journal
https://read.qxmd.com/read/38424085/down-regulation-of-mkp-1-in-hippocampus-protects-against-stress-induced-depression-like-behaviors-and-neuroinflammation
#1
JOURNAL ARTICLE
Mengjun Geng, Qiujing Shao, Jiacheng Fu, Jingyang Gu, Laipeng Feng, Liqin Zhao, Cong Liu, Junlin Mu, Xiaoli Zhang, Mingjun Zhao, Xinsheng Guo, Cai Song, Yan Li, Huiying Wang, Changhong Wang
Chronic stress is the primary environmental risk factor for major depressive disorder (MDD), and there is compelling evidence that neuroinflammation is the major pathomechanism linking chronic stress to MDD. Mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) is a negative regulator of MAPK signaling pathways involved in cellular stress responses, survival, and neuroinflammation. We examined the possible contributions of MKP-1 to stress-induced MDD by comparing depression-like behaviors (anhedonia, motor retardation, behavioral despair), neuroinflammatory marker expression, and MAPK signaling pathways among rats exposed to chronic unpredictable mild stress (CUMS), overexpressing MKP-1 in the hippocampus, and CUMS-exposed rats underexpressing MKP-1 in the hippocampus...
March 1, 2024: Translational Psychiatry
https://read.qxmd.com/read/38424036/apoe-genotype-specific-methylation-patterns-are-linked-to-alzheimer-disease-pathology-and-estrogen-response
#2
JOURNAL ARTICLE
Rebecca Panitch, Nathan Sahelijo, Junming Hu, Kwangsik Nho, David A Bennett, Kathryn L Lunetta, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Jun
The joint effects of APOE genotype and DNA methylation on Alzheimer disease (AD) risk is relatively unknown. We conducted genome-wide methylation analyses using 2,021 samples in blood (91 AD cases, 329 mild cognitive impairment, 1,391 controls) and 697 samples in brain (417 AD cases, 280 controls). We identified differentially methylated levels in AD compared to controls in an APOE genotype-specific manner at 25 cytosine-phosphate-guanine (CpG) sites in brain and 36 CpG sites in blood. Additionally, we identified seven CpG sites in the APOE region containing TOMM40, APOE, and APOC1 genes with P < 5 × 10-8 between APOE ε4 carriers and non-carriers in brain or blood...
February 29, 2024: Translational Psychiatry
https://read.qxmd.com/read/38418845/epigenome-wide-association-study-identifies-neonatal-dna-methylation-associated-with-two-year-attention-problems-in-children-born-very-preterm
#3
JOURNAL ARTICLE
Marie Camerota, Barry M Lester, Francisco Xavier Castellanos, Brian S Carter, Jennifer Check, Jennifer Helderman, Julie A Hofheimer, Elisabeth C McGowan, Charles R Neal, Steven L Pastyrnak, Lynne M Smith, Thomas Michael O'Shea, Carmen J Marsit, Todd M Everson
Prior research has identified epigenetic predictors of attention problems in school-aged children but has not yet investigated these in young children, or children at elevated risk of attention problems due to preterm birth. The current study evaluated epigenome-wide associations between neonatal DNA methylation and attention problems at age 2 years in children born very preterm. Participants included 441 children from the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) Study, a multi-site study of infants born < 30 weeks gestational age...
February 28, 2024: Translational Psychiatry
https://read.qxmd.com/read/38418498/comparing-stem-cells-transdifferentiation-and-brain-organoids-as-tools-for-psychiatric-research
#4
REVIEW
Alfredo Bellon
The inaccessibility of neurons coming directly from patients has hindered our understanding of mental illnesses at the cellular level. To overcome this obstacle, six different cellular approaches that carry the genetic vulnerability to psychiatric disorders are currently available: Olfactory Neuroepithelial Cells, Mesenchymal Stem Cells, Pluripotent Monocytes, Induced Pluripotent Stem Cells, Induced Neuronal cells and more recently Brain Organoids. Here we contrast advantages and disadvantages of each of these six cell-based methodologies...
February 28, 2024: Translational Psychiatry
https://read.qxmd.com/read/38418443/adhd-medications-use-and-risk-of-mortality-and-unintentional-injuries-a-population-based-cohort-study
#5
JOURNAL ARTICLE
Helen-Maria Vasiliadis, Carlotta Lunghi, Elham Rahme, Louis Rochette, Martin Gignac, Victoria Massamba, Fatoumata Binta Diallo, Alvine Fansi, Samuele Cortese, Alain Lesage
We assessed the association between the use of medications for attention-deficit/hyperactivity disorder (ADHD) and the risk of all-cause mortality and unintentional injuries leading to emergency department (ED) or hospital admission in individuals aged ≤24 years with ADHD. We conducted a population-based retrospective cohort study between 2000 and 2021 using Quebec health administrative data. Individuals were followed from the first ADHD diagnosis or ADHD medication claim until turning 25, death, or study end...
February 28, 2024: Translational Psychiatry
https://read.qxmd.com/read/38413576/%C3%A2%C2%B5-opioid-receptor-antagonism-facilitates-the-anxiolytic-like-effect-of-oxytocin-in-mice
#6
JOURNAL ARTICLE
Khalin E Nisbett, Leandro F Vendruscolo, George F Koob
Mood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation. Previous studies have demonstrated that oxytocin reduced depression- and anxiety-like behavior in male and female mice, and opioid receptor activation reduced depression-like behavior. However, it remains unclear whether the endogenous opioid system interacts with the oxytocin system to facilitate emotion regulation in male and female mice...
February 28, 2024: Translational Psychiatry
https://read.qxmd.com/read/38413577/estrogen-signaling-in-the-dorsal-raphe-regulates-binge-like-drinking-in-mice
#7
JOURNAL ARTICLE
Valeria C Torres Irizarry, Bing Feng, Xiaohua Yang, Nirali Patel, Sarah Schaul, Lucas Ibrahimi, Hui Ye, Pei Luo, Leslie Carrillo-Sáenz, Penghua Lai, Maya Kota, Devin Dixit, Chunmei Wang, Amy W Lasek, Yanlin He, Pingwen Xu
Estrogens promote binge alcohol drinking and contribute to sex differences in alcohol use disorder. However, the mechanisms are largely unknown. This study aims to test if estrogens act on 5-hydroxytryptamine neurons in the dorsal raphe nucleus (5-HTDRN ) to promote binge drinking. We found that female mice drank more alcohol than male mice in chronic drinking in the dark (DID) tests. This sex difference was associated with distinct alterations in mRNA expression of estrogen receptor α (ERα) and 5-HT-related genes in the DRN, suggesting a potential role of estrogen/ERs/5-HT signaling...
February 27, 2024: Translational Psychiatry
https://read.qxmd.com/read/38413574/nightmares-share-genetic-risk-factors-with-sleep-and-psychiatric-traits
#8
JOURNAL ARTICLE
Hanna M Ollila, Nasa Sinnott-Armstrong, Katri Kantojärvi, Martin Broberg, Teemu Palviainen, Samuel Jones, Vili Ripatti, Anita Pandit, Robin Rong, Kati Kristiansson, Nils Sandman, Katja Valli, Christer Hublin, Samuli Ripatti, Elisabeth Widen, Jaakko Kaprio, Richa Saxena, Tiina Paunio
Nightmares are vivid, extended, and emotionally negative or negative dreams that awaken the dreamer. While sporadic nightmares and bad dreams are common and generally harmless, frequent nightmares often reflect underlying pathologies of emotional regulation. Indeed, insomnia, depression, anxiety, or alcohol use have been associated with nightmares in epidemiological and clinical studies. However, the connection between nightmares and their comorbidities are poorly understood. Our goal was to examine the genetic risk factors for nightmares and estimate correlation or causality between nightmares and comorbidities...
