Journals Journal of Ophthalmic Inflamma...

Journal of Ophthalmic Inflammation and Infection
Mohammad Soleimani, Seyed Mahbod Baharnoori, Sadegh Ghafarian, Mehrnaz Atighehchian, Kasra Cheraqpour, Seyed Ali Tabatabaei, Hamidreza Ghanbari, Mahdi Soleimanzadeh, Faezeh Moghimpour Bijani, Solmaz Almasi, Haniyeh Zeidabadinejad, Ali Davarpanah, Marzieh Sajedi, Bahram Bohrani Sefidan, Samer Habeel, Ahmad Masoumi, Mohammad Hossein Zamani, Ali R Djalilian
BACKGROUND: Infectious keratitis is a serious ocular condition, which can lead to corneal scarring, vision loss, and even blindness. Pediatric infectious keratitis accounts for about 13% of all cases, although there is a lack of comprehensive data regarding keratitis in less than two years of age population group. This study was aimed to determine predisposing factors, clinical characteristics, microbial profile, and management of infectious keratitis in a population of children aged less than two years...
July 15, 2024: Journal of Ophthalmic Inflammation and Infection
Piotr J Gaca, Rafal Nowak, Robert Rejdak, Magdalena Rejdak, Maja Nowak, Beata Flis, Mohammad Javed Ali
No abstract text is available yet for this article.
July 10, 2024: Journal of Ophthalmic Inflammation and Infection
Jérôme Galand, Ioannis Papasavvas, Carl P Herbort
BACKGROUND: HLA-A29 birdshot retinochoroiditis (BRC) is a primary stromal choroiditis (PSC), the hallmark being the choroidal rice-shaped hypopigmented fundus lesions ("birdshot lesions"). BRC is characterised by dual independent retinal vasculitis and choroiditis, the former often preceding manifest choroidal lesions. The purpose of this study was to analyse the type and severity of retinal vasculitis and determine whether it represented a diagnostic contribution. Medical records of patients with the diagnosis of BRC examined in the uveitis clinic of the Centre for Ophthalmic Specialised care (COS) in Lausanne from 1994 to 2020, were retrospectively reviewed...
July 9, 2024: Journal of Ophthalmic Inflammation and Infection
Mohammad Shiravani, Mahmood Nejabat, Alireza Attar
BACKGROUND: Scorpion envenomation, a prevalent medical emergency in rural areas, demands immediate attention due to its potential severity. While ocular manifestations are uncommon, they can lead to significant complications such as corneal ulceration. We present a unique case of corneal ulceration subsequent to a yellow scorpion (Hemiscorpius lepturus) sting near the eye, a scenario not previously documented. CASE PRESENTATION: A 34-year-old male sought medical care following a scorpion sting despite prior anti-venom treatment...
June 25, 2024: Journal of Ophthalmic Inflammation and Infection
Zixuan Wu, Jinfeng Xu, Yi Hu, Xin Peng, Zheyuan Zhang, Xiaolei Yao, Qinghua Peng
BACKGROUND: Nonspecific Orbital Inflammation (NSOI) represents a persistent and idiopathic proliferative inflammatory disorder, characterized by polymorphous lymphoid infiltration within the orbit. The transcription factor Interferon Regulatory Factor 8 (IRF8), integral to the IRF protein family, was initially identified as a pivotal element for the commitment and differentiation of myeloid cell lineage. Serving as a central regulator of innate immune receptor signaling, IRF8 orchestrates a myriad of functions in hematopoietic cell development...
June 20, 2024: Journal of Ophthalmic Inflammation and Infection
Xie Fang, Guoli Lan, Yuan Lin, Zhiwen Xie, Yanlin Zhong, Shunrong Luo, Xianwen Xiao, Lianghuan Luo, Yiqiu Zhang, Hanqiao Li, Huping Wu
OBJECTIVE: To estimate the pterygium ocular surface state, and compare with healthy eyes and dry eyes. To investigate the inflammation due to pterygia growth by tear Lymphotoxin-alpha (LT α) test. DESIGN: Prospective, single-center study. PARTICIPANTS: 400 patients, divided into 100 pterygium group, 100 mild dry eye group, 100 moderate dry eye group, and 100 age-and sex-matched normal controls. METHODS: The non-invasive break-up time (NIBUT), tear meniscus height (TMH) test, corneal fluorescein staining (CFS), meibomian gland loss score (MGs), and lipid layer thickness (LLT) were evaluated in all patients...
June 14, 2024: Journal of Ophthalmic Inflammation and Infection
Elena Ros-Sánchez, David Oliver-Gutierrez, Paul Buck, Tetiana Goncