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Journals Clinical Pharmacology : Advanc...

Clinical Pharmacology : Advances and Applications

https://read.qxmd.com/read/38225988/severe-hypertensive-response-to-atropine-therapy-for-bradycardia-associated-with-dexmedetomidine-case-report-and-literature-review
#1
Yong Li, Ju Gao, Lin Jiang, Canlin Sun, Hua Hong, Dapeng Yu
Dexmedetomidine is a selective and potent α2 -adrenoceptor agonist used for sedation, analgesia, and anxiolysis, with minimal respiratory depression; therefore, it is widely used in clinical practice. Transient hypertension has been reported to be an indication for the use of dexmedetomidine. The authors report three female patients who experienced hypertensive crisis when used atropine to treat bradycardia caused by dexmedetomidine. The transient hypertension is a relatively common side effect of dexmedetomidine, hypertensive crisis seen with coadministration of atropine is much less frequently reported...
2024: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/38197085/effectiveness-of-drug-repurposing-and-natural-products-against-sars-cov-2-a-comprehensive-review
#2
REVIEW
Paula Andrea Velásquez, Juan C Hernandez, Elkin Galeano, Jaime Hincapié-García, María Teresa Rugeles, Wildeman Zapata-Builes
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a betacoronavirus responsible for the COVID-19 pandemic, causing respiratory disorders, and even death in some individuals, if not appropriately treated in time. To face the pandemic, preventive measures have been taken against contagions and the application of vaccines to prevent severe disease and death cases. For the COVID-19 treatment, antiviral, antiparasitic, anticoagulant and other drugs have been reused due to limited specific medicaments for the disease...
2024: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/38090388/comparison-of-efficacy-and-safety-between-dronedarone-and-amiodarone-used-during-the-blind-period-in-patients-with-atrial-fibrillation-after-catheter-ablation
#3
JOURNAL ARTICLE
Yihan Li, Tong Hu, Mingjie Lin, Qinhong Wang, Wenqiang Han, Jingquan Zhong
BACKGROUND: Dronedarone is an effective drug for maintaining the sinus rhythm in patients with atrial fibrillation (AF). The efficacy and safety of dronedarone versus amiodarone in patients with AF after catheter ablation (CA) needs more evidence. We retrospectively compared the efficacy and safety of dronedarone and amiodarone in our hospital. METHODS: Patients who underwent CA from January 2021 to January 2022 and used dronedarone (n=229) or amiodarone (n=202) during the blind period were enrolled...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/38022754/ipratropium-bromide-salbutamol-induced-acute-urinary-retention-as-a-result-of-medication-error-a-case-report-and-review-of-cases-in-the-literature
#4
Mohammed Abdullah Kubas, Fahmi Y Al-Ashwal, Orwa Khaled Babattah, Akram Ameen Alsaqqaf
Medication errors have the potential to cause serious toxicity and hospitalization. This case report describes a 25-year woman who suffered serious side effects and was ‎hospitalized after receiving intravenous ipratropium bromide/salbutamol. This was due to a medication error in its preparation and administration. The caregiver diluted an intravenous antibiotic with the incorrect diluent (nebulizer solution), which led to serious toxicity, including acute urine retention and sinus tachycardia, and then resulted in patient hospitalization...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/37811521/allopurinol-induced-stevens-johnson-syndrome-sjs
#5
Takla R Anis, John Meher
Allopurinol is a commonly used medication that lowers uric acid production which is essential for gout treatment and prevention. Although many patients tolerate allopurinol therapy without severe complications; Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are life-threatening delayed hypersensitivity reactions that have been reported especially among Asian and African American patients. We describe a case of allopurinol-induced SJS in a 95-year-old Asian female. The patient started allopurinol 13 days prior to presenting to the emergency room (ER)...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/37554660/recent-advances-in-messenger-ribonucleic-acid-mrna-vaccines-and-their-delivery-systems-a-review
#6
REVIEW
Wubetu Yihunie, Getinet Nibret, Yibeltal Aschale
Messenger ribonucleic acid (mRNA) was found as the intermediary that transfers genetic information from DNA to ribosomes for protein synthesis in 1961. The emergency use authorization of the two covid-19 mRNA vaccines, BNT162b2 and mRNA-1273, is a significant achievement in the history of vaccine development. Because they are generated in a cell-free environment using the in vitro transcription (IVT) process, mRNA vaccines are risk-free. Moreover, chemical modifications to the mRNA molecule, such as cap structures and changed nucleosides, have proved critical in overcoming immunogenicity concerns, achieving sustained stability, and achieving effective, accurate protein production in vivo...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/37427084/recommendations-of-gentamicin-dose-based-on-different-pharmacokinetic-pharmacodynamic-targets-for-intensive-care-adult-patients-a-redefining-approach
#7
JOURNAL ARTICLE
Mohammad Yaseen Abbasi, Weerachai Chaijamorn, Kamonthip Wiwattanawongsa, Taniya Charoensareerat, Thitima Doungngern
BACKGROUND: In addition to the maximum plasma concentration (Cmax ) to the minimum inhibitory concentration (MIC) ratio, the 24-hour area under the concentration-time curve (AUC24h ) to MIC has recently been suggested as pharmacokinetic/pharmacodynamic (PK/PD) targets for efficacy and safety in once-daily dosing of gentamicin (ODDG) in critically ill patients. PURPOSE: This study aimed to predict the optimal effective dose and risk of nephrotoxicity for gentamicin in critically ill patients for two different PK/PD targets within the first 3 days of infection...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/37397409/erratum-a-multicenter-randomized-double-blind-placebo-controlled-trial-assessing-efficacy-and-safety-of-a-novel-low-dose-turmeric-extract-formulation-in-healthy-adults-with-chronic-knee-pain-corrigendum
#8
(no author information available yet)
[This corrects the article DOI: 10.2147/CPAA.S307464.].
