journal
https://read.qxmd.com/read/37753095/pivotal-role-of-tissue-resident-memory-lymphocytes-in-the-control-of-mucosal-infections-can-mucosal-vaccination-induce-protective-tissue-resident-memory-t-and-b-cells
#1
JOURNAL ARTICLE
https://read.qxmd.com/read/37753094/a-clash-on-the-toll-pathway-competitive-action-between-pesticides-and-zymosan-a-on-components-of-innate-immunity-in-apis-mellifera
#2
JOURNAL ARTICLE
Dani Sukkar, Ali Kanso, Philippe Laval-Gilly, Jairo Falla-Angel
BACKGROUND: The immune system of honeybees includes multiple pathways that may be affected by pesticide exposure decreasing the immune competencies of bees and increasing their susceptibility to diseases like the fungal Nosema spp. infection, which is detected in collapsed colonies. METHODS: To better understand the effect of the co-presence of multiple pesticides that interact with bees like imidacloprid and amitraz, we evaluated the expression of immune-related genes in honeybee hemocytes...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753093/the-immune-checkpoint-adenosine-2a-receptor-is-associated-with-aggressive-clinical-outcomes-and-reflects-an-immunosuppressive-tumor-microenvironment-in-human-breast-cancer
#3
JOURNAL ARTICLE
Basma Zohair, Dounia Chraa, Ibtissam Rezouki, Hamza Benthami, Ibtissam Razzouki, Mohamed Elkarroumi, Daniel Olive, Mehdi Karkouri, Abdallah Badou
BACKGROUND: The crosstalk between the immune system and cancer cells has aroused considerable interest over the past decades. To escape immune surveillance cancer cells evolve various strategies orchestrating tumor microenvironment. The discovery of the inhibitory immune checkpoints was a major breakthrough due to their crucial contribution to immune evasion. The A2AR receptor represents one of the most essential pathways within the TME. It is involved in several processes such as hypoxia, tumor progression, and chemoresistance...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753092/reprogramming-of-treg-cells-in-the-inflammatory-microenvironment-during-immunotherapy-a-literature-review
#4
REVIEW
Xinyan Wu, Zhigang Zhou, Qiang Cao, Yuquan Chen, Junling Gong, Qi Zhang, Yi Qiang, Yanfeng Lu, Guangzhu Cao
Regulatory T cells (Treg), as members of CD4+ T cells, have garnered extensive attention in the research of tumor progression. Treg cells have the function of inhibiting the immune effector cells, preventing tissue damage, and suppressing inflammation. Under the stimulation of the tumor inflammatory microenvironment (IM), the reprogramming of Treg cells enhances their suppression of immune responses, ultimately promoting tumor immune escape or tumor progression. Reducing the number of Treg cells in the IM or lowering the activity of Treg cells while preventing their reprogramming, can help promote the body's anti-tumor immune responses...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753091/c-reactive-protein-deficiency-ameliorates-experimental-abdominal-aortic-aneurysms
#5
JOURNAL ARTICLE
Yu Fu, Haole Liu, Kexin Li, Panpan Wei, Naqash Alam, Jie Deng, Meng Li, Haibin Wu, Xue He, Haiwen Hou, Congcong Xia, Rong Wang, Weirong Wang, Liang Bai, Baohui Xu, Yankui Li, Yi Wu, Enqi Liu, Sihai Zhao
BACKGROUND: C-reactive protein (CRP) levels are elevated in patients with abdominal aortic aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA pathogenesis. METHODS: CRP deficient and wild type (WT) male mice were subjected to AAA induction via transient intra-aortic infusion of porcine pancreatic elastase. AAAs were monitored by in situ measurements of maximal infrarenal aortic external diameters immediately prior to and 14 days following elastase infusion...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753090/structural-biology-of-complement-receptors
#6
REVIEW
Jorge Santos-López, Karla de la Paz, Francisco J Fernández, M Cristina Vega
The complement system plays crucial roles in a wide breadth of immune and inflammatory processes and is frequently cited as an etiological or aggravating factor in many human diseases, from asthma to cancer. Complement receptors encompass at least eight proteins from four structural classes, orchestrating complement-mediated humoral and cellular effector responses and coordinating the complex cross-talk between innate and adaptive immunity. The progressive increase in understanding of the structural features of the main complement factors, activated proteolytic fragments, and their assemblies have spurred a renewed interest in deciphering their receptor complexes...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753089/the-prognostic-biological-markers-of-immunotherapy-for-non-small-cell-lung-cancer-current-landscape-and-future-perspective
