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Journal of Gastric Cancer

Yasuhiro Okumura, Manabu Takamatsu, Manabu Ohashi, Yorimasa Yamamoto, Noriko Yamamoto, Hiroshi Kawachi, Satoshi Ida, Koshi Kumagai, Souya Nunobe, Naoki Hiki, Takeshi Sano
A 55-year-old man visited our hospital for a detailed examination of a gastric submucosal tumor that was first detected 10 years prior. The tumor continued to grow and had developed a depressed area in its center. A histopathological examination of biopsy specimens revealed gastric adenocarcinoma of the fundic gland type (GA-FG). It was diagnosed as T2 based on the invasion depth as determined by white-light endoscopy and endoscopic ultrasonography. A total gastrectomy with lymphadenectomy was performed and a GA-FG in the mucosa and submucosa was confirmed histopathologically...
December 2018: Journal of Gastric Cancer
Hyun Lim, Jeong Hoon Lee, Young Soo Park, Hee Kyong Na, Ji Yong Ahn, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
Purpose: This study aimed to evaluate immediate outcomes and clinical courses of patients with early gastric carcinoma with lymphoid stroma (GCLS) who underwent endoscopic resection. Materials and Methods: We retrospectively reviewed the medical records of 40 patients (mean age, 56.9 years; 90.0% male) who underwent endoscopic resection and were pathologically diagnosed with GCLS confined to the mucosa or to the submucosa between March 1998 and December 2017. Results: Forty GCLS lesions in 40 patients were treated using endoscopic resection...
December 2018: Journal of Gastric Cancer
Eun Jeong Jang, Min-Chan Kim, So-Hyun Nam
Purpose: To determine the incidence of incisional hernia (IH) in mini-laparotomy wounds and analyze the risk factors of IH following laparoscopic distal gastrectomy in patients with gastric cancer. Materials and Methods: A total of 565 patients who underwent laparoscopic distal gastrectomy for gastric cancer at Dong-A University Hospital, Busan, South Korea, between June 2010 and December 2015, were enrolled. IH was diagnosed through physical examination or computed tomography imaging...
December 2018: Journal of Gastric Cancer
Ines Gockel, Boris Jansen-Winkeln, Linda Haase, Philipp Rhode, Matthias Mehdorn, Stefan Niebisch, Yusef Moulla, Orestis Lyros, Florian Lordick, Katrin Schierle, Christian Wittekind, René Thieme
Purpose: Gastric cancer (GC) patients with peritoneal metastasis (PM) have poor prognosis. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) in combination with systemic chemotherapy is a novel treatment option for patients in stage IV of the disease. Materials and Methods: Between November 2015 and June 2018, prospective data collection was performed in 24 patients with GC and PM (median age, 57; range, 44-75 years). These patients underwent 46 PIPAC procedures with a median number of 2 interventions per patient (range, 1-6)...
December 2018: Journal of Gastric Cancer
Shubin Song, Xiliang Cong, Fengke Li, Yingwei Xue
Purpose: Fibrinogen and platelets have been reported to play important roles in tumorigenesis and cancer progression. The aim of this research was to investigate the combination of functions of fibrinogen, platelets, and mean platelet volume (MPV) in predicting the survival of patients with gastric cancer (GC). Materials and Methods: A retrospective study was conducted with 1,946 patients with GC and 299 patients with benign gastric tumor to analyze their fibrinogen, platelet, and MPV levels, and other clinicopathological characteristics along with their prognoses...
December 2018: Journal of Gastric Cancer
Shengxing Zhu, Jihua Shi, Shanfeng Zhang, Zhen Li
Purpose: Kallikrein (KLK) proteases are hormone-like signaling molecules with critical functions in different cancers. This study investigated the expression of KLK6 in gastric cancer and its potential role in the growth, migration, and invasion of gastric cancer cells. Materials and Methods: In this study, we compared protein levels of KLK6, vascular endothelial growth factor (VEGF), and matrix metallopeptidase (MMP) 9 in normal gastric epithelial and gastric cancer cell lines by western blot...
December 2018: Journal of Gastric Cancer
Youjin Kim, Kyoung-Mee Kim, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim, Su Jin Lee, Seung Tae Kim, Jeeyun Lee, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Se Hoon Park
Purpose: We aimed to discuss the roles of radiation and chemotherapy as adjuvant treatment in patients with staged IB GC who were enrolled in the adjuvant chemoradiotherapy in stomach tumors (ARTIST) trial. Materials and Methods: Among the 458 patients who were enrolled in the ARTIST trial, 99 had stage IB disease. The patients were randomly assigned to receive either adjuvant chemoradiotherapy with capecitabine plus cisplatin (XP, n=50) or chemoradiotherapy (XPRT, n=49)...
