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Medical Mycology Journal

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https://read.qxmd.com/read/30814468/adherence-and-cytotoxicity-of-candida-spp-to-hacat-and-a549-cells
#1
Tomoe Ichikawa, Yuri Kutsumi, Jumpei Sadanaga, Moeko Ishikawa, Daisuke Sugita, Reiko Ikeda
Candida species are opportunistic fungal pathogens that cause superficial or invasive infections. Recently, the incidence of infection by non-Candida albicans species, especially Candida glabrata, has increased. In this study, we analyzed the adhesion and cytotoxicity of various Candida spp. that are part of the normal human microbiota. C. albicans adheres well to cell culture plates and to cultured cells. C. glabrata selectively adheres to epithelial cells rather than to cell culture plates. Candida parapsilosis insufficiently adheres to confluent monolayers of human lung epithelial A549 and keratinocyte HaCaT cells...
2019: Medical Mycology Journal
https://read.qxmd.com/read/30814467/antifungal-susceptibility-of-japanese-isolates-of-nannizia-fulva-formerly-microsporum-fulvum
#2
Rui Kano, Karin Oshimo, Teru Fukutomi, Hiroshi Kamata
Human and animal dermatophytoses are most commonly treated with systemic antifungal drugs such as itraconazole (ITZ) and terbinafine (TRF). The antifungal susceptibility of Nannizia fulva, however, remains poorly documented. In the present study, we investigated the in vitro susceptibility of N. fulva to ITZ and TRF using the CLSI M38-A2 test. The mean MICs for the 12 tested strains were 0.6542 mg/L (range: 0.0625-1 mg/L) for ITZ and 0.15625 mg/L (range: <0.003125-0.5 mg/L) for TRF. These results indicate that ITZ and TRF at standard veterinary doses should be efficacious against N...
2019: Medical Mycology Journal
https://read.qxmd.com/read/30814466/multiple-skin-abscesses-caused-by-rhizopus-sp-infection-after-candida-albicans-infection-in-an-immunocompromised-patient
#3
Koji Makino, Jun Aoi, Sho Egashira, Noritoshi Honda, Yosuke Kubo, Yoko Kawakami, Hideyuki Hayashi, Takashi Mochizuki
A 66-year-old woman with diabetes who was treated with prednisolone (15 mg/day) for autoimmune hepatitis developed multiple erythematous nodules with retention of purulent fluid on her lower right limb. Candida albicans was cultured from the nodules. She was started on oral fluconazole, and the lesions subsided. However, multiple dark-red abscesses and indurations newly appeared on the left crus. Histopathological examination showed numerous branched hyphae, and tissue culture yielded a Rhizopus microsporus-related fungus...
2019: Medical Mycology Journal
https://read.qxmd.com/read/30814465/identification-of-a-novel-variant-form-of-aspergillus-fumigatus-calc-and-generation-of-anti-calc-monoclonal-antibodies
#4
Shogo Takatsuka, Tatsuya Inukai, Shun Kawakubo, Takashi Umeyama, Masahiro Abe, Keigo Ueno, Yasutaka Hoshino, Yuki Kinjo, Yoshitsugu Miyazaki, Satoshi Yamagoe
Aspergillus fumigatus is a critical human fungal pathogen that infects the host via inhalation of airborne conidia. These conidia then germinate to form filamentous hyphae, which secrete various elements to survive in the host lung.Elements such as proteins secreted by A. fumigatus can act as virulence factors in host tissues. Among secreted proteins, we were interested in the thaumatin-like proteins of A. fumigatus. In our analysis of the function of thaumatin-like proteins, we found that, like CalA and CalB, CalC has a secreted form...
2019: Medical Mycology Journal
https://read.qxmd.com/read/30814464/onychomycosis-of-the-middle-finger-of-a-japanese-judo-athletedue-to-trichophyton-tonsurans
#5
Tomotaka Sato, Hirokazu Kitahara, Haruki Honda, Fuminori Katsukawa, Masataro Hiruma, Takashi Yaguchi
We present a 17-year-old Japanese male high school student, who had applied steroid ointment for atopic dermatitis, with fingernail onychomycosis due to Trichophyton tonsurans. He was found positive for T. tonsurans infection based on hairbrush culture performed due to an epidemic of T. tonsurans infection in his judo club. The hairbrush culture method is very important in screening for this infection, and dermatologists should examine the entire body of athletes who are found positive using this method. For the diagnosis of T...
