journal
https://read.qxmd.com/read/38532900/roles-of-organokines-in-intervertebral-disc-homeostasis-and-degeneration
#1
REVIEW
Yuxin He, Sheng Liu, Hui Lin, Fan Ding, Zengwu Shao, Liming Xiong
The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532899/characterization-of-sensory-and-motor-dysfunction-and-morphological-alterations-in-late-stages-of-type-2-diabetic-mice
#2
JOURNAL ARTICLE
Ting Tian, Haofeng Li, Sensen Zhang, Maojun Yang
Diabetic neuropathy is the most common complication of diabetes and lacks effective treatments. Although sensory dysfunction during the early stages of diabetes has been extensively studied in various animal models, the functional and morphological alterations in sensory and motor systems during late stages of diabetes remain largely unexplored. In the current work, we examined the influence of diabetes on sensory and motor function as well as morphological changes in late stages of diabetes. The obese diabetic Leprdb/db mice (db/db) were used for behavioral assessments and subsequent morphological examinations...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532898/cushing-s-syndrome-during-pregnancy-two-case-reports
#3
Sumita Cholekho, Yuke Liu, Huiwen Tan
BACKGROUND: Cushing's syndrome (CS) during pregnancy is a rare endocrine disorder characterized by hypercortisolism, which is significantly associated with maternal-fetal complications. Despite its rarity, CS during pregnancy may be related to a high risk of complications for both the mother and fetus.The aim of the present case study is to update the diagnostic approach to CS during pregnancy and the therapeutic strategies for this medical condition to minimize maternal-fetal complications...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532897/correlation-between-seminal-plasma-biochemical-markers-and-semen-parameters-in-idiopathic-oligoasthenoteratospermia-identification-of-biomarkers-for-l-carnitine-therapy
#4
JOURNAL ARTICLE
Qilong Yuan, Ruifang Hong, Yunping Ni, Manbo Jiang, Juan Liu, Zhiqiang Chen, Dongyu Yang
BACKGROUND: L-carnitine therapy for idiopathic sperm abnormalities exhibits variable effectiveness, and currently, there are no established criteria to predict patient response. This study investigated correlations between seminal plasma markers and semen parameters to identify biomarkers that can guide indications for L-carnitine therapy indications in patients with idiopathic sperm abnormalities. METHODS: A retrospective review was conducted on 223 male patients with idiopathic oligoasthenoteratospermia, who sought medical attention at our clinic between January 2020 and October 2022...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532896/investigating-the-impact-of-elevated-urinary-trace-elements-on-non-alcoholic-fatty-liver-disease-using-vibration-controlled-transient-elastography
#5
JOURNAL ARTICLE
Chenxiao Wang, Xin Shang, Yu Fu, Panpan Guo, Ping Wang, Shuxun Yan
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a global public health concern. However, limited data are available on urinary trace elements and NAFLD caused by various exposure factors. This study aimed to investigate the relationship between the presence of 16 trace elements in urine and NAFLD using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: By utilizing the NHANES data from 2017 to 2018, 1613 participants who fulfilled the research criteria were identified from the initial pool of 2979 participants with available urine trace element detection data...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532895/cryptorchidism-and-puberty
#6
REVIEW
Wiwat Rodprasert, Helena E Virtanen, Jorma Toppari
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532894/developmental-potential-of-non-and-mono-pronuclear-zygotes-and-associated-clinical-outcomes-in-ivf-cycles
#7
JOURNAL ARTICLE
Mengyi Zhu, Qiyin Dong, Yurong Zhu, Yun Le, Tengfei Wang, Yuanping Zhou, Sheng Yang
PURPOSE: This study aims to evaluate the developmental potential of 0PN, 1PN, and 2PN zygotes in IVF cycles and compare their clinical outcomes. METHODS: We conducted a retrospective cohort study involving IVF patients. Blastocyst formation rates were assessed with 0PN, 1PN, and 2PN zygotes. Subsequently, we collected clinical outcome data following the transfer of these zygotes. RESULTS: The overall blastulation rate was similar between 0PN (29...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529400/causal-relationship-between-genetically-predicted-type-2-diabetes-mellitus-and-male-infertility
#8
JOURNAL ARTICLE
Cuihua Fan, Jiandong Zhang, Dongbiao Qiu
BACKGROUND: Diabetes mellitus (DM) stands as the most prevalent endocrine abnormality affecting the physiological systems and organs and impairing the male reproductive functions. Type 2 Diabetes Mellitus (T2DM), accounting for about 90-95% of DM, is closely associated with male infertility. However, the magnitude of the causal relationships between T2DM and male infertility remains unclear. The current investigation was to explore the causal relationship between T2DM and male infertility utilizing the Mendelian Randomization (MR) analysis...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529399/overlapping-action-of-t-3-and-t-4-during-xenopus-laevis-development
