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Journal of Ophthalmic Inflammation and Infection

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https://read.qxmd.com/read/30806850/non-paraneoplastic-autoimmune-retinopathy-multimodal-testing-characteristics-of-13-cases
#1
Saira Khanna, Aline Martins, Zackery Oakey, Mihai Mititelu
BACKGROUND: Non-paraneoplastic autoimmune retinopathy (npAIR) is a rare autoimmune disease that primarily affects retinal photoreceptor function and results in profound and often times permanent vision loss. Delay in diagnosis and treatment initiation may contribute to the poor visual prognosis. METHODS: A retrospective chart review of all patients diagnosed with autoimmune retinopathy at the University of Wisconsin-Madison Eye Clinics between January 2012 and January 2017 was performed...
February 26, 2019: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30788635/unilateral-endogenous-candida-endophthalmitis-after-extracorporeal-shock-wave-lithotripsy-for-a-renal-stone-in-an-immunocompetent-woman-a-case-report
#2
Mohammad Shirvani, Shahla Hosseini, Merhrnoosh Maalhagh, Mehrdad Afarid, Ali Mirza-Khanlooi, Sahar Mohaghegh
PURPOSE: To report a case of endogenous Candida endophthalmitis that may cause catastrophic sight-threatening outcomes, after extracorporeal shock wave lithotripsy (ESWL) in a healthy woman. CASE PRESENTATION: A 32-year-old woman presented to the ophthalmology clinic with the symptom of blurred vision and floater in her right eye. She underwent ESWL for renal stone 1 week prior to her presentation. Fundus examination showed an elevated white lesion in para-fovea with fluffy border...
February 20, 2019: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30778743/evaluation-of-the-etiology-of-persistent-iritis-after-cataract-surgery
#3
Kristin Neatrour, Allison McAlpine, Timothy Brooks Owens, Rupal H Trivedi, Lynn J Poole Perry
BACKGROUND: The purpose of this study was to evaluate patients with persistent iritis after cataract surgery to determine its incidence and risk factors. Adjusting the management of patients at risk could allow for a more predictable post-operative course and outcome. A retrospective chart review was performed of patients who had post-operative iritis longer than 1 month after cataract surgery during a 2-year period at Storm Eye Institute at the Medical University of South Carolina (MUSC) in Charleston, South Carolina...
February 18, 2019: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30694420/injectable-0-19-mg-fluocinolone-acetonide-intravitreal-implant-for-the-treatment-of-non-infectious-uveitic-macular-edema
#4
Lea F Weber, Stefanie Marx, Gerd U Auffarth, Alexander F Scheuerle, Tamer Tandogan, Christian Mayer, Ramin Khoramnia
BACKGROUND: A retrospective observational clinical study to evaluate the safety and effectiveness of the injectable 0.19-mg fluocinolone acetonide intravitreal implant (ILUVIEN) in the treatment of non-infectious uveitic macular edema. RESULTS: Data are presented from eight patients (11 eyes) with non-infectious uveitic macular edema who were treated with a 0.19-mg fluocinolone acetonide implant. Nine out of 11 eyes were pseudophakic prior to implantation of fluocinolone acetonide implant, and both phakic eyes required cataract surgery during the follow-up period (the median follow-up was 19 months; range, 8-42 months)...
January 29, 2019: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30659387/the-ghost-of-the-great-imitator-prognostic-factors-for-poor-outcome-in-syphilitic-uveitis
#5
Rafael de Pinho Queiroz, Daniele Viana Inês, Felipe Telöken Diligenti, Victor Haygert Schnor, Jacobo Melamed, Wesley Ribeiro Campos, Daniel Vítor Vasconcelos-Santos
BACKGROUND: Syphilitic uveitis is reemerging globally, may lead to any type of intraocular inflammation, and is potentially sight-threatening. We aim to characterize clinical features and prognostic factors in patients with syphilitic posterior uveitis. METHODS: Retrospective chart review at two tertiary university-based referral centers in Brazil. Clinical data, laboratory results, and treatment outcomes were analyzed. Statistical analysis was performed using Fisher's exact test for categorical variables and Mann-Whitney U test for continuous variables...
