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American Journal of Nuclear Medicine and Molecular Imaging

Jadith Ziegler, Michelle Zalles, Nataliya Smith, Debra Saunders, Megan Lerner, Kar-Ming Fung, Maulin Patel, Jonathan D Wren, Florea Lupu, James Battiste, Rheal A Towner
Glioblastomas (GBM) are deadly brain tumors that currently do not have long-term patient treatments available. GBM overexpress the angiogenesis factor VEGF and its receptor VEGFR2. ETLD1 (epidermal growth factor, latrophilin and seven transmembrane domain-containing protein 1), a G-protein coupled receptor (GPCR) protein, we discovered as a biomarker for high-grade gliomas, is also a novel regulator of angiogenesis. Since it was established that VEGF regulates ELTD1, we wanted to establish if VEGFR2 is also associated with ELTD1, by targeted antibody inhibition...
2019: American Journal of Nuclear Medicine and Molecular Imaging
Rikke J Petersen, Nick S Nielsen, Helle H Johannesen, Adam E Hansen, Sofie Jespersen, Caroline J Arnbjerg, Johan Löfgren, Mette S Kjær, Mette R Clausen, Andreas Kjær, Susanne D Nielsen, Barbara M Fischer
This feasibility study set out to investigate the use of FDG-PET/DW-MRI in chronic hepatitis C patients to examine changes in local liver inflammation after treatment with direct-acting antivirals (DAA). Twelve patients with chronic hepatitis C were prospectively enrolled, performing FDG-PET/DW-MRI prior to and after DAA treatment. PET/DW-MRI included PET acquisition 60 and 90 min after FDG-injection, DIXON, for attenuation correction, T2- and DW-MRI with 10 b-values between 0-700 s/mm2 . The following parameters were measured from fusion of 3 volumes of interest (VOIs) placed in the liver parenchyma: Mean standard uptake value after 60 and 90 minutes (SUVmean60 and SUVmean90 ), total Apparent Diffusion Coefficient (ADC), perfusion fraction (PF), pseudo-diffusion (D*) and perfusion-free diffusion (D)...
2019: American Journal of Nuclear Medicine and Molecular Imaging
Ana de la Fuente, Stefan Kramer, Nicole Mohr, Stefanie Pektor, Benedikt Klasen, Nicole Bausbacher, Matthias Miederer, Rudolf Zentel, Frank Rösch
Polymeric micelles are of increasing interest as drug delivery vehicles since they can accumulate in tumor tissue through EPR effect and deliver their hydrophobic cargo. The pharmacology can be visualized and quantified noninvasively by molecular imaging techniques. Here, a novel, fast and efficient technique for radiolabeling various HPMA-LMA based micellar aggregates with hydrophobic oxine-complexes of the trivalent radiometals 68 Ga and 111 In was investigated. The radiometal-oxine complexes resemble the hydrophobic drug 111 In[In]-oxine considered for the diagnosis of infection and inflammation...
2019: American Journal of Nuclear Medicine and Molecular Imaging
Ashutosh Dash, Rubel Chakravarty
Targeted molecular imaging with positron emission tomography (PET) constitutes a successful technique for detecting and diagnosing disease conditions promptly and accurately, and for effectively prognosticating outcomes and treating patients with a tailored and more individualized intervention. In order to expand the success of PET in nuclear medicine, it is important to assure access to radiotracers of desired quantities and qualities. In this context, the benefit of accessing PET radiotracers through a radionuclide generator (RNG) cannot be overstated, as generators offer the potential of enriching the PET radiotracer arsenal at the medical centers both with and without onsite cyclotrons...
2019: American Journal of Nuclear Medicine and Molecular Imaging
Rustain Morgan, Bennett B Chin, Ryan Lanning
Inflammatory changes and residual disease are difficult to distinguish after high dose, definitive radiotherapy of head and neck malignancies. FDG uptake located within a high dose field may more likely represent inflammatory changes, and FDG uptake outside of the radiation field could represent unsuspected and under treated disease. In situ knowledge of the precise radiotherapy fields, therefore, may be useful in distinguishing these etiologies. This study aimed to evaluate the clinical feasibility of rapid integration of radiation treatment field images during follow-up FDG PET/CT imaging...