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/37387793/use-of-intramuscular-ephedrine-sulfate-during-kidney-transplantation
#9
Gaurav P Patel, Susan A Smith, Michelle Romej, Billynda McAdoo, Elizabeth A Wilson
Hypotension during kidney transplantation can be common. Vasopressor use during these procedures is often avoided, with a fear of decreasing renal perfusion in the transplanted kidney. However, adequate perfusion for the rest of the body is also necessary, and given that these patients often have underlying hypertension or other comorbid conditions, an appropriate mean arterial pressure (MAP) has to be maintained. Intramuscular injections of ephedrine have been studied in the anesthesiology literature in a variety of case types, and it is seen as a safe and effective method to boost MAP...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/37255963/effects-of-tofogliflozin-and-anagliptin-alone-or-in-combination-on-glucose-metabolism-and-atherosclerosis-related-markers-in-patients-with-type-2-diabetes-mellitus
#10
JOURNAL ARTICLE
Shosaku Nomura, Akira Shouzu, Takehito Taniura, Yoshinori Okuda, Seitaro Omoto, Masahiko Suzuki, Tomoki Ito, Nagaoki Toyoda
PURPOSE: In people with type 2 diabetes mellitus (T2DM), both glucose metabolism abnormalities and atherosclerosis risk are significant concerns. This study aims to investigate the effects of the sodium-glucose cotransporter 2 inhibitor tofogliflozin (TOFO) and the dipeptidyl peptidase-4 inhibitor anagliptin (ANA) on markers of glucose metabolism and atherosclerosis when administered individually or in combination. METHODS: Fifty T2DM patients were divided into two groups (receiving either TOFO or ANA monotherapy) and observed for 12 weeks (observation points: 0 and 12 weeks)...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/37155501/cefepime-induced-neutropenia-a-case-report-and-literature-review
#11
Somaya Koraysh, Junais Koleri, Maisa Ali
Cefepime is a fourth-generation cephalosporin utilized in treatment of multiple Gram-negative and -positive infections. The current report presents a case of 50-year-old man admitted with epidural abscess who developed neutropenia after prolonged use of cefepime. The neutropenia developed after 24 days of cefepime treatment and resolved 4 days after cessation of cefepime. Assessment of the patient's profile indicated no other possible cause for neutropenia. A literature review was done, and is presented herein to compare and identify the pattern of cefepime-induced neutropenia in 15 patients...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/36941908/systematic-review-of-safety-of-rts-s-with-as01-and-as02-adjuvant-systems-using-data-from-randomized-controlled-trials-in-infants-children-and-adults
#12
REVIEW
Wubetu Yihunie, Bekalu Kebede, Bantayehu Addis Tegegne, Melese Getachew, Dehnnet Abebe, Yibeltal Aschale, Habtamu Belew, Bereket Bahiru
BACKGROUND: Emergence of antimalarial drugs and insecticides resistance alarms scientists to develop a safe and effective malaria vaccine. A pre-erythrocytic malaria vaccine called RTS,S has made great strides. AIM: The review was aimed to assess the safety of the candidate malaria vaccine RTS,S with AS01 and AS02 adjuvants using data from Phase I-III randomized controlled clinical trials (RCTs). METHODS: This systematic review was conducted based on PRISMA 2020...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/36880014/a-phase-1-multicenter-open-label-study-to-evaluate-the-pharmacokinetics-of-iberdomide-in-subjects-with-mild-moderate-or-severe-hepatic-impairment-compared-with-healthy-subjects
#13
JOURNAL ARTICLE
Yiming Cheng, Ying Ye, Allison Gaudy, Atalanta Ghosh, Yongjun Xue, Alice Wang, Simon Zhou, Yan Li
INTRODUCTION: Iberdomide, a novel cereblon modulator (CELMoD® ), is currently under clinical investigation for hematology indications. To evaluate the influence of hepatic impairment on the pharmacokinetics (PK) of iberdomide and its major active metabolite M12, a phase 1, multicenter, open-label study was conducted in healthy subjects and subjects with mild, moderate, and severe hepatic impairment. METHODS: Forty subjects were enrolled in the study and divided into five groups based on hepatic function...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/36644519/chemical-versus-mechanical-and-chemical-venous-thromboembolism-prophylaxis-in-neurocritically-ill-patients-a-cohort-study
#14
JOURNAL ARTICLE
Abdulrahman I Alshaya, Hayaa Alyahya, Reema Alzoman, Rawa Faden, Omar A Alshaya, Khalid Al Sulaiman, Faisal Alanazi, Sara Aldekhyl
PURPOSE: Patients admitted with neurocritical illness are presumed to be at high risk for venous thromboembolism (VTE). The administration of chemical and/or mechanical VTE prophylaxis is a common practice in critically ill patients. Recent data did not show a significant difference in the incidence of VTE between chemical compared to a combined chemical and mechanical VTE prophylaxis in critically ill patients with limited data in neurocritically ill population. The objective of this study is to investigate the incidence of VTE between chemical alone compared to chemical and mechanical VTE prophylaxis in neurocritically ill patients...
