Sylvie Chevret, Lila Bouadma, Claire Dupuis, Charles Burdet, Jean-Francois Timsit
No abstract text is available yet for this article.
September 29, 2023: Annals of Intensive Care
Joris Pensier, Audrey De Jong, Clément Monet, Yassir Aarab, Clément Le Bihan, Mathieu Capdevila, Inès Lakbar, Lucas Stock, Fouad Belafia, Gerald Chanques, Nicolas Molinari, Samir Jaber
BACKGROUND: In studies prior to lung-protective ventilation, liver cirrhosis in acute respiratory distress syndrome (ARDS) was associated with high mortality rates. Since patients with cirrhosis have been excluded from many trials on ARDS, their outcome when treated with lung-protective ventilation is unclear. The objectives were to assess whether cirrhosis is associated with mortality in ARDS and trends over time in mortality and severity. METHODS: We conducted a retrospective analysis of a prospective observational cohort conducted in a 20-bed tertiary ICU from October 2003 to December 2021...
September 29, 2023: Annals of Intensive Care
Bernard Cholley, Mirela Bojan, Benoit Guillon, Emmanuel Besnier, Mathieu Mattei, Bruno Levy, Alexandre Ouattara, Nadir Tafer, Clément Delmas, David Tonon, Bertrand Rozec, Jean-Luc Fellahi, Pascal Lim, François Labaste, François Roubille, Thibaut Caruba, Philippe Mauriat
No abstract text is available yet for this article.
September 29, 2023: Annals of Intensive Care
Tong Hao, Lei Chen, Changde Wu, Jianfeng Xie, Chenglong Li, Haixiu Xie, Zhongtao Du, Ling Liu, Yi Yang, Songqiao Liu, Xiaotong Hou, Haibo Qiu
BACKGROUND: Limited data are available on renal complications in patients with acute fulminant myocarditis (AFM) receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) support in China. To evaluate the impact of renal complications on outcomes in adult patients with AFM supported with VA-ECMO. METHODS: Data were extracted from Chinese Society of ExtraCorporeal Life Support (CSECLS) Registry database. Adult patients who were diagnosed with AFM receiving VA-ECMO support in the database were included...
September 27, 2023: Annals of Intensive Care
Vincent Joussellin, Vincent Bonny, Savino Spadaro, Sébastien Clerc, Mélodie Parfait, Martina Ferioli, Antonin Sieye, Yorschua Jalil, Vincent Janiak, Andrea Pinna, Martin Dres
BACKGROUND: This study hypothesized that patients with extubation failure exhibit a loss of lung aeration and heterogeneity in air distribution, which could be monitored by chest EIT and lung ultrasound. Patients at risk of extubation failure were included after a successful spontaneous breathing trial. Lung ultrasound [with calculation of lung ultrasound score (LUS)] and chest EIT [with calculation of the global inhomogeneity index, frontback center of ventilation (CoV), regional ventilation delay (RVD) and surface available for ventilation] were performed before extubation during pressure support ventilation (H0) and two hours after extubation during spontaneous breathing (H2)...
September 26, 2023: Annals of Intensive Care
Melchior Gautier, Vincent Joussellin, Jacques Ropers, Lina El Houari, Alexandre Demoule, Thomas Similowski, Alain Combes, Matthieu Schmidt, Martin Dres
BACKGROUND: Venovenous extracorporeal membrane oxygenation (VV ECMO) is frequently associated with deep sedation and neuromuscular blockades, that may lead to diaphragm dysfunction. However, the prevalence, risk factors, and evolution of diaphragm dysfunction in patients with VV ECMO are unknown. We hypothesized that the prevalence of diaphragm dysfunction is high and that diaphragm activity influences diaphragm function changes. METHODS: Patients with acute respiratory distress syndrome (ARDS) requiring VV ECMO were included in two centers...