#7
REVIEW
Shuai Liang, Hanyu Wang, Haixia Tian, Zhicheng Xu, Min Wu, Dong Hua, Chengming Li
The emergence of immunotherapy, particularly programmed cell death 1 (PD-1) and programmed cell death ligand-1 (PD-L1) produced profound transformations for treating non-small cell lung cancer (NSCLC). Nevertheless, not all NSCLC patients can benefit from immunotherapy in clinical practice. In addition to limited response rates, exorbitant treatment costs, and the substantial threats involved with immune-related adverse events, the intricate interplay between long-term survival outcomes and early disease progression, including early immune hyperprogression, remains unclear...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753088/cchfv-vaccine-development-current-challenges-limitations-and-future-directions
#8
REVIEW
Büşra Ahata, Günseli Bayram Akçapınar
Crimean-Congo hemorrhagic fever (CCHF) is the most prevalent tick-borne viral disease affecting humans. The disease is life-threatening in many regions of the developing world, including Africa, Asia, the Middle East, and Southern Europe. In line with the rapidly increasing disease prevalence, various vaccine strategies are under development. Despite a large number of potential vaccine candidates, there are no approved vaccines as of yet. This paper presents a detailed comparative analysis of current efforts to develop vaccines against CCHFV, limitations associated with current efforts, and future research directions...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753087/heterologous-dna-prime-protein-boost-immunization-with-a-monomeric-sars-cov-2-spike-antigen-redundantizes-the-trimeric-receptor-binding-domain-structure-to-induce-neutralizing-antibodies-in-old-mice
#9
JOURNAL ARTICLE
Dominik Pflumm, Alina Seidel, Fabrice Klein, Rüdiger Groß, Lea Krutzke, Stefan Kochanek, Joris Kroschel, Jan Münch, Katja Stifter, Reinhold Schirmbeck
A multitude of alterations in the old immune system impair its functional integrity. Closely related, older individuals show, for example, a reduced responsiveness to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines. However, systematic strategies to specifically improve the efficacy of vaccines in the old are missing or limited to simple approaches like increasing the antigen concentration or injection frequencies. We here asked whether the intrinsic, trimeric structure of the SARS-CoV-2 spike (S) antigen and/or a DNA- or protein-based antigen delivery platform affects priming of functional antibody responses particularly in old mice...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753086/dried-urine-spot-method-for-detection-of-schistosoma-mansoni-circulating-cathodic-antigen-in-resource-limited-settings-a-proof-of-concept-study
#10
JOURNAL ARTICLE
Abdallah Zacharia, Twilumba Makene, Clemence Kinabo, George Ogweno, Faraja Lyamuya, Billy Ngasala
BACKGROUND: Among the challenges in schistosomiasis surveillance and mapping surveys is the lack of a sensitive diagnostic method especially in low transmission setting. Currently, the WHO recommends the use point-of-care circulating cathodic antigen (Schisto POC-CCA) tests for surveillance and mapping of intestinal schistosomiasis. However, Schisto POC-CCA test has its drawbacks, one of which is the timely availability of test kits. One approach to overcoming this challenge is to develop a low-cost sampling method that allows for the collection and transport of urine specimens even in resource-limited settings...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753085/novel-cerna-network-construction-associated-with-programmed-cell-death-in-acute-rejection-of-heart-allograft-in-mice
#11
JOURNAL ARTICLE
Yiwen Guo, Yixi Zhang, Jia Yu, Yuqi Dong, Zhitao Chen, Chuchen Zhu, Xitao Hong, Zhonghao Xie, Min Zhang, Shuai Wang, Yichen Liang, Xiaoshun He, Weiqiang Ju, Maogen Chen
BACKGROUND: T cell-mediated acute rejection(AR) after heart transplantation(HT) ultimately results in graft failure and is a common indication for secondary transplantation. It's a serious threat to heart transplant recipients. This study aimed to explore the novel lncRNA-miRNA-mRNA networks that contributed to AR in a mouse heart transplantation model. METHODS: The donor heart from Babl/C mice was transplanted to C57BL/6 mice with heterotopic implantation to the abdominal cavity...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753084/reovirus-infection-of-tumor-cells-reduces-the-expression-of-nkg2d-ligands-leading-to-impaired-nk-cell-cytotoxicity-and-functionality
