Laura Schreiber, Sakhila Ghimire, Andreas Hiergeist, Kathrin Renner, Michael Althammer, Nathalie Babl, Alice Peuker, Gabriele Schoenhammer, Katrin Hippe, Andre Gessner, Christin Albrecht, Fransziska Pielmeier, Maike Büttner-Herold, Heiko Bruns, Petra Hoffmann, Wolfgang Herr, Ernst Holler, Katrin Peter, Marina Kreutz, Carina Matos
Vitamin D3 regulates a variety of biological processes irrespective of its well-known importance for calcium metabolism. Epidemiological and animal studies indicate a role in immune regulation, intestinal barrier function and microbiome diversity. Here, we analyzed the impact of different vitamin D3- containing diets on C57BL/6 and BALB/c mice, with a particular focus on gut homeostasis and also investigated effects on immune cells in vitro . Weak regulatory effects were detected on murine T cells. By trend, the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 suppressed IFN, GM-CSF and IL-10 cytokine secretion in T cells of C57BL/6 but not BALB/c mice, respectively...
2024: Frontiers in Immunology