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Journal of Gastrointestinal Oncology

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April 2019: Journal of Gastrointestinal Oncology
Vinay Balasaheb Pawar, Ravindra Surude, Nikhil Sonthalia, Samit Jain, Qais Contractor, Pravin Rathi
Primary lymphomas of the digestive tract are uncommon heterogenous group of neoplasms that primarily affects stomach. Lymphomatous involvement of small intestine is amongst the rare lymphomas; ampullary involvement is even rarer. It is important to recognize this entity early as it mimics periampullary neoplasms and its management is different. We present the case of a 14-year-old male who presented with rapidly progressive obstructive jaundice and weight loss and ultimately was diagnosed to have ampullary Burkitt's lymphoma...
April 2019: Journal of Gastrointestinal Oncology
Markus Joerger, Ulrich Güller, Sara Bastian, Christoph Driessen, Roger von Moos
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and the second most common cause of cancer death worldwide. Besides sorafenib, regorafenib and lenvatinib, recent data have shown clinical activity of the PD-1 monoclonal antibody nivolumab. We present the case of a sorafenib-refractory patient probably experiencing progressive disease during immune checkpoint inhibitor combination treatment with the anti-PD-1 monoclonal antibody nivolumab and the anti-GITR monoclonal antibody BMS-986156 within a clinical phase-1 trial followed by a prolonged tumor response according to RECIST v...
April 2019: Journal of Gastrointestinal Oncology
Megan Greally, Rajiv Agarwal, Imane El Dika, Ali Shamseddine, Ashwaq El-Olayan, Yolla Haibe, Viktoriya Paroder, Jinru Shia, Ghassan K Abou-Alfa, Geoffrey Y Ku
Esophageal carcinoma is an aggressive malignancy and outcomes remain poor. Immune checkpoint inhibitors are a standard-of-care in the third-line and beyond settings, although benefit is modest. Herein, we report the case of a patient who achieved a partial response to salvage chemotherapy following treatment with an immune checkpoint inhibitor despite having chemo-refractory disease. A 41-year-old male, with a history of Crohn's disease, was diagnosed with Her2-positive metastatic esophageal adenocarcinoma to lungs and lymph nodes...
April 2019: Journal of Gastrointestinal Oncology
Malav P Parikh, Prashanthi N Thota, Siva Raja, Sudish Murthy, Usman Ahmad, Niyati M Gupta, Madhusudhan R Sanaka
Patients with esophageal adenocarcinoma (EAC) invading submucosa (T1b) are traditionally treated with esophagectomy and with chemoradiotherapy in poor surgical patients. Endoscopic submucosal dissection (ESD) has emerged as an alternative treatment in these patients. In this case series, we analyzed the outcomes of ESD in EAC staged T1bN0 by endoscopic ultrasound (EUS). Patients with EAC staged T1bN0M0 by EUS and PET scan who underwent ESD by a single operator (MS) between 2014 and 2017 at our institution were included...
April 2019: Journal of Gastrointestinal Oncology
Michael A Cummings, Kenneth Y Usuki, Fergal J Fleming, Mohamedtaki A Tejani, Alan W Katz
Rectal cancer in elderly patients can be difficult to manage. Short course radiation therapy (SCRT) has shown to be effective when given immediately prior to surgery. Here we report outcomes of elderly patients who underwent SCRT either alone or prior to resection. Between 2010 and 2015, elderly patients with rectal cancer and no distant metastatic disease were identified. Symptoms at diagnosis, therapies, toxicities, and pathologic and clinical response were recorded from patient charts. The SCRT prescription dose was 5 Gy ×5 to the rectal tumor and 4 Gy ×5 to the mesorectum, omitting the iliac nodes...
April 2019: Journal of Gastrointestinal Oncology
Omar Abdel-Rahman, Winson Y Cheung
Current North American guidelines endorse the use of flexible sigmoidoscopy every 10 years as an alternative to fecal testing for the screening of colorectal cancer (CRC). The present study aims to evaluate its performance in a hypothetical population-based scenario, using data from the Surveillance, Epidemiology and End Results (SEER)-18 database. We explored the SEER database with the SEER*stat software. All cases diagnosed as colorectal carcinoma within the age group of 50-74 years during the year 2010 were included...