2019: American Journal of Nuclear Medicine and Molecular Imaging
Irina Velikyan, Philip Schweighöfer, Joachim Feldwisch, Johanna Seemann, Fredrik Y Frejd, Henrik Lindman, Jens Sörensen
[68 Ga]Ga-ABY-025/PET-CT targeting human epidermal growth factor receptor type 2 (HER2) has demonstrated its potential clinical value for the detection and quantification of HER2 in a phase I clinical study with breast cancer patients. Previously, the radiopharmaceutical was prepared manually, however larger scale of multicenter clinical trials and routine healthcare requires automation of the production process to limit the operator radiation dose, improve tracer manufacturing robustness, and provide on-line documentation for good manufacturing practice (GMP) compliance...
2019: American Journal of Nuclear Medicine and Molecular Imaging
Rozh H Al-Mashhadi, Jacob F Bentzon, Lars P Tolbod
Autoradiography using phosphor imaging screens is often used to characterize tissue distribution of positron emission tomography (PET) radiotracers. PET tracers emit positrons with limited penetration range, and valid quantitative autoradiography can therefore only be achieved in thin tissue slices. However, in some settings, quantitative tracer profiling in thick tissues is required. Our aim was to develop a reliable method for this purpose. In this paper, we present a method based on total intensity projections (TIPs) of PET and computed tomography (CT) images...
2019: American Journal of Nuclear Medicine and Molecular Imaging
Ian R Sigal, Ronnie Sebro
Sarcomas are rare tumors of mesenchymal origin. Sarcomas display significant histological heterogeneity, resulting in significant imaging heterogeneity. 18 F-FDG PET has is increasingly used for the evaluation, staging and surveillance of patients with sarcomas. 18 F-FDG PET maximum SUV has been shown to be correlated with sarcoma grade and overall survival. This has led to interest in alternative PET tracers to assess the biological characteristics of tumors and guide treatment decisions. Here we investigate novel PET/CT tracers used for the evaluation of sarcomas over the past 20 years and summarize what we have learned about sarcoma tumor biology from these studies...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Suchitra Sundaram, James Driscoll, Mariano Fernandez-Ulloa, Marcos de Lima, Ehsan Malek
18 F-fluorodeoxyglucose positron emission tomography integrated with computed tomography (18 F-FDG PET/CT) is an effective modality to assess disease burden, detect extra-medullary disease and monitor minimal residual disease (MRD) for multiple myeloma (MM) patients. This modality of imaging is incorporated in the International Myeloma Working Group (IMWG) response criteria that are widely used in MM clinical trials. Interpretative pitfalls are commonly encountered in 18 F-FDG PET/CT studies and proper interpretation requires knowledge of the normal physiologic distribution of the tracer affecting available 18 F-FDG for tumor tissue uptake...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Ramin Alipour, Steven Smith, Sandeep K Gupta
Differentiation of benign and malignant parotid uptake on Fluorine 18 Fluro-Deoxy-Glucose Positron Emission Tomography-Computed Tomography (18 F FDG PET-CT) is of paramount importance due to the poor prognosis of the later but usual quantitative measures such as standardized uptake value (SUV) are not reliable for this purpose. Metabolic heterogeneity, being a characteristic of malignant tumors, would potentially be able to make this distinction. In this study, seventy-one FDG-avid parotid lesions were retrospectively separated histologically into benign and malignant groups...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Raheleh Taghvaei, Mahdi Zirakchian Zadeh, Reza Sirous, Sara Pourhassan Shamchi, William Y Raynor, Siavash Mehdizadeh Seraj, Mateen Moghbel, Shiyu Wang, Thomas J Werner, Hongming Zhuang, Abass Alavi
