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Journals Journal of Gastrointestinal On...

Journal of Gastrointestinal Oncology

https://read.qxmd.com/read/38196549/the-prognostic-value-of-the-number-of-metastatic-lymph-nodes-on-the-long-term-survival-of-intrahepatic-cholangiocarcinoma-using-the-seer-database
#1
JOURNAL ARTICLE
Juwan Kim, Dai Hoon Han, Gi Hong Choi, Kyung Sik Kim, Jin Sub Choi, Sung Hyun Kim
BACKGROUND: In the 8th edition of the American Joint Committee on Cancer, the nodal staging of intrahepatic cholangiocarcinoma (ICC) is classified as N0 and N1 in accordance with lymph node (LN) metastases. Recently, several studies have reported that the number of metastatic LNs is associated with prognosis in patients with ICC. However, the majority of these studies were published in Eastern countries, and there are few available data for Western countries. This study aimed to investigate the association between metastatic LN number and prognosis in ICC patients using the Surveillance, Epidemiology, and End Results (SEER) database...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196548/effect-of-ramucirumab-plus-paclitaxel-in-advanced-gastric-cancer-according-to-the-status-of-programmed-cell-death-ligand-1-pd-l1-expression
#2
JOURNAL ARTICLE
Dae-Ho Choi, Jeeyun Lee, Ho Yeong Lim, Won Ki Kang, Jae Yeon Jang, Youngkyung Jeon, Sun Young Jeong, Ye Ji Jung, Seung Tae Kim
BACKGROUND: Ramucirumab, an anti-vascular endothelial growth factor receptor (VEGFR) monoclonal antibody (mAb), inhibits angiogenesis and reduces tumor activity. Programmed cell death-ligand 1 (PD-L1) might act upon VEGFR2 to induce cancer cell angiogenesis and metastasis. Herein, we investigated the efficacy of combining ramucirumab and paclitaxel according to the status of PD-L1 expression in patients with advanced gastric cancer (AGC). METHODS: This analysis included AGC patients who received ramucirumab plus paclitaxel as 2nd line therapy between December 1, 2018, and February 28, 2022, at Samsung Medical Center...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196547/lymph-node-metastasis-related-lncrna-gas6-as1-facilitates-the-progression-of-esophageal-squamous-cell-carcinoma
#3
JOURNAL ARTICLE
Yujie Xie, Zhanfei Zhang, Dongmei Lai, Jin Liang, Zhengang Zhao, Weicheng Lu, Junli Ke, Wanli Lin, Haiquan He
BACKGROUND: Lymph node metastasis is the main type of metastasis in esophageal squamous cell carcinoma (ESCC), especially when the primary tumor invasion depth reaches above the adventitia layer (T3 stage), the incidence of lymph node metastasis increases sharply. Abnormal expression of long non-coding RNAs (lncRNAs) has been confirmed in ESCC, but there are still many unknown connections between lncRNAs and lymph node metastasis. METHODS: We used transcriptome sequencing (RNA-seq) to analyze 10 pairs of ESCC tissues with primary tumor stage T3 and their paired normal epithelium...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196546/effect-of-low-level-creatinine-clearance-on-short-term-postoperative-complications-in-patients-with-colorectal-cancer
#4
JOURNAL ARTICLE
Wei-Sheng Chen, Ji Lin, Wei-Teng Zhang, Wen-Jing Chen, Emmanuel M Gabriel, Paul C Kuo, Antonio Caycedo-Marulanda, Yi-Qi Cai, Xiao-Dong Chen, Wen-Yi Wu
BACKGROUND: Renal function is closely related to cancer prognosis. Since preoperative renal insufficiency has been identified as a risk factor for postoperative complications, this study aimed to investigate the effect of preoperative creatinine clearance rate (CrCl) on short-term prognosis of patients undergoing colorectal surgery. METHODS: A retrospective analysis was conducted of the electronic health records of 526 adult patients who underwent elective colorectal cancer (CRC) surgery from September 2014 to February 2019 at the First Affiliated Hospital of Wenzhou Medical University...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196545/immunotherapy-before-liver-transplant-in-unresectable-hepatocellular-carcinoma-a-case-report
#5
Hyejee Ohm, Raida Khwaja, Hatim Karachiwala
BACKGROUND: Hepatocellular carcinoma (HCC) is a leading cause of global cancer mortality, with liver transplantation as the sole curative treatment. For advanced disease, first-line systemic therapies including immune checkpoint inhibitors (ICIs) have shown a survival benefit, but there is scarce data on clinical outcomes when used prior to transplantation. CASE DESCRIPTION: We present three case studies of patients who received immunotherapy with atezolizumab/bevacizumab or ipilimumab/nivolumab before liver transplant...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196544/efficacy-safety-and-predictors-of-fruquintinib-plus-anti-programmed-death-receptor-1-pd-1-antibody-in-refractory-microsatellite-stable-metastatic-colorectal-cancer-in-a-real-world-setting-a-retrospective-cohort-study