April 2019: Journal of Gastrointestinal Oncology
Ricardo Yamada, Beatriz Bassaco, Stephen Bracewell, Kirkpatrick Gillen, Madison Kocher, Heather Collins, Michael Bret Anderson, Marcelo Guimaraes
Background: Conventional transarterial chemoembolization (c-TACE) is a common treatment for unresectable hepatocellular carcinoma (HCC). It is associated with increased overall survival (OS) when compared to conservative management. The purpose of this study is to analyze all c-TACE with mitomycin in patients with HCC at a single institution to determine safety, efficacy, and prognostic factors in a long-term follow-up. Methods: Retrospective analysis of patients with HCC treated only with c-TACE with Mitomycin between 2007 and 2012...
April 2019: Journal of Gastrointestinal Oncology
Eke Ransome, Li Tong, Jairo Espinosa, Jesse Chou, Vishal Somnay, Gitonga Munene
Background: Intrahepatic cholangiocarcinoma (IHC) is a malignancy with an increasing incidence. Surgery is the only treatment modality associated with long term survival. The objective of this study is to utilize a nationwide representative database to quantify the trends in incidence, and surgery for IHC in the United States from 2004-2014, as well as identify any disparities in the receipt of surgery. Methods: All patients admitted with a diagnosis of IHC between 2005 and 2014 were identified from the Nationwide Inpatient Sample (NIS) database...
April 2019: Journal of Gastrointestinal Oncology
Emily J Anstadt, Richard Shumway, Joseph Colasanto, David Grew
Background: Stereotactic body radiation therapy (SBRT) is a safe and effective option for treatment of liver metastases. However, existing data are mostly reported by high-volume centers. There have been reports that advanced radiotherapy techniques performed at low-volume centers result in inferior outcomes. Our goal was to assess the implementation of SBRT for the treatment of liver metastases at a low-volume center by studying the efficacy and toxicity of this technology through retrospective database review at a single, community-based institution...
April 2019: Journal of Gastrointestinal Oncology
Thanet Sophonnithiprasert, Pensri Saelee, Tanett Pongtheerat
Background: Hepatocellular carcinoma (HCC) is a common malignancy found throughout the world that most often occurs in males. The cancer is associated with many risk factors such as viral infection, cirrhosis, alcohol, smoking, and fungal toxins. GSTM1 and GSTT1 are detoxification enzymes activated by the cleansing of carcinogenic compounds. Low DNA copy numbers of Glutathione S-transferases M1 and T1 result in a loss of enzyme activity, which causes carcinogenesis factors. DNA copy number variants (CNVs) were determined to compare the differences between the frequencies of GSTM1 and GSTT1 in a control group and patients...
April 2019: Journal of Gastrointestinal Oncology
Angelica Petrillo, Maria Maddalena Laterza, Giuseppe Tirino, Luca Pompella, Annalisa Pappalardo, Jole Ventriglia, Beatrice Savastano, Annamaria Auricchio, Michele Orditura, Fortunato Ciardiello, Gennaro Galizia, Ferdinando De Vita
Background: Neoangiogenesis has proven to be a relevant pathogenetic mechanism in gastric cancer (GC) and lymphatic spread represents an important well-known prognostic factor. Vascular endothelial growth factor C (VEGF-C) plays a key role in lymphangiogenesis and its blood levels in GC patients are easily measurable. This analysis aimed to investigate the prognostic role of preoperative VEGF-C blood levels. Methods: VEGF-C serum levels were determined by enzyme-linked immunoadsorbent assay (ELISA) in 186 patients observed at our institution from January 2004 until December 2009 and 82 healthy subjects...
April 2019: Journal of Gastrointestinal Oncology
Ramachandra Chowdappa, Ajeet Ramamani Tiwari, Namrata Ranganath, Rekha V Kumar
Background: Little has been reported regarding differences between malignancies that develop at the anastomotic site (ASC) and those that develop at the remnant stump (RSC) in gastric stump carcinomas (GSC). The purpose of our study was to compare clinical, pathological and survival characteristics of ASC patients with those of RSC patients. Methods: Patients who underwent surgery for GSC between January 2005 and December 2017 were analyzed. Of the total 112 patients, 22 patients were excluded from the study due to extensive loss of data...
April 2019: Journal of Gastrointestinal Oncology
Chibueze Onyemkpa, Alan Davis, Michael McLeod, Tolutope Oyasiji
Background: Goblet cell carcinoids (GCC) and other atypical neuroendocrine tumors (NET) of the appendix as well as appendiceal adenocarcinoma are usually managed with the same algorithm as colon cancers. This study investigates clinicopathological features that are predictive of survival outcomes for appendiceal NET and adenocarcinoma. Survival profiles for the histologic subtypes of appendiceal NET and adenocarcinoma were compared. Methods: A retrospective review of appendiceal NET and adenocarcinoma for patients who are 18 years and above in the SEER database from 2010 to 2014...
