Natacha Kapandji, Michael Darmon, Sandrine Valade, Maud Salmona, Jérôme Legoff, Lara Zafrani, Elie Azoulay, Virginie Lemiale
BACKGROUND: Unlike other viruses, the pathogenicity of human metapneumovirus (hMPV) in adults remains uncertain. To address this question, a retrospective monocentric cohort including all patients admitted to ICU with hMPV infection between January 1, 2010, and June 30, 2018 was performed. The characteristics of hMPV infected patients were studied and compared to matched influenza infected patients. Consecutively, a systematic review and meta-analyses investigating PUBMED, EMBASE and COCHRANE databases was conducted to explore the hMPV infections in adult patients (PROSPERO number: CRD42018106617)...
March 20, 2023: Annals of Intensive Care
Diane Naouri, Albert Vuagnat, Gaëtan Beduneau, Martin Dres, Tai Pham, Alain Mercat, Alain Combes, Alexandre Demoule, Antoine Kimmoun, Matthieu Schmidt, Matthieu Jamme
No abstract text is available yet for this article.
March 19, 2023: Annals of Intensive Care
Mathieu Acquier, Alexandre Boyer, Bertrand Guidet, Alexandre Lautrette, Jean Reignier, Guillaume Thiery, René Robert
BACKGROUND: In France, physician-assisted suicide or euthanasia are not legal but are still debated. French intensive care unit (ICU) health care workers (HCWs) have an insider's perspective on the global quality of the patient's end-of-life, whether it occurs in ICU or not. However, their opinion about euthanasia/physician-assisted suicide remains unknown. The aim of this study is to investigate the opinion of French ICU HCWs about physician-assisted suicide/euthanasia. RESULTS: A total of 1149 ICU HCWs participated to a self-administered anonymous questionnaire: 411 (35...
March 18, 2023: Annals of Intensive Care
Khalil Chaïbi, Franck Ehooman, Bertrand Pons, Laurent Martin-Lefevre, Eric Boulet, Alexandre Boyer, Guillaume Chevrel, Nicolas Lerolle, Dorothée Carpentier, Nicolas de Prost, Alexandre Lautrette, Anne Bretagnol, Julien Mayaux, Saad Nseir, Bruno Megarbane, Marina Thirion, Jean-Marie Forel, Julien Maizel, Hodane Yonis, Philippe Markowicz, Guillaume Thiery, Frédérique Schortgen, Cécile Couchoud, Didier Dreyfuss, Stephane Gaudry
BACKGROUND: The extent of the consequences of an episode of severe acute kidney injury (AKI) on long-term outcome of critically ill patients remain debated. We conducted a prospective follow-up of patients included in a large multicenter clinical trial of renal replacement therapy (RRT) initiation strategy during severe AKI (the Artificial Kidney Initiation in Kidney Injury, AKIKI) to investigate long-term survival, renal outcome and health related quality of life (HRQOL). We also assessed the influence of RRT initiation strategy on these outcomes...
March 13, 2023: Annals of Intensive Care
Thomas Daix, Armelle Mathonnet, Scott Brakenridge, Pierre-François Dequin, Jean-Paul Mira, Frederique Berbille, Michel Morre, Robin Jeannet, Teresa Blood, Jacqueline Unsinger, Jane Blood, Andrew Walton, Lyle L Moldawer, Richard Hotchkiss, Bruno François
BACKGROUND: Profound lymphopenia is an independent predictor of adverse clinical outcomes in sepsis. Interleukin-7 (IL-7) is essential for lymphocyte proliferation and survival. A previous phase II study showed that CYT107, a glycosylated recombinant human IL-7, administered intramuscularly reversed sepsis-induced lymphopenia and improved lymphocyte function. Thepresent study evaluated intravenous administration of CYT107. This prospective, double-blinded, placebo-controlled trial was designed to enroll 40 sepsis patients, randomized 3:1 to CYT107 (10 µg/kg) or placebo, for up to 90 days...
