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ISRN Obstetrics and Gynecology

Beril Yüksel, Sevtap Kilic, Nese Lortlar, Nicel Tasdemir, Semra Sertyel, Yesim Bardakci, Tarik Aksu, Sertaç Batioglu
Objectives. To investigate the effect of cigarette smoke exposure during intrauterine period on neonatal rat testis. Methods. Twenty-five rats were randomized to be exposed to cigarette smoke with the Walton Smoking Machine or to room air during their pregnancies. The newborn male rats (n = 21) were grouped as group 1 (n = 15) which were exposed to cigarette smoke during intrauterine life and group 2 (n = 6) which were exposed to room air during intrauterine life. The orchiectomy materials were analyzed with TUNEL immunofluorescent staining for detection of DNA damage...
2014: ISRN Obstetrics and Gynecology
Chythra R Rao, Lara E E de Ruiter, Parvati Bhat, Veena Kamath, Asha Kamath, Vinod Bhat
Introduction. Preterm birth is the leading cause of newborn deaths and the second leading cause of death in children under five years old. Three-quarters of them could be saved with current, cost-effective interventions. The aim of this study was to identify the risk factors of preterm birth in a secondary care hospital in Southern India. Methods. In the case-control study, records of 153 antenatal women with preterm birth were included as cases. Age matched controls were women who had a live birth after 37 weeks of gestational age...
2014: ISRN Obstetrics and Gynecology
Jyothi Shetty, Ashwini Vishalakshi, Deeksha Pandey
Background. Parenteral opioids, thus, are still popular for pain relief in labor in many countries throughout the world. Aim. To evaluate and compare the efficacy of intramuscular tramadol and pentazocine in the first stage of labor. Method. Sixty-five patients were divided into pentazocine group and tramadol group. Subjects received either 30 mg pentazocine or 1 mg/kg tramadol intramuscularly. Pain was assessed using visual analog scale (VAS) before the administration of the drug, at 1 h, 2 h, 4 h, and at full dilatation...
2014: ISRN Obstetrics and Gynecology
Catiele Garcia Gervásio, Marcelo Picinin Bernuci, Marcos Felipe Silva-de-Sá, Ana Carolina Japur de Sá Rosa-E-Silva
Background. Although chronic hyperandrogenism, a typical feature of polycystic ovary syndrome, is often associated with disturbed reproductive performance, androgens have been shown to promote ovarian follicle growth in shorter exposures. Here, we review the main effects of androgens on the regulation of early folliculogenesis and the potential of their application in improving follicular in vitro growth. Review. Androgens may affect folliculogenesis directly via androgen receptors (ARs) or indirectly through aromatization to estrogen...
2014: ISRN Obstetrics and Gynecology
Sümeyra Nergiz Avcioğlu, Sündüz Özlem Altinkaya, Mert Küçük, Selda Demircan-Sezer, Hasan Yüksel
Objective. The aim of this study was to investigate whether platelet indices-mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) would be useful as noninvasive biomarkers for determining the severity of endometriosis. Methods. A retrospective review of the medical charts of 164 patients diagnosed with endometriosis and who were operated on between 2001 and 2013 was performed. The stage of endometriosis was determined according to revised American Society for Reproductive Medicine criteria...
2014: ISRN Obstetrics and Gynecology
Keerti Singh, Kandamaran Krishnamurthy, Camille Greaves, Latha Kandamaran, Anders L Nielsen, Alok Kumar
Objectives. To study the prevalence and the pattern of major congenital malformations and its contribution to the overall perinatal morbidity and mortality. Methods. It is a retrospective population based study. It includes all major congenital malformations in newborns during 1993-2012. The data was collected from the birth register, the neonatal admission register and the individual patient records at the Queen Elizabeth Hospital where over 90% of deliveries take place and it is the only facility for the care of sick newborns in this country...
2014: ISRN Obstetrics and Gynecology
Azam Sadat Mousavi, Samieh Karimi, Mitra Modarres Gilani, Setareh Akhavan, Elahe Rezayof
β -human chorionic gonadotropin (HCG) level is not a reliable marker for early identification of persistent gestational trophoblastic neoplasia (GTN) after evacuation of hydatidiform mole. Thus, this study was conducted to evaluate β -HCG regression after evacuation as a predictive factor of malignant GTN in complete molar pregnancy. Methods. In this cross-sectional study, we evaluated a total of 260 patients with complete molar pregnancy. Sixteen of the 260 patients were excluded. Serum levels of HCG were measured in all patients before treatment and after evacuation...
