journal
https://read.qxmd.com/read/39010904/maternal-bisphenols-exposure-and-thyroid-function-in-children-a-systematic-review-and-meta-analysis
#1
JOURNAL ARTICLE
Jiani Liu, Min Tian, Haiyue Qin, Danrong Chen, Sabitina Mrisho Mzava, Xu Wang, Francis Manyori Bigambo
BACKGROUND: Evidence from animal experiments and epidemiological studies has reported controversial results about the effects of prenatal bisphenols (BPs) exposure on childhood thyroid function. This study aims to explore the associations of prenatal exposure to BPs with thyroid-related hormones (THs) in newborns and early childhood, with a particular focus on the sex-dependent and exposure level effects. METHODS: Correlated studies were systematically searched from PubMed, Web of Science, Medline, Cochrane, and Embase until February 21, 2024...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010903/variety-of-genetic-defects-in-gnrh-and-hypothalamic-pituitary-signaling-and-development-in-normosmic-patients-with-ihh
#2
JOURNAL ARTICLE
Małgorzata Kałużna, Bartłomiej Budny, Michał Rabijewski, Agnieszka Dubiel, Małgorzata Trofimiuk-Müldner, Kosma Szutkowski, Adam Piotrowski, Elżbieta Wrotkowska, Alicja Hubalewska-Dydejczyk, Marek Ruchała, Katarzyna Ziemnicka
INTRODUCTION: Normosmic isolated hypogonadotropic hypogonadism (nIHH) is a clinically and genetically heterogeneous disorder. Deleterious variants in over 50 genes have been implicated in the etiology of IHH, which also indicates a possible role of digenicity and oligogenicity. Both classes of genes controlling GnRH neuron migration/development and hypothalamic/pituitary signaling and development are strongly implicated in nIHH pathogenesis. The study aimed to investigate the genetic background of nIHH and further expand the genotype-phenotype correlation...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010902/the-pathogenic-mechanism-of-monosodium-urate-crystal-induced-kidney-injury-in-a-rat-model
#3
JOURNAL ARTICLE
Delun Li, Yimeng Li, Xuesheng Chen, Jianting Ouyang, Danyao Lin, Qiaoru Wu, Xinwen Fu, Haohao Quan, Xiaowan Wang, Shouhai Wu, Siyu Yuan, Anqi Liu, Jiaxiong Zhao, Xiaowu Liu, Gangxing Zhu, Chuang Li, Wei Mao
OBJECTIVE: (MSU) crystals usually in the kidney tubules especially collecting ducts in the medulla. Previous animal models have not fully reproduced the impact of MSU on kidneys under non-hyperuricemic conditions. METHODS: In the group treated with MSU, the upper pole of the rat kidney was injected intrarenally with 50 mg/kg of MSU, while the lower pole was injected with an equivalent volume of PBS solution. The body weight and kidney mass of the rats were observed and counted...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010901/genetic-and-non-genetic-factors-in-prediction-of-early-pubertal-development-in-chinese-girls
#4
JOURNAL ARTICLE
Weiqin Li, Yuexin Du, Lingyan Feng, Panpan Song, Leishen Wang, Shuang Zhang, Wei Li, Dandan Zhu, Huikun Liu
OBJECTIVE: The objective of this study is to develop a combined predictive model for early pubertal development (EPD) in girls based on both non-genetic and genetic factors. METHODS: The case-control study encompassed 147 girls diagnosed with EPD and 256 girls who exhibited normal pubertal development. The non-genetic risk score (NGRS) was calculated based on 6 independent biochemical predictors screened by multivariate logistic regressions, and the genetic risk score (GRS) was constructed using 28 EPD related single-nucleotide polymorphisms (SNPs)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010900/serum-insl3-measured-by-lc-ms-ms-in-pubertal-girls-and-in-girls-with-precocious-puberty-during-gnrh-agonist-treatment
#5
JOURNAL ARTICLE
Jakob Albrethsen, Casper P Hagen, Anders Juul
INTRODUCTION: The peptide hormone Insulin-like Factor 3 (INSL3) is a biomarker of testicular Leydig cells in the male but is also expressed by the theca cells of the ovaries. With the advent of sensitive assays INSL3 can be quantified in female circulation, and we suggest that circulating INSL3 is a novel biomarker for pubertal development in girls. The aim of the study is to quantify INSL3 by LC-MS/MS in sera from normal girls during pubertal transition, and during gonadal suppression by GnRH agonist therapy in girls with central precocious puberty (CPP)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010899/association-between-triglyceride-glucose-index-and-hyperuricemia-a-new-evidence-from-china-and-the-united-states
