journal
https://read.qxmd.com/read/38482462/anti-thymic-stromal-lymphopoietin-monoclonal-antibody-in-patients-with-chronic-rhinosinusitis-with-nasal-polyps-dubhe-rationale-and-design-of-a-multicenter-randomized-double-blind-placebo-controlled-study
#1
JOURNAL ARTICLE
Shen Shen, Mu Xian, Bing Yan, Feng Lan, Chengshuo Wang, Luo Zhang
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) has a complex pathogenesis and is difficult to treat, which brings a huge economic burden to society. Despite all the progress in the treatment of CRSwNP, some patients with CRSwNP still experience recurrence. Therefore, there is an urgent need to develop novel drugs and treatments for CRSwNP. Thymic stromal lymphopoietin (TSLP) is produced by epithelial cells and mediates type 2 and nontype 2 inflammation through various downstream cellular immune and inflammatory pathways...
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38482461/prevalence-of-allergic-sensitization-to-platanus-occidentalis-among-adults-with-allergic-rhinitis-a-multicenter-study
#2
JOURNAL ARTICLE
Martín Bedolla-Barajas, Javier Domínguez-Morales, Ilse Mariana Loya-Barriga, Angie Bedolla-Pulido, Luis Alfredo Jiménez-Huerta, Jaime Morales-Romero
BACKGROUND: In the Americas there are few studies that have evaluated the frequency of allergic sensitization to Platanus occidentalis or sycamore pollen in adult patients with allergic rhinitis (AR). OBJECTIVE: To determine the prevalence of allergic sensitization to P. occidentalis and to identify factors associated with its presentation. METHODS: A cross-sectional study was carried out in 3 centers distributed in the northwest, west, and southeast of Mexico...
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38482460/correlation-of-blomia-tropicalis-specific-immunoglobulin-epsilon-profiles-with-family-history-of-atopy-in-a-filipino-population
#3
JOURNAL ARTICLE
Chanie Y Patanindagat, Jamie Ezra B Tarun, Ryla Jasmine T Pajaro, Jhon Jerald D Pintucan, Patricia Nichole M Quilang, Maureen B Sabit, John Donnie A Ramos
BACKGROUND: House dust mites are the major source of indoor allergens in the tropical and subtropical regions with Blomia tropicalis (Bt) allergens as one of the leading causative agents of sensitization among patients from the tropics. Despite the clinical importance of Bt in various populations, its allergenicity remains unclear among Filipino allergic patients. OBJECTIVE: This study determined the sensitization profiles of allergic Filipinos against Bt allergens and its correlation with atopy...
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38482459/accessibility-to-plasma-derived-medicinal-products-in-malaysia-the-challenges-faced-by-patients-with-inborn-errors-of-immunity
#4
JOURNAL ARTICLE
Bruce Wee Diong Lim, Amir Hamzah Abdul Latiff
Inborn errors of immunity (IEI) (also known as primary immunodeficiencies) is an umbrella term for a growing group of over 450 different disorders that are characterized by defects in some of the components of the immune system. IEI are chronic diseases of genetic origin that render individuals suffering from them susceptible to infections. The mainstay of treatments for most patients with IEI, that is, predominantly antibody deficiencies is immunoglobulin replacement therapy (IRT), which is commonly delivered intravenously...
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38482458/does-omalizumab-increase-the-risk-of-malignancy-a-retrospective-case-control-study-in-a-single-tertiary-hospital
#5
JOURNAL ARTICLE
Hyun Jee Kim, Suh Young Lee, Sang-Heon Cho, Hye-Ryun Kang
No abstract text is available yet for this article.
