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Clinics and Research in Hepatology and Gastroenterology

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https://read.qxmd.com/read/30773354/domino-liver-transplantation-the-risk-of-disease-recurrence
#1
Filoména Conti, Fanny Mochel, Yvon Calmus
No abstract text is available yet for this article.
February 14, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30772328/predictive-criteria-of-response-to-endoscopic-treatment-for-severe-strictures-in-primary-sclerosing-cholangitis
#2
Nora Cazzagon, Olivier Chazouillères, Christophe Corpechot, Sanaâ El Mouhadi, Edouard Chambenois, Benoit Desaint, Ulriikka Chaput, Sara Lemoinne, Lionel Arrivé
BACKGROUND: The aim of this study was to identify predictive criteria of improvement after endoscopic treatment (ET) for severe strictures of extrahepatic bile ducts in patients with primary sclerosing cholangitis (PSC). METHODS: PSC patients who had at least one ET for severe stricture were included. Features of magnetic resonance cholangiography (MRC), performed before ET, were evaluated according to a standard model of interpretation, and a radiologic qualitative score of probability of improvement after ET was built...
February 13, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30772327/clinical-and-psychological-characteristics-of-patients-with-globus
#3
Michel Bouchoucha, Noëlle Girault-Lidvan, Maria Hejnar, Florence Mary, Gheorges Airinei, Robert Benamouzig
BACKGROUND/AIMS: Psychological factors are involved in many functional gastrointestinal disorders including globus. The aim of the present study was to assess the clinical and psychological correlates associated with globus. PATIENTS AND METHODS: 707 patients (69% female, 45.2 ± 16.5 years, BMI 27.2 ± 11.7 kg/m2 ) filled an MMPI-2 questionnaire and a standard Rome III clinical questionnaire and were included in this cross sectional study. Data analysis was performed using a univariate analysis and a multivariate logistic regression with a backwards selection procedure on significant scales after a univariate analysis...
February 13, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30770336/non-alcoholic-fatty-liver-disease-causes-dissociated-changes-in-metabolic-liver-functions
#4
Peter Lykke Eriksen, Michael Sørensen, Henning Grønbæk, Stephen Hamilton-Dutoit, Hendrik Vilstrup, Karen Louise Thomsen
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a major health concern affecting 25% of the world's population. It is generally held that a fatty liver does not influence liver function, but quantitative measurements of metabolic liver functions have not been systematically performed. We aimed to study selected hepatocellular metabolic functions in patients with different stages of NAFLD. METHODS: Twenty-five non-diabetic, biopsy-proven NAFLD patients [12 with simple steatosis; 13 with non-alcoholic steatohepatitis (NASH)] and ten healthy controls were included in a cross-sectional study...
February 12, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30745167/cold-guillotine-of-adherent-clot-in-delayed-post-polypectomy-bleeding
#5
Vincent Zimmer
No abstract text is available yet for this article.
February 7, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30737024/is-laparoscopy-contraindicated-for-advanced-gallbladder-cancer
#6
LETTER
Jun-Ke Wang, Zhen-Ru Wu, Hai-Jie Hu, Fu-Yu Li
No abstract text is available yet for this article.
February 5, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30737023/liver-and-kidney-function-in-refractory-heart-failure-the-narrow-gate-to-achieve-post-transplant-survival
#7
EDITORIAL
Marco Masetti, Luciano Potena
Substantial evidence is underscoring the importance of a combined assessment of liver and kidney function in patients with refractory heart failure, to stratify early post- heart transplant risk: multi-organ dysfunction, while identifying sickest patients on the list is also associated with a high risk of post transplant complications. In this issue of the Journal, Dr. Lebray provides an analysis of combined kidney and liver function patients undergoing heart transplant, identifying potential boundaries for futility of transplantation, because of excessive post-operative risk...