#6
JOURNAL ARTICLE
Xiaolin Yang, Xianli Yin, Xiaozhou Qu, Geyang Guo, Yidong Zeng, Wu Liu, Mateusz Jagielski, Zhenyang Liu, Huijun Zhou
BACKGROUND: Patients with microsatellite stable (MSS) advanced colorectal cancer (CRC) have few alternatives for salvage therapy and a large unmet clinical need. Preclinical studies demonstrate that fruquintinib combined with anti-programmed death protein 1 (PD-1) has a synergistic anti-tumor effect. But a few phase 2 clinical studies show inconsistent efficacy of this combination therapy in CRC. The aim of this study was to investigate the efficacy, safety, and predictors of fruquintinib plus PD-1 antibodies in refractory MSS metastatic CRC (mCRC) in a real-world setting...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196543/risk-factors-for-remnant-gastric-cancer-after-distal-gastrectomy-for-gastric-cancer-a-retrospective-database-review
#7
JOURNAL ARTICLE
Shinya Sakamoto, Ikuo Wada, Kiyohiko Omichi, Shunsaku Furuke, Yusuke Kitani, Masayuki Takegami, Keiichi Nasu, Kentaro Inada, Yukiko Takahama, Michiro Takahashi, Tsuyoshi Maeshiro
BACKGROUND: The number of patients with remnant gastric cancer (RGC) following gastrectomy for gastric cancer (GC) is increasing due to the increasing number of patients undergoing function-preserving gastrectomy and improved outcomes for patients with GC. A few studies involving a small number of cases reported male sex, old age, differentiated type, tumor depth and synchronous multiple GC were associated with RGC development. However, the risk factors for RGC development had not been fully understood...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196542/identification-of-acetylshikonin-as-a-novel-tubulin-polymerization-inhibitor-with-antitumor-activity-in-human-hepatocellular-carcinoma-cells
#8
JOURNAL ARTICLE
Siming Hu, Yongchuan Li, Junqiu Zhou, Kun Xu, Yanqing Pang, Ralf Weiskirchen, Matthias Ocker, Fen Ouyang
BACKGROUND: Microtubules are attractive targets for anticancer drugs. However, the microtubule-targeting agents (MTAs) currently in clinical use exhibit inevitable drug resistance. Therefore, there is an urgent need to discover novel MTAs for the clinical treatment of cancer. METHODS: Bioactive compounds extracted from Lithospermum erythrorhizon were assessed for in vitro anti-proliferative activities against a panel of human cancer cell lines using cell counting kit-8 (CCK-8) assay...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196541/development-and-validation-of-a-nomogram-to-predict-pathological-complete-response-in-patients-with-locally-advanced-gastric-adenocarcinoma-treated-with-neoadjuvant-chemotherapy-in-combination-with-pd-1-antibodies
#9
JOURNAL ARTICLE
Liang Li, Guanglong Chen, Emerson Y Chen, Matthew R Strickland, Weijie Zhao, Jialin Zhang, Zhi Li
BACKGROUND: Currently, the survival benefits of combining neoadjuvant chemotherapy with programmed death 1 (PD-1) antibody immunotherapy in advanced gastric adenocarcinoma remain controversial. Emerging evidence suggests that the survival benefits of neoadjuvant therapy in advanced gastric adenocarcinoma hinge upon the attainment of pathological complete response (pCR). Therefore, the prediction of pCR in patients undergoing neoadjuvant chemotherapy combined with PD-1 antibody immunotherapy holds significant importance and is beneficial for the individualized treatment of gastric cancer (GC) patients...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196540/durable-response-to-first-line-parp-inhibition-in-brca-mutated-metastatic-cholangiocarcinoma-case-report
#10
Jarrod T Smith, Shashank Sama, Vaia Florou, Christopher Nevala-Plagemann, Ignacio Garrido-Laguna
BACKGROUND: Cholangiocarcinoma (CCA) is an increasingly prevalent malignancy worldwide, with poor outcomes even when diagnosed at an early stage. While recent trials have shown benefit from the addition of immunotherapy to standard-of-care chemotherapy, the improvement in overall survival is modest. Multiple novel therapies for advanced CCA targeting actionable genetic alterations have been approved in recent years; BRCA1/2 mutations are identified in up to 5% of CCA patients and may be an additional target for novel treatment approaches...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196539/a-methylation-related-signature-for-predicting-prognosis-and-sensitivity-to-first-line-therapies-in-gastric-cancer
#11
JOURNAL ARTICLE
