journal
https://read.qxmd.com/read/37744960/evaluating-immune-responses-to-pneumococcal-vaccines
#21
REVIEW
Bernard Yu-Hor Thong, Ruby Pawankar, Hae-Sim Park, Amir Hamzah Abdul Latiff
Streptococcus pneumoniae (pneumococcus) is a significant cause of bacterial infections ranging from mild infections affecting the respiratory tract such as otitis media and sinusitis to severe diseases including bacteremia, pneumonia, and invasive pneumococcal disease (IPD) (eg, meningitis, septic arthritis, and endocarditis). Pneumococcal vaccines were first developed in the 1970s as capsular pneumococcal polysaccharide vaccines, which were T-cell independent and hence lacked immunologic memory. Subsequently in the year 2000, pneumococcal conjugate vaccines (PCV) conjugated to a protein to increase immunogenicity were developed and made commercially available...
September 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37744959/real-world-physician-practices-on-the-diagnosis-and-management-of-allergic-rhinitis-in-the-philippine-setting
#22
JOURNAL ARTICLE
Maria Cristina V Balotro-Torres, Frances M Tan, Cecilia Gretchen Navarro-Locsin, Marysia T Recto, Joel A Romualdez, Josephine B Ramos, Emily G Resurreccion, Rommel Crisenio M Lobo, Eloisa S de Guia, Ma Fredelita Carreon-Asuncion, Jean Bousquet
BACKGROUND: Physician awareness and adherence to guidelines varies among countries and between types of physician practice. Identifying the needs of the physician and patient is essential to improve patient outcome. Data on physician diagnosis and management of allergic rhinitis (AR) in the Philippines is currently limited. OBJECTIVE: Study objectives are to assess awareness and use of guidelines, practices on diagnosis and management of intermittent and persistent AR, reasons for choice of therapy, and familiarity with immunotherapy...
September 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37744958/drug-allergy-knowledge-attitude-and-practice-a-survey-among-doctors-and-pharmacists-in-public-health-facilities-of-sabah-malaysia
#23
JOURNAL ARTICLE
Melinda See Kee Kwan, Sze Ling Tan, Thamron Keowmani, Sor Leng Goh, James Yau Hon Voo, Hoo Seng Tan, Mohd Ridzuan Bin Zakaria, Sivaraj Raman, Jackie Chit Khong Ho, Diyanah Khan Binti Zainullah Faidin, Nur'Ain Binti Madi, Khamisah Binti Itim
BACKGROUND: Given the deficits in allergists and testing capacity, the diagnosis of drug allergy is largely dependent on the clinician's and pharmacist's judgment. The ability to recognize drug allergies and respond appropriately is crucial to patient safety. Currently, there is a void in the evidence that limits the ability to recommend comprehensive and swift improvements on this front. OBJECTIVE: This study thus aimed to evaluate the knowledge, attitude, and practice toward drug allergy among doctors and pharmacists working in public healthcare facilities in Sabah, Malaysia...
September 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37744957/pediatric-allergies-in-japan-coronavirus-disease-pandemic-related-risk-factors
#24
JOURNAL ARTICLE
Yuri Takaoka, Akihiro Maeta, Atsuko Nakano, Masaaki Hamada, Yukiko Hiraguchi, Tomoko Kawakami, Ikuo Okafuji, Yutaka Takemura, Makoto Kameda, Kyoko Takahashi, Shohei Akagawa, Kaori Anzai, Shinichi Sumimoto, Kenji Bando, Masaaki Doi, Masahiro Enomoto, Shiori Fujikawa, Akiko Ikeda, Megumi Nagai, Atsuko Nishiyama, Keita Otsuka, Satoko Shimizu, Yukiko Sugimoto, Yukiko Tanaka, Yuko Tanaka, Yuya Tanaka, Ryohei Wakahara, Koji Yamasaki
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic impacted various parts of society, including Japanese children with allergies. OBJECTIVE: This study investigated risk factors for pediatric allergic diseases associated with the state of emergency owing to the COVID-19 pandemic in Japan, including during school closures. METHODS: Parents of pediatric patients (0-15 years) with allergies were enrolled and queried regarding the impact of school closure on pediatric allergies compared to that before the COVID-19 pandemic...
September 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37744956/pandemic-effects-on-the-care-of-patients-with-inborn-errors-of-immunity
#25
EDITORIAL
Amir Hamzah Abdul Latiff
No abstract text is available yet for this article.
September 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388817/drug-induced-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis-interpreting-the-systematic-reviews-on-immunomodulatory-therapies
#26
REVIEW
Bernard Yu-Hor Thong
Drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are non-immunoglobulin E-mediated severe cutaneous adverse reactions with a high risk of morbidity, mortality, and physical and mental health impact. These are associated with certain high-risk drugs, human leukocyte antigen (HLA)-specific genotypes and ethnicities. HLA class I-restricted oligoclonal CD8 cytotoxic T-cell responses occur at the tissue level in SJS/TEN. Cytotoxic T cells are the T effector cells that result in keratinocyte apoptosis (cell death) mediated by T effector molecules granzyme B, perforin, granulysin, gamma interferon, tumor necrosis factor-alpha, and lipocalin-2...