December 2018: Journal of Gastric Cancer
Yuya Sato, Hitoshi Katai, Maiko Ito, Masahiro Yura, Sho Otsuki, Yukinori Yamagata, Shinji Morita
Purpose: To evaluate the status of number 3b lymph node (LN) station in patients with adenocarcinoma of the esophagogastric junction (AEG) and to investigate the optimal indications for radical proximal gastrectomy (PG) for AEG. Materials and Methods: Data of 51 patients with clinically advanced Siewert types II and III AEG who underwent total gastrectomy (TG) between April 2010 and July 2017 were reviewed. The proportion of metastatic LNs at each LN station was examined...
December 2018: Journal of Gastric Cancer
Jin-Jo Kim
The incidence of gastroesophageal junction adenocarcinoma (GEJAC) in Western countries has increased in recent decades, in addition to a rise in the incidence of esophageal adenocarcinoma (EAC). Gastroesophageal reflux disease (GERD), obesity, smoking, alcohol consumption, and low Helicobacter pylori (HP) infection rate have been nominated as risk factors for such cancers. Among these risk factors, the increased prevalence of GERD and obesity and the decreased prevalence of HP infection are of special interest owing to the currently increasing prevalence of GEJAC in Western countries...
December 2018: Journal of Gastric Cancer
Ho Seok Seo, Miyoung Choi, Sang-Yong Son, Min Gyu Kim, Dong-Seok Han, Han Hong Lee
The prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea, and physicians, including surgeons, have been focusing on its treatment. Indeed, in Korea, medical treatment using a proton pump inhibitor is the mainstream treatment for GERD, while awareness of surgical treatment is limited. Accordingly, to promote the understanding of surgical treatment for GERD, the Korean Anti-Reflux Surgery Study Group published the Evidence-Based Practice Guideline for the Surgical Treatment of GERD. The guideline consists of 2 sections: fundamental information such as the definition, symptoms, and diagnostic tools of GERD and a recommendation statement about its surgical treatment...
December 2018: Journal of Gastric Cancer
Jihyun Kwon, Hye Sook Han, Hee Kyung Kim, Seung-Woo Baek, Yaewon Yang, Ki Hyeong Lee, Seung-Myoung Son, Won-Dong Kim, Dae Hoon Kim, Hyo Yung Yun
We report a rare case of long-term survival in a patient who received local therapy and salvage chemotherapy for recurrent metastases, along with a literature review. A 65-year-old male patient underwent subtotal gastrectomy for advanced gastric adenocarcinoma. Six months after gastrectomy, 2 metastatic intra-abdominal lymph node enlargements were detected, which were treated with radiotherapy. At 55 months after gastrectomy, an abdominal wall mass was detected, which was treated by surgical resection. The patient received 5-fluorouracil/leucovorin/irinotecan chemotherapy for 27 months before and after radiotherapy and docetaxel chemotherapy for 6 months after surgical resection of the abdominal wall metastasis...
September 2018: Journal of Gastric Cancer
Dong-Wook Kim, Dong-Guk Park, Sanghyun Song, Ye Seob Jee
Purpose: This study aimed to examine the outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis (PM) of advanced gastric cancer (AGC). Materials and Methods: Between May 2015 and June 2017, 38 CRS and HIPEC procedures were performed in patients with PM of AGC at the Dankook University Hospital. We prospectively collected and analyzed data regarding PM grade, morbidity and mortality rates, and short-term follow-up results (median, 13...
September 2018: Journal of Gastric Cancer
Hayemin Lee, Cho Hyun Park, Seung Man Park, Wook Kim, Hyung Min Chin, Jin Jo Kim, Kyo Young Song, Sung Geun Kim, Kyong Hwa Jun, Jeong Goo Kim, Han Hong Lee, Junhyun Lee, Dong Jin Kim
Purpose: The surgical outcomes of end-stage renal disease (ESRD) patients undergoing radical gastrectomy for gastric cancer were inferior compared with those of non-ESRD patients. This study aimed to evaluate the short- and long-term surgical outcomes of ESRD patients undergoing laparoscopic gastrectomy (LG) and open gastrectomy (OG) for gastric cancer. Materials and Methods: Between 2004 and 2014, 38 patients (OG: 21 patients, LG: 17 patients) with ESRD underwent gastrectomy for gastric cancer...