2019: Medical Mycology Journal
https://read.qxmd.com/read/30504637/-erratum
#6
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://read.qxmd.com/read/30504620/-term-20
#7
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://read.qxmd.com/read/30504619/tinea-corporis-due-to-trichophyton-erinacei-probably-transmitted-from-a-hedgehog
#8
Jonghun Kim, Hitoshi Tsuchihashi, Masataro Hiruma, Rui Kano, Shigaku Ikeda
A 26-year-old female homemaker presented with an approximately 2-month history of an erythematous lesion with agminated seropapules in the right popliteal fossa associated with scales and crusts. The lesion was initially treated as contact dermatitis, but there was no improvement. KOH examination revealed filamentous fungi. The fungal culture was positive, and the morphological characteristics were identical to those of Trichophyton mentagrophytes complex. The fungus was identified as T. erinacei based on genetic analysis...
2018: Medical Mycology Journal
https://read.qxmd.com/read/30504618/current-status-of-azole-resistant-aspergillus-fumigatus-isolates-in-east-asia
#9
Daisuke Hagiwara
Aspergillus fumigatus is a saprophytic fungus that is a major causative pathogen for aspergillosis. Only a few classes of antifungals are used for treating this life-threatening fungal infection. Azoles are the first-line drugs and are widely used for the management and prophylaxis of aspergillosis. An emerging issue is the increasing incidence of resistant isolates worldwide. In particular, environmentally derived tandem-repeat-type azole-resistant mutations, such as Cyp51A TR34/L98H, and Cyp51A TR46/Y121F/T289A, have emerged over the last decade...
2018: Medical Mycology Journal
https://read.qxmd.com/read/30504617/heterogeneity-in-pathogenicity-related-properties-and-stress-tolerance-in-aspergillus-fumigatus-clinical-isolates
#10
Daisuke Hagiwara, Hiroki Takahashi, Hiroshi Takagi, Akira Watanabe, Katsuhiko Kamei
Stress responses and pathogenicity have been extensively studied in Aspergillus fumigatus, the main causative pathogen of life-threatening aspergillosis. The heterogeneity in this pathogen's biology has recently attracted increasing attention. In the present work, we used 16 clinically isolated strains to investigate several properties relevant to the pathogenicity of A. fumigatus, namely, gliotoxin production, elastase activity, hypoxia growth, adaptation to iron-limiting conditions, and growth upon nitrosative, oxidative, and high osmotic stresses...
2018: Medical Mycology Journal
https://read.qxmd.com/read/30504616/visceral-mycoses-in-autopsied-cases-in-japan-from-1989-to-2013
#11
Yuhko Suzuki, Tomiteru Togano, Hitoshi Ohto, Hikaru Kume
BACKGROUND AND METHODS: Our group has continuously studied the epidemiology of visceral mycoses (VM) among autopsy cases in Japan from 1989 to 2013. RESULTS: First, from a total of 11,149 autopsied cases, 571 (5.1%) cases of VM were observed in 2013. It was significantly higher than those of 2005 (p < 0.05) and earlier. Notably, incidence of cases with mucormycetes (Muc) in 2013 was higher than that of 1997 and earlier (p < 0.001), especially in leukemia cases...
2018: Medical Mycology Journal
https://read.qxmd.com/read/30175815/-term-19
#12
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://read.qxmd.com/read/30175814/-lactosylceramide-enriched-lipid-raft-mediated-infection-immunity
#13
REVIEW
Kazuhisa Iwabuchi
More than 100 years have passed since Elie Metchnikoff discovered phagocytes. As molecular biological techniques have been developed and improved, we have gained deeper knowledge about the molecular mechanisms of immunological responses to invasion. The innate immune system is the inborn defense mechanism and the first line of defense against all kinds of pathogenic organisms, including bacteria, fungi, viruses, etc. Innate immunity was originally considered to comprise non-specific reactions. However, we now know that innate immune systems develop molecular mechanisms specific to pathogenic microorganisms...
