journal
https://read.qxmd.com/read/38495894/transplantation-platform-to-study-recurrence-of-disease
#1
JOURNAL ARTICLE
George William Burke, Alla Mitrofanova, Antonio Miguel Fontanella, Francesco Vendrame, Gaetano Ciancio, Rodrigo M Vianna, David Roth, Phillip Ruiz, Carolyn L Abitbol, Jayanthi Chandar, Sandra Merscher, Alberto Pugliese, Alessia Fornoni
Beyond the direct benefit that a transplanted organ provides to an individual recipient, the study of the transplant process has the potential to create a better understanding of the pathogenesis, etiology, progression and possible therapy for recurrence of disease after transplantation while at the same time providing insight into the original disease. Specific examples of this include: 1) recurrence of focal segmental glomerulosclerosis (FSGS) after kidney transplantation, 2) recurrent autoimmunity after pancreas transplantation, and 3) recurrence of disease after orthotopic liver transplantation (OLT) for cirrhosis related to progressive steatosis secondary to jejuno-ileal bypass (JIB) surgery...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495893/associations-of-perchlorate-nitrate-and-thiocyanate-exposure-with-arthritis-and-inflammation-indicators-in-young-and-middle-aged-adults-nhanes-2005-2016
#2
JOURNAL ARTICLE
Hui Zhao, Xuyang Chen, Jianping Ni, Lanlan Fang, Yuting Chen, Yubo Ma, Guoqi Cai, Faming Pan
BACKGROUND: Perchlorates, nitrates, and thiocyanates are prevalent environmental chemicals. Their potential association with arthritis remains unexplored. This study aimed to investigate the link between perchlorate, nitrate, and thiocyanate exposure and arthritis, as well as the potential role of inflammation in this context. METHODS: Utilizing the National Health and Nutrition Examination Survey (NHANES) data spanning from 2005 to 2016, the study enrolled 6597 participants aged 20-59 (young and middle-aged), of which 1045 had arthritis...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495892/interferon-lambda-in-respiratory-viral-infection-immunomodulatory-functions-and-antiviral-effects-in-epithelium
#3
REVIEW
Yong-Guang Liu, Su-Wei Jin, Shan-Shan Zhang, Tian-Ji Xia, Yong-Hong Liao, Rui-Le Pan, Ming-Zhu Yan, Qi Chang
Type III interferon (IFN-λ), a new member of the IFN family, was initially considered to possess antiviral functions similar to those of type I interferon, both of which are induced via the JAK/STAT pathway. Nevertheless, recent findings demonstrated that IFN-λ exerts a nonredundant antiviral function at the mucosal surface, preferentially produced in epithelial cells in contrast to type I interferon, and its function cannot be replaced by type I interferon. This review summarizes recent studies showing that IFN-λ inhibits the spread of viruses from the cell surface to the body...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495891/construction-of-an-aerolysin-based-multi-epitope-vaccine-against-aeromonas-hydrophila-an-in-silico-machine-learning-and-artificial-intelligence-supported-approach
#4
JOURNAL ARTICLE
Abdullah S Alawam, Maher S Alwethaynani
Aeromonas hydrophila , a gram-negative coccobacillus bacterium, can cause various infections in humans, including septic arthritis, diarrhea (traveler's diarrhea), gastroenteritis, skin and wound infections, meningitis, fulminating septicemia, enterocolitis, peritonitis, and endocarditis. It frequently occurs in aquatic environments and readily contacts humans, leading to high infection rates. This bacterium has exhibited resistance to numerous commercial antibiotics, and no vaccine has yet been developed. Aiming to combat the alarmingly high infection rate, this study utilizes in silico techniques to design a multi-epitope vaccine (MEV) candidate against this bacterium based on its aerolysin toxin, which is the most toxic and highly conserved virulence factor among the Aeromonas species...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495890/trim28-facilitates-type-i-interferon-activation-by-targeting-tbk1
#5
JOURNAL ARTICLE
Fang Hua, Tim Nass, Kislay Parvatiyar
Type I interferons play a fundamental role in innate host defense against viral infections by eliciting the induction of an antiviral gene program that serves to inhibit viral replication. Activation of type I interferon is regulated by the IRF3 transcription factor, which undergoes phosphorylation-dependent activation by the upstream kinase, TBK1, during viral infection. However, the mechanisms by which TBK1 achieves activation to support signaling to IRF3 remain incompletely understood. Here we identified the E3 ubiquitin ligase, tripartite motif containing 28 (TRIM28), as a positive regulator of type I interferon activation by facilitating TBK1 signaling...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495889/prolyl-hydroxylase-inhibition-protects-against-murine-mc903-induced-skin-inflammation-by-downregulating-tslp
#6
JOURNAL ARTICLE
Anupriya Gupta, Mi Hye Song, Dong Hyuk Youn, Dohyeon Ku, Varun Sasidharan Nair, Kwonik Oh
Previously, we reported an anti-inflammatory effect of mTORC1 in a mouse model of type 2 skin inflammation. TSLP, one of the epithelial cell-derived cytokines, was upregulated by Raptor deficiency or rapamycin treatment, which was inhibited by dimethyloxalylglycine (DMOG). However, it remains unclear how DMOG regulates TSLP expression and type 2 skin inflammation. In this study, we investigated the protective effect of DMOG on MC903 (calcipotriol)-induced type 2 skin inflammation. Morphological and immunological changes were assessed by H-E staining, flow cytometry and RT-qPCR...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495888/comprehensive-molecular-and-cellular-characterization-of-endoplasmic-reticulum-stress-related-key-genes-in-renal-ischemia-reperfusion-injury
#7
JOURNAL ARTICLE
Hao Zhang, Chaoyue Zheng, Yue Xu, Xiaopeng Hu
BACKGROUND: Renal ischemia-reperfusion injury (RIRI) is an inevitable complication in the process of kidney transplantation and lacks specific therapy. The study aims to determine the underlying mechanisms of RIRI to uncover a promising target for efficient renoprotection. METHOD: Four bulk RNA-seq datasets including 495 renal samples of pre- and post-reperfusion were collected from the GEO database. The machine learning algorithms were utilized to ascertain pivotal endoplasmic reticulum stress genes...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495887/level-of-il-6-tnf-and-il-1%C3%AE-and-age-related-diseases-a-systematic-review-and-meta-analysis
#8
Anna Tylutka, Łukasz Walas, Agnieszka Zembron-Lacny
INTRODUCTION: Chronic low-grade inflammation is an important aspect of morbidity and mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL)-6, tumor necrosis factor (TNF) or IL-1β) is a risk factor in cardiovascular and neurodegenerative diseases and is also associated with sarcopenia and frailties. The objective of this study was to assess each cytokine: IL-6, TNF, and IL-1β separately in the elderly with comorbidities against controls without diseases according to the data published in the available literature...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495886/a-bcl11b-n797k-variant-isolated-from-an-immunodeficient-patient-inhibits-early-thymocyte-development-in-mice
#9
JOURNAL ARTICLE
Kazuaki Matsumoto, Kazuki Okuyama, Tom Sidwell, Motoi Yamashita, Takaho Endo, Naoko Satoh-Takayama, Hiroshi Ohno, Tomohiro Morio, Ellen V Rothenberg, Ichiro Taniuchi
BCL11B is a transcription factor with six C2 H2 -type zinc-finger domains. Studies in mice have shown that Bcl11b plays essential roles in T cell development. Several germline heterozygous BCL11B variants have been identified in human patients with inborn errors of immunity (IEI) patients. Among these, two de novo mis-sense variants cause asparagine (N) to lysine (K) replacement in distinct zinc-finger domains, BCL11BN441K and BCL11BN807K . To elucidate the pathogenesis of the BCL11BN807K variant, we generated a mouse model of BCL11BN807K by inserting the corresponding mutation, Bcl11bN797K , into the mouse genome...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495885/cancer-cells-and-viruses-share-common-glycoepitopes-exciting-opportunities-toward-combined-treatments
#10
REVIEW
René Roy