March 12, 2023: Annals of Intensive Care
Willem Boer, Walter Verbrugghe, Eric Hoste, Rita Jacobs, Philippe G Jorens
The use of citrate, through reversible binding of calcium, has become the preferred choice for anticoagulation in continuous renal replacement therapy in the critically ill patient. Though generally considered as very efficacious in acute kidney injury, this type of anticoagulation can cause acid-base disorders as well as citrate accumulation and overload, phenomena which have been well described. The purpose of this narrative review is to provide an overview of some other, non-anticoagulation effects of citrate chelation during its use as anticoagulant...
March 11, 2023: Annals of Intensive Care
Simon Bourcier, Maxime Coutrot, Alexis Ferré, Nicolas Van Grunderbeeck, Julien Charpentier, Sami Hraiech, Elie Azoulay, Saad Nseir, Nadia Aissaoui, Jonathan Messika, Pierre Fillatre, Romain Persichini, Serge Carreira, Alexandre Lautrette, Clément Delmas, Nicolas Terzi, Bruno Mégarbane, Jean-Baptiste Lascarrou, Keyvan Razazi, Xavier Repessé, Claire Pichereau, Damien Contou, Aurélien Frérou, François Barbier, Stephan Ehrmann, Etienne de Montmollin, Benjamin Sztrymf, Elise Morawiec, Naïke Bigé, Danielle Reuter, David Schnell, Olivier Ellrodt, Jean Dellamonica, Alain Combes, Matthieu Schmidt
BACKGROUND: Severe hypothyroidism (SH) is a rare but life-threatening endocrine emergency. Only a few data are available on its management and outcomes of the most severe forms requiring ICU admission. We aimed to describe the clinical manifestations, management, and in-ICU and 6-month survival rates of these patients. METHODS: We conducted a retrospective, multicenter study over 18 years in 32 French ICUs. The local medical records of patients from each participating ICU were screened using the International Classification of Disease 10th revision...
March 9, 2023: Annals of Intensive Care
Zheng-Yii Lee, Luis Ortiz-Reyes, Charles Chin Han Lew, M Shahnaz Hasan, Lu Ke, Jayshil J Patel, Christian Stoppe, Daren K Heyland
BACKGROUND: A recent landmark randomized controlled trial (RCT) in septic patients demonstrated an increased risk of death and persistent organ dysfunction with intravenous Vitamin C (IVVC) monotherapy, which represents a disparate result from previous systematic reviews and meta-analyses (SRMA). We performed an updated SRMA of IVVC monotherapy to summarize and explore heterogeneity across current trials and conduct trial sequential analysis (TSA) to guard against type-I or type-II statistical errors...
March 7, 2023: Annals of Intensive Care
Rafael Mahieu, Carole Lemarié, Delphine Douillet, Alain Mercat, Hélène Cormier, Matthieu Eveillard, Vincent Dubée, Jérémie Riou, Achille Kouatchet
BACKGROUND: Unique blood culture (UBC) has been proposed to limit the number of venipuncture and to decrease the risk of BC contaminations (BCC) without affecting their yield. We hypothesized that a multi-faceted program based on UBC in the ICU may reduce the rate of contaminants with a similar performance for bloodstream infections (BSI) identification. METHODS: In a before and after design, we compared the proportion of BSI and BCC. A first 3-year period with multi-sampling (MS) strategy followed by a 4-month washout period, where staff received education and training for using UBC, and a 32-month period, where UBC was routinely used, while education and feedback were maintained...
March 3, 2023: Annals of Intensive Care
Sandra Jonmarker, Felix Alarcón, Jacob Litorell, Anders Granholm, Eva Joelsson Alm, Michelle Chew, Lene Russell, Sarah Weihe, Emilie Kabel Madsen, Nick Meier, Jens Wolfgang Leistner, Johan Mårtensson, Jacob Hollenberg, Anders Perner, Maj-Brit Nørregaard Kjær, Marie Warrer Munch, Martin Dahlberg, Maria Cronhjort, Rebecka Rubenson Wahlin
BACKGROUND: Thromboembolism is more common in patients with critical COVID-19 than in other critically ill patients, and inflammation has been proposed as a possible mechanism. The aim of this study was to investigate if 12 mg vs. 6 mg dexamethasone daily reduced the composite outcome of death or thromboembolism in patients with critical COVID-19. METHODS: Using additional data on thromboembolism and bleeding we did a post hoc analysis of Swedish and Danish intensive care unit patients enrolled in the blinded randomized COVID STEROID 2 trial comparing 12 mg vs...