2018: Medical Mycology Journal
https://read.qxmd.com/read/30175813/-laser-therapies-for-onychomycosis-in-japan
#14
REVIEW
Utako Kimura, Yasushi Suga
Various treatment methods other than oral and topical antifungal medications have been employed to treat onychomycosis. Treatment methods include mechanical removal of the affected part of the nail plate by using a toenail cutter or grinder and chemical removal by using occlusive dressing therapy with salicylic acid plaster or urea cream. In recent years, laser therapies have received attention as modalities for treatment of onychomycosis. Favorable outcomes in patients with onychomycosis have been reported in Japan from treatment combining carbon dioxide laser and topical antifungal drug, treatment with photodynamic therapy, and treatment with Nd:YAG laser...
2018: Medical Mycology Journal
https://read.qxmd.com/read/30175812/-identification-of-heparin-binding-proteins-on-the-cell-surface-of-cryptococcus-neoformans
#15
Reiko Ikeda, Tomoe Ichikawa, Yu-Ki Tsukiji, Kohei Kawamura, Ayano Kikuchi, Yo-Ichi Ishida, Yuki Ogasawara
Interactions between virulence factors of pathogens and host responses play an important role in the establishment of infection by microbes. We focused on interactions between Cryptococcus neoformans proteins and heparin, which is abundant on host epithelial cells. Surface proteins were extracted and analyzed. Fractions from anion-exchange column chromatography interacted with heparin in surface plasmon resonance analyses. Heparin-binding proteins were purified and then separated by gel electrophoresis; and were identified as transaldolase, glutathione-disulfide reductase, and glyoxal oxidase...
2018: Medical Mycology Journal
https://read.qxmd.com/read/30175811/-next-generation-sequencing-analysis-of-bacterial-flora-in-bovine-prototheca-mastitic-milk
#16
Rui Kano, Yuki Kobayashi, Akitoyo Nishikawa, Ryo Murata, Takuya Itou, Takaaki Ito, Kazuyuki Suzuki, Hiroshi Kamata
Prototheca zopfii is an achlorophyllic algae that causes bovine mastitis, resulting in a reduction in milk production and the secretion of thin, watery milk with white flakes. The aim of the present study was to evaluate the bacterial flora in the udder environment in protothecal mastitis. We used metagenomic next-generation sequencing (NGS) analysis to identify 16S rRNA genes from bacterial flora present in milk samples from protothecal mastitic dairy cows.Seven clinical strains of P. zopfii genotype 2 were isolated from 7 milk samples from 7 cases (Holstein cow) of protothecal mastitis; another 9 milk samples were obtained from 9 normal Holstein cows...
2018: Medical Mycology Journal
https://read.qxmd.com/read/29848912/-erratum
#17
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://read.qxmd.com/read/29848911/-term-18
#18
(no author information available yet)
No abstract text is available yet for this article.
2018: Medical Mycology Journal
https://read.qxmd.com/read/29848910/-investigation-of-virulence-factors-by-omics-approaches
#19
REVIEW
Azusa Takahashi-Nakaguchi, Daisuke Hagiwara, Hiroki Takahashi, Kanae Sakai, Takahito Toyotome, Akira Watanabe, Katsuhiko Kamei, Tohru Gonoi
 Aspergillus fumigatus is the predominant fungal pathogen responsible for life-threatening systemic infections in humans. Recently developed high-throughput whole genome sequencing (WGS) and RNA-Seq technologies have proven to be powerful tools for systematically investigating pathogenic organisms. In this review, we present new virulence factors obtained through our "omics" researches on A. fumigatus. We first sequenced genomes of A. fumigatus stains isolated from one infected patient at different time points, and made an important finding that although the genome (microsatellites) type of the infected strain remained unchanged, the strain exhibited several genetic changes, including acquiring therapeutic drug resistance, during patient treatment for 1...
2018: Medical Mycology Journal
https://read.qxmd.com/read/29848909/role-of-fks-gene-in-the-susceptibility-of-pathogenic-fungi-to-echinocandins
#20
Yasuhiro Hori, Kazutoshi Shibuya
Echinocandins are antifungal agents that specifically inhibit the biosynthesis of 1,3-β-D-glucan, a major structural component of fungal cell walls. Echinocandins are recommended as first-line or alternative/salvage therapy for candidiasis and aspergillosis in antifungal guidelines of various countries. Resistance to echinocandins has been reported in recent years. The mechanism of echinocandin resistance involves amino acid substitutions in hot spot regions of the FKS gene product, the catalytic subunit of 1,3-β-D-glucan synthase...
2018: Medical Mycology Journal
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