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388816/experience-of-lanadelumab-administration-in-hereditary-angioedema-a-case-series-of-4-patients-in-portugal
#27
JOURNAL ARTICLE
Ana Graça Bernardino, Manuel Branco Ferreira, Célia Costa, Joana Caiado, Elisa Pedro, Amélia Spínola Santos
No abstract text is available yet for this article.
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388815/eosinophil-granule-proteins-as-a-biomarker-in-managing-asthma-and-allergies
#28
REVIEW
Chang-Keun Kim, Zak Callaway, Ruby Pawankar
In the past few decades, biomarkers have been successfully used for the diagnosis, treatment, and monitoring of disease. Taking together clinical, genetic, lifestyle, and information on relevant biomarkers, the therapy of diseases can be personalized to an individual. Several novel biomarkers have been recently reported for allergic diseases. However, to interpret the validity of biomarker data, the validation of their reliability, precision, and reproducibility is imperative. Once validated, they can be used in therapeutic product development and in clinical practice...
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388814/the-pathophysiology-of-postacute-sequelae-of-covid-19-pasc-possible-role-for-persistent-inflammation
#29
REVIEW
Gailen D Marshall
UNLABELLED: As the SARS-CoV-2-induced pandemic wanes, a substantial number of patients with acute Corona Virus-induced disease (COVID-19 continue to have symptoms for a prolonged time after initial infection. These patients are said to have postacute sequelae of COVID (PASC) or "long COVID". The underlying pathophysiology of this syndrome is poorly understood and likely quite heterogeneous. The role of persistent, possibly deviant inflammation as a major factor in comorbidity is suspected...
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388813/apaaaci-allergy-week-on-climate-change-one-health-and-digital-health
#30
EDITORIAL
Ruby Pawankar, Jiu-Yao Wang
No abstract text is available yet for this article.
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388812/air-pollution-and-allergy-in-malaysia-the-need-for-evidence-and-action
#31
JOURNAL ARTICLE
Fatimah Ahamad, Amir Hamzah Abdul Latiff, Jemilah Mahmood
There is a scarcity in both epidemiological studies and forecast models on the impact of air pollution on respiratory allergic responses in Malaysia. The quantification of baseline allows for an understanding of the severity of the impact and target areas for intervention. High-quality forecasts not only provide information for the assessment of potential outcomes but also the dissemination of public health warnings, such as the application of mobile-based early warning systems. There is a need for a data repository system that facilitates research on such studies...
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388811/autoimmune-manifestations-of-ctla-4-haploinsufficiency-in-two-patients-of-southeast-asian-ethnicity
#32
Xin Rong Lim, Yi Wye Lai, Choon Guan Chua, Yen Loo Lim, Siong See Joyce Lee, Chia Wei Lim, Yu-Hor Bernard Thong, Wei-Lynn Justina Tan
We report 2 patients who first developed cutaneous manifestations, followed by autoimmune phenomena, infections, and hypogammaglobulinemia. They were initially diagnosed with common variable immunodeficiency; however, the diagnosis was revised to cytotoxic T-lymphocyte antigen 4 haploinsufficiency after genetic and functional testing.
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37388810/management-of-hereditary-angioedema-in-resource-constrained-settings-a-consensus-statement-from-indian-subcontinent
#33
JOURNAL ARTICLE
Ankur Kumar Jindal, Archan Sil, Ridhima Aggarwal, Keshavamurthy Vinay, Anuradha Bishnoi, Deepti Suri, Amit Rawat, Muthu Sendhil Kumaran, Biman Saikia, Rashmi Sarkar, Lalit Gupta, D Dinesh Kumar, Rashmi Jindal, T U Sukumaran, Jose Ouseph, Hilary Longhurst, Ruby Pawankar, Surjit Singh, Sunil Dogra
Hereditary angioedema (HAE) is an uncommon disorder characterized clinically by recurrent episodes of nonitchy subcutaneous and/or submucosal swellings. The estimated prevalence of HAE is ~ 1: 10,000 to 1: 50,000. There are no prevalence data from India, however, estimates suggest that there are 27,000 to 135,000 patients with HAE in India at present. The majority of these, however, remain undiagnosed. Replacement of plasma-derived or recombinant C1-esterase inhibitor (C1-INH) protein, administered intravenously, is the treatment of choice during the management of acute episodes of angioedema (i...
June 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37389101/association-between-prenatal-and-neonatal-risk-factors-and-development-of-bronchiolitis-in-early-life
#34
JOURNAL ARTICLE
Po-Sung Chen, Yi-Fen Tsai, Hong-Ren Yu, Chih-Hsing Hung, Wei-Yu Chen, Ching-Wei Lin, Ju Lee, Chih-An Chen, Hui-Ju Tsai, Jiu-Yao Wang
UNLABELLED: Bronchiolitis is the most common seasonal viral respiratory disorder in infants. However, risk factors for the development of bronchiolitis, particularly during pregnancy, remain unclear. METHODS: A questionnaire was administered to the parents of the hospitalized infants with acute bronchiolitis to obtain information regarding patients' medical, family, and prenatal exposure history. Logistic regression with adjustment was performed to evaluate risk factors associated with bronchiolitis in the infants...