March 2, 2023: Annals of Intensive Care
Damien Roux, Nicolas Benichou, David Hajage, Laurent Martin-Lefèvre, Nicolas de Prost, Nicolas Lerolle, Dimitri Titeca-Beauport, Eric Boulet, Julien Mayaux, Bruno Mégarbane, Khaoula Mahjoub, Dorothée Carpentier, Saad Nseir, Florence Tubach, Jean-Damien Ricard, Didier Dreyfuss, Stéphane Gaudry
BACKGROUND: Sepsis prognosis correlates with antibiotic adequacy at the early phase. This adequacy is dependent on antibacterial spectrum, bacterial resistance profile and antibiotic dosage. Optimal efficacy of beta-lactams mandates concentrations above the minimal inhibitory concentration (MIC) of the targeted bacteria for the longest time possible over the day. Septic acute kidney injury (AKI) is the most common AKI syndrome in ICU and often mandates renal replacement therapy (RRT) initiation...
February 25, 2023: Annals of Intensive Care
Lina Jeantin, Claire Dupuis, Geoffroy Vellieux, Pierre Jaquet, Etienne de Montmollin, Jean-François Timsit, Romain Sonneville
BACKGROUND: Electroencephalography (EEG) is recommended for the practical approach to the diagnosis and prognosis of encephalitis. We aimed to investigate the prognostic value of standard EEG (std EEG) in adult patients with severe herpes simplex encephalitis. METHODS: We performed a retrospective analysis of consecutive ICU patients with severe herpes simplex encephalitis in 38 French centers between 2006 and 2016. Patients with at least one std EEG study performed at ICU admission were included...
February 23, 2023: Annals of Intensive Care
Ashish K Khanna, Takahiro Kinoshita, Annamalai Natarajan, Emma Schwager, Dustin D Linn, Junzi Dong, Erina Ghosh, Francesco Vicario, Kamal Maheshwari
BACKGROUND: Intensivists target different blood pressure component values to manage intensive care unit (ICU) patients with sepsis. We aimed to evaluate the relationship between individual blood pressure components and organ dysfunction in critically ill septic patients. METHODS: In this retrospective observational study, we evaluated 77,328 septic patients in 364 ICUs in the eICU Research Institute database. Primary exposure was the lowest cumulative value of each component; mean, systolic, diastolic, and pulse pressure, sustained for at least 120 min during ICU stay...
February 20, 2023: Annals of Intensive Care
Ignacio Martin-Loeches, Andrew F Shorr, Richard G Wunderink, Marin H Kollef, Jean-François Timsit, Brian Yu, Jennifer A Huntington, Erin Jensen, Christopher J Bruno
BACKGROUND: The pivotal ASPECT-NP trial showed ceftolozane/tazobactam was non-inferior to meropenem for the treatment of ventilated hospital-acquired/ventilator-associated bacterial pneumonia (vHABP/VABP). Here, we evaluated treatment outcomes by degree of respiratory or cardiovascular dysfunction. METHODS: This was a subset analysis of data from ASPECT-NP, a randomized, double-blind, non-inferiority trial ( NCT02070757). Adults with vHABP/VABP were randomized 1:1 to 3 g ceftolozane/tazobactam or 1 g meropenem every 8 h for 8-14 days...