January 18, 2019: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30617430/blue-light-versus-green-light-fundus-autofluorescence-in-normal-subjects-and-in-patients-with-retinochoroidopathy-secondary-to-retinal-and-uveitic-diseases
#6
Millena Gomes Bittencourt, Muhammad Hassan, Muhammad Sohail Halim, Rubbia Afridi, Nam V Nguyen, Carlos Plaza, Anh N T Tran, Mohamed Ibrahim Ahmed, Quan Dong Nguyen, Yasir Jamal Sepah
PURPOSE: The aim of this study is to evaluate the differences in the fundus autofluorescence (FAF) signal between the blue light autofluorescence (BAF) from Spectralis® (Heidelberg, CA) and green light autofluorescence (GAF) 200TxTM (OPTOS, UK, in normal subjects and in patients with retinochoroidopathies (RC). METHODS: In this prospective study, FAF was performed using BL (λ = 488 nm) and GL (λ = 532 nm) on normal subjects and patients with RC. The corresponding pairs of BAF and GAF images from both groups were analyzed using Photoshop...
January 8, 2019: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30594950/urinary-%C3%AE-2-microglobulin-and-disease-activity-in-patients-with-tubulointerstitial-nephritis-and-uveitis-syndrome
#7
Lorraine M Provencher, Aaron M Fairbanks, Michael D Abramoff, Nasreen A Syed
BACKGROUND: Urinary β2-microglobulin (Uβ2M) is elevated in tubulointerstitial nephritis and uveitis (TINU) syndrome and has emerged as an important diagnostic tool. This study aims to determine whether Uβ2M correlates with uveitis activity in TINU. METHODS: Retrospective observational case series of nine patients with TINU and ≥ 30 days follow-up. Presenting symptoms, visual acuity, uveitis characteristics, follow-up, Uβ2M, serum creatinine (SCr), urinalysis, and renal biopsy results were collected...
December 29, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30515606/laser-flare-photometry-a-cost-effective-method-for-early-detection-of-endophthalmitis-after-intravitreal-injection-of-anti-vegf-agents
#8
Vânia Lages, Béatrice Gehrig, Carl P Herbort
BACKGROUND: Intravitreal injection of anti-vascular endothelial growth factor agents is the most common intraocular procedure worldwide, inevitably causing more cases of post-injection endophthalmitis. The purpose of this study was to evaluate the utility of laser flare photometry in monitoring inflammation after intravitreal injection of anti-vascular endothelial growth factor agents, particularly to detect early stage post-injection endophthalmitis. A retrospective case review was performed of all patients who underwent flare assessment by laser flare photometry before and after intravitreal injection of bevacizumab or aflibercept at the Centre for Ophthalmic Specialized Care in Lausanne, Switzerland, between January 2015 and May 2018...
December 4, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30515585/syphilitic-uveitis-misdiagnosed-as-viral-retinitis-a-misleading-history
#9
Manisha Agarwal, Richa Ranjan, Lagan Paul, Deepa Sharma
BACKGROUND: Syphilitic uveitis is an infective uveitis and a great mimicker. Misdiagnosis can lead to delay in the specific treatment resulting in deterioration of uveitis and loss of vision. FINDINGS: A 38-year-old unmarried female presented with pain, redness, and blurring of vision in the left eye for the last 5 days. She denied history of any sexual exposure in the past. Anterior segment examination of the right eye was normal and the left eye showed keratic precipitates with anterior chamber cells and iris pigments on anterior lens capsule...
December 4, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30460590/clinical-presentations-management-outcomes-and-diagnostic-dilemma-in-kocuria-endophthalmitis
#10
Vivek Pravin Dave, Joveeta Joseph, Avinash Pathengay, Rajeev R Pappuru
AIM: To describe the clinical presentations and management outcomes of Kocuria endophthalmitis and discuss diagnostic dilemmas DESIGN: Retrospective interventional comparative case series INTERVENTION: Eight unilateral cases with culture-proven Kocuria endophthalmitis from January 2013 to December 2017 underwent vitrectomy/vitreous biopsy and intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation. MAIN OUTCOME MEASURES: The mean age at presentation, etiology, number of interventions, interval between inciting event and presentation, type of intravitreal antibiotic used, and anatomic and functional outcomes were reported...