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38482457/the-treatment-efficacy-of-dupilumab-in-autosomal-dominant-hyper-immunoglobulin-e-syndrome-with-severe-atopic-dermatitis
#6
Weifeng Li, Qiqi Qi, Weipeng Wang, Dongqin Li
Hyper-immunoglobulin E syndrome (HIES) is a primary immunodeficiency disease characterized by atopic dermatitis, recurrent skin and lung infections, and significantly elevated serum immunoglobulin E levels. Autosomal dominant and loss-of-function pathogenic variants in the STAT3 gene are the most common causes of the disease and studies have shown that the presence of IL-4 receptor (IL-4R) is upregulated in patients with dominant-negative mutations in the STAT3 gene expression. Dupilumab is a monoclonal antibody that targets the IL-4α receptor and improves the symptoms of atopic dermatitis by inhibiting IL-4 and IL-13...
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38482456/biomarkers-in-allergen-immunotherapy-focus-on-eosinophilic-inflammation
#7
REVIEW
Chang-Keun Kim, Zak Callaway, Jin-Sung Park, Ruby Pawankar, Takao Fujisawa
Asthma and allergic rhinitis (AR) are 2 of the most common chronic inflammatory disorders and they appear to be on the rise. Current pharmacotherapy effectively controls symptoms but does not alter the underlying pathophysiology. Allergen immunotherapy (AIT) is an evidence-based therapy for asthma and AR and has been recognized as the only therapeutic method that actually modifies the allergic disease process. There is a lack of objective markers that accurately and reliably reflect the therapeutic benefits of AIT...
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38482455/a-prospective-observational-study-correlating-possible-novel-biomarkers-with-disease-severity-and-antihistamine-response-in-chronic-spontaneous-urticaria
#8
JOURNAL ARTICLE
Divya Bhatia, Hitaishi Mehta, Anuradha Bishnoi, Niharika Srivastava, Keshavamurthy Vinay, Davinder Parsad, Muthu Sendhil Kumaran
BACKGROUND: Role of complement fraction 5a (C5a), interleukin (IL)-9, and apolipoprotein (apo) A-IV as biomarkers of disease severity and antihistamine response in chronic spontaneous urticaria (CSU) remains elusive. OBJECTIVE: To identify the role of C5a, IL-9, and apo A-IV as potential biomarkers in predicting disease severity and antihistamine response in CSU patients. METHODS: This was a prospective observational study of 95 patients and 42 controls...
March 2024: Asia Pacific Allergy
https://read.qxmd.com/read/38094097/a-case-of-white-bean-allergy
#9
Teruaki Matsui, Nayu Sato, Masashi Nakamura, Yukiko Iwawaki, Katsumasa Kitamura, Yoshihiro Takasato, Shiro Sugiura, Kayoko Matsunaga, Komei Ito
White bean allergy is uncommon and rarely reported. Herein, we report a case of white bean allergy in a patient with Down syndrome. A 7-year-old girl with Down syndrome experienced allergic symptoms twice after eating white bean and visited our hospital for a food allergy investigation. An ImmunoCAP assay revealed a white bean-specific IgE (13.4 kUA /L) in the patient's serum. In addition, her skin prick test result was positive. Moreover, ingestion of 2 g of boiled white beans in an oral food challenge test induced intermittent cough, desaturation, generalized urticaria, abnormal sleep, and mild hypotension...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094096/activities-and-concentration-of-alpha-1-antitrypsin-and-cystatin-c-in-serum-from-patients-with-house-dust-mite-asthma
#10
JOURNAL ARTICLE
Mailani Dwi Hidayati, Febriana Catur Iswanti, Samsuridjal Djauzi, Sukamto Koesnoe, Mohamad Sadikin
BACKGROUND: The proteolytic activities of house dust mite (HDM) allergens are involved in the pathogenesis of asthma by cleaving T-junction protein complexes, increasing the permeability of airway epithelial cells, and enabling the allergens to reach the interstitial tissue. The human body contains natural protease inhibitors such as alpha-1 antitrypsin (AAT) with antiserine protease activity and cystatin C with anticysteine protease activity. OBJECTIVE: This study aimed to investigate the behavior of serum AAT and cystatin C levels in patients with HDM-allergic asthma...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094095/apaaaci-2023-international-conference-the-innovation-revolution-in-allergy-asthma-and-immunology
#11
EDITORIAL
Bernard Yu-Hor Thong, Ruby Pawankar
No abstract text is available yet for this article.
