journal
https://read.qxmd.com/read/38605972/advancing-diabetes-treatment-the-role-of-mesenchymal-stem-cells-in-islet-transplantation
#1
REVIEW
Lisha Mou, Tony Bowei Wang, Xinyu Wang, Zuhui Pu
Diabetes mellitus, a prevalent global health challenge, significantly impacts societal and economic well-being. Islet transplantation is increasingly recognized as a viable treatment for type 1 diabetes that aims to restore endogenous insulin production and mitigate complications associated with exogenous insulin dependence. We review the role of mesenchymal stem cells (MSCs) in enhancing the efficacy of islet transplantation. MSCs, characterized by their immunomodulatory properties and differentiation potential, are increasingly seen as valuable in enhancing islet graft survival, reducing immune-mediated rejection, and supporting angiogenesis and tissue repair...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605971/editorial-challenges-associated-with-identifying-preclinical-animal-models-for-the-development-of-immune-based-therapies
#2
EDITORIAL
Kainat Jamil, Shardulendra P Sherchand, Rajan P Adhikari, An Coosemans
No abstract text is available yet for this article.
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605970/deciphering-the-developmental-trajectory-of-tissue-resident-foxp3-regulatory-t-cells
#3
REVIEW
Fernando Alvarez, Zhiyang Liu, Alexandre Bay, Ciriaco A Piccirillo
Foxp3+ TREG cells have been at the focus of intense investigation for their recognized roles in preventing autoimmunity, facilitating tissue recuperation following injury, and orchestrating a tolerance to innocuous non-self-antigens. To perform these critical tasks, TREG cells undergo deep epigenetic, transcriptional, and post-transcriptional changes that allow them to adapt to conditions found in tissues both at steady-state and during inflammation. The path leading TREG cells to express these tissue-specialized phenotypes begins during thymic development, and is further driven by epigenetic and transcriptional modifications following TCR engagement and polarizing signals in the periphery...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605969/the-gastrointestinal-microbiota-in-the-development-of-me-cfs-a-critical-view-and-potential-perspectives
#4
REVIEW
Andreas Stallmach, Stefanie Quickert, Christian Puta, Philipp A Reuken
Like other infections, a SARS-CoV-2 infection can also trigger Post-Acute Infection Syndromes (PAIS), which often progress into myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ME/CFS, characterized by post-exercise malaise (PEM), is a severe multisystemic disease for which specific diagnostic markers or therapeutic concepts have not been established. Despite numerous indications of post-infectious neurological, immunological, endocrinal, and metabolic deviations, the exact causes and pathophysiology remain unclear...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605968/salicin-alleviates-periodontitis-via-tas2r143-gustducin-signaling-in-fibroblasts
#5
JOURNAL ARTICLE
Zhiying Zhang, Zhiyan Zhou, Jiaxin Liu, Liwei Zheng, Xian Peng, Lei Zhao, Xin Zheng, Xin Xu
INTRODUCTION: Cells expressing taste signaling elements in non-gustatory tissues have been described as solitary chemosensory cells (SCCs) or tuft cells. These "taste-like" cells play a critical role in the maintenance of tissue homeostasis. Although the expression of SCC markers and taste signaling constituents has been identified in mouse gingivae, their role in periodontal homeostasis is still unclear. METHODS: Public RNA sequencing datasets were re-analyzed and further validated with RT-PCR/qRT-PCR and immunofluorescent staining to explore the expression of TAS2Rs and downstream signaling constituents in mouse gingival fibroblasts (MGFs)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605967/bioinformatic-validation-and-machine-learning-based-exploration-of-purine-metabolism-related-gene-signatures-in-the-context-of-immunotherapeutic-strategies-for-nonspecific-orbital-inflammation
#6
JOURNAL ARTICLE
Zixuan Wu, Chi Fang, Yi Hu, Xin Peng, Zheyuan Zhang, Xiaolei Yao, Qinghua Peng