#12
JOURNAL ARTICLE
Raghad Khaleafi, Jelena Zeleznjak, Sapir Cordela, Shani Drucker, Tihana Lenac Rovis, Stipan Jonjic, Yotam Bar-On
In recent years, reoviruses have been of major interest in immunotherapy because of their oncolytic properties. Preclinical and clinical trials, in which reovirus was used for the treatment of melanoma and glioblastoma, have paved the way for future clinical use of reovirus. However, little is known about how reovirus infection affects the tumor microenvironment and immune response towards infected tumor cells. Studies have shown that reovirus can directly stimulate natural killer (NK) cells, but how reovirus affects cellular ligands on tumor cells, which are ultimately key to tumor recognition and elimination by NK cells, has not been investigated...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753083/targeting-intracellular-galectins-for-cancer-treatment
#13
REVIEW
Rita Nehmé, Yves St-Pierre
Although considerable attention has been paid to the role of extracellular galectins in modulating, positively or negatively, tumor growth and metastasis, we have witnessed a growing interest in the role of intracellular galectins in response to their environment. This is not surprising as many galectins preferentially exist in cytosolic and nuclear compartments, which is consistent with the fact that they are exported outside the cells via a yet undefined non-classical mechanism. This review summarizes our most recent knowledge of their intracellular functions in cancer cells and provides some directions for future strategies to inhibit their role in cancer progression...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753082/glucose-6-phosphate-dehydrogenase-deficiency-and-long-term-risk-of-immune-related-disorders
#14
JOURNAL ARTICLE
Ariel Israel, Alejandro A Schäffer, Matitiahu Berkovitch, David J Ozeri, Eugene Merzon, Ilan Green, Avivit Golan-Cohen, Eytan Ruppin, Shlomo Vinker, Eli Magen
INTRODUCTION: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic disorder that is particularly prevalent in Africa, Asia, and the Middle East. This study aimed to assess the long-term health risks associated with G6PD deficiency. METHODS: A retrospective cohort study was conducted using data from a national healthcare provider in Israel (Leumit Health Services). A total of 7,473 G6PD-deficient individuals were matched with 29,892 control subjects in a 1:4 ratio, based on age, gender, socioeconomic status, and ethnic groups...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753081/unleashing-the-power-of-shark-variable-single-domains-vnars-broadly-neutralizing-tools-for-combating-sars-cov-2
#15
REVIEW
Olivia Cabanillas-Bernal, Blanca J Valdovinos-Navarro, Karla E Cervantes-Luevano, Noemi Sanchez-Campos, Alexei F Licea-Navarro
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a joint global effort to develop vaccines and other treatments that could mitigate the negative effects and the rapid spread of the virus. Single-domain antibodies derived from various sources, including cartilaginous fish, camelids, and humans, have gained attention as promising therapeutic tools against coronavirus disease 2019. Shark-derived variable new antigen receptors (VNARs) have emerged as the smallest naturally occurring antigen-binding molecules...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753080/serum-pro-inflammatory-biomarkers-associated-with-improvement-in-quality-of-life-in-pulmonary-tuberculosis
#16
JOURNAL ARTICLE
Laura E Carreto-Binaghi, Luis Gustavo Sartillo-Mendoza, Marcela Muñoz-Torrico, Silvia Guzmán-Beltrán, Claudia Carranza, Martha Torres, Yolanda González, Esmeralda Juárez
INTRODUCTION: Pulmonary dysfunction is an underestimated complication in tuberculosis (TB) infection, affecting quality of life (QoL). Although respiratory function tests objectively reflect lung disturbances in a specific moment, predictors of illness severity at the time of diagnosis are still lacking. METHODS: We measured serum pro-inflammatory cytokines (TNF-α and IL-8), eicosanoids (PGE2, LTB4, RvD1, Mar1, and LXA4), a marker of tissue damage (cell-free nucleosomes), and indicators of redox status (malonaldehyde, 8-isoprostane, total oxidants, and antioxidants), as well as a score of radiological abnormalities (SRA) and a QoL questionnaire, in 25 patients with pulmonary TB at the time of diagnosis (t0) and two months after the initiation of treatment (t2)...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753079/pemphigus-vulgaris-as-an-immune-related-adverse-event-in-recurrent-metastatic-esophageal-squamous-cell-carcinoma-treated-with-ipilimumab-plus-nivolumab-a-case-report-and-literature-review