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094094/induction-of-a-type-2-inflammatory-chronic-rhinosinusitis-in-c57bl-6-mice
#12
JOURNAL ARTICLE
Ying Li, Ping He, Bing Yan, Yimin Ren, Bangyu Cui, Ming Wang, Siyuan Ma, Jun Yang, Luo Zhang, Chengshuo Wang
BACKGROUND: Eosinophilic chronic rhinosinusitis (CRS) has been widely studied for its intractability and high recurrence rate. It can be divided into pure and mixed type 2 CRS subtypes. Mouse models that reflect pure type 2 inflammation of CRS are lacking. OBJECTIVE: This study aims to establish a relatively pure type 2 CRS mouse model and compare it with 2 mixed type 2 CRS models. METHODS: Three mouse CRS models were constructed: (1) aerosol ovalbumin (OVA) + aspergillus oryzae-derived protease (AP); (2) intranasal OVA + AP; (3) Intraperitoneal then intranasal OVA + AP (n = 10 per group)...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094093/association-of-interleukin-13-gene-single-nucleotide-polymorphism-rs1800925-with-allergic-asthma-in-asian-population-a-meta-analysis
#13
JOURNAL ARTICLE
Kenneth V Gaceja, Zaynah Faith R Ancheta, Abigail Charisse A Buna, Sandra Mae S Clarencio, Maria Angelica R Garrido, John Donnie A Ramos
BACKGROUND: The interleukin-13 (IL-13) gene has been associated with allergic asthma pathogenesis due to its role in IgE synthesis. The IL-13 single nucleotide polymorphism (SNP) rs1800925 has been implicated in exacerbated allergic asthma symptoms in different ethnicities. OBJECTIVES: To determine the association of IL-13 SNP rs1800925 with allergic asthma symptoms in the Asian population. METHODS: Major databases were searched for studies on the association of IL-13 rs1800925 with allergic asthma in various Asian populations published between 2010 and February 2022...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094092/apaaaci-clinical-pathway-on-direct-provocation-testing-for-penicillin-allergy-delabeling
#14
JOURNAL ARTICLE
Philip Hei Li, Bernard Yu-Hor Thong, Ruby Pawankar, Chandima Jeewandara, Rommel Crisenio M Lobo, Hye-Ryun Kang, Padukudru Anand Mahesh, Juan Meng, Sonomjamts Munkhbayarlakh, Duy Le Pham, Ticha Rerkpattanapipat, Min-Moon Tang, Masao Yamaguchi, Amir Hamzah Abdul Latiff, Iris Rengganis, Jiu-Yao Wang, Luo Zhang, Michaela Lucas
BACKGROUND: Allergy to penicillin is commonly reported in many countries and is an overwhelming global public health concern. Penicillin allergy labels can lead to the use of less effective antibiotics and can be associated with antimicrobial resistance. Appropriate assessment of suspected penicillin allergy (often including skin testing, followed by drug provocation testing [DPT] performed by allergists) can prevent the unnecessary restriction of penicillin or delabelling. Many countries in the Asia Pacific (AP) have very limited access to allergy services, and there are significant disparities in the methods of evaluating penicillin allergy...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094091/preprandial-food-dependent-exercise-induced-anaphylaxis-to-banana
#15
Thatchai Kampitak
Food-dependent exercise-induced anaphylaxis is a disorder in which a reaction develops only in association with physical exertion that generally takes place postprandially. The reaction that occurs following food intake after exercise is uncommon. Banana is an infrequent cause of anaphylaxis, which has been previously reported in combination with postprandial exercise in only 1 patient. A probable case of preprandial food-dependent exercise-induced anaphylaxis to banana is described herein together with a brief review of recent related literature...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094090/application-of-nasal-irrigation-in-the-treatment-of-chronic-rhinosinusitis
#16
REVIEW
Ling Jin, Kai Fan, Shaoqing Yu
