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Dementia and Geriatric Cognitive Disorders Extra

Katherine A Gifford, Dandan Liu, Jacquelyn E Neal, Michelle A Babicz, Jennifer L Thompson, Lily E Walljasper, Margaret E Wiggins, Maxim Turchan, Kimberly R Pechman, Katie E Osborn, Lealani Mae Y Acosta, Susan P Bell, Timothy J Hohman, David J Libon, Kaj Blennow, Henrik Zetterberg, Angela L Jefferson
Background/Aims: This study evaluated neuroimaging and biological correlates, psychometric properties, and regression-based normative data of the 12-word Philadelphia Verbal Learning Test (PVLT), a list-learning test. Methods: Vanderbilt Memory and Aging Project participants free of clinical dementia and stroke ( n = 230, aged 73 ± 7 years) completed a neuropsychological protocol and brain MRI. A subset ( n = 111) underwent lumbar puncture for analysis of Alzheimer's disease (AD) and axonal integrity cerebrospinal fluid (CSF) biomarkers...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Robert Mathew, Sauda Pavithran, P Byju
Background: Neuropsychiatric manifestations of patients with idiopathic normal pressure hydrocephalus (iNPH) have not been studied in a systematic way. Aim: To study the spectrum of neuropsychiatric abnormalities in patients with iNPH. Patient Selection and Evaluation: Patients attending 3 different tertiary care centers during three consecutive time periods spanning from 2010 to 2015 were analyzed for neuropsychiatric manifestations. Patients diagnosed as having probable or possible iNPH as per the consensus criteria were included in the study...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Linda Helena Jütten, Ruth Elaine Mark, Margriet Maria Sitskoorn
Objective: To evaluate whether the mixed virtual reality dementia simulator training Into D'mentia increased informal caregivers' understanding for people with dementia, their empathy, sense of competence, relationship quality with the care receiver, and/or decreased burden, depression, and anxiety. Methods: A quasi-experimental longitudinal study with an intervention group ( n = 145) and a control group ( n = 56) was conducted. All participants were informal caregivers of people with dementia...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Anna Miley-Akerstedt, Vesna Jelic, Kristina Marklund, Håkan Walles, Torbjörn Åkerstedt, Göran Hagman, Christin Andersson
Background/Aims: Many patients presenting to a memory disorders clinic for subjective memory complaints do not show objective evidence of decline on neuropsychological data, have nonpathological biomarkers for Alzheimer's disease, and do not develop a neurodegenerative disorder. Lifestyle variables, including subjective sleep problems and stress, are factors known to affect cognition. Little is known about how these factors contribute to patients' subjective sense of memory decline. Understanding how lifestyle factors are associated with the subjective sense of failing memory that causes patients to seek a formal evaluation is important both for diagnostic workup purposes and for finding appropriate interventions and treatment for these persons, who are not likely in the early stages of a neurodegenerative disease...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Malene Schjønning Nielsen, Anja Hviid Simonsen, Volkert Siersma, Knut Engedal, Vesna Jelic, Birgitte Bo Andersen, Mala Naik, Steen Gregers Hasselbalch, Peter Høgh
Aim: To examine diagnostic and prognostic potential of quantitative electroencephalography (qEEG) analyzed by the statistical pattern recognition (SPR) method in patients with cognitive impairment. We compared the differential diagnostic ability of SPR to visual EEG analysis. Correlation between SPR findings and cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers were evaluated. Methods: It is a multicenter cohort study involving 129 patients, (mild cognitive impairment [MCI], AD, and healthy controls)...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Estelle Gillès de Pélichy, Karsten Ebbing, Alcina Matos Queiros, Cécile Hanon, Armin von Gunten, Zaia Sellah, Henk Verloo
Background / Aims: The advent of mobile old age psychiatry intervention teams supports policies maintaining older adults in their habitual living environments, even those who are very old and suffering from acute cognitive and psychiatric impairments. Analyzing sociodemographic data, clinical and health characteristics, reasons for crisis-oriented psychiatric consultations, and other therapeutic suggestions for supporting home- or nursing home-dwelling older adult patients suffering from an onset of a psychiatric crisis...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Jenny Häggström, Ulf Rosenhall, Christina Hederstierna, Per Östberg, Esma Idrizbegovic