The role of fluorodeoxyglucose-positron emission tomography (FDG-PET) has been well established in assessment of lymphoma, including non-Hodgkin lymphoma (NHL). The aim of this study was to compare changes and survival predictive values of various quantification parameters of FDG-PET/CT in patients with relapsing/refractory lymphoma before and after radioimmunotherapy (RIT). Data from 17 patients with relapsing/refractory NHL, treated with targeted RIT after chemotherapy/radiotherapy, were retrospectively collected...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Ewa Pasquereau-Kotula, Benoit Hosten, Fortune Hontonnou, Nicolas Vignal, Florent Antoni, Jean-Luc Poyet, Nathalie Rizzo-Padoin, Laure Sarda-Mantel
Bioluminescence imaging (BLI) is widely used for in-vivo monitoring of anti-cancer therapy in mice. [18 F]MEL050 is a Positron Emission Tomography (PET) radiotracer which specifically targets melanin. We evaluated planar BLI and [18 F]MEL050-PET/CT for therapy (pro-apoptotic peptide LZDP) monitoring in a mouse model of metastatic pigmented melanoma. Twelve B6-albino mice were intravenously injected with B16-F10-luc2 cells on day 0 (D0). The mice received daily from D2 to D17 either an inactive peptide (G1, n=6), or LZDP (G2, n=6)...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Francesco Fiz, Matteo Bauckneht, Arnoldo Piccardo, Cristina Campi, Alberto Nieri, Roberta Piva, Giulia Ferrarazzo, Nathan Artom, Silvia Morbelli, Cecilia Marini, Michele Piana, Marcello Bagnasco, Marco Canepa, Gianmario Sambuceti
Increasing evidence links atherosclerosis to a decreased bone thickness. This correlation could reflect a bone/plaque interaction. Hereby we analyzed Hounsfield density (HU) and mineral turnover in bone and in the arterial calcifications (AC), using a computational method applied to PET/CT data. 79 18 F-NaF PET/CT from patients with AC were retrospectively analyzed. Mean AC density and background-corrected uptake (TBR) were estimated after semi-automatic isocontour segmentation. The same values were assessed in the trabecular bone, using an automatic adaptive thresholding method...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Hyung-Jun Im, Meiyappan Solaiyappan, Inki Lee, Tyler Bradshaw, Najat C Daw, Fariba Navid, Barry L Shulkin, Steve Y Cho
This study was to validate reliability and clinical utility of a PET tumor segmentation method using multi-level Otsu (MO-PET) in standard National Electrical Manufacturers Association (NEMA) image quality (IQ) phantom and patients with osteosarcoma. The NEMA IQ phantom was prepared with a lesion-to-background ratio (LBR) of either 8:1, 4:1, or 1.5:1. The artificial lesions in the phantom were segmented using MO-PET, gradient-based method (PETedge), relative threshold methods, and background threshold methods...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Chae-Moon Hong, Ho-Sung Ryu, Byeong-Cheol Ahn
Combined use of 18 F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl)nortropane (FP-CIT) for dopamine transporter imaging and 18 F-fludeoxyglucose (FDG) for glucose metabolism shows good diagnostic performance for differential diagnosis of Parkinson disease (PD) and Parkinson plus syndrome (multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies). A recent study showed that 18 F-FP-CIT positron emission tomography (PET) with early perfusion imaging is useful for the differential diagnosis of PD and Parkinson plus syndrome with lower radiation exposure, time, and cost...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Christos Sachpekidis, Leyun Pan, Boris A Hadaschik, Klaus Kopka, Uwe Haberkorn, Antonia Dimitrakopoulou-Strauss