Nasal irrigation (NI) for the local treatment of chronic rhinosinusitis (CRS) has some specificity due to the deep anatomical site of the sinuses. The purpose of this review is to help standardize the application of NI in healthcare practice, improve the prevention and treatment of CRS, and facilitate further research on the local treatment of CRS in the future. We searched the PubMed database for 342 articles in the last decade, using the keywords "saline nasal irrigation" and "chronic rhinosinusitis." We summarize the studies on the mechanism of action, rinsing solution, rinsing apparatus, and rinsing method of NI for CRS...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/38094089/immunological-mechanisms-of-tolerance-central-peripheral-and-the-role-of-t-and-b-cells
#17
REVIEW
Xun Meng, Janice A Layhadi, Sean T Keane, Natanya J K Cartwright, Stephen R Durham, Mohamed H Shamji
T and B cells are key components of the adaptive immune system. Through their immune properties and their interactions with other immune cells and cytokines around them, they build a complex network to achieve immune tolerance and maintain homeostasis of the body. This is achieved through mechanisms of central and peripheral tolerance, both of which are associated with advantages and disadvantages. For this reason, the immune system is tightly regulated and their dysregulation can result in the subsequent initiation of various diseases...
December 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37744963/optimal-period-for-achieving-sustained-unresponsiveness-in-peanut-oral-immunotherapy
#18
JOURNAL ARTICLE
Kosei Yamashita, Toshinori Nakamura, Takanori Imai, Aiko Honda, Yuki Okada, Mayu Maeda, Taro Kamiya
BACKGROUND: Oral immunotherapy (OIT) can help children with persistent food allergies achieve sustained unresponsiveness (SU). However, the optimal therapeutic period for obtaining SU remains unclear. OBJECTIVE: We aimed to retrospectively investigate the association between the OIT treatment period and achievement of SU. METHODS: We enrolled patients who received OIT for peanut allergy between January 1, 2018 and December 31, 2022. OIT comprised the build-up phase, maintenance phase, complete avoidance, and an oral food challenge (OFC) for confirming SU...
September 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37744962/a-14-year-old-boy-with-severe-erythema-multiforme-due-to-amoxicillin
#19
Mami Kurihara, Shingo Yamanishi, Saeko Ozaki, Ruby Pawankar
The most common cause of erythema multiforme (EM) in children is infectious diseases which account for approximately 90% of cases. Drug eruptions are another common cause. Here we are reporting about a male patient aged 14 years with lymphadenitis who developed severe diffuse erythema during the course of treatment with medications including several antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs). Based on the pathological findings of the skin biopsy, the skin rash was due to EM. Upon investigating the underlying cause of EM, viral antibody was positive for Coxsackie A6, lymphocyte transformation testing (LTT) was positive for one of the NSAIDs, and the patch test (PT) was positive for amoxicillin...
September 2023: Asia Pacific Allergy
https://read.qxmd.com/read/37744961/the-relevance-of-oral-food-challenge-in-a-patient-allergic-to-peanut-and-tree-nuts
#20
Rita Limão, Borja Bartolomé, Fátima Cabral Duarte
Peanut allergy is one of the most common food allergies in childhood. In vitro cross-sensitization between peanut and tree nuts (TN) is high, but only a subgroup of patients allergic to peanut will have a concomitant allergy to one or several TN. In this article, the authors report a case of a 12-year-old boy who experienced 1 episode of lips and mouth itching, generalized urticarial, and eyelid angioedema 20 minutes after ingestion of peanut at 4 years of age. The immunoallergological study revealed the presence of a concomitant allergy to peanut, pistachio, and cashew confirmed with medically supervised oral food challenges (OFC) in a child who had never eaten these TN...
September 2023: Asia Pacific Allergy
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