BACKGROUND: Nonspecific orbital inflammation (NSOI) represents a perplexing and persistent proliferative inflammatory disorder of idiopathic nature, characterized by a heterogeneous lymphoid infiltration within the orbital region. This condition, marked by the aberrant metabolic activities of its cellular constituents, starkly contrasts with the metabolic equilibrium found in healthy cells. Among the myriad pathways integral to cellular metabolism, purine metabolism emerges as a critical player, providing the building blocks for nucleic acid synthesis, such as DNA and RNA...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605966/the-expression-of-ctla-4-in-hepatic-alveolar-echinococcosis-patients-and-blocking-ctla-4-to-reverse-t-cell-exhaustion-in-echinococcus-multilocularis-infected-mice
#7
JOURNAL ARTICLE
Yuxuan Yang, Tana Wuren, Binjie Wu, Shilei Cheng, Haining Fan
Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by the infection of Echinococcus multilocularis ( E. multilocularis ) larvae. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) produces inhibitory signals and induces T cell exhaustion, thereby inhibiting the parasiticidal efficacy of the liver immune system. Therefore, the purpose of this study is to explore how T-cell exhaustion contributes to AE and whether blocking CTLA-4 could reverse T cell exhaustion. Here we discovered that the expression of CTLA-4 was increased in the infiltrating margin around the lesion of the liver from AE patients by using western blot and immunohistochemistry assay...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605965/modular-design-of-bi-and-multi-specific-knob-domain-fusions
#8
JOURNAL ARTICLE
Mikhail Kuravsky, Glyn F Gibbons, Callum Joyce, Anthony Scott-Tucker, Alex Macpherson, Alastair D G Lawson
INTRODUCTION: The therapeutic potential of bispecific antibodies is becoming widely recognised, with over a hundred formats already described. For many applications, enhanced tissue penetration is sought, so bispecifics with low molecular weight may offer a route to enhanced potency. Here we report the design of bi- and tri-specific antibody-based constructs with molecular weights as low as 14.5 and 22 kDa respectively. METHODS: Autonomous bovine ultra-long CDR H3 (knob domain peptide) modules have been engineered with artificial coiled-coil stalks derived from Sin Nombre orthohantavirus nucleocapsid protein and human Beclin-1, and joined in series to produce bi- and tri-specific antibody-based constructs with exceptionally low molecular weights...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605964/the-predictive-value-of-pd-l1-expression-in-response-to-anti-pd-1-pd-l1-therapy-for-biliary-tract-cancer-a-systematic-review-and-meta-analysis
#9
Seung Bae Yoon, Sang Myung Woo, Jung Won Chun, Dong Uk Kim, Jaihwan Kim, Joo Kyung Park, Hoonsub So, Moon Jae Chung, In Rae Cho, Jun Heo
BACKGROUND: Recently, anti-programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immunotherapy offers promising results for advanced biliary tract cancer (BTC). However, patients show highly heterogeneous responses to treatment, and predictive biomarkers are lacking. We performed a systematic review and meta-analysis to assess the potential of PD-L1 expression as a biomarker for treatment response and survival in patients with BTC undergoing anti-PD-1/PD-L1 therapy...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605963/probiotic-lactic-acid-bacteria-promote-anti-tumor-immunity-through-enhanced-major-histocompatibility-complex-class-i-restricted-antigen-presentation-machinery-in-dendritic-cells
#10
JOURNAL ARTICLE
Suguru Saito, Alato Okuno, Zhenzi Peng, Duo-Yao Cao, Noriko M Tsuji
Lactic acid bacteria (LAB) possess the ability to argument T cell activity through functional modification of antigen presenting cells (APCs), such as dendritic cells (DCs) and macrophages. Nevertheless, the precise mechanism underlying LAB-induced enhancement of antigen presentation in APCs remains incompletely understood. To address this question, we investigated the detailed mechanism underlying the enhancement of major histocompatibility complex (MHC) class I-restricted antigen presentation in DCs using a probiotic strain known as Lactococcus lactis subsp...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605962/new-insight-into-arginine-and-tryptophan-metabolism-in-macrophage-activation-during-tuberculosis
#11
REVIEW
Kangling Zhang, Abhishek Mishra, Chinnaswamy Jagannath
Arginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of arginine into citrulline and nitric oxide (NO), while Interleukin-4 (IL4) promotes arginase activation, shifting arginine metabolism toward ornithine. Concomitantly, IFN-γ triggers indoleamine 2,3-dioxygenase 1 (IDO1) and Interleukin-4 induced 1 (IL4i1), resulting in the conversion of tryptophan into kynurenine and indole-3-pyruvic acid...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605961/co-formulation-of-the-rf1v-plague-vaccine-with-depot-formulated-cytokines-enhances-immunogenicity-and-efficacy-to-elicit-protective-responses-against-aerosol-challenge-in-mice