#9
JOURNAL ARTICLE
Alicia Tribondeau, David Du Pasquier, Médine Benchouaia, Corinne Blugeon, Nicolas Buisine, Laurent M Sachs
Thyroid hormones are involved in many biological processes such as neurogenesis, metabolism, and development. However, compounds called endocrine disruptors can alter thyroid hormone signaling and induce unwanted effects on human and ecosystems health. Regulatory tests have been developed to detect these compounds but need to be significantly improved by proposing novel endpoints and key events. The Xenopus Eleutheroembryonic Thyroid Assay (XETA, OECD test guideline no. 248) is one such test. It is based on Xenopus laevis tadpoles, a particularly sensitive model system for studying the physiology and disruption of thyroid hormone signaling: amphibian metamorphosis is a spectacular (thus easy to monitor) life cycle transition governed by thyroid hormones...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529398/exploring-the-potential-of-pheophorbide-a-a-chlorophyll-derived-compound-in-modulating-glut-for-maintaining-glucose-homeostasis
#10
JOURNAL ARTICLE
Saptadipa Paul, Anuma Pallavi, Nikhil R Gandasi
INTRODUCTION: Pheophorbide A, a chlorophyll-breakdown product, is primarily investigated for its anti-oxidant and anti-inflammatory activity. Recent reports on pheophorbide A have shown its potential in lowering blood glucose levels, thus leading to the exploration of its use in diabetes management. Literature has also shown its effect on enhanced insulin secretion, whereas its mechanism on glucose stimulated insulin secretion (GSIS) in pancreatic β cells remains unexplored. METHODS: In-silico and in-vitro investigations were used to explore the effect of pheophorbide A on class I glucose transporters (GLUTs)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529397/editorial-new-advances-on-hypothalamus-pituitary-stem-cell-biology
#11
EDITORIAL
Leonard Cheung, Shannon W Davis, Maria Ines Perez-Millan
No abstract text is available yet for this article.
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529396/safety-tolerability-pharmacokinetics-and-pharmacokinetic-pharmacodynamic-modeling-of-cetagliptin-in-patients-with-type-2-diabetes-mellitus
#12
JOURNAL ARTICLE
Chen Zhou, Sufeng Zhou, Jie Wang, Lijun Xie, Zhanhui Lv, Yuqing Zhao, Lu Wang, Huan Luo, Daosheng Xie, Feng Shao
AIMS: To evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of cetagliptin (CAS number:2243737-33-7) in Chinese patients with type 2 diabetes mellitus (T2DM). A population PK/PD model was developed to quantify the PK and PD characteristics of cetagliptin in patients. MATERIALS AND METHODS: 32 Chinese adults with T2DM were enrolled in this study. The subjects were randomly assigned to receive either cetagliptin (50 mg or 100 mg), placebo, or sitagliptin (100 mg) once daily for 14 days...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529395/clinical-features-of-early-onset-type-2-diabetes-and-its-association-with-triglyceride-glucose-body-mass-index-a-cross-sectional-study
#13
JOURNAL ARTICLE
Yanjuan Jiang, Xiaoyang Lai
OBJECTIVE: The incidence of early-onset type 2 diabetes (T2D) has increased significantly, with insulin resistance (IR) and obesity being the main drivers of its onset. This study aims to investigate the clinical characteristics of early-onset T2D and its association with triglyceride glucose body mass index (TyG-BMI), an emerging surrogate of IR. METHODS: A total of 1000 adults newly diagnosed with T2D were enrolled and divided into early-onset T2D (18~40 years, N=500) and late-onset T2D groups (≥40 years, N=500)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529394/ultrasound-guided-fine-needle-aspiration-thyroglobulin-in-the-diagnosis-of-lymph-node-metastasis-of-differentiated-papillary-thyroid-carcinoma-and-its-influencing-factors
#14
JOURNAL ARTICLE
Xuejiao Su, Lei Shang, Can Yue, Buyun Ma
BACKGROUND: Ultrasound-guided fine needle aspiration thyroglobulin (FNA-Tg) is recommended for the diagnosis of lymph node metastasis (LNM) in differentiated thyroid cancer (DTC), but its optimal cutoff value remains controversial, and the effect of potential influencing factors on FNA-Tg levels is unclear. METHOD: In this study, a retrospective analysis was conducted on 281 patients diagnosed with DTC, encompassing 333 lymph nodes. We analyze the optimal cutoff value and diagnostic efficacy of FNA-Tg, while also evaluating the potential influence of various factors on FNA-Tg...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529393/sirtuin-1-serum-concentration-in-healthy-children-dependence-on-sex-age-stage-of-puberty-body-weight-and-diet