April 2019: Journal of Gastrointestinal Oncology
Hugo Herrscher, Thierry Artzner, François Severac, François Faitot, Jean-Emmanuel Kurtz, Ralph Janssen-Langenstein, Quentin Maestraggi, Francis Schneider, Baptiste Michard
Background: Admission and management of patients with solid malignancies in intensive care unit (ICU) is a controversial topic. To this day, there is no data published concerning patients with gastric cancers hospitalized in ICU. This single center retrospective study reports the characteristics, outcome and prognostic factors of patients hospitalized in ICU for medical reasons over a period of 10 years. Methods: We performed a single center retrospective study which reports the characteristics, outcome and prognostic factors of patients hospitalized in ICU for medical reasons over a period of 10 years...
April 2019: Journal of Gastrointestinal Oncology
Dionigi Lorusso, Aurore Giliberti, Margherita Bianco, Giulio Lantone, Gioacchino Leandro
Background: Unresectable gastric or pancreatic malignancies are the most common cause of gastric outlet obstruction (GOO). Although several authors reported better outcomes in patients submitted to gastric partitioning gastrojejunostomy (GPGJ) compared to conventional gastrojejunostomy (CGJ), clinical experience with GPGJ is poor, studies comparing the two techniques are few and no randomized trials were performed. Our systematic review aimed at comparing GPGJ (partial or complete) with CGJ in patients operated for GOO for gastric or pancreatic cancer...
April 2019: Journal of Gastrointestinal Oncology
Nathawadee Lerttanatum, Chadin Tharavej, Yuda Chongpison, Anapat Sanpavat
Background: Nowadays, preoperative radio-chemotherapy is a standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). Tumor regression grade (TRG), referring to a classification of cancer response to preoperative treatment, can predict a prognosis of survival. Many TRG systems are proposed for use in esophageal cancer, but none of them has become standard grading system. This research compared five TRG systems, including Mandard system, Chirieac system, Schneider system, Hermann system, and Japan Esophageal Society (JES) system, to find the most accurately predictive system...
April 2019: Journal of Gastrointestinal Oncology
Marwa Ferchichi, Raja Jouini, Wafa Koubaa, Fatma Khanchel, Imen Helal, Dhafer Hadad, Norsaf Bibani, Aschraf Chadli-Debbiche, Ehsen BenBrahim
Background: Pancreatic ductal adenocarcinoma (PDAC) and ampullary adenocarcinoma (AAC) are 2 gastrointestinal cancers that share overlapping symptoms. Although some studies have proposed the hypothesis of differences in pathogenesis and prognosis in these 2 cancers; they remain treated similarly. The classification of AAC into three subtypes [pancreatobiliary (PB), intestinal (IT) and mixed (M)] is especially crucial for the 3 axes of patients management (diagnosis, prognosis and therapy)...
April 2019: Journal of Gastrointestinal Oncology
Gianluca Tomasello, Michele Ghidini, Antonio Costanzo, Antonio Ghidini, Alessandro Russo, Sandro Barni, Rodolfo Passalacqua, Fausto Petrelli
Background: Even when resectable pancreatic cancer (PC) is associated with a dismal prognosis. Initial presentation varies according with primary tumor location. Aim of this systematic review and meta-analysis was to evaluate the prognosis associated with site (head versus body/tail) in patients with PC. Methods: We searched PubMed, Cochrane Library, SCOPUS, Web of Science, EMBASE, Google Scholar, LILACS, and CINAHL databases from inception to March 2018. Studies reporting information on the independent prognostic role of site in PC and comparing overall survival (OS) in head versus body/tail tumors were selected...
April 2019: Journal of Gastrointestinal Oncology
Priyanka Vij, Debbie Chen, Chiu-Hsieh Hsu, Viraj Pandit, Pamela Omesiete, Emad Elquza, Aaron Scott, Alejandro Cruz, Valentine Nfonsam
Background: Studies have explored the relationship between inflammatory bowel disease (IBD) [ulcerative colitis (UC) and Crohn's disease (CD)] and colon cancer (CC). Additionally, racial disparities in the incidence of CC is well known. However, the impact of racial disparity in IBD patients who develop CC remains unclear. The aim of this study is to address the knowledge gap in this particular group of patients. Methods: A retrospective analysis was done using the National Inpatient Sample (NIS) database from 2011...
April 2019: Journal of Gastrointestinal Oncology
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