68 Ga-PSMA-11 PET/CT performed 60 min post tracer injection (p.i.) can underestimate prostate cancer (PC) local recurrence, due to high 68 Ga-PSMA-11 urinary bladder accumulation. Aim of this analysis is to evaluate the complementary role of early dynamic and parametric PET imaging in patients with PC local recurrence. Sixteen patients with PC biochemical relapse attributed to local recurrence underwent dynamic 68 Ga-PSMA-11 PET/CT scanning of the pelvis and whole-body PET/CT. Data analysis was based on visual analysis of the PET/CT scans, SUV calculations, quantitative analysis based on two-tissue compartment and Patlak models as well as parametric imaging based on Patlak analysis...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Irma Soldevilla-Gallardo, Sevastian S Medina-Ornelas, Cynthia Villarreal-Garza, Enrique Bargalló-Rocha, Claudia Hs Caro-Sánchez, Rodrigo Hernández-Ramírez, Enrique Estrada-Lobato
Our study examines the association between two Positron Emission Mammography (PEM) semi-quantitative parameters: PUVmax (maximum uptake value) and LTB (lesion to background) baseline and the end of Neoadjuvant chemotherapy (NAC) with pathologic response in each of the following breast cancer subtype: Triple negative breast cancer (TPN), HER2-positive, and ER-positive/HER2-negative cancers. One-hundred and eight patients, 71 with invasive ductal carcinoma and 37 with infiltrating lobular carcinoma were evaluate with 18 F-FDG-PEM scans before and after of NAC...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Francisco Osvaldo García-Pérez, Jenny Davanzo, Sergio López-Buenrostro, Clara Santos-Cuevas, Guillermina Ferro-Flores, Miguel A Jímenez-Ríos, Anna Scavuzzo, Zael Santana-Ríos, Sevastián Medina-Ornelas
Positron emission tomography (PET) with prostate-specific membrane antigen (PSMA) has found widespread use for the diagnosis of biochemical recurrence of prostate cancer (PCa). Unfortunately, PET/CT is not as widely available; thus a PSMA-targeting compound for scintigraphy is of special interest. The aim of this study was to compare 99m Tc-EDDA/HYNIC-iPSMA and 68 Ga-PSMA-11 PET/CT qualitatively and semi-quantitatively. Twenty-three patients with metastatic PCa were underwent 99m Tc-EDDA/HYNIC-iPSMA SPECT/CT followed by 68 Ga-PSMA-11 PET/CT...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Elin Pauwels, Frederik Cleeren, Guy Bormans, Christophe M Deroose
Somatostatin receptors (SSTRs) are variably expressed by a variety of malignancies. Using radiolabeled somatostatin analogs (SSAs), the presence of SSTRs on tumor cells may be exploited for molecular imaging and for peptide receptor radionuclide therapy. 111 In-DTPA-octreotide has long been the standard in SSTR scintigraphy. A major leap forward was the introduction of gallium-68 labeled SSAs for positron emission tomography (PET) offering improved sensitivity. Tracers currently in clinical use are 68 Ga-DOTA-Tyr3 -octreotide (68 Ga-DOTATOC), 68 Ga-DOTA-Tyr3 -octreotate (68 Ga-DOTATATE) and 68 Ga-DOTA-1-NaI3 -octreotide (68 Ga-DOTANOC), collectively referred to as 68 Ga-DOTA-peptides...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Ahmed El-Sabbagh, Medhat M Osman, Mark Fesler, Tarek Helmy, Nadeem Parker, Razi Muzaffar
This study aims to detect the potential impact of chemotherapy on the coronary calcium scoring (CCS) in lymphoma patients undergoing FDG-PET/CT at baseline and for therapy response using the CT portion of the exam to calculate the CCS. One hundred twelve lymphoma patients were included in the study based on having both baseline and at least 2 post-chemotherapy scans. The unenhanced CT portions of the scans were reviewed to measure the CCS which was then extracted using the Toshiba Vital Program. Agatston scores were assessed as category 1 with zero CCS unit and categories 2 to 5 having more than >1, 11, 101, and 400 CCS units respectively...
2018: American Journal of Nuclear Medicine and Molecular Imaging
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