Katarzyna Pachulska-Wieczorek, Leszek Błaszczyk, Julita Gumna, Yuri Nishida, Agniva Saha, Marcin Biesiada, David J Garfinkel, Katarzyna J Purzycka
The long terminal repeat (LTR) and non-LTR retrotransposons comprise approximately half of the human genome, and we are only beginning to understand their influence on genome function and evolution. The LTR retrotransposon Ty1 is the most abundant mobile genetic element in the S. cerevisiae reference genome. Ty1 replicates via an RNA intermediate and shares several important structural and functional characteristics with retroviruses. However, unlike retroviruses Ty1 retrotransposition is not infectious. Retrotransposons integrations can cause mutations and genome instability...
March 2016: Mobile Genetic Elements