February 5, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30737022/psychosocial-outcome-and-resilience-after-paediatric-liver-transplantation-in-young-adults
#8
Katrin Mayer, Norman Junge, Imke Goldschmidt, Christoph Leiskau, Thomas Becker, Frank Lehner, Nicolas Richter, Rolf van Dick, Ulrich Baumann, Eva-Doreen Pfister
BACKGROUND AND OBJECTIVE: The long-term psychosocial outcome of young adults after paediatric liver transplantation (LT) was investigated with the focus on day-to-day living. We aimed to capture patients' subjective perceptions of well-being and autonomy based on key physical outcome parameters. METHODS: All patients following paediatric LT at Hannover Medical School born before 2002 with a post-transplant follow-up of at least four years were included in this study...
February 5, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30713033/pre-treatment-with-fk506-reduces-hepatic-ischemia-reperfusion-injury-in-rats
#9
Feng Chen, Ya-Min Zhang, Jing-Tao Wang, Jian Wang, Zi-Lin Cui, Zi-Rong Liu
AIM: The study is aimed to investigate the protective effects and possible mechanism of tacrolimus (FK506) pre-treatment in hepatic ischemia-reperfusion injury in rats. METHODS: The rats were randomly assigned into four groups, which were S, IR, L and H group, and then all groups were subjected to 60min of 70% partial warm liver ischemia, except S group. Rats in the L and H group were pre-treated with two different doses FK506 at 60min before ischemia. The rats of the IR group received an identical volume of normal saline...
January 31, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30713032/early-high-levels-of-regulatory-t-cells-and-t-helper-1-may-predict-the-progression-of-recurrent-hepatitis-c-after-liver-transplantation
#10
K Ghazal, O Morales, C Barjon, G Dahlqvist, L Aoudjehane, L Ouaguia, N Delhem, F Conti
BACKGROUND: Immune response failure against hepatitis C virus (HCV) has been associated with an increased regulatory T cell (Treg) activity. After liver transplantation (LT), 80% of patients experience an accelerated progression of hepatitis C recurrence. The aim of this work was to assess the involvement of Tregs, T helper (Th) 1, 2 and 17 cells in recurrent hepatitis C. METHODS: Peripheral blood cells obtained before and one month after LT from 22 recipients were analysed...
January 31, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30709757/intraductal-deployment-of-two-fully-covered-metallic-stents-for-anastomotic-strictures-following-living-donor-liver-transplantation
#11
Ben Warner, Deepak Joshi, Michael Heneghan, Parthi Srinivasan, Andreas Prachalias, Phillip Harrison
No abstract text is available yet for this article.
January 29, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30686691/incidence-and-characteristics-of-young-onset-colorectal-cancer-in-the-united-states-an-analysis-of-seer-data-collected-from-1988-to-2013
#12
Weibing Wang, Wenbin Chen, Jianjiang Lin, Qinsong Shen, Xile Zhou, Caizhao Lin
BACKGROUND: The incidence of colorectal cancer (CRC) has significantly increased in adults < 50 years old who are below the screening age. OBJECTIVES: The primary objective was to evaluate the age-standardized incidence (ASI) of young-onset CRC from 1988 to 2013. The secondary objective was to assess factors associated with cancer-specific death (CSD). METHODS: We accessed data of 64,854 CRC patients (20-49 years old) from the United States Surveillance, Epidemiology, and End Results Program (SEER) database...
January 24, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30685128/cap-assisted-underwater-endoscopic-mucosal-resection-of-an-anorectal-mucosal-prolapse-polyp
#13
Vincent Zimmer, Bert Bier
No abstract text is available yet for this article.