2014: ISRN Obstetrics and Gynecology
Aruna Nigam, Pikee Saxena, Anita S Acharya, Archana Mishra, Swaraj Batra
Cervical cancer is the third most common cancer in women worldwide. The role of human papilloma virus (HPV) in the genesis of cervical carcinoma is well documented. The HPV 16 and 18 are found to be most commonly associated with invasive cervical carcinoma. The advent of cervical carcinoma vaccine has advanced the hopes that eradication of cervical carcinoma might be possible in future. The scenario of prevention of cervical carcinoma is completely different in developed and developing countries. The implementation of the vaccination as a routine in India is still controversial...
2014: ISRN Obstetrics and Gynecology
Cleine Aglacy Nunes Miranda, Erika Galvão Lima, Diego Breno Soares de Lima, Ricardo Ney Oliveira Cobucci, Maria da Conceição de Mesquita Cornetta, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Roberto Medeiros de Azevedo, Jenner Chrystian Veríssimo de Azevedo, Josélio Maria Galvão de Araújo, José Veríssimo Fernandes
Objective. To evaluate the prevalence of HSV-1 and HSV-2 in pregnant and nonpregnant women, testing the correlation between DNA of the viruses with colposcopic and/or cytological changes, and evaluate association with sociodemographic characteristics and sexual activity. Methods. Included in this study were 106 pregnant and 130 nonpregnant women treated at primary health care units of Natal, Brazil, in the period 2010-2011. The patients were examined by colposcopy, and two cervical specimens were collected: one for cytology examination and another for analysis by PCR for detection of HSV-1 and HSV-2...
2014: ISRN Obstetrics and Gynecology
Jyothi Shetty, Vinod Aahir, Deeksha Pandey, Prashanth Adiga, Asha Kamath
Introduction. Recent evidence indicates that clinical examination, for determination of fetal head position, is subjective and inaccurate. Present study was aimed to compare transabdominal ultrasound for fetal head position with vaginal examination during first stage of labor. Material and Methods. This prospective study was performed at a tertiary center during a two-year period. Before or after clinically indicated vaginal examinations, transverse suprapubic transabdominal real-time ultrasound fetal head position assessment was done...
2014: ISRN Obstetrics and Gynecology
Chidozie E Mbada, Olubukayomi E Adebayo, Adebanjo B Adeyemi, Olujide O Arije, Olumide O Dada, Olabisi A Akinwande, Taofeek O Awotidebe, Ibidun A Alonge
Background. Engagement in physical exercise in pregnancy is hamstrung by safety concerns, skepticism about usefulness, and limited individualized prescription guidelines. This study assessed knowledge and attitude of pregnant women towards antenatal exercises (ANEx). Methods. The cross-sectional study recruited 189 pregnant women from six selected antenatal clinics in Ile-Ife, South-West, Nigeria. Data were obtained on maternal characteristics, knowledge, and attitude towards ANEx. Results. Relaxation and breathing (59...
2014: ISRN Obstetrics and Gynecology
Clarissa Velayo, Takuya Ito, Yupeng Dong, Miyuki Endo, Rika Sugibayashi, Kiyoe Funamoto, Keita Iida, Nobuo Yaegashi, Yoshitaka Kimura
Introduction. Prenatal programming secondary to maternal protein restriction renders an inherent susceptibility to neural compromise in neonates and any addition of glucocorticosteroids results in further damage. This is an investigation of consequent global gene activity due to effects of antenatal steroid therapy on a protein restriction mouse model. Methods. C57BL/6N pregnant mice were administered control or protein restricted diets and subjected to either 100  μ g/Kg of dexamethasone sodium phosphate with normosaline or normosaline alone during late gestation (E10-E17)...
2014: ISRN Obstetrics and Gynecology
Juliana Sayuri Kubotani, Antonio Fernandes Moron, Edward Araujo Júnior, Miriam Raquel Diniz Zanetti, Vanessa Cardoso Marques Soares, Julio Elito Júnior
The aims of this study were to compare perineal distensibility between women with twin and singleton pregnancies and to correlate these women's perineal distensibility with anthropometric data. This prospective cross-sectional case-control study was conducted among nulliparous women, of whom 20 were pregnant with twins and 23 with a single fetus. Perineal distensibility was evaluated in the third trimester by means of Epi-no, which was introduced into the vagina and inflated up to the maximum tolerable limit...
2014: ISRN Obstetrics and Gynecology
Samira Khayat, Masoomeh Kheirkhah, Zahra Behboodi Moghadam, Hamed Fanaei, Amir Kasaeian, Mani Javadimehr
Premenstrual syndrome (PMS) is a common disorder. Although the etiology of PMS is not clear, to relieve from this syndrome different methods are recommended. One of them is use of medicinal herbs. This study was carried out to evaluate effects of ginger on severity of symptoms of PMS. This study was a clinical trial, double-blinded work, and participants were randomly allocated to intervention (n = 35) and control (n = 35) groups. To determine persons suffering from PMS, participants completed daily record scale questionnaire for two consecutive cycles...