November 20, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30392069/atypical-white-dot-syndrome-with-choriocapillaris-ischemia-in-a-patient-with-latent-tuberculosis
#11
Sana Khochtali, Nesrine Abroug, Imen Ksiaa, Sourour Zina, Sonia Attia, Moncef Khairallah
BACKGROUND: White dot syndromes (WDS) are a group of idiopathic multifocal inflammatory conditions that can be recognized and distinguished by lesion morphology, other specific clinical features, imaging findings, and disease course. Our purpose is to describe an atypical case of WDS with choriocapillaris ischemia shown by multimodal imaging including swept-source OCT angiography (OCTA) in a 30-year-old woman with latent tuberculosis. FINDINGS: At presentation, visual acuity in the left eye was 20/500...
November 3, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30357549/comparative-in-vitro-effectiveness-of-a-novel-contact-lens-multipurpose-solution-on-acanthamoeba-castellanii
#12
Alyssa C Fears, Rebecca C Metzinger, Stephanie Z Killeen, Robert S Reimers, Chad J Roy
BACKGROUND: A multipurpose contact lens cleaning solution (MPS) containing novel active ingredients under development was compared to two commercially available MPS solutions for effectiveness against Acanthamoeba isolates. METHODS: The Acanthamoeba isolate A. castellanii was propagated for trophozoite or cyst-containing cultures for the purpose of assessment of effectiveness of each MPS. An alamar blue-based cellular respiration assay was used to assess effectiveness against trophozoites; Trypan blue hemocytometer-based microscopic counts measured cysticidal effects...
October 24, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30328571/acute-multifocal-retinitis-a-retrospective-review-of-35-cases
#13
Sana Khochtali, Salma Gargouri, Sourour Zina, Imen Ksiaa, Nesrine Abroug, Sonia Zaouali, Bechir Jelliti, Sonia Attia, Moncef Khairallah
BACKGROUND: Acute multifocal retinitis is a rare condition that has been considered to be often idiopathic. The purpose of this study was to analyze clinical features and causes of acute multifocal retinitis. RESULTS: This study is a retrospective review of the charts of 35 patients with acute multifocal retinitis. Patients with three or more retinal lesions in at least one eye, with at least one lesion of less than 500 μm in size were included. All patients had complete ophthalmological examination, fundus photography, and fluorescein angiography...
October 17, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30327966/discovery-of-tear-biomarkers-in-children-with-chronic-non-infectious-anterior-uveitis-a-pilot-study
#14
Sheila T Angeles-Han, Steven Yeh, Purnima Patel, Duc Duong, Kirsten Jenkins, Kelly A Rouster-Stevens, Mekibib Altaye, Ndate Fall, Sherry Thornton, Sampath Prahalad, Gary N Holland
BACKGROUND: Biomarkers in easily obtained specimens that accurately predict uveitis in children with juvenile idiopathic arthritis (JIA) are needed. Aqueous humor has been studied for biomarkers, but is not routinely available. We evaluated tears from children with chronic anterior uveitis (CAU) for biomarkers reported in aqueous humor. In this pilot study, we used Schirmer strips to collect tears from seven children (nine eyes); three children had JIA- associated uveitis (JIA-U) and four had idiopathic disease (I-CAU)...
October 16, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30317398/swept-source-oct-in-patients-with-multiple-evanescent-white-dot-syndrome
#15
Felipe Pereira, Luiz H Lima, Alexandre Gomes B de Azevedo, Claudio Zett, Michel E Farah, Rubens Belfort
BACKGROUND: Swept-source optical coherence tomography (SS-OCT) has a higher scanning rate and longer wavelength in comparison with spectral-domain OCT (SD-OCT), allowing an improved imaging of retinal vascular plexuses and choriocapillaris. The present two patients diagnosed with multiple evanescent white dot syndrome (MEWDS) underwent fundus autofluorescence (FAF), en-face SS-OCT, and SS-OCT angiography (OCTA) imaging, and its features were described and correlated. RESULTS: The clinical and imaging findings of both cases were consistent with the diagnosis of MEWDS...