Background/Aim: Central auditory processing disorder (CAPD) might precede the onset of Alzheimer's disease (AD). A method of evaluating CAPD is the dichotic digits test (DDT). The aim was to address this in a longitudinal setting. Methods: A total of 136 individuals were assessed with peripheral and central hearing tests at baseline and at 5-year follow-up. Results: Subjects with AD showed a significant decline in DDT scores of the right ear from baseline to follow-up...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Lianne M J Sanders, Tibor Hortobágyi, Mala Balasingham, Eddy A Van der Zee, Marieke J G van Heuvelen
Background/Aims: Reliable and valid neuropsychological tests for patients with dementia are scarce. To improve the assessment of attention and inhibitory control in dementia, we determined the feasibility, test-retest reliability, and validity of a Flanker task. Methods: Participants with all-cause diagnosed dementia ( n = 22, mean age 84 years; mean Mini-Mental State Examination [MMSE] score = 19.4) performed a computerized Flanker task twice within 7 days. The Flanker task required participants to indicate the direction of target arrows flanked by congruent or incongruent arrows...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Menizibeya O Welcome
Background: Accumulating data suggest a crucial role of the intestinal microbiota in the development and progression of neurodegenerative diseases. More recently, emerging reports have revealed an association between intestinal microbiota dysfunctions and dementia, a debilitating multifactorial disorder, characterized by progressive deterioration of cognition and behavior that interferes with the social and professional life of the sufferer. However, the mechanisms of this association are not fully understood...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Sara Wong, Claudia Jacova
Background: Research on person-centered cognitive testing is beginning to emerge. The current study is the first to focus on eliciting concrete preferences around the test experience. Methods: Adults ≥50 years old completed the Attitudes Around Cognitive Testing (AACT) questionnaire on AACT elicits preferences for cognitive tests, the importance attributed to having choices, and willingness to engage in testing. Results: Data are reported for 289 respondents...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Catharina A Melander, Basel Kikhia, Malin Olsson, Britt-Marie Wälivaara, Stefan Sävenstedt
Background: A major and complex challenge when trying to support individuals with dementia is meeting the needs of those who experience changes in behaviour and mood. Aim: To explore how a sensor measuring electrodermal activity (EDA) impacts assistant nurses' structured assessments of problematic behaviours amongst people with dementia and their choices of care interventions. Methods: Fourteen individuals with dementia wore a sensor that measured EDA...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Yağmur Tetik Aydoğdu, Onur Aydoğdu, H Serap İnal
Background/Aims: The purpose of our study was to investigate the effects of dual-task training on balance, mobility, functional independence, and fear of falling in geriatrics with chronic stroke. Methods: Fifty-three geriatrics diagnosed with stroke were included in our study. The elderly were divided into 2 groups, i.e., those walking with (intervention group, n = 25) and those walking without (controls, n = 28) dual-task training. Results: We found statistically significant improvements in all parameters between pre- and posttreatment in both groups ( p < 0...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
A J Larner
Background/Aims: "Number needed to" metrics may hold more intuitive appeal for clinicians than standard diagnostic accuracy measures. The aim of this study was to calculate "number needed to diagnose" (NND), "number needed to predict" (NNP), and "number needed to misdiagnose" (NNM) for neurological signs of possible value in assessing cognitive status. Methods: Data sets from pragmatic diagnostic accuracy studies examining easily observed and dichotomised neurological signs ("attended alone" sign, "attended with" sign, head turning sign, applause sign, la maladie du petit papier ) were analysed to calculate the NND, NNP, and NNM...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Francesca Morganti, Alex Soli, Paola Savoldelli, Gloria Belotti
Background: In health-care settings, the use of the Neuropsychiatric Inventory-Nursing Home (NPI-NH) may not always be consistent with the authors' guidelines, which affects its reliability. To avoid this bias, a diary version of the NPI (NPI-Diary) was developed. Aims: This study aimed to evaluate the psychometric properties (internal consistency and reliability) of the NPI-Diary, and examined its convergence with the NPI-NH. Methods: Two raters administered the NPI-NH and NPI-Diary to 40 participants with Alzheimer's disease, selected randomly from a hospital's weekly turnover...
September 2018: Dementia and Geriatric Cognitive Disorders Extra
Miriam Goudsmit, Jos van Campen, Thelma Schilt, Chris Hinnen, Sanne Franzen, Ben Schmand
Background: Diagnosing dementia in elderly immigrants is often difficult due to language and cultural barriers, low education, and illiteracy. We compared the diagnostic accuracy of the Rowland Universal Dementia Assessment Scale (RUDAS) to that of the Mini Mental State Examination (MMSE). Methods: A total of 144 patients (42 with intact cognition, 44 with mild cognitive impairment [MCI], and 58 with dementia) were administered both instruments and were diagnosed by specialists blinded for MMSE and RUDAS results...
May 2018: Dementia and Geriatric Cognitive Disorders Extra
Carola G Schipke, Ann De Vos, Manuel Fuentes, Dirk Jacobs, Eugeen Vanmechelen, Oliver Peters
Background/Aims: Major depressive disorder (MDD) can cooccur with early Alzheimer's disease (AD) or may cause memory problems independently of AD. Previous studies have suggested that the AD-related cerebrospinal fluid (CSF) biomarkers tau and Aβ(1-42) could help discriminate between early AD and depression unrelated to AD. Moreover, the postsynaptic protein neurogranin and presynaptic BACE1 have increasingly gained attention as potential new AD biomarkers, but they have not yet been investigated concerning depression...
May 2018: Dementia and Geriatric Cognitive Disorders Extra
Boris Punchik, Elena Komissarov, Vladimir Zeldez, Tamar Freud, Tali Samson, Yan Press
Background: The use of feeding tubes (FTs) in patients with advanced dementia does not yield positive health outcomes and can have a negative effect. Methods: A cross-sectional study assessed the knowledge and attitudes of physicians on the use of FTs for patients with advanced dementia. Results: 201 of 240 doctors (83.8%) participated in the study; 61.7% of the doctors claimed that FTs prevent aspiration, 51.7% that they prevent pneumonia, and 38...
May 2018: Dementia and Geriatric Cognitive Disorders Extra
Jacinta A Lucke, Roos C van der Mast, Jelle de Gelder, Noor Heim, Bas de Groot, Simon P Mooijaart, Gerard J Blauw
Aim: The study aim was to investigate whether cognitive impairment, measured by the Six-Item Cognitive Impairment Test (6-CIT), is an independent predictor of adverse outcomes in acutely hospitalized older patients. Methods: This was a prospective multicenter study including acutely hospitalized patients aged 70 years and older. Multivariable logistic regression was used to investigate whether impaired cognition (6-CIT ≥11 points) was an independent predictor of 90-day adverse outcome, a composite measure of functional decline and mortality...
May 2018: Dementia and Geriatric Cognitive Disorders Extra
Casper de Boer, Holly V Echlin, Alica Rogojin, Bianca R Baltaretu, Lauren E Sergio
Background: Noninvasive interventions to aid healthy cognitive aging are considered an important healthcare priority. Traditional approaches typically focus on cognitive training or aerobic exercise training. In the current study, we investigate the effect of exercises that directly combine cognitive and motor functions on visuomotor skills and general cognition in elderly with various degrees of cognitive deficits. Subjects and Methods: A total of 37 elderly, divided into four groups based on their level of cognition, completed a 16-week cognitive-motor training program...
May 2018: Dementia and Geriatric Cognitive Disorders Extra
Benedicte Sørensen Strøm, Jūratė Šaltytė Benth, Knut Engedal
Objectives: The primary aim was to examine how communication abilities changed over time among nursing home residents with moderate-to-severe dementia who were attending the Sonas programme and to explore whether changes in communication abilities were related to cognitive ability. Method: A longitudinal secondary descriptive study method was employed, where 56 people with moderate-to-severe dementia attended a 45-min Sonas group session twice a week for 24 weeks...
May 2018: Dementia and Geriatric Cognitive Disorders Extra
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