olivera
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of cancer morbidity and mortality. Findings of microvascular invasion (MVI) in patients with HCC have emerged as an important prognostic factor for poor survival after tumor resection. AIM: This study evaluated the relation between MVI and HCC within various anatomical Couinaud's segments of the liver. METHOD: A multicenter retrospective review of HCC records was conducted from 2012 to 2017...
2023: International Journal of Hepatology
https://read.qxmd.com/read/37056327/inhibition-of-gluconeogenesis-by-boldine-in-the-perfused-liver-therapeutical-implication-for-glycemic-control
#9
JOURNAL ARTICLE
Laís Cristina Lima Silva, Gustavo Henrique de Souza, Vanesa de Oliveira Pateis, Ana Paula Ames-Sibin, Beatriz Paes Silva, Lívia Bracht, Jurandir Fernando Comar, Rosane Marina Peralta, Adelar Bracht, Anacharis Babeto Sá-Nakanishi
The alkaloid boldine occurs in the Chilean boldo tree ( Peumus boldus ). It acts as a free radical scavenger and controls glycemia in diabetic rats. Various mechanisms have been proposed for this effect, including inhibited glucose absorption, stimulated insulin secretion, and increased expression of genes involved in glycemic control. Direct effects on glucose synthesis and degradation were not yet measured. To fill this gap, the present study is aimed at ensuring several metabolic pathways linked to glucose metabolism (e...
2023: International Journal of Hepatology
https://read.qxmd.com/read/36816714/gamma-glutamyl-transferase-a-friend-against-cholestatic-itch-a-retrospective-observational-data-analysis-in-patients-with-extrahepatic-cholestasis
#10
JOURNAL ARTICLE
Floris W Haijer, Cornelis B Van Vliet, Marjolein G J Brusse-Keizer, Job A M Van der Palen, Marjo J Kerbert-Dreteler, Jeroen J Kolkman
METHODS: We included 235 patients with chronic extrahepatic cholestasis due to pancreatic cancer, cholangiocarcinoma, or papillary carcinoma. RESULTS: GGT was significantly higher in patients without pruritus (median 967, IQR 587-1571) compared to patients with pruritus (median 561 IQR 266-1084 IU/l) ( p < 0.01). In contrast, median alkaline phosphatase (AP) was 491 U/L (IQR; 353-684) in patients with pruritus and was not significantly different from 518 U/L (IQR; 353-726) in patients without pruritus ( p = 0...
2023: International Journal of Hepatology
https://read.qxmd.com/read/36748010/liver-injury-patterns-and-hepatic-toxicity-among-people-living-with-and-without-hiv-and-attending-care-in-urban-uganda
#11
JOURNAL ARTICLE
Clara Wekesa, Rosalind Parkes-Ratanshi, Gregory D Kirk, Ponsiano Ocama
INTRODUCTION: The evaluation of the patterns of liver injury, derived from liver chemistry panels, often may narrow on probable causes of the liver insult especially when coupled with clinical history, examination, and other diagnostic tests. METHODS: Among people living with and without HIV and attending care, we used the R ratio to evaluate for liver injury patterns. Liver injury patterns were defined as cholestatic ( R < 2), mixed ( R = 2-5), and hepatocellular ( R > 5)...
2023: International Journal of Hepatology
https://read.qxmd.com/read/36643337/clinical-profile-and-limitations-in-the-management-of-hbv-patients-attending-clinic-at-a-district-hospital-in-ghana
#12
JOURNAL ARTICLE
Amoako Duah, Yvonne A Nartey
BACKGROUND: Chronic hepatitis B (CHB) is estimated to cause between 500,000 and 1.2 million deaths worldwide every year through cirrhosis and hepatocellular carcinoma (HCC). Liver cirrhosis and HCC are the commonest liver diseases causing death in Ghana. The most critical problem in the management of CHB in sub-Saharan Africa is the high cost of investigations and antiviral drugs. There is scanty information concerning newly diagnosed CHB patients and their management challenges in Ghana...