October 13, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30306361/endogenous-endophthalmitis-a-9-year-retrospective-study-at-a-tertiary-referral-hospital-in-malaysia
#16
Rosiah Muda, Valarmathy Vayavari, Deivanai Subbiah, Hamisah Ishak, Azian Adnan, Shelina Oli Mohamed
BACKGROUND: The objective of this study was to determine the clinical presentation, systemic risk factors, source of infective microorganism, treatment outcomes, and prognostic indicators of endogenous endophthalmitis at a main tertiary referral hospital for uveitis in Malaysia. A retrospective review of medical records of 120 patients (143 eyes) with endogenous endophthalmitis over a period of 9 years between January 2007 and December 2015 was undertaken. RESULTS: Identifiable systemic risk factors were present in 79...
October 11, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30306353/filamentous-gram-negative-bacteria-masquerading-as-actinomycetes-in-infectious-endophthalmitis-a-review-of-three-cases
#17
Joveeta Joseph, Savitri Sharma, Vivek Pravin Dave
BACKGROUND: To report microbiological diagnostic dilemma posed by observation of unusual morphology of bacteria in the vitreous sample of a series of three cases of bacterial endophthalmitis. RESULTS: A non-comparative, descriptive case series is described. All three cases presented to the retina-vitreous clinic with a clinical diagnosis of acute endophthalmitis between January and April 2018. Two patients had a past history of cataract surgery, and one had antecedent trauma within 1-2 days of presentation...
October 11, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30209691/an-update-on-inflammatory-choroidal-neovascularization-epidemiology-multimodal-imaging-and-management
#18
REVIEW
Aniruddha Agarwal, Alessandro Invernizzi, Rohan Bir Singh, William Foulsham, Kanika Aggarwal, Sabia Handa, Rupesh Agrawal, Carlos Pavesio, Vishali Gupta
Inflammatory choroidal neovascular membranes are challenging to diagnose and manage. A number of uveitic entities may be complicated by the development of choroidal neovascularization leading to a decrease in central visual acuity. In conditions such as punctate inner choroidopathy, development of choroidal neovascularization is extremely common and must be suspected in all cases. On the other hand, in patients with conditions such as serpiginous choroiditis, and multifocal choroiditis, it may be difficult to differentiate between inflammatory choroiditis lesions and choroidal neovascularization...
September 12, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30141181/rituximab-and-bilateral-hsv-epithelial-keratitis-in-a-patient-with-mucous-membrane-pemphigoid
#19
LETTER
W Bernauer, S Schuler, L Borradori
BACKGROUND: B cell depleting therapy is widely used for lymphoproliferative diseases and immune-mediated disorders, including mucous membrane pemphigoid. The latter is an autoimmune blistering disease affecting predominantly the mucosae potentially associated with devastating complications. METHODS: A 71-year-old patient with severe mucous membrane pemphigoid involving ocular, oral pharyngeal and laryngeal involvement is described. To control the disease, the patient was given rituximab therapy in combination with oral corticosteroids...
August 23, 2018: Journal of Ophthalmic Inflammation and Infection
https://read.qxmd.com/read/30076485/necrotising-retinopathy-like-lesions-as-a-manifestation-of-ocular-sarcoidosis
#20
Florence Rasquin, Nacima Kisma, Laure Van Bol
BACKGROUND: A 56-year-old Caucasian man presented with a 2-weeks history of decreased vision in the right eye. Vitritis, papillitis, cystoid macular oedema and inferior diffuse retinal infiltration were noticed. Extensive blood work-up, anterior chamber paracentesis with polymerase chain reaction (PCR) and Goldmann-Witmer coefficient, tuberculin skin test (PPD-test), fluorodeoxyglucose Positron Emission Tomography CT scan (FDG-PET/CT), lymph node biopsy and pars plana vitrectomy were performed...
August 3, 2018: Journal of Ophthalmic Inflammation and Infection
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