March 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37389100/real-world-data-a-relevant-component-in-the-framework-of-scientific-evidence
#35
REVIEW
Giorgio W Canonica, Lorenzo Del Moro, Giovanni Costanzo, Emanuele Nappi, Giovanni Paoletti
Explanatory randomized controlled clinical trials test hypotheses to see if the intervention causes an outcome of interest in optimal circumstances, that is, established by selecting patients based on inclusion and exclusion criteria and controlled environments. They assess the "efficacy" of an intervention. On the contrary, it is crucial for society to address issues related to real-world clinical practices. This need can be fulfilled by real-world studies. We discuss the challenges in obtaining real-world evidence in asthma, debating the importance of including patients who are typically excluded from randomized controlled clinical trials to ensure the generalizability of the results...
March 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37389099/a-new-journey-of-asia-pacific-allergy
#36
EDITORIAL
Ruby Pawankar, Luo Zhang
No abstract text is available yet for this article.
March 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37389098/covid-19-in-the-asia-pacific-impact-on-climate-change-allergic-diseases-and-one-health
#37
REVIEW
Ruby Pawankar, Bernard Y Thong, Marysia T Recto, Jiu-Yao Wang, Amir Hamzah Abdul Latiff, Ting-Fan Leung, Philip H Li, Rommel Crisenio M Lobo, Michela Lucas, Jae-Won Oh, Wasu Kamchaisatian, Mizuho Nagao, Iris Rengganis, Zarir F Udwadia, Raja Dhar, Sonomjamts Munkhbayarlakh, Logii Narantsetseg, Duy L Pham, Yuan Zhang, Luo Zhang
Climate change and environmental factors such as air pollution and loss of biodiversity are known to have a major impact not only on allergic diseases but also on many noncommunicable diseases. Coronavirus disease 2019 (COVID-19) resulted in many environmental changes during the different phases of the pandemic. The use of face masks, enhanced hand hygiene with hand rubs and sanitizers, use of personal protective equipment (gowns and gloves), and safe-distancing measures, reduced the overall incidence of respiratory infections and other communicable diseases...
March 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37389097/thyroid-disease-post-covid-19-infection-report-of-a-case-with-new-onset-autoimmune-thyroid-disease
#38
Anh Ngoc Trinh, Kim Han Nguyen, Dinh Van Nguyen
We present hyperthyroidism with autoimmune thyroid disease, which developed a few weeks after the COVID-19 infection in a patient with no prior thyroid disease. Our case was described with clinical presentations, diagnostic tests, and subsequent patient management and compared to other similar reported cases. A 28-year-old female patient with no prior history of thyroid dysfunction developed hyperthyroidism 8 weeks after COVID-19 infection, confirmed by low thyroid stimulating hormone, high free thyroxine 4, and thyroid receptor antibody...
March 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37389096/the-epithelial-barrier-theory-development-and-exacerbation-of-allergic-and-other-chronic-inflammatory-diseases
#39
REVIEW
Umut Can Kucuksezer, Cevdet Ozdemir, Duygu Yazici, Yagiz Pat, Yasutaka Mitamura, Manru Li, Na Sun, Paolo D'Avino, Xiangting Bu, Xueyi Zhu, Mubeccel Akdis, Kari Nadeau, Ismail Ogulur, Cezmi A Akdis
It is now longer than half a century, humans, animals, and nature of the world are under the influence of exposure to many newly introduced noxious substances. These exposures are nowadays pushing the borders to be considered as the causative or exacerbating factors for many chronic disorders including allergic, autoimmune/inflammatory, and metabolic diseases. The epithelial linings serve as the outermost body's primary physical, chemical, and immunological barriers against external stimuli. The "epithelial barrier theory" hypothesizes that these diseases are aggravated by an ongoing periepithelial inflammation triggered by exposure to a wide range of epithelial barrier-damaging insults that lead to "epithelitis" and the release of alarmins...
March 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37389095/immunological-dysfunction-and-mast-cell-activation-syndrome-in-long-covid
#40
REVIEW
Stevent Sumantri, Iris Rengganis
At least 65 million people around the world suffer from long COVID-19, with the majority of cases occurring in the productive age (36-50 years old). Individuals with long COVID-19 are confounded with multiple organ system dysfunctions, long-term organ injury sequelae, and a decreased quality of life. There is an overlapping of risk factors between long COVID-19 and other postviral infection syndromes, so advances in research could also benefit other groups of patients. Long COVID-19 is the consequence of multiple immune system dysregulation, such as T-cell depletion, innate immune cell hyperactivity, lack of naive T and B cells, and elevated signature of pro-inflammatory cytokines, together with persistent severe acute respiratory syndrome-coronavirus 2 reservoir and other consequences of acute infection...
March 2023: Asia Pacific Allergy
journal
journal
43606
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.