February 27, 2024: Translational Psychiatry
https://read.qxmd.com/read/38413564/convergent-and-divergent-genes-expression-profiles-associated-with-brain-wide-functional-connectome-dysfunction-in-deficit-and-non-deficit-schizophrenia
#9
JOURNAL ARTICLE
Chao Zhou, Xiaowei Tang, Miao Yu, Hongying Zhang, Xiaobin Zhang, Ju Gao, Xiangrong Zhang, Jiu Chen
Deficit schizophrenia (DS) is a subtype of schizophrenia characterized by the primary and persistent negative symptoms. Previous studies have identified differences in brain functions between DS and non-deficit schizophrenia (NDS) patients. However, the genetic regulation features underlying these abnormal changes are still unknown. This study aimed to detect the altered patterns of functional connectivity (FC) in DS and NDS and investigate the gene expression profiles underlying these abnormal FC. The study recruited 82 DS patients, 96 NDS patients, and 124 healthy controls (CN)...
February 27, 2024: Translational Psychiatry
https://read.qxmd.com/read/38409260/the-structure-of-psychiatric-comorbidity-without-selection-and-assortative-mating
#10
JOURNAL ARTICLE
Ziada Ayorech, Fartein Ask Torvik, Rosa Cheesman, Espen M Eilertsen, Mathias Valstad, Ludvig Daae Bjørndal, Espen Røysamb, Alexandra Havdahl, Eivind Ystrøm
The widespread comorbidity observed across psychiatric disorders may be the result of processes such as assortative mating, gene-environment correlation, or selection into population studies. Between-family analyses of comorbidity are subject to these sources of bias, whereas within-family analyses are not. Because of Mendelian inheritance, alleles are randomly assigned within families, conditional on parental alleles. We exploit this variation to compare the structure of comorbidity across broad psychiatric polygenic scores when calculated either between-family (child polygenic scores) or within-family (child polygenic scores regressed on parental polygenic scores) in over 25,000 genotyped parent-offspring trios from the Norwegian Mother Father and Child Cohort study (MoBa)...
February 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38409192/polygenic-risk-for-major-depression-attention-deficit-hyperactivity-disorder-neuroticism-and-schizophrenia-are-correlated-with-experience-of-intimate-partner-violence
#11
JOURNAL ARTICLE
Andrew Ratanatharathorn, Luwei Quan, Karestan C Koenen, Lori B Chibnik, Marc G Weisskopf, Natalie Slopen, Andrea L Roberts
Research has suggested that mental illness may be a risk factor for, as well as a sequela of, experiencing intimate partner violence (IPV). The association between IPV and mental illness may also be due in part to gene-environment correlations. Using polygenic risk scores for six psychiatric disorders - attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD), bipolar disorder (BPD), major depressive disorder (MDD), neuroticism, and schizophrenia-and a combined measure of overall genetic risk for mental illness, we tested whether women's genetic risk for mental illness was associated with the experience of three types of intimate partner violence...
February 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38409093/transcriptomic-effects-of-paternal-cocaine-seeking-on-the-reward-circuitry-of-male-offspring
#12
JOURNAL ARTICLE
Nan Huang, Jian Cui, Guangyuan Fan, Tao Pan, Kunxiu Han, Kailiang Xu, Changyou Jiang, Xing Liu, Feifei Wang, Lan Ma, Qiumin Le
It has been previously established that paternal development of a strong incentive motivation for cocaine can predispose offspring to develop high cocaine-seeking behavior, as opposed to sole exposure to the drug that results in drug resistance in offspring. However, the adaptive changes of the reward circuitry have not been fully elucidated. To infer the key nuclei and possible hub genes that determine susceptibility to addiction in offspring, rats were randomly assigned to three groups, cocaine self-administration (CSA), yoked administration (Yoke), and saline self-administration (SSA), and used to generate F1...