Chenlin Cao, Zhiyong Luo, Hong Zhang, Shuo Yao, Hui Lu, Kun Zheng, Yali Wang, Man Zou, Wan Qin, Huihua Xiong, Xianglin Yuan, Yihua Wang, Rodrigo Nascimento Pinheiro, Renata D'Alpino Peixoto, Yanmei Zou, Hua Xiong
BACKGROUND: Methylation modification patterns play a crucial role in human cancer progression, especially in gastrointestinal cancers. We aimed to use methylation regulators to classify patients with gastric adenocarcinoma and build a model to predict prognosis, promoting the application of precision medicine. METHODS: We obtained RNA sequencing data and clinical data from The Cancer Genome Atlas (TCGA) database (n=335) and Gene Expression Omnibus (GEO) database (n=865)...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196538/efficacy-and-safety-of-regorafenib-as-second-line-treatment-for-patients-with-hepatocellular-carcinoma-and-macrovascular-invasion-and-or-extrahepatic-metastasis
#12
JOURNAL ARTICLE
Yan Zhao, Weiling Liu, Lu Zheng, Sharad Goyal, Joy Awosika, Hailing Wang, Shujun Yang
BACKGROUND: Macrovascular invasion and(or) extrahepatic metastasis are the main clinical characteristics of Chinese patients with hepatocellular carcinoma (HCC) after entering the second-line treatment. The aim of this study was to explore the efficacy and safety of regorafenib as a second-line treatment for these patients with HCC. METHODS: We selected 253 patients with primary liver cancer who were treated in Henan Cancer Hospital from June 2017 to September 2020...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196537/-cyp1b1-promotes-colorectal-cancer-liver-metastasis-by-enhancing-the-growth-of-metastatic-cancer-cells-via-a-fatty-acids-dependent-manner
#13
JOURNAL ARTICLE
Lei Jin, Ju Huang, Lei Guo, Bo Zhang, Qin Li, Hui Li, Mincheng Yu, Peiyi Xie, Qiang Yu, Zheng Chen, Shuang Liu, Yongfeng Xu, Yongsheng Xiao, Ming Lu, Qinghai Ye
BACKGROUND: Liver metastasis (LM) accounts for most colorectal cancer (CRC)-related deaths. However, how metastatic CRC cells gain the ability to survive and grow in liver remains largely unknown. METHODS: First, we screened differentially expressed genes (DEGs) between LM and paired primary tumors (PTs) in Gene Expression Omnibus (GEO) database, and identified cytochrome P450 1B1 ( CYP1B1) as the only common differential gene. Then, we verified messenger RNA (mRNA) and protein expression level in clinical specimens...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196536/protective-effects-of-palbociclib-on-colitis-associated-colorectal-cancer
#14
JOURNAL ARTICLE
Li Yang, Jiani Gao, Yuqin Zhang, Eduardo A Perez, Yuchen Wu, Tianan Guo, Cong Li, Hao Wang, Ye Xu
BACKGROUND: Chronic or recurrent inflammatory injury to the intestinal mucosa is closely related to inflammation-related colorectal cancer (CRC). This study aimed to examine the protective effects of palbociclib, a stimulator of interferon genes (STING) antagonist, on colitis-related colorectal carcinogenesis. METHODS: Bioinformatic analyses, including Gene Ontology (GO) enrichment, gene set enrichment analysis (GSEA), and network analysis, were conducted. Male C57BL/6 mice were administered azoxymethane (AOM) and dextran sulfate sodium (DSS), followed by treatment with palbociclib for 6 weeks...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196535/oncological-role-of-surgical-resection-in-patients-with-pancreatic-ductal-adenocarcinoma-with-liver-only-synchronous-metastases-in-a-single-center-retrospective-study
#15
JOURNAL ARTICLE
Sohei Satoi, Tomohisa Yamamoto, Daisuke Hashimoto, So Yamaki, Yuki Matsui, Tsukasa Ikeura, Shogen Boku, Nobuhiro Shibata, Denys Tsybulskyi, Mitsugu Sekimoto
BACKGROUND: Surgical resection for liver-only synchronous metastases of pancreatic ductal adenocarcinoma remains controversial. We investigated the role of conversion surgery in patients with a favorable response to systemic chemotherapy. METHODS: Patients (n=49) were diagnosed liver-only synchronous metastases using staging laparoscopy or open laparotomy between 2007 and 2022. Clinical outcomes were retrospectively compared among patients who underwent conversion surgery (n=10), upfront surgery with or without short-term neoadjuvant chemotherapy (UpS/short NAC) for oligometastases and occult metastases limited to the liver (n=8), and chemotherapy only for resectable or borderline resectable disease with occult liver-only metastases (n=31)...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196534/the-efficacy-and-safety-of-endoscopic-mucosal-dissection-for-early-gastrointestinal-cancer-and-precancerous-lesions
#16
COMMENT
Qingbo Feng, Chang Yu, Ruoyi Li, Qiuju Ren, Fei Xie, Shengli Chen, Maijian Wang
No abstract text is available yet for this article.