September 26, 2023: Annals of Intensive Care
Patrick D Collins, Lorenzo Giosa, Sushil Kathar, Valentina Camarda, Filippo Palmesino, Darshan Eshwar, Nicholas A Barrett, Andrew Retter, Francesco Vasques, Barnaby Sanderson, Sze M Mak, Louise Rose, Luigi Camporota
BACKGROUND: Data on the prevalence and clinical impact of extrapulmonary findings at screening computed tomography (CT) on initiation of veno-venous extracorporeal membrane oxygenation (V-V ECMO) are limited. We aimed to identify the prevalence of extrapulmonary findings on screening CT following V-V ECMO initiation. We hypothesized that extrapulmonary findings would influence clinical management and outcome. METHODS: Retrospective analysis (2011-2021) of admission screening CT including head, abdomen and pelvis with contrast of consecutive patients on initiation of V-V ECMO...
September 26, 2023: Annals of Intensive Care
Manu L N G Malbrain, Pietro Caironi, Robert G Hahn, Juan V Llau, Marcia McDougall, Luís Patrão, Emily Ridley, Alan Timmins
Although effective and appropriate fluid management is a critical aspect of quality care during hospitalization, the widespread adoption of consistent policies that ensure adequate fluid stewardship has been slow and heterogenous. Despite evidence-based guidelines on fluid management being available, clinical opinions continue to diverge on important aspects of care in this setting, and the consistency of guideline implementation is far from ideal. A multidisciplinary panel of leading practitioners and experts convened to discuss best practices for ongoing staff education, intravenous fluid therapy, new training technologies, and strategies to track the success of institutional fluid stewardship efforts...
September 25, 2023: Annals of Intensive Care
Morgan Roué, Alexis F Guédon, Nathanaël Lapidus, Keyvan Razazi, Geoffroy Hariri, Elise Morawiec, Cyrielle Desnos, Stéphane Ederhy, Ariel Cohen, Armand Mekontso Dessap, Muriel Fartoukh, Vincent Labbé
BACKGROUND: Acute myocardial infarction (AMI) is one of the major cardiac complications in patients hospitalized in the intensive care unit (ICU) for non-cardiac disease. A better knowledge of ischemic and bleeding risks in these patients is needed to identify those most likely to benefit from specific cardiac management. We therefore assessed the incidence and predictors of a composite outcome of severe ischemic event (AMI recurrence, ischemic stroke), major bleeding, or all-cause death in this setting...
September 19, 2023: Annals of Intensive Care
Stéphane Jouneau, Jean-Damien Ricard, Agathe Seguin-Givelet, Naïke Bigé, Damien Contou, Thibaut Desmettre, Delphine Hugenschmitt, Sabrina Kepka, Karinne Le Gloan, Bernard Maitre, Gilles Mangiapan, Sylvain Marchand-Adam, Alessio Mariolo, Tania Marx, Jonathan Messika, Elise Noël-Savina, Mathieu Oberlin, Ludovic Palmier, Morgan Perruez, Claire Pichereau, Nicolas Roche, Marc Garnier, Mikaël Martinez
INTRODUCTION: Primary spontaneous pneumothorax (PSP) is the presence of air in the pleural space, occurring in the absence of trauma and known lung disease. Standardized expert guidelines on PSP are needed due to the variety of diagnostic methods, therapeutic strategies and medical and surgical disciplines involved in its management. METHODS: Literature review, analysis of the literature according to the GRADE (Grading of Recommendation, Assessment, Development and Evaluation) methodology; proposals for guidelines rated by experts, patients and organizers to reach a consensus...
September 19, 2023: Annals of Intensive Care
Roberto Roncon-Albuquerque, Sérgio Gaião, Francisco Vasques-Nóvoa, Carla Basílio, Ana Rita Ferreira, Alberto Touceda-Bravo, Rodrigo Pimentel, Ana Vaz, Sofia Silva, Guiomar Castro, Tiago Veiga, Hélio Martins, Francisco Dias, Catarina Pereira, Gonçalo Marto, Isabel Coimbra, Juan Ignacio Chico-Carballas, Paulo Figueiredo, José Artur Paiva
BACKGROUND: Extubation during extracorporeal oxygenation (ECMO) in severe acute respiratory distress syndrome (ARDS) has not been well studied. Despite the potential benefits of this strategy, weaning from ECMO before liberation from invasive mechanical ventilation remains the most frequent approach. Our aim was to evaluate the safety and feasibility of a standardized approach for extubation during ECMO in patients with severe ARDS. RESULTS: We conducted a prospective observational study to assess the safety and feasibility of a standardized approach for extubation during ECMO in severe ARDS among 254 adult patients across 4 intensive care units (ICU) from 2 tertiary ECMO centers over 6 years...