2014: ISRN Obstetrics and Gynecology
Richelle N Olsen, Jennifer Shepherd, Anup Katheria
Objective. Abnormal umbilical artery Doppler (UAD) studies are associated with poor neonatal outcomes. We sought to determine if postnatal measures of systemic blood flow (SBF), as measured by functional echocardiography (fECHO), could identify which fetuses with abnormal UAD were at the highest risk of adverse outcomes. Study Design. This is a retrospective review of fetuses with abnormal UAD who received fECHO in the first 72 hours of life. Measures of SBF (right ventricular output (RVO) and superior vena cava (SVC) flow) were performed and compared with prenatal variables and postnatal outcomes...
2014: ISRN Obstetrics and Gynecology
Adam Ostrzenski
Objectives. To test applicability of the new surgical concept for labioreduction of the labia minora. Study Design. The observational, prospective, case series study was designed. Subjects. Three consecutive subjects were included. Methods. The application of new surgical intervention was tested. Main Outcome Measures. A primary outcome measured applicability of the fenestration labioplasty and secondary measures was used to evaluate surgical resolution of medical, emotional, and social symptoms; aesthetic outcomes; and potential complications...
2014: ISRN Obstetrics and Gynecology
Xavier Catteau, Philippe Simon, Jean-Christophe Noël
Objectives. In Belgium, very few studies have focused on cervical high-risk human papillomaviruses (hrHPV) prevalence and the relationship between HPV and cervical cytological abnormalities. The aim of this study was to investigate hrHPV prevalence and its relationship with cytological screening and histological results in the French-speaking community in Belgium (Brussels and Wallonia). Methods. A total of 58,265 liquid-based cytology tests were performed during this period. All cases of ASC-US, ASC-H, LSIL, and HSIL were tested by Hybrid Capture 2 for hrHPV screening...
2014: ISRN Obstetrics and Gynecology
Alhossain A Khalafallah, Abdul-Rauf O Ibraheem, Qiong Yue Teo, Abdul-Majeed Albarzan, Ramanathan Parameswaran, Emily Hooper, Toly Pavlov, Amanda E Dennis, Terry Hannan
Pregnancy is a hypercoagulable state associated with an increased risk of venous thromboembolic disease (VTE). We retrospectively studied 38 Caucasian pregnant women with thrombophilia risk and compared their obstetric outcomes with a matched cohort without known thrombophilia risk during the period between January 2007 and December 2010. There were (2) cases with factor V Leiden, (6) prothrombin gene mutation, (1) antithrombin III deficiency, (2) protein C deficiency, (3) protein S deficiency, (10) MTHFR mutation, (7) anti-cardiolipin antibodies, and (1) lupus anticoagulant...
2014: ISRN Obstetrics and Gynecology
Haruhiko Kanasaki, Aki Oride, Tomomi Mitsuo, Kohji Miyazaki
Objective. To examine retrospectively the occurrence of stress urinary incontinence (SUI) in patients who underwent transvaginal mesh repair (TVM) for pelvic organ prolapse (POP). Methods. The presence of preoperative SUI and postoperative changes in SUI was retrospectively analyzed for 105 patients who underwent TVM for POP between September 2009 and September 2012. Results. Preoperative SUI was observed in almost half of the patients (n = 50) who underwent TVM surgery. No significant differences were seen in patient age, pelvic organ prolapse quantification (POP-Q) stage, or primary POP complaint between those with and without preoperative SUI...
2014: ISRN Obstetrics and Gynecology
Athanasios Protopapas, Georgios Giannoulis, Ioannis Chatzipapas, Stavros Athanasiou, Themistoklis Grigoriadis, Dimitrios Haidopoulos, Dimitrios Loutradis, Aris Antsaklis
We conducted this prospective cohort study to standardize our laparoscopic technique of excision of posterior deep infiltrating endometriosis (DIE) nodules, according to their size, location, and geometry, including 36 patients who were grouped, according to principal pelvic expansion of the nodule, into groups with central (group 1) and lateral (group 2) lesions, and according to nodule size, into ≤2 cm (group A) and >2 cm (group B) lesions, respectively. In cases of group 1 the following operative steps were more frequently performed compared to those of group 2: suspension of the rectosigmoid, colpectomy, and placement of bowel wall reinforcement sutures...
2014: ISRN Obstetrics and Gynecology
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