2023: International Journal of Hepatology
https://read.qxmd.com/read/36618760/hepatitis-c-seroconversion-remains-high-among-patients-with-regular-hemodialysis-study-of-associated-risk-factors
#13
JOURNAL ARTICLE
Ni Wayan Wina Dharmesti, I Dewa Nyoman Wibawa, Yenny Kandarini
METHODS: An analytical cross-sectional study involving patients from 2 dialysis units (1 referral hospital and 1 private dialysis unit) in Denpasar, Bali, Indonesia, from January 2020 to December 2021. We evaluated age, gender, duration of hemodialysis, vascular access, history of transfusion, history of surgery, diabetes mellitus, hepatitis B, human immunodeficiency virus (HIV) infection, and type of dialyzer as possible risk factors of hepatitis C seroconversion among hemodialysis patients...
2022: International Journal of Hepatology
https://read.qxmd.com/read/36578273/assessment-of-clinical-characteristics-and-outcomes-of-liver-diseases-unique-to-pregnancy-at-a-tertiary-hospital-in-ethiopia-a-retrospective-cohort-study
#14
JOURNAL ARTICLE
Sintayehu Mekonnen, Henok Fisseha, Tewodros Getinet
BACKGROUND: Liver disease is a rare complication of pregnancy that can lead to several consequences and require specific intervention with implications for both the mother and fetus. This study is aimed at assessing the clinical profile and associated complications of liver diseases unique to pregnancy at St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. Methodology . This study is a retrospective cohort study of all identified cases admitted to the obstetrics ward and intensive care unit (ICU) from January 2018 to December 2020 at St...
2022: International Journal of Hepatology
https://read.qxmd.com/read/36158230/serological-evidence-of-hepatitis-b-and-e-and-dengue-coinfection-in-chadian-patients-and-impact-on-lipidemia-profile
#15
JOURNAL ARTICLE
Alexandre Kanga Djasrabe, Borris Rosnay Tietcheu Galani, Moussa Mahamat Ali, Fissou Henry Yandai, Bessimbaye Nadlaou, Mayann Habkreo, Nicolas Yanou Njintang
Objective: Viral hepatitis is an endemic disease in Chad. However, few studies have documented coinfection cases and their impact on cardiovascular risk. This study is aimed at analyzing hepatitis B, E and dengue coinfection in a Chadian cohort and gauge its effect on lipidemia. Patients and Methods . From February to May 2021, 179 subjects were recruited from the Department of Gastroenterology and Internal Medicine of the National Reference University Hospital of N'Djamena and tested for viral hepatitis markers, including HBsAg and IgM/IgG anti-HEV and dengue infection, using the NS1/IgM/IgG kit...
2022: International Journal of Hepatology
https://read.qxmd.com/read/36117519/spleen-and-liver-stiffness-evaluation-by-arfi-imaging-a-reliable-tool-for-a-short-term-monitoring-of-portal-hypertension
#16
JOURNAL ARTICLE
Andreas Binzberger, Mark Hänle, Matthias Pfahler, Wolfgang Kratzer, Thomas Seufferlein, Eugen Zizer
BACKGROUND: Assessment of hepatic venous pressure gradient (HVPG) is the most reliable, though invasive method for evaluation of portal hypertension. Non-invasive, elastography-based techniques are well established in diagnosis, but not in monitoring of portal hypertension. The aim of our prospective study was to determine the value of acoustic radiation force impulse (ARFI) elastography technique of the liver and spleen in diagnosis and monitoring of portal hypertension. METHODS: We prospectively assessed portal hypertension by HVPG and corresponding elastography of the liver and spleen in 31 patients with liver cirrhosis and an indication for primary prophylaxis by non-cardio selective beta-blockers...