September 18, 2023: Annals of Intensive Care
Julia Herzig-Nichtweiß, Farid Salih, Sascha Berning, Michael P Malter, Johann O Pelz, Piergiorgio Lochner, Matthias Wittstock, Albrecht Günther, Angelika Alonso, Hannah Fuhrer, Silvia Schönenberger, Martina Petersen, Felix Kohle, Annekatrin Müller, Alexander Gawlitza, Waldemar Gubarev, Martin Holtkamp, Bernd J Vorderwülbecke
BACKGROUND: Acute symptomatic epileptic seizures are frequently seen in neurocritical care. To prevent subsequent unprovoked seizures, long-term treatments with antiseizure medications are often initiated although supporting evidence is lacking. This study aimed at prospectively assessing the risk of unprovoked seizure relapse with respect to the use of antiseizure medications. It was hypothesized that after a first acute symptomatic seizure of structural etiology, the cumulative 12-month risk of unprovoked seizure relapse is ≤ 25%...
September 15, 2023: Annals of Intensive Care
Laëtitia Gutman, Vanessa Pauly, Laurent Papazian, Antoine Roch
BACKGROUND: Exposure to air pollutants promotes inflammation, cancer, and mortality in chronic diseases. Acute respiratory distress syndrome (ARDS) is a common condition among intensive care unit patients and is associated with a high mortality rate. ARDS is characterized by significant lung inflammation, which can be replicated in animal models by acute exposure to high doses of various air pollutants. Recently, several clinical studies have been conducted in different countries to investigate the role of chronic or acute air pollutant exposure in enhancing both ARDS incidence and severity...
September 13, 2023: Annals of Intensive Care
Kamil Polok, Jakub Fronczek, Bertrand Guidet, Antonio Artigas, Dylan W De Lange, Jesper Fjølner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Bernhard Wernly, Bernardo Bollen Pinto, Joerg C Schefold, Dorota Studzińska, Michael Joannidis, Sandra Oeyen, Brian Marsh, Finn H Andersen, Rui Moreno, Maurizio Cecconi, Hans Flaatten, Christian Jung, Wojciech Szczeklik
BACKGROUND: Non-invasive ventilation (NIV) has been commonly used to treat acute respiratory failure due to COVID-19. In this study we aimed to compare outcomes of older critically ill patients treated with NIV before and during the COVID-19 pandemic. METHODS: We analysed a merged cohort of older adults admitted to intensive care units (ICUs) due to respiratory failure. Patients were enrolled into one of two prospective observational studies: before COVID-19 (VIP2-2018 to 2019) and admitted due to COVID-19 (COVIP-March 2020 to January 2023)...
September 12, 2023: Annals of Intensive Care
Tjokosela Tikiso, Valentin Fuhrmann, Christina König, Dominik Jarczak, Stefanie Iwersen-Bergmann, Stefan Kluge, Sebastian G Wicha, Jörn Grensemann
BACKGROUND: In acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We studied the pharmacokinetics of linezolid in critically ill patients with ACLF during continuous renal replacement therapy compared to patients without concomitant liver failure (NLF). METHODS: In this prospective cohort study, patients received linezolid 600 mg bid. Linezolid serum samples were analyzed by high-performance liquid chromatography...
September 12, 2023: Annals of Intensive Care
Dominika Kanschik, Raphael Romano Bruno, Georg Wolff, Malte Kelm, Christian Jung
BACKGROUND: Virtual reality (VR) and augmented reality (AR) are rapidly developing technologies that offer a wide range of applications and enable users to experience digitally rendered content in both physical and virtual space. Although the number of studies about the different use of VR and AR increases year by year, a systematic overview of the applications of these innovative technologies in intensive care medicine is lacking. The aim of this systematic review was to provide a detailed summary of how VR and AR are currently being used in various areas of intensive care medicine...