February 11, 2023: Annals of Intensive Care
João Gonçalves-Pereira, André Oliveira, Tatiana Vieira, Ana Rita Rodrigues, Maria João Pinto, Sara Pipa, Ana Martinho, Sofia Ribeiro, José-Artur Paiva
BACKGROUND: The past years have witnessed dramatic changes in the population admitted to the intensive care unit (ICU). Older and sicker patients are now commonly treated in this setting due to the newly available sophisticated life support. However, the short- and long-term benefit of this strategy is scarcely studied. METHODS: The Critically Ill patients' mortality by age: Long-Term follow-up (CIMbA-LT) was a multicentric, nationwide, retrospective, observational study addressing short- and long-term prognosis of patients admitted to Portuguese multipurpose ICUs, during 4 years, according to their age and disease severity...
February 11, 2023: Annals of Intensive Care
Heiner Nebelung, Natalie Wotschel, Hanns-Christoph Held, Johanna Kirchberg, Jürgen Weitz, Christoph Georg Radosa, Michael Laniado, Ralf-Thorsten Hoffmann, Verena Plodeck
BACKGROUND: The aim of this study was to assess the usefulness of adding thoracic CT to abdominal CT in intensive care unit (ICU) patients with signs of infection after abdominopelvic surgery. METHODS: 143 thoracoabdominal CTs of ICU patients with signs of infection after abdominopelvic surgery were retrospectively reviewed for thoracic pathologies. It was determined if pathologic findings were visible only on thoracic CT above the diaphragmatic dome or also on abdominal CT up to the diaphragmatic dome...
February 10, 2023: Annals of Intensive Care
Jeanne Iachkine, Niccolò Buetti, Harm-Jan de Grooth, Anaïs R Briant, Olivier Mimoz, Bruno Mégarbane, Jean-Paul Mira, Xavier Valette, Cédric Daubin, Damien du Cheyron, Leonard A Mermel, Jean-François Timsit, Jean-Jacques Parienti
BACKGROUND: The anatomic site for central venous catheter insertion influences the risk of central venous catheter-related intravascular complications. We developed and validated a predictive score of required catheter dwell time to identify critically ill patients at higher risk of intravascular complications. METHODS: We retrospectively conducted a cohort study from three multicenter randomized controlled trials enrolling consecutive patients requiring central venous catheterization...
January 16, 2023: Annals of Intensive Care
Tak Kyu Oh, In-Ae Song
BACKGROUND: The difference in survival outcomes between closed and open intensive care unit (ICU) designs with respect to trained intensivist coverage remains unknown. We aimed to investigate whether trained intensivist coverage is associated with mortality in critically ill patients admitted to the ICU in South Korea. METHODS: This population-based cohort study used nationwide registration data from South Korea. This study enrolled all adult patients admitted to the ICU between January 1, 2016, and December 31, 2019...
January 13, 2023: Annals of Intensive Care
Thomas Schmoch, Patrick Möhnle, Markus A Weigand, Josef Briegel, Michael Bauer, Frank Bloos, Patrick Meybohm, Didier Keh, Markus Löffler, Gunnar Elke, Thorsten Brenner, Holger Bogatsch
BACKGROUND: Sepsis and septic shock are frequently accompanied by coagulopathy. Since the sepsis-induced coagulopathy (SIC) score was first described, subsequent studies from Asia revealed a SIC prevalence of 40-60%. In Europe, however, SIC prevalence in patients fulfilling sepsis criteria according to the third international consensus definition (SEPSIS-3) has not yet been evaluated. METHODS: The Critical Care Trials Group of the German Sepsis Competence Network (SepNet) conducted a secondary analysis of two randomized controlled trials...
January 12, 2023: Annals of Intensive Care
Diane Naouri, Albert Vuagnat, Gaëtan Beduneau, Martin Dres, Tai Pham, Alain Mercat, Alain Combes, Alexandre Demoule, Antoine Kimmoun, Matthieu Schmidt, Matthieu Jamme
INTRODUCTION: Studies regarding coronavirus disease 2019 (COVID-19) were mainly performed in the initial wave, but some small-scale data points to prognostic differences for patients in successive waves. We therefore aimed to study the impact of time on prognosis of ICU-admitted COVID-19 patients. METHOD: We performed a national retrospective cohort study, including all adult patients hospitalized in French ICUs from March 1, 2020 to June 30, 2021, and identified three surge periods...
January 12, 2023: Annals of Intensive Care
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