#6
JOURNAL ARTICLE
Ruoyu Gou, Danni Dou, Mi Tian, Xiaoyu Chang, Yonggang Zhao, Xin Meng, Guanghua Li
BACKGROUND: Hyperuricemia (HUA) is a glo\bal public health problem. The etiology of HUA is complex and efficient and accurate assessment metrics are still lacking when conducting large-scale epidemiologic screening. The aim of this study was to evaluate the association of the triglyceride glucose (TyG) index, TyG-body mass index (BMI), TyG-waist-to-height ratio (WHtR) with the risk of HUA. METHODS: Based on data collected from the National Health and Nutrition Examination Survey (NHANES) in the United States and the China Health and Aging Longitudinal Study (CHARLS) in China, a total of 14,286 U...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010898/short-term-effect-of-low-dose-roxadustat-combined-with-erythropoiesis-stimulating-agent-treatment-for-erythropoietin-resistant-anemia-in-patients-undergoing-maintenance-hemodialysis
#7
JOURNAL ARTICLE
Qiaoying Xu, Jingjing Huang, Qingzhen Liu, Xueling Wang, Haiying Liu, Yan Song, Fulin Dou, Shasha Lv, Gang Liu
BACKGROUND: Erythropoietin resistance is present in some patients with chronic kidney disease, especially in those undergoing hemodialysis, and is often treated using roxadustat rather than iron supplements and erythropoiesis-stimulating agents (ESAs). However, some patients cannot afford full doses of roxadustat. This retrospective study investigated the efficacy of low-dose roxadustat combined with recombinant human erythropoietin (rhuEPO) therapy in 39 patients with erythropoietin-resistant renal anemia undergoing maintenance hemodialysis (3-4 sessions/week)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010897/microbiological-profile-of-diabetic-foot-infections-in-china-and-worldwide-a-20-year-systematic-review
#8
JOURNAL ARTICLE
Yu-Dun Qu, Shuan-Ji Ou, Wei Zhang, Jia-Xuan Li, Chang-Liang Xia, Yang Yang, Jia-Bao Liu, Yun-Fei Ma, Nan Jiang, Ye-Yang Wang, Bo Chen, Bin Yu, Yong Qi, Chang-Peng Xu
INTRODUCTION: Pathogens causing diabetic foot infections (DFIs) vary by region globally; however, knowledge of the causative organism is essential for effective empirical treatment. We aimed to determine the incidence and antibiotic susceptibility of DFI pathogens worldwide, focusing on Asia and China. METHODS: Through a comprehensive literature search, we identified published studies on organisms isolated from DFI wounds from January 2000 to December 2020. RESULTS: Based on our inclusion criteria, we analyzed 245 studies that cumulatively reported 38,744 patients and 41,427 isolated microorganisms...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39010896/association-between-maternal-lipid-profiles-and-vitamin-d-status-in-second-trimester-and-risk-of-lga-or-sga-a-retrospective-study
#9
JOURNAL ARTICLE
Xianhua Zheng, Kefeng Lai, Chengyi Liu, Yuan Chen, Xiaodan Zhang, Weixiang Wu, Mingyong Luo, Chunming Gu
BACKGROUND: Accumulating evidence has linked dyslipidemia during pregnancy to the risk of delivering infants born either large for gestational age (LGA) or small for gestational age (SGA). However, the effects of the vitamin D status on these relationships require further investigation. This study investigated whether the relationship between lipid profiles and the risk of LGA or SGA was influenced by vitamin D levels during the second trimester. METHODS: Maternal lipid profile levels, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and vitamin D levels, were measured in a cohort of 6,499 pregnant women during the second trimester...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006368/decoding-connections-in-the-european-population-serum-uric-acid-sex-hormone-binding-globulin-total-testosterone-estradiol-and-female-infertility-advanced-bidirectional-and-mediative-mendelian-randomization
#10
JOURNAL ARTICLE
Zilong Tan, Jianwu Shen, Yuxiao Huang, Junru Li, Mengdi Ding, Aochuan Sun, Jing Hong, Yan Yang, Sheng He, Xueying Zhu, Ran Luo
BACKGROUND: Despite observational links between serum uric acid (SUA), sex hormone-related phenotypes, and female infertility, the causality behind these associations remains uncertain. OBJECTIVE: This study utilizes Bidirectional Two-Sample and Mediation Mendelian Randomization to explore the causal relationships and mediation effects of sex hormone-binding globulin (SHBG), total testosterone (TT), and estradiol on these associations. METHODS: We analyzed single-nucleotide polymorphisms (SNPs) associated with SUA and sex hormone levels using data from large-scale GWAS of European populations...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006367/nutritional-and-exercise-interventions-to-improve-conception-in-women-suffering-from-obesity-and-distinct-nosological-entities