Aberrant glycosylation patterns of glycoproteins and glycolipids have long been recognized as one the major hallmarks of cancer cells that has led to numerous glycoconjugate vaccine attempts. These abnormal glycosylation profiles mostly originate from the lack of key glycosyltransferases activities, mutations, over expressions, or modifications of the requisite chaperone for functional folding. Due to their relative structural simplicity, O -linked glycans of the altered mucin family of glycoproteins have been particularly attractive in the design of tumor associated carbohydrate-based vaccines...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495884/neoadjuvant-systemic-therapy-for-hepatocellular-carcinoma
#11
REVIEW
R Connor Chick, Samantha M Ruff, Timothy M Pawlik
Surgical resection and liver transplant remain the only curative therapies for most patients with hepatocellular carcinoma (HCC). Systemic therapy options have typically been ineffective, but recent advances, such as the combination of immune checkpoint inhibitors and targeted therapies, have shown great promise. Neoadjuvant systemic therapy in resectable or locally advanced HCC is under active investigation with encouraging results in small, early-phase trials. Many of these completed and ongoing trials include combinations of systemic therapy (e...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495883/strain-specific-differences-in-vitamin-d3-response-impact-on-gut-homeostasis
#12
JOURNAL ARTICLE
Laura Schreiber, Sakhila Ghimire, Andreas Hiergeist, Kathrin Renner, Michael Althammer, Nathalie Babl, Alice Peuker, Gabriele Schoenhammer, Katrin Hippe, Andre Gessner, Christin Albrecht, Fransziska Pielmeier, Maike Büttner-Herold, Heiko Bruns, Petra Hoffmann, Wolfgang Herr, Ernst Holler, Katrin Peter, Marina Kreutz, Carina Matos
Vitamin D3 regulates a variety of biological processes irrespective of its well-known importance for calcium metabolism. Epidemiological and animal studies indicate a role in immune regulation, intestinal barrier function and microbiome diversity. Here, we analyzed the impact of different vitamin D3- containing diets on C57BL/6 and BALB/c mice, with a particular focus on gut homeostasis and also investigated effects on immune cells in vitro . Weak regulatory effects were detected on murine T cells. By trend, the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 suppressed IFN, GM-CSF and IL-10 cytokine secretion in T cells of C57BL/6 but not BALB/c mice, respectively...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495882/corrigendum-erbb2-her2-receptor-tyrosine-kinase-regulates-human-papillomavirus-promoter-activity
#13
Snježana Mikuličić, Merha Shamun, Annika Massenberg, Anna-Lena Franke, Kirsten Freitag, Tatjana Döring, Johannes Strunk, Stefan Tenzer, Thorsten Lang, Luise Florin
[This corrects the article DOI: 10.3389/fimmu.2024.1335302.].
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495881/extracellular-vesicle-mediated-pre-metastatic-niche-formation-via-altering-host-microenvironments
#14
REVIEW
Ying Li, Yan Zheng, Xiaojie Tan, Yongxing Du, Yingxin Wei, Shanglong Liu
The disordered growth, invasion and metastasis of cancer are mainly attributed to bidirectional cell-cell interactions. Extracellular vesicles (EVs) secreted by cancer cells are involved in orchestrating the formation of pre-metastatic niches (PMNs). Tumor-derived EVs mediate bidirectional communication between tumor and stromal cells in local and distant microenvironments. EVs carrying mRNAs, small RNAs, microRNAs, DNA fragments, proteins and metabolites determine metastatic organotropism, enhance angiogenesis, modulate stroma cell phenotypes, restructure the extracellular matrix, induce immunosuppression and modify the metabolic environment of organs...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495880/modulation-of-myeloid-derived-suppressor-cell-functions-by-oral-inflammatory-diseases-and-important-oral-pathogens
#15
REVIEW
Fernando García-Arévalo, Ana Gabriela Leija-Montoya, Javier González-Ramírez, Mario Isiordia-Espinoza, Idanya Serafín-Higuera, Dulce Martha Fuchen-Ramos, J Gustavo Vazquez-Jimenez, Nicolas Serafín-Higuera