September 2018: Journal of Gastric Cancer
Chang Hyun Kim, Seung-Man Park, Jin-Jo Kim
Purpose: The aim of this study was to investigate the impact of preoperative low body mass index (BMI) on both the short- and long-term outcomes in patients with gastric cancer. Materials and Methods: A total of 510 patients with gastric cancer were divided into the following 3 groups: low BMI group (≤18.5 kg/m2 , n=51), normal BMI group (18.6-24.9 kg/m2 , n=308), and high BMI group (≥25.0 kg/m2 , n=151). Results: There were significantly more stage III/IV patients in the low BMI group than in the other groups (P=0...
September 2018: Journal of Gastric Cancer
Jae-Seok Min, Chang Min Lee, Sung Il Choi, Kyung Won Seo, Do Joong Park, Yong Hae Baik, Myoung-Won Son, Won Hyuk Choi, Sungsoo Kim, Kyung Ho Pak, Min Gyu Kim, Joong-Min Park, Sang Ho Jeong, Moon-Soo Lee, Sungsoo Park
Purpose: To investigate the current status of adjuvant chemotherapy (AC) regimens in Korea and the difference in efficacy of AC administered by surgical and medical oncologists in patients with stage II or III gastric cancers. Materials and Methods: We performed a retrospective observational study among 1,049 patients who underwent curative resection and received AC for stage II and III gastric cancers between February 2012 and December 2013 at 29 tertiary referral university hospitals in Korea...
September 2018: Journal of Gastric Cancer
Oh Jeong, Mi Ran Jung, Seong Yeob Ryu
Purpose: With increasing life expectancy, the presence of comorbidities has become a major concern in elderly patients who require surgery. However, little is known about the impact of different comorbidities on the outcomes of laparoscopic total gastrectomy (LTG). In this study, we investigated the impact of comorbidities on postoperative complications in patients undergoing LTG for gastric carcinoma. Materials and Methods: We retrospectively reviewed the cases of 303 consecutive patients who underwent LTG for gastric carcinoma between 2005 and 2016...
September 2018: Journal of Gastric Cancer
Stephen O'Brien, Maria Twomey, Fiachra Moloney, Richard G Kavanagh, Brian W Carey, Derek Power, Michael M Maher, Owen J O'Connor, Criostoir Ó'Súilleabháin
Purpose: Surgical resection for gastric adenocarcinoma is associated with significant post-operative morbidity and mortality. The aim of this study was to assess the prognostic significance of sarcopenia in patients undergoing resection for gastric adenocarcinoma with respect to post-operative morbidity and survival. Materials and Methods: A retrospective analysis was conducted on a cohort of consecutive patients who underwent surgical resection for gastric adenocarcinoma between 2008 and 2014...
September 2018: Journal of Gastric Cancer
Jacopo Desiderio, Camille L Stewart, Virginia Sun, Laleh Melstrom, Susanne Warner, Byrne Lee, Hans F Schoellhammer, Vijay Trisal, Benjamin Paz, Yuman Fong, Yanghee Woo
Purpose: Enhanced recovery after surgery (ERAS) protocols for gastric cancer patients have shown improved outcomes in Asia. However, data on gastric cancer ERAS (GC-ERAS) programs in the United States are sparse. The purpose of this study was to compare perioperative outcomes before and after implementation of an GC-ERAS protocol at a National Comprehensive Cancer Center in the United States. Materials and Methods: We reviewed medical records of patients surgically treated for gastric cancer with curative intent from January 2012 to October 2016 and compared the GC-ERAS group (November 1, 2015-October 1, 2016) with the historical control (HC) group (January 1, 2012-October 31, 2015)...
September 2018: Journal of Gastric Cancer
Hyun Woo Kwon, Liang An, Hye Ryeong Kwon, Sungsoo Park, Sungeun Kim
Purpose: This study investigated whether the metabolic avidity of primary tumors and/or metastatic lymph nodes (LNs) measured by 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) was related to survival after surgery in patients with advanced gastric cancer (AGC). Materials and Methods: One hundred sixty-eight patients with AGC who underwent preoperative 18 F-FDG PET/CT and curative resection were included. The 18 F-FDG avidity of the primary gastric tumor and LNs was determined quantitatively and qualitatively...
September 2018: Journal of Gastric Cancer
Tadayoshi Hashimoto, Yukinori Kurokawa, Masaki Mori, Yuichiro Doki
Although the incidence of gastroesophageal junction (GEJ) adenocarcinoma has been increasing worldwide, no standardized surgical strategy for its treatment has been established. This study aimed to provide an update on the surgical treatment of GEJ adenocarcinoma by reviewing previous reports and propose recommended surgical approaches. The Siewert classification is widely used for determining which surgical procedure is used, because previous studies have shown that the pattern of lymph node (LN) metastasis depends on tumor location...
September 2018: Journal of Gastric Cancer
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