#17
Hajime Nakamura, Aika Shionoya, Yohei Arihara, Naotaka Hayasaka, Tomohiro Kubo, Makoto Usami, Shintaro Sugita, Hisashi Uhara, Kohichi Takada
Ipilimumab plus nivolumab therapy is approved for patients with unresectable advanced esophageal squamous cell carcinoma (ESCC). Although a combination of immune checkpoint inhibitors (ICIs), compared to conventional chemotherapy, can improve overall survival in patients with advanced ESCC, this increases the incidence of immune-related adverse events (irAEs). Here, we describe an ESCC case that developed pemphigus vulgaris (PV), an extremely rare cutaneous irAE, during ipilimumab plus nivolumab treatment. The patient achieved a partial response to treatment...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753078/revealing-the-biological-mechanism-of-acupuncture-in-alleviating-excessive-inflammatory-responses-and-organ-damage-in-sepsis-a-systematic-review
#18
REVIEW
Lin Yang, Dan Zhou, Jiaojiao Cao, Fangyuan Shi, Jiaming Zeng, Siqi Zhang, Guorui Yan, Zhihan Chen, Bo Chen, Yi Guo, Xiaowei Lin
Sepsis is a systemic inflammation caused by a maladjusted host response to infection. In severe cases, it can cause multiple organ dysfunction syndrome (MODS) and even endanger life. Acupuncture is widely accepted and applied in the treatment of sepsis, and breakthroughs have been made regarding its mechanism of action in recent years. In this review, we systematically discuss the current clinical applications of acupuncture in the treatment of sepsis and focus on the mechanisms of acupuncture in animal models of systemic inflammation...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753077/mild-to-moderate-post-covid-19-alters-markers-of-lymphocyte-activation-exhaustion-and-immunometabolic-responses-that-can-be-partially-associated-by-physical-activity-level-an-observational-sub-analysis-fit-covid-study
#19
JOURNAL ARTICLE
Bruna Spolador de Alencar Silva, Telmo Pereira, Luciele Guerra Minuzzi, Camila Souza Padilha, Caique Figueiredo, Tiago Olean-Oliveira, Ivete Vera Medeiros Dos Santos, Ana Elisa von Ah Morano, Osmar Marchioto Júnior, José Procópio Jabur Ribeiro, Vanessa Ribeiro Dos Santos, Marília Seelaender, Alexandre Abílio Teixeira, Ronaldo Vagner T Dos Santos, Valdir de Aquino Lemos, Ana Paula Coelho Figueira Freire, Gilson Pires Dorneles, Bruna Marmett, André Olean-Oliveira, Marcos F S Teixeira, Patrícia M Seraphim, Armando Caseiro, Ricardo Aurino Pinho, Hashim Islam, Jonathan Peter Little, Karsten Krüger, José César Rosa-Neto, Manuel-João Coelho-E-Silva, Fábio Santos Lira
AIM: This study aimed to evaluate if physical activity is associated with systemic and cellular immunometabolic responses, in young adults after mild-to-moderate COVID-19 infection. METHODS: Mild- to- moderate post-COVID-19 patients (70.50 ± 43.10 days of diagnosis; age: 29.4 (21.9- 34.9) years; BMI: 25.5 ± 4.3 kg m2 n = 20) and healthy age-matched controls (age: 29.3 (21.2 - 32.6) years; BMI: 25.4 ± 4.7 kg m2 ; n = 20) were evaluated. Physical activity levels (PAL), body composition, dietary habits, muscular and pulmonary function, mental health, sleep quality, metabolic parameters, immune phenotypic characterization, stimulated whole blood and PBMC culture (cytokine production), mRNA, and mitochondrial respiration in PBMCs were evaluated...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37753076/pd-1-blockade-and-radiotherapy-combination-for-advanced-epstein-barr-virus-associated-intrahepatic-cholangiocarcinoma-a-case-report-and-literature-review
#20
Chun-Xu Liao, Chang-Song Deng, Xia Liang, Jian-Chuan Yang, Zhi-Zhong Chen, Xiao-Ying Lin, Cai-Feng Lin, Shen Chen, Song-Song Wu
Advanced intrahepatic cholangiocarcinoma (ICC) is a rare malignant tumor of biliary epithelial cells, known for its extremely unfavorable prognosis. In the absence of intervention, patients typically survive for less than 5 months. Current guidelines from the Chinese Society of Clinical Oncology (CSCO), National Comprehensive Cancer Network (NCCN), and European Society for Medical Oncology (ESMO) recommend chemotherapy-based systemic therapy as the standard treatment for advanced ICC. However, the first-line regimen, consisting of gemcitabine in combination with cisplatin, generally results in a median survival of approximately one year, which is considered suboptimal...
2023: Frontiers in Immunology
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