#12
JOURNAL ARTICLE
Darrell R Galloway, Jiahui Li, Nguyen X Nguyen, Frank W Falkenberg, Lisa Henning, Robert Krile, Ying-Liang Chou, James N Herron, J Scott Hale, E Diane Williamson
This study evaluated a depot-formulated cytokine-based adjuvant to improve the efficacy of the recombinant F1V (rF1V) plague vaccine and examined the protective response following aerosol challenge in a murine model. The results of this study showed that co-formulation of the Alhydrogel-adsorbed rF1V plague fusion vaccine with the depot-formulated cytokines recombinant human interleukin 2 (rhuIL-2) and/or recombinant murine granulocyte macrophage colony-stimulating factor (rmGM-CSF) significantly enhances immunogenicity and significant protection at lower antigen doses against a lethal aerosol challenge...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605960/crosstalk-between-hypoxia-inducible-factor-1%C3%AE-and-short-chain-fatty-acids-in-inflammatory-bowel-disease-key-clues-toward-unraveling-the-mystery
#13
REVIEW
Jinyin Xiao, Xiajun Guo, Zhenquan Wang
The human intestinal tract constitutes a complex ecosystem, made up of countless gut microbiota, metabolites, and immune cells, with hypoxia being a fundamental environmental characteristic of this ecology. Under normal physiological conditions, a delicate balance exists among these complex "residents", with disruptions potentially leading to inflammatory bowel disease (IBD). The core pathology of IBD features a disrupted intestinal epithelial barrier, alongside evident immune and microecological disturbances...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605959/new-findings-on-cd16-bright-cd62l-dim-neutrophil-subtypes-in-sepsis-associated-ards-an-observational-clinical-study
#14
JOURNAL ARTICLE
Jing Zhang, Chencheng Gao, Zhenxing Zhu, Danyang Li, Lai Qu, Qiuli Xue, Guoqiang Wang, Tong Ji, Fang Wang
BACKGROUND: The CD16bright CD62Ldim neutrophil subtype is a recently identified neutrophil subtype. The aim of this study was to evaluate changes of peripheral blood CD16bright CD62Ldim neutrophils in patients with sepsis-associated ARDS. METHODS: We prospectively recruited adult patients with sepsis-associated ARDS in the intensive care unit (ICU). Patient demographic data, medical history information, and laboratory data were collected within 48 hours of enrollment, and flow cytometry was applied to analyze the CD16bright CD62Ldim neutrophil subtype in the patients' peripheral blood...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605958/efficacy-and-safety-of-bvac-c-in-hpv-type-16-or-18-positive-cervical-carcinoma-who-failed-1st-platinum-based-chemotherapy-a-phase-i-iia-study
#15
JOURNAL ARTICLE
Chel Hun Choi, Jeong-Won Lee, Duk-Soo Bae, Eun-Suk Kang, Duck Cho, Yong-Man Kim, Kidong Kim, Jae-Weon Kim, Hee Seung Kim, Young-Tae Kim, Jung-Yun Lee, Myong Cheol Lim, Taegwon Oh, Boyeong Song, Insu Jeon, Myunghwan Park, Wu Hyun Kim, Chang-Yuil Kang, Byoung-Gie Kim
BACKGROUND: BVAC-C, a B cell- and monocyte-based immunotherapeutic vaccine transfected with recombinant HPV E6/E7, was well tolerated in HPV-positive recurrent cervical carcinoma patients in a phase I study. This phase IIa study investigates the antitumor activity of BVAC-C in patients with HPV 16- or 18-positive cervical cancer who had experienced recurrence after a platinum-based combination chemotherapy. PATIENTS AND METHODS: Patients were allocated to 3 arms; Arm 1, BVAC-C injection at 0, 4, 8 weeks; Arm 2, BVAC-C injection at 0, 4, 8, 12 weeks; Arm 3, BVAC-C injection at 0, 4, 8, 12 weeks with topotecan at 2, 6, 10, 14 weeks...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605957/the-potential-of-short-chain-fatty-acid-epigenetic-regulation-in-chronic-low-grade-inflammation-and-obesity
#16
REVIEW
Julia Kopczyńska, Magdalena Kowalczyk