#11
REVIEW
Evdoxia Gitsi, Sarantis Livadas, Georgia Argyrakopoulou
Infertility among women, particularly those living with obesity, presents a multifaceted challenge with implications for reproductive health worldwide. Lifestyle interventions, mainly focusing on weight loss, have emerged as promising strategies to improve fertility outcomes in this population. This review aims to explore the effectiveness of various lifestyle interventions, encompassing dietary modifications and exercise regimens, in enhancing fertility outcomes among women with obesity and associated conditions such as polycystic ovary syndrome, congenital adrenal hyperplasia, type 2 diabetes mellitus, premenopause, hypothyroidism and eating disorders...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006366/individualized-luteal-phase-support-in-frozen-thawed-embryo-transfer-after-intramuscular-progesterone-administration-might-rectify-live-birth-rate
#12
JOURNAL ARTICLE
Fazilet Kübra Boynukalin, Yusuf Aytac Tohma, Zalihe Yarkıner, Meral Gultomruk, Gürkan Bozdag, Sinan Ozkavukcu, Mustafa Bahçeci, Berfu Demir
BACKGROUND: The serum P concentrations are suggested to have an impact on pregnancy outcome. However there is no consensus about the optimal progesterone cut-off during the luteal phase. Few studies evaluated the effectiveness of a "rescue protocol" for low serum P concentrations and most of these studies used vaginal progesterone administration. There is paucity of data on the effectiveness of rescue protocol using intramuscular progesterone (IM-P) in frozen-thawed embryo transfer (FET)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006365/fatty-infiltration-in-the-musculoskeletal-system-pathological-mechanisms-and-clinical-implications
#13
REVIEW
Yihua Zhu, Yue Hu, Yalan Pan, Muzhe Li, Yuanyuan Niu, Tianchi Zhang, Haitao Sun, Shijie Zhou, Mengmin Liu, Yili Zhang, Chengjie Wu, Yong Ma, Yang Guo, Lining Wang
Fatty infiltration denotes the anomalous accrual of adipocytes in non-adipose tissue, thereby generating toxic substances with the capacity to impede the ordinary physiological functions of various organs. With aging, the musculoskeletal system undergoes pronounced degenerative alterations, prompting heightened scrutiny regarding the contributory role of fatty infiltration in its pathophysiology. Several studies have demonstrated that fatty infiltration affects the normal metabolism of the musculoskeletal system, leading to substantial tissue damage...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006364/triglyceride-glucose-index-as-a-potential-predictor-of-major-adverse-cardiovascular-and-cerebrovascular-events-in-patients-with-coronary-heart-disease-complicated-with-depression
#14
JOURNAL ARTICLE
Weizhe Zhao, Junqing Wang, Dong Chen, Wanli Ding, Jiqiu Hou, YiWei Gui, Yunlin Liu, Ruiyi Li, Xiang Liu, Zhiqi Sun, Haibin Zhao
BACKGROUND: Triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance and metabolic abnormalities, which is closely related to the prognosis of a variety of diseases. Patients with both CHD and depression have a higher risk of major adverse cardiovascular and cerebrovascular events (MACCE) and worse outcome. TyG index may be able to predict the adverse prognosis of this special population. METHODS: The retrospective cohort study involved 596 patients with both CHD and depression between June 2013 and December 2023...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006363/causal-relationships-exist-between-polycystic-ovary-syndrome-and-adverse-pregnancy-and-perinatal-outcomes-a-mendelian-randomization-study
#15
JOURNAL ARTICLE
Yuanlin Ma, Jiahao Cai, Lok-Wan Liu, Tianrui Wen, Weina Huang, Wenhui Hou, Zixin Wei, Yan Xu, Yanwen Xu, Yizi Wang, Qingyun Mai