The oral cavity presents a diverse microbiota in a dynamic balance with the host. Disruption of the microbial community can promote dysregulation of local immune response which could generate oral diseases. Additionally, alterations in host immune system can result in inflammatory disorders. Different microorganisms have been associated with establishment and progression of the oral diseases. Oral cavity pathogens/diseases can modulate components of the inflammatory response. Myeloid-derived suppressor cells (MDSCs) own immunoregulatory functions and have been involved in different inflammatory conditions such as infectious processes, autoimmune diseases, and cancer...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495879/exercise-intensity-governs-tumor-control-in-mice-with-breast-cancer
#16
JOURNAL ARTICLE
Igor L Gomes-Santos, Ashwin S Kumar, Franziska Hausmann, Max N Meyer, Sarah Z Shiferaw, Zohreh Amoozgar, Rakesh K Jain, Dai Fukumura
INTRODUCTION: Exercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis is that the benefit depends on the exercise intensity. METHODS: We subjected mice to low intensity (Li), moderate intensity (Mi) or high intensity (Hi) exercise, or untrained control (Co) groups based on their individual maximal running capacity. RESULTS: We found that exercise intensity played a critical role in tumor control...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495878/deep-analysis-of-skin-molecular-heterogeneities-and-their-significance-on-the-precise-treatment-of-patients-with-psoriasis
#17
JOURNAL ARTICLE
Shengxiao Zhang, Minjing Chang, Leilei Zheng, Can Wang, Rong Zhao, Shan Song, Jiawei Hao, Lecong Zhang, Caihong Wang, Xiaofeng Li
BACKGROUND: Psoriasis is a highly heterogeneous autoinflammatory disease. At present, heterogeneity in disease has not been adequately translated into concrete treatment options. Our aim was to develop and verify a new stratification scheme that identifies the heterogeneity of psoriasis by the integration of large-scale transcriptomic profiles, thereby identifying patient subtypes and providing personalized treatment options whenever possible. METHODS: We performed functional enrichment and network analysis of upregulated differentially expressed genes using microarray datasets of lesional and non-lesional skin samples from 250 psoriatic patients...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495877/contribution-of-cerebrospinal-fluid-antibody-titers-and-sex-to-acute-cerebral-blood-flow-in-patients-with-anti-nmdar-autoimmune-encephalitis
#18
JOURNAL ARTICLE
Ailiang Miao, Kai Wang
OBJECTIVE: The objective of this study was to elucidate the contribution of cerebrospinal fluid (CSF) antibody titers (AT) and sex to acute cerebral blood flow (CBF) in patients diagnosed with anti- N -methyl-d-aspartate receptor autoimmune encephalitis (NMDAR AE). METHODS: Forty-five patients diagnosed with NMDAR AE were recruited from December 2016 to January 2023. The acute CBF in patients with NMDAR AE at the early stage of the disease was analyzed using arterial spin labeling...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495876/leukemic-mutation-flt3-itd-is-retained-in-dendritic-cells-and-disrupts-their-homeostasis-leading-to-expanded-th17-frequency
#19
JOURNAL ARTICLE
Patrick A Flynn, Mark D Long, Yoko Kosaka, Nicola Long, Jessica S Mulkey, Jesse L Coy, Anupriya Agarwal, Evan F Lind
Dendritic cells (DC) are mediators between innate and adaptive immune responses to pathogens and tumors. DC development is determined by signaling through the receptor tyrosine kinase Fms-like tyrosine kinase 3 (FLT3) in bone marrow myeloid progenitors. Recently the naming conventions for DC phenotypes have been updated to distinguish between "Conventional" DCs (cDCs) and plasmacytoid DCs (pDCs). Activating mutations of FLT3, including Internal Tandem Duplication (FLT3-ITD), are associated with poor prognosis for acute myeloid leukemia (AML) patients...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495875/editorial-cardiometabolic-diseases-and-inflammatory-responses
#20
EDITORIAL
Nadine Suffee, Wilfried Le Goff, Jianmin Chen
No abstract text is available yet for this article.
2024: Frontiers in Immunology
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