2023: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/36523399/anti-diarrheal-activities-of-hydromethanolic-crude-extract-and-solvent-fractions-of-acacia-seyal-fabaceae-roots-in-mice-response-to-letter
#15
COMMENT
Assefa Kebad Mengesha, Eshetie Melese Birru, Meaza Adugna
No abstract text is available yet for this article.
2022: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/36471876/a-response-to-article-anti-diarrheal-activity-of-hydromethanolic-crude-extract-and-solvent-fractions-of-acacia-seyal-fabaceae-roots-in-mice-letter
#16
JOURNAL ARTICLE
Novaria Sari Dewi Panjaitan, Fitriana Fitriana, Sarwo Handayani
No abstract text is available yet for this article.
2022: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/36411816/anti-diarrheal-activities-of-hydromethanolic-crude-extract-and-solvent-fractions-of-acacia-seyal-fabaceae-roots-in-mice
#17
JOURNAL ARTICLE
Assefa Kebad Mengesha, Eshetie Melese Birru, Meaza Adugna
BACKGROUND: Traditionally, the root of Acacia seyal is used for the treatment of diarrhea. However, its efficacy has not been scientifically evaluated. Thus, this study aimed to validate the antidiarrheal activities using hydromethanolic crude extract and solvent fractions of Acacia seyal roots in mice. METHODS: In each model, mice were divided into five groups of six mice at random. Group I mice (negative controls) were given 1mL/100 g distilled water for hydromethanolic crude extract tests as well as n-hexane, ethyl acetate and aqueous fractions, while groups II, III, and IV were given 100 mg/kg, 200 mg/kg, and 400 mg/kg of hydromethanolic crude extract or solvent fractions...
2022: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/36177387/fidaxomicin-use-in-the-pediatric-population-with-clostridioides-difficile
#18
REVIEW
Meredith B Oliver, Byron P Vaughn
Clostridioides difficile infection (CDI) remains a devastating infection both in hospital settings and in the community. While a number of antibiotics have anti- C. difficile activity, fidaxomicin is unique as a minimally absorbed antibiotic with narrow spectrum of activity. These features make it an appealing option for pediatric CDI to balance safety and efficacy. The purpose of this structured review was to outline the clinical evidence for safety and efficacy of fidaxomicin for pediatric CDI. A structured literature search was performed to identify relevant clinical data...
2022: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/35975122/neural-net-modeling-of-checkpoint-inhibitor-related-myocarditis-and-steroid-response
#19
JOURNAL ARTICLE
Filip Stefanovic, Andres Gomez-Caminero, David M Jacobs, Poornima Subramanian, Igor Puzanov, Maya R Chilbert, Steven G Feuerstein, Yan Yatsynovich, Benjamin Switzer, Jerome J Schentag
BACKGROUND: Serious but rare side effects associated with immunotherapy pose a difficult problem for regulators and practitioners. Immune checkpoint inhibitors (ICIs) have come into widespread use in oncology in recent years and are associated with rare cardiotoxicity, including potentially fatal myocarditis. To date, no comprehensive model of myocarditis progression and outcomes integrating time-series based laboratory and clinical signals has been constructed. In this paper, we describe a time-series neural net (NN) model of ICI-related myocarditis derived using supervised machine learning...
2022: Clinical Pharmacology: Advances and Applications
https://read.qxmd.com/read/35958046/clinical-impact-of-semaglutide-a-glucagon-like-peptide-1-receptor-agonist-on-obesity-management-a-review
#20
REVIEW
Nasser M Alorfi, Alanood S Algarni
PURPOSE: Obesity and overweight pose a threat to health and are more common than undernutrition among adults. It is categorized by fat accumulation and a body mass index (BMI) of > 30. A significant increase in worldwide obesity has been ongoing over several decades. Over the past few years, several strategies have been followed for weight management and to counteract the increasing prevalence of the disease; however, room for improvement with pharmacological options still exists. This review aimed to digest selected past clinical and experimental studies and understand the role of semaglutide treatment for obesity...
2022: Clinical Pharmacology: Advances and Applications
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