February 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38409080/selective-alterations-of-endocannabinoid-system-genes-expression-in-obsessive-compulsive-disorder
#13
JOURNAL ARTICLE
Fabio Bellia, Antonio Girella, Eugenia Annunzi, Beatrice Benatti, Matteo Vismara, Alberto Priori, Fabiana Festucci, Federico Fanti, Dario Compagnone, Walter Adriani, Bernardo Dell'Osso, Claudio D'Addario
Obsessive Compulsive Disorder (OCD) is listed as one of the top 10 most disabling neuropsychiatric conditions in the world. The neurobiology of OCD has not been completely understood and efforts are needed in order to develop new treatments. Beside the classical neurotransmitter systems and signalling pathways implicated in OCD, the possible involvement of the endocannabinoid system (ECS) has emerged in pathophysiology of OCD. We report here selective downregulation of the genes coding for enzymes allowing the synthesis of the endocannabinoids...
February 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38403656/association-of-emotional-and-behavioral-problems-with-the-development-of-the-substantia-nigra-subthalamic-nucleus-and-red-nucleus-volumes-and-asymmetries-from-childhood-to-adolescence-a-longitudinal-cohort-study
#14
JOURNAL ARTICLE
Yanpei Wang, Leilei Ma, Jiali Wang, Ningyu Liu, Weiwei Men, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Yong He, Qi Dong, Sha Tao
The substantia nigra (SN), subthalamic nucleus (STN), and red nucleus (RN) have been widely studied as important biomarkers of degenerative diseases. However, how they develop in childhood and adolescence and are affected by emotional behavior has not been studied thus far. This population-based longitudinal cohort study used data from a representative sample followed two to five times. Emotional and behavioral problems were assessed with the Strengths and Difficulties Questionnaire (SDQ). Linear mixed models were used to map developmental trajectories and behavioral regulation...
February 26, 2024: Translational Psychiatry
https://read.qxmd.com/read/38402231/neurophysiological-evidence-that-frontoparietal-connectivity-and-gaba-a-receptor-changes-underpin-the-antidepressant-response-to-ketamine
#15
JOURNAL ARTICLE
Rachael L Sumner, Rebecca L McMillan, Anna Forsyth, Suresh D Muthukumaraswamy, Alexander D Shaw
Revealing the acute cortical pharmacodynamics of an antidepressant dose of ketamine in humans with depression is key to determining the specific mechanism(s) of action for alleviating symptoms. While the downstream effects are characterised by increases in plasticity and reductions in depressive symptoms-it is the acute response in the brain that triggers this cascade of events. Computational modelling of cortical interlaminar and cortico-cortical connectivity and receptor dynamics provide the opportunity to interrogate this question using human electroencephalography (EEG) data recorded during a ketamine infusion...
February 24, 2024: Translational Psychiatry
https://read.qxmd.com/read/38402197/extracellular-matrix-abnormalities-in-the-hippocampus-of-subjects-with-substance-use-disorder
#16
JOURNAL ARTICLE
Jake Valeri, Charlotte Stiplosek, Sinead M O'Donovan, David Sinclair, Kathleen A Grant, Ratna Bollavarapu, Donna M Platt, Craig A Stockmeier, Barbara Gisabella, Harry Pantazopoulos
Contextual triggers are significant factors contributing to relapse in substance use disorders (SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as mediators of reward memories. Chondroitin sulfate proteoglycans (CSPGs) are a subset of ECM molecules that form perineuronal nets (PNN) around inhibitory neurons. PNNs restrict synaptic connections and help maintain synapses. Rodent models suggest that modulation of PNNs may strengthen contextual reward memories in SUD. However, there is currently a lack of information regarding PNNs in the hippocampus of people with SUD as well as how comorbidity with major depressive disorder (MDD) may affect PNNs...