2022: International Journal of Hepatology
https://read.qxmd.com/read/36117518/arsenic-induced-injury-of-mouse-hepatocytes-through-lysosome-and-mitochondria-an-in-vitro-study
#17
JOURNAL ARTICLE
Amal Santra, Debasree Bishnu, Suman Santra, Subhadip Ghatak, Partha Sarathi Mukherjee, Gopal Krishna Dhali, Abhijit Chowdhury
Background and Aims: The cellular mechanism of liver injury related to arsenic toxicity is ill defined. It is thought that oxidative stress and mitochondrial dysfunction may play some role in arsenic-induced liver damage. In this study, we evaluated subcellular events within the primary cultured mouse hepatocytes when exposed to inorganic arsenic. Methods: Primary cultured mouse hepatocytes were treated with 10  μ M arsenic for different time periods. Reactive oxygen species (ROS) formation, functional changes of the lysosome and mitochondria, and mode of hepatocytes death were studied by laser confocal microscopy, fluorescence spectroscopy, and flow cytometry...
2022: International Journal of Hepatology
https://read.qxmd.com/read/36052277/host-factors-in-the-natural-history-of-chronic-hepatitis-b-role-of-genetic-determinants
#18
JOURNAL ARTICLE
Turyadi, Billy Witanto, Korri E El-Khobar, M Luthfi Parewangi, M Rezki Rasyak, Dhita P Wibowo, Meta D Thedja, Irawan Yusuf, Muh Nasrum Massi, Ilhamjaya Patellongi, Din Syafruddin, David H Muljono
Background: The host immune system plays an important role in hepatitis B virus (HBV) infection manifestation. Genetic polymorphisms of several inflammatory cytokines, including TNF- α and IL-10, have been associated with chronic hepatitis B (CHB) progression, although with contradicting results. CHB progression can be categorized into four phases, immune tolerance (IT), immune clearance (IC), low/no replicative (LR), and e-negative hepatitis (ENH), with HBeAg seroconversion as an important milestone...
2022: International Journal of Hepatology
https://read.qxmd.com/read/35991003/practice-towards-hepatitis-b-virus-infection-prevention-and-its-associated-factors-among-undergraduate-students-at-hawassa-university-college-of-medicine-and-health-sciences-hawassa-sidama-ethiopia-2021-cross-sectional-study
#19
JOURNAL ARTICLE
Amdehiwot Aynalem, Bedilu Deribe, Mohammed Ayalew, Abyalew Mamuye, Eskinder Israel, Andualem Mebratu, Dawit Getachew Assefa
Background: Hepatitis B virus infection is a major global health burden accounting for 2.7% of all deaths globally. Being part of the health care system, the risk of exposure to hepatitis B viral infection among medical and health science students is found to be high. In Ethiopia, particularly in this study area, very little is known about the practice of students towards hepatitis B virus infection prevention and its associated factors. Objective: The aim of this study was to assess the practice towards hepatitis B virus infection prevention and its associated factors among undergraduate students at Hawassa University College of Medicine and Health Sciences, Hawassa, Ethiopia, 2021...
2022: International Journal of Hepatology
https://read.qxmd.com/read/35845752/pregnancy-is-not-associated-with-an-increased-risk-of-decompensation-transplant-or-death-in-compensated-cirrhosis
#20
JOURNAL ARTICLE
Monica Mullin, Maya Djerboua, Monika Sarkar, Jacquie Lu, Maria P Velez, Susan Brogly, Norah A Terrault, Jennifer A Flemming
BACKGROUND AND AIMS: Childbirth in women with cirrhosis is increasing and associated with a higher risk of perinatal outcomes compared to the general population. Whether pregnancy influences the risk of liver-related events compared to nonpregnant women with cirrhosis is unclear. This study evaluates the association between pregnancy and liver-related outcomes in women with compensated cirrhosis. Approach and Results . Population-based retrospective matched cohort study in Ontario, Canada, using routinely collected healthcare data...
2022: International Journal of Hepatology
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