September 11, 2023: Annals of Intensive Care
Hamid Merdji, Vincent Bataille, Anais Curtiaud, Laurent Bonello, François Roubille, Bruno Levy, Pascal Lim, Francis Schneider, Hadi Khachab, Jean-Claude Dib, Marie-France Seronde, Guillaume Schurtz, Brahim Harbaoui, Gerald Vanzetto, Severine Marchand, Caroline Eva Gebhard, Patrick Henry, Nicolas Combaret, Benjamin Marchandot, Benoit Lattuca, Caroline Biendel, Guillaume Leurent, Edouard Gerbaud, Etienne Puymirat, Eric Bonnefoy, Ferhat Meziani, Clément Delmas
AIMS: Impact of skin mottling has been poorly studied in patients admitted for cardiogenic shock. This study aimed to address this issue and identify determinants of 30-day and 1-year mortality in a large cardiogenic shock cohort of all etiologies. METHODS AND RESULTS: FRENSHOCK is a prospective multicenter observational registry conducted in French critical care units between April and October, 2016. Among the 772 enrolled patients (mean age 65.7 ± 14...
September 6, 2023: Annals of Intensive Care
Carolina Secreto, Dara Chean, Andry van de Louw, Achille Kouatchet, Philippe Bauer, Marco Cerrano, Etienne Lengliné, Colombe Saillard, Laurent Chow-Chine, Anders Perner, Peter Pickkers, Marcio Soares, Jordi Rello, Frédéric Pène, Virginie Lemiale, Michael Darmon, Sofiane Fodil, Ignacio Martin-Loeches, Sangeeta Mehta, Peter Schellongowski, Elie Azoulay, Djamel Mokart
BACKGROUND: Acute respiratory failure (ARF) is the leading cause of intensive care unit (ICU) admission in patients with Acute Myeloid Leukemia (AML) and data on prognostic factors affecting short-term outcome are needed. METHODS: This is a post-hoc analysis of a multicenter, international prospective cohort study on immunocompromised patients with ARF admitted to ICU. We evaluated hospital mortality and associated risk factors in patients with AML and ARF; secondly, we aimed to define specific subgroups within our study population through a cluster analysis...
September 2, 2023: Annals of Intensive Care
Yann Marquet, Guillaume Hékimian, Guillaume Lebreton, Mathieu Kerneis, Philippe Rouvier, Pierre Bay, Alexis Mathian, Nicolas Bréchot, Juliette Chommeloux, Matthieu Petit, Melchior Gautier, Lucie Lefevre, Ouriel Saura, David Levy, Paul Quentric, Quentin Moyon, Sofia Ortuno, Matthieu Schmidt, Pascal Leprince, Charles-Edouard Luyt, Alain Combes, Marc Pineton de Chambrun
BACKGROUND: Fulminant myocarditis is a rare and severe disease whose definite and etiological diagnoses rely on pathological examination. Albeit, myocardial biopsy can be associated with significant morbidity and mortality, its therapeutic consequences are unclear. We conducted a study to determine the diagnostic yield, the safety and the therapeutic consequences of myocardial biopsy in patients with fulminant clinically suspected myocarditis unweanable from mechanical circulatory support (MCS)...
August 31, 2023: Annals of Intensive Care
Liangshan Wang, Chenglong Li, Xin Hao, Peter Rycus, Joseph E Tonna, Peta Alexander, Eddy Fan, Hong Wang, Feng Yang, Xiaotong Hou
BACKGROUND: Percutaneous cannulation is now accepted as the first-line strategy for extracorporeal cardiopulmonary resuscitation (ECPR) in adults. However, previous studies comparing percutaneous cannulation to surgical cannulation have been limited by small sample size and single-center settings. This study aimed to compare in-hospital outcomes in cardiac arrest (CA) patients who received femoro-femoral ECPR with percutaneous vs surgical cannulation. METHODS: Adults with refractory CA treated with percutaneous (percutaneous group) or surgical (surgical group) femoro-femoral ECPR between January 2008 and December 2019 were extracted from the international Extracorporeal Life Support Organization registry...
August 30, 2023: Annals of Intensive Care
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