INTRODUCTION: Previous observational studies have shown that polycystic ovary syndrome (PCOS) was associated with adverse pregnancy and perinatal outcomes. However, it remains controversial whether PCOS is an essential risk factor for these adverse pregnancy and perinatal outcomes. We aimed to use instrumental variables in a two-sample Mendelian randomization (MR) study to determine causality between PCOS and adverse pregnancy and perinatal outcomes. MATERIALS AND METHODS: Summary statistics were extracted from a recent genome-wide association study (GWAS) meta-analysis conducted in PCOS, which included 10,074 cases and 103,164 controls of European ancestry...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006362/effects-of-weight-loss-rate-on-myostatin-and-follistatin-dynamics-in-patients-with-obesity
#16
JOURNAL ARTICLE
Satoshi Kurose, Katsuko Onishi, Takumi Miyauchi, Kazuhisa Takahashi, Yutaka Kimura
BACKGROUND: Exercise-induced cytokines involved in controlling body composition include myostatin (MST) and follistatin (FST), both of which are influenced by physical activity. This study investigated changes in body composition and physical activity during a weight loss program, as well as the impact on serum MST and FST levels at various weight loss rates. METHODS: A total of 126 patients with obesity who completed a 6-month weight loss program were divided into three groups based on weight loss rate (%): low (< 3%), middle (3-10%), and high (≥10%)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006361/maternal-vitamin-a-and-d-status-in-second-and-third-trimester-of-pregnancy-and-bone-mineral-content-in-offspring-at-nine-years-of-age
#17
RANDOMIZED CONTROLLED TRIAL
Astrid Kamilla Stunes, Mats Peder Mosti, Miriam Katarina Gustafsson, Torunn Børsting, Per Medbøe Thorsby, Signe Nilssen Stafne, Unni Syversen
INTRODUCTION: Maternal nutritional and vitamin status during pregnancy may have long-term effects on offspring health and disease. The aim of this study was to examine the associations between maternal vitamin A and D status in pregnancy and offspring bone mineral content (BMC) at nine years of age. METHODS: This is a post-hoc study of a randomized control trial including 855 pregnant women from two Norwegian cities; Trondheim and Stavanger. The women were randomized into an exercise intervention or standard antenatal care...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006360/effect-of-the-degree-of-follicular-diameter-%C3%A2-18mm-differentiation-on-the-day-of-hcg-administration-to-the-outcome-of-controlled-ovarian-hyperstimulation-coh
#18
JOURNAL ARTICLE
Hongyi Xu, Qi Chen, Jiarong Tian, Xin Chen, Xin Zhang, Xin Li, Ying Wu, Changjun Zhang, Ying Zhang
OBJECTIVE: To explore the impact of the level of differentiation in a minimum of two follicles with a diameter of ≥18 mm on the outcome of controlled ovarian hyperstimulation on the day of human chorionic gonadotropin (hCG) administration. METHODS: Single-center data from January 2018 to December 2021 was retrospectively analyzed for 1,199 patients with fresh embryo transfer for assisted reproduction. The absolute value of the standard deviation of the follicle size of at least 2 follicles ≥18 mm in diameter in both ovaries on the day of hCG was taken as the degree of differentiation of the dominant follicle after ovulation induction, based on the standard deviation response to the degree of dispersion of the data...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006359/the-clinical-characteristics-and-pathogenic-variants-of-primary-pigmented-nodular-adrenocortical-disease-in-210-patients-a-systematic-review
#19
JOURNAL ARTICLE
Julian Sun, Lin Ding, Liping He, Hang Fu, Rui Li, Jing Feng, Jianjun Dong, Lin Liao
AIMS: Primary pigmented nodular adrenocortical disease (PPNAD), as a rare kind of Cushing's syndrome, is frequently misdiagnosed. To get a better understanding of the disease, we analyzed the clinical characteristics and pathogenic variants of PPNAD. METHODS: Databases were searched, and the pathogenic variants and clinical manifestations of patients were summarized from the relevant articles. RESULTS: A total of 210 patients in 86 articles were enrolled with a median age of 22 and a female-to-male ratio of 2:1...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/39006358/corrigendum-trends-in-acupuncture-for-infertility-a-scoping-review-with-bibliometric-and-visual-analysis
#20
Ziyu Tian, Chongyang Zhang, Xing Liao, Sihong Yang, Yuying Hong, Anni Shi, Fei Yan, Ting Pan, Jiajia Zhang, Yan Meng, Nicola Robinson, Peng Bai, Weijuan Gang
[This corrects the article DOI: 10.3389/fendo.2024.1351281.].
2024: Frontiers in Endocrinology
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