February 24, 2024: Translational Psychiatry
https://read.qxmd.com/read/38396013/effect-of-antipsychotic-drugs-on-group-ii-metabotropic-glutamate-receptor-expression-and-epigenetic-control-in-postmortem-brains-of-schizophrenia-subjects
#17
JOURNAL ARTICLE
Jon DelaCuesta-Barrutia, Oihane Martínez-Peula, Guadalupe Rivero, Jon A Santas-Martín, Eva Munarriz-Cuezva, Iria Brocos-Mosquera, Patricia Miranda-Azpiazu, Rebeca Diez-Alarcia, Benito Morentin, William G Honer, Luis F Callado, Amaia M Erdozain, Alfredo Ramos-Miguel
Antipsychotic-induced low availability of group II metabotropic glutamate receptors (including mGlu2 R and mGlu3 R) in brains of schizophrenia patients may explain the limited efficacy of mGlu2/3 R ligands in clinical trials. Studies evaluating mGlu2/3 R levels in well-designed, large postmortem brain cohorts are needed to address this issue. Postmortem samples from the dorsolateral prefrontal cortex of 96 schizophrenia subjects and matched controls were collected. Toxicological analyses identified cases who were (AP+) or were not (AP-) receiving antipsychotic treatment near the time of death...
February 23, 2024: Translational Psychiatry
https://read.qxmd.com/read/38395985/task-state-skin-potential-abnormalities-can-distinguish-major-depressive-disorder-and-bipolar-depression-from-healthy-controls
#18
JOURNAL ARTICLE
Hailong Lyu, Huimin Huang, Jiadong He, Sheng Zhu, Wanchu Hong, Jianbo Lai, Tongsheng Gao, Jiamin Shao, Jianfeng Zhu, Yubo Li, Shaohua Hu
Early detection of bipolar depression (BPD) and major depressive disorder (MDD) has been challenging due to the lack of reliable and easily measurable biological markers. This study aimed to investigate the accuracy of discriminating patients with mood disorders from healthy controls based on task state skin potential characteristics and their correlation with individual indicators of oxidative stress. A total of 77 patients with BPD, 53 patients with MDD, and 79 healthy controls were recruited. A custom-made device, previously shown to be sufficiently accurate, was used to collect skin potential data during six emotion-inducing tasks involving video, pictorial, or textual stimuli...
February 23, 2024: Translational Psychiatry
https://read.qxmd.com/read/38395959/coexpression-network-analysis-of-the-adult-brain-sheds-light-on-the-pathogenic-mechanism-of-ddr1-in-schizophrenia-and-bipolar-disorder
#19
JOURNAL ARTICLE
Selena Aranda, Gerard Muntané, Elisabet Vilella
DDR1 has been linked to schizophrenia (SCZ) and bipolar disorder (BD) in association studies. DDR1 encodes 58 distinct transcripts, which can be translated into five isoforms (DDR1a-e) and are expressed in the brain. However, the transcripts expressed in each brain cell type, their functions and their involvement in SCZ and BD remain unknown. Here, to infer the processes in which DDR1 transcripts are involved, we used transcriptomic data from the human brain dorsolateral prefrontal cortex of healthy controls (N = 936) and performed weighted gene coexpression network analysis followed by enrichment analyses...
February 23, 2024: Translational Psychiatry
https://read.qxmd.com/read/38395947/a-multi-cohort-study-of-the-hippocampal-radiomics-model-and-its-associated-biological-changes-in-alzheimer-s-disease
#20
JOURNAL ARTICLE
Huwei Xia, Xiaoqian Luan, Zhengkai Bao, Qinxin Zhu, Caiyun Wen, Meihao Wang, Weihong Song
There have been no previous reports of hippocampal radiomics features associated with biological functions in Alzheimer's Disease (AD). This study aims to develop and validate a hippocampal radiomics model from structural magnetic resonance imaging (MRI) data for identifying patients with AD, and to explore the mechanism underlying the developed radiomics model using peripheral blood gene expression. In this retrospective multi-study, a radiomics model was developed based on the radiomics discovery group (n = 420) and validated in other cohorts...
February 23, 2024: Translational Psychiatry
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