January 23, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30683632/correlation-between-the-depdc5-rs1012068-polymorphism-and-the-risk-of-hbv-related-hepatocellular-carcinoma
#14
Wenxuan Liu, Ning Ma, Dongqiang Zhao, Xia Gao, Xiaolin Zhang, Lei Yang, Liu Dianwu
INTRODUCTION: HBV and/or HCV infection is the main cause of hepatocellular carcinoma (HCC), but the molecular mechanisms by which HBV promotes HCC are not clear. In 2011, the result of a GWAS revealed a common variant of DEPDC5 affected HCC susceptibility in patient with chronic HCV infection in Japan. This study investigated the correlation between DEPDC5 polymorphism and HBV-related HCC. MATERIALS AND METHODS: 1289 samples of Han population were involved in northern China and peripheral blood samples were obtained, including 506 healthy controls, 217 Hepatitis B chronic (CHB) and 258 liver cirrhosis (LC), and 308 HBV-related HCC patients...
January 22, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30670355/hbsag-levels-as-a-guide-for-finite-treatment-duration-of-chronic-hepatitis-b
#15
LETTER
Dzhamal Abdurakhmanov, Elhan Ibragimov, Teona Rozina, Elena Nikulkina, Natalya Mazurchik
No abstract text is available yet for this article.
January 19, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30635235/combined-heart-and-liver-transplantation-state-of-knowledge-and-outlooks
#16
REVIEW
Pascal Lebray, Shaida Varnous
Various types of liver impairment have been described in patients with end-stage heart failure who are awaiting heart transplantation. The liver impairment may be severe, characterized by a high model for end-stage liver disease (MELD) Score and/or the presence of ascites, both of which are associated with a high risk of failure after single heart transplantation. A liver function assessment is therefore necessary before registration on the heart transplant list, moreover in case of long-developing heart failure, such as with congenital heart disease or in the presence of risk factors for chronic liver disease including excessive alcohol consumption, metabolic syndrome or chronic viral hepatitis B or C...
January 8, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30616879/hcv-infected-dialysis-patients-history-is-changing
#17
EDITORIAL
Lucia Parlati, Stanislas Pol
No abstract text is available yet for this article.
January 4, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30612958/assessment-of-liver-fibrosis-by-transient-elastography-fibroscan-%C3%A2-in-patients-with-a1at-deficiency
#18
Olivier Guillaud, Jérôme Dumortier, Julie Traclet, Lioara Restier, Philippe Joly, Colette Chapuis-Cellier, Alain Lachaux, Jean François Mornex
BACKGROUND: Alpha-1-antitrypsin deficiency (A1ATD) is a common genetic condition which predisposes to emphysema and liver disorders. It is estimated that 10-15% of homozygous individuals for the Z allele (PiZZ) may develop liver fibrosis. The optimal modalities to detect liver disease in PiZZ adult patients need to be defined. The aim of this prospective study was to perform a systematic non-invasive evaluation of the liver fibrosis by elastometry using Fibroscan® in a cohort of A1ATD patients with emphysema...
January 3, 2019: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30594597/autoimmune-hepatitis-in-patients-with-multiple-sclerosis-the-role-of-immunomodulatory-treatment
#19
Eirini I Rigopoulou, Sofia Gyftaki, Pinelopi Arvaniti, Vana Tsimourtou, George K Koukoulis, Georgios Hadjigeorgiou, George N Dalekos
BACKGROUND: Development of autoimmune hepatitis (AIH) has been sporadically reported in patients with multiple sclerosis (MS) either concurrently or after treatment with immunomodulatory drugs, including interferon-beta (IFN-β) and steroids. AIM: To report a large cohort of 14 patients with MS diagnosed with AIH during an assessment of deranged liver function tests (LFTs). PATIENTS AND METHODS: From 2005 to 2017, we prospectively identified 14 (13 women) patients with MS who suffered also from AIH after investigation in our department for the presence of deranged LFTs...
December 26, 2018: Clinics and Research in Hepatology and Gastroenterology
https://read.qxmd.com/read/30594596/sofosbuvir-directly-promotes-the-clonogenic-capability-of-human-hepatocellular-carcinoma-cells
#20
LETTER
Jiaye Liu, Wanlu Cao, Buyun Ma, Meng Li, Maikel P Peppelenbosch, Qiuwei Pan
No abstract text is available yet for this article.
December 26, 2018: Clinics and Research in Hepatology and Gastroenterology
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