Obesity and chronic low-grade inflammation, often occurring together, significantly contribute to severe metabolic and inflammatory conditions like type 2 diabetes (T2D), cardiovascular disease (CVD), and cancer. A key player is elevated levels of gut dysbiosis-associated lipopolysaccharide (LPS), which disrupts metabolic and immune signaling leading to metabolic endotoxemia, while short-chain fatty acids (SCFAs) beneficially regulate these processes during homeostasis. SCFAs not only safeguard the gut barrier but also exert metabolic and immunomodulatory effects via G protein-coupled receptor binding and epigenetic regulation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605956/high-frequencies-of-alpha-common-cold-coronavirus-sars-cov-2-cross-reactive-functional-cd4-and-cd8-memory-t-cells-are-associated-with-protection-from-symptomatic-and-fatal-sars-cov-2-infections-in-unvaccinated-covid-19-patients
#17
JOURNAL ARTICLE
Pierre-Gregoire Coulon, Swayam Prakash, Nisha R Dhanushkodi, Ruchi Srivastava, Latifa Zayou, Delia F Tifrea, Robert A Edwards, Cesar J Figueroa, Sebastian D Schubl, Lanny Hsieh, Anthony B Nesburn, Baruch D Kuppermann, Elmostafa Bahraoui, Hawa Vahed, Daniel Gil, Trevor M Jones, Jeffrey B Ulmer, Lbachir BenMohamed
BACKGROUND: Cross-reactive SARS-CoV-2-specific memory CD4+ and CD8+ T cells are present in up to 50% of unexposed, pre-pandemic, healthy individuals (UPPHIs). However, the characteristics of cross-reactive memory CD4+ and CD8+ T cells associated with subsequent protection of asymptomatic coronavirus disease 2019 (COVID-19) patients (i.e., unvaccinated individuals who never develop any COVID-19 symptoms despite being infected with SARS-CoV-2) remains to be fully elucidated. METHODS: This study compares the antigen specificity, frequency, phenotype, and function of cross-reactive memory CD4+ and CD8+ T cells between common cold coronaviruses (CCCs) and SARS-CoV-2...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605955/optimizing-cryopreservation-conditions-for-use-of-fucosylated-human-mesenchymal-stromal-cells-in-anti-inflammatory-immunomodulatory-therapeutics
#18
JOURNAL ARTICLE
Jesús I Gil-Chinchilla, Carlos Bueno, Carlos M Martínez, Ana Ferrández-Múrtula, Ana M García-Hernández, Miguel Blanquer, Mar Molina-Molina, Agustín G Zapata, Robert Sackstein, Jose M Moraleda, David García-Bernal
Mesenchymal stem/stromal cells (MSCs) are being increasingly used in cell-based therapies due to their broad anti-inflammatory and immunomodulatory properties. Intravascularly-administered MSCs do not efficiently migrate to sites of inflammation/immunopathology, but this shortfall has been overcome by cell surface enzymatic fucosylation to engender expression of the potent E-selectin ligand HCELL. In applications of cell-based therapies, cryopreservation enables stability in both storage and transport of the produced cells from the manufacturing facility to the point of care...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605954/the-intricate-dance-of-non-coding-rnas-in-myasthenia-gravis-pathogenesis-and-treatment
#19
REVIEW
Benqiao Wang, Ying Zhu, Dan Liu, Chunxiang Hu, Ruixia Zhu
Myasthenia gravis (MG) stands as a perplexing autoimmune disorder affecting the neuromuscular junction, driven by a multitude of antibodies targeting postsynaptic elements. However, the mystery of MG pathogenesis has yet to be completely uncovered, and its heterogeneity also challenges diagnosis and treatment. Growing evidence shows the differential expression of non-coding RNAs (ncRNAs) in MG has played an essential role in the development of MG in recent years. Remarkably, these aberrantly expressed ncRNAs exhibit distinct profiles within diverse clinical subgroups and among patients harboring various antibody types...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38605953/development-of-a-customizable-mouse-backbone-spectral-flow-cytometry-panel-to-delineate-immune-cell-populations-in-normal-and-tumor-tissues
#20
JOURNAL ARTICLE
Ana Leda F Longhini, Inés Fernández-Maestre, Margaret C Kennedy, Matthew G Wereski, Shoron Mowla, Wenbin Xiao, Scott W Lowe, Ross L Levine, Rui Gardner
INTRODUCTION: In vivo studies of cancer biology and assessment of therapeutic efficacy are critical to advancing cancer research and ultimately improving patient outcomes. Murine cancer models have proven to be an invaluable tool in pre-clinical studies. In this context, multi-parameter flow cytometry is a powerful method for elucidating the profile of immune cells within the tumor microenvironment and/or play a role in hematological diseases. However, designing an appropriate multi-parameter panel to comprehensively profile the increasing diversity of immune cells across different murine tissues can be extremely challenging...
2024: Frontiers in Immunology
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