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196533/two-families-with-gastric-adenocarcinoma-and-proximal-polyposis-of-the-stomach-gapps-case-reports-and-literature-review
#17
Takashi Sakuma, Tomohiro Sera, Rika Aoyama, Akinari Sawada, Hiroaki Kasashima, Kana Ogisawa, Haruka Bamba, Masakazu Yashiro
BACKGROUND: Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS), a hereditary gastric polyposis syndrome that presents with fundic gastric polyposis, is associated with an increased risk of gastric adenocarcinoma. The four patterns of point mutation in the adenomatous polyposis coli ( APC ) promoter 1B region have been identified as the cause of GAPPS. GAPPS was first reported in 2012, and only 33 families with GAPPS have been reported worldwide to date. Therefore, the clinical management for GAPPS are still controversial...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196532/patterns-and-kinetics-of-hepatocellular-carcinoma-relapse-post-liver-transplantation-oligorecurrence-and-role-of-local-therapies
#18
JOURNAL ARTICLE
Timothy A Lin, Nicole Paul, Harry Luu, Diana Cheung, Behnam Saberi, Shane Ottmann, Ahmet Gurakar, Mark Yarchoan, Amol Narang, Amy Kim, Jeffrey J Meyer
BACKGROUND: Amongst patients with recurrent hepatocellular carcinoma (HCC) post-liver transplantation, systemic therapy options may be limited by immunosuppression or poor performance status. Thus, we aimed to assess the impact of metastasis-directed therapy to all sites of disease (MDT-All) in HCC patients with limited disease recurrence [i.e., oligorecurrence (oligoM1)] post-transplantation and characterize pre-transplant characteristics associated with oligoM1. METHODS: In this retrospective cohort study, patients at a single institution with recurrent HCC post-liver transplantation were identified...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196531/prognostic-value-of-the-ratio-of-pretreatment-carcinoembryonic-antigen-to-tumor-volume-in-rectal-cancer
#19
JOURNAL ARTICLE
Zhiming Zeng, Decai Ma, Pan Zhu, Kexin Niu, Shuai Fu, Xiaohui Di, Junying Zhu, Peiyi Xie
BACKGROUND: As a commonly used biomarker in rectal cancer (RC), the prognostic value of carcinoembryonic antigen (CEA) remains underexplored. This study aims to evaluate the prognostic value of pretreatment CEA/tumor volume in RC. METHODS: This retrospective study included patients who underwent pretreatment magnetic resonance imaging (MRI) with histologically confirmed primary rectal adenocarcinoma from November 2012 to April 2018. Patients were divided into high-risk and low-risk groups according to the median values of CEA/Diapath (CEA to pathological diameter), CEA/DiaMRI (CEA to MRI tumor diameter), and CEA/VolMRI (CEA to MRI tumor volume)...
December 31, 2023: Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/38196530/postpartum-related-intrahepatic-cholangiocarcinoma-with-fgfr2-fusion-and-severe-hyperbilirubinemia-with-response-to-fgfr-inhibitor-pemigatinib-case-report-and-review
#20
Leslie Washburn, Amit Mahipal, Aminah Jatoi, Lisa Kottschade, Nguyen Tran
BACKGROUND: Cholangiocarcinoma during postpartum or pregnancy is a rare presentation. There are limited cases reported in the literature. Diagnosis can be delayed as presenting signs and symptoms may be attributed to pregnancy or postpartum state. CASE DESCRIPTION: We present the case of a 33-year-old postpartum woman with intrahepatic cholangiocarcinoma with severe hyperbilirubinemia who was found to have fibroblast growth factor receptor 2 ( FGFR2 )-adenosylhomocysteinase like 1 ( AHCYL1 ) fusion on next-generation sequencing (NGS)...
December 31, 2023: Journal of Gastrointestinal Oncology
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