#15
JOURNAL ARTICLE
Anna Fedorczak, Andrzej Lewiński, Renata Stawerska
INTRODUCTION: Sirtuin 1 (SIRT1) is known to be involved in sensing cellular energy levels and regulating energy metabolism. This study aimed to evaluate fasting serum SIRT1 levels in healthy children, and to analyse the influence of age, sex, puberty, body weight, height, and diet on its concentration. METHODS: 47 healthy children aged 4-14 with weight and height within normal range and no chronic disease were included into the study. Fasting serum SIRT1 concentrations were estimated by Enzyme Linked Immunosorbent Assay (ELISA)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529392/the-thrombotic-risk-in-cushing-s-syndrome-questions-answers-and-the-algorithm-to-consider-in-its-assessment-part-i-thrombotic-risk-not-related-to-surgery
#16
REVIEW
Agata Hanna Bryk-Wiązania, Mari Minasyan, Renata Świątkowska-Stodulska, Anetta Undas, Alicja Hubalewska-Dydejczyk, Susan M Webb, Elena Valassi, Aleksandra Gilis-Januszewska
INTRODUCTION: Recently, it has been reported that there is a great diversity in strategies used for thromboprophylaxis in patients with Cushing's syndrome (CS). An aim of this review was to discuss these practices in light of the existing data on the thrombotic risk in patients with CS and guidelines for medically ill patients. METHODS: The four relevant topics and questions on thrombotic risk in CS were identified. The current guidelines on prevention and diagnosis of venous thromboembolism (VTE) were reviewed for the answers...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529391/total-weight-loss-rather-than-preoperative-body-mass-index-correlates-with-remission-of-irregular-menstruation-after-sleeve-gastrectomy-in-patients-with-polycystic-ovary-syndrome
#17
JOURNAL ARTICLE
Yian Zhao, Sisi Xiong, Teng Liu, Jiaxin Shu, Tao Zhu, Shumin Li, Mingwei Zhong, Shigang Zhao, Xin Huang, Shaozhuang Liu
INTRODUCTION: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. Some retrospective studies with small sample sizes have reported that bariatric metabolic surgery is effective in remission of irregular menstruation in patients with PCOS and obesity. However, the correlation between preoperative body mass index (BMI), postoperative weight loss, and remission of irregular menstruation in patients with obesity and PCOS after sleeve gastrectomy (SG) is lack of consensus...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529390/a-lactate-metabolism-related-signature-predicting-patient-prognosis-and-immune-microenvironment-in-ovarian-cancer
#18
JOURNAL ARTICLE
Linhua Zhu, Zhuoqun Lin, Kai Wang, Jiaxin Gu, Xiaojing Chen, Ruizhe Chen, Lingfang Wang, Xiaodong Cheng
INTRODUCTION: Ovarian cancer (OV) is a highly lethal gynecological malignancy with a poor prognosis. Lactate metabolism is crucial for tumor cell survival, proliferation, and immune evasion. Our study aims to investigate the role of lactate metabolism-related genes (LMRGs) in OV and their potential as biomarkers for prognosis, immune microenvironment, and immunotherapy response. METHODS: Ovarian samples were collected from the TCGA cohort. And 12 lactate-related pathways were identified from the MsigDB database...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529389/independent-association-of-general-and-central-adiposity-with-risk-of-gallstone-disease-observational-and-genetic-analyses
#19
JOURNAL ARTICLE
Min Zhang, Ye Bai, Yutong Wang, Huijie Cui, Wenqiang Zhang, Li Zhang, Peijing Yan, Mingshuang Tang, Yunjie Liu, Xia Jiang, Ben Zhang
BACKGROUND: General obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat distribution on GSD. METHODS: We first investigated the observational association of central adiposity, characterized by waist-to-hip ratio (WHR), with GSD risk using data from UK Biobank (N=472,050). We then explored the genetic relationship using summary statistics from the largest genome-wide association study of GSD ( ncase =43,639, ncontrol =506,798) as well as WHR, with and without adjusting for body mass index (BMI) (WHR: n =697,734; WHRadj BMI: n =694,649)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529388/cost-effective-prognostic-evaluation-of-breast-cancer-using-a-star-nomogram-model-based-on-routine-blood-tests
#20
JOURNAL ARTICLE
Caibiao Wei, Yihua Liang, Dan Mo, Qiumei Lin, Zhimin Liu, Meiqin Li, Yuling Qin, Min Fang
BACKGROUND: Breast cancer (BC) is the most common and prominent deadly disease among women. Predicting BC survival mainly relies on TNM staging, molecular profiling and imaging, hampered by subjectivity and expenses. This study aimed to establish an economical and reliable model using the most common preoperative routine blood tests (RT) data for survival and surveillance strategy management. METHODS: We examined 2863 BC patients, dividing them into training and validation cohorts (7:3)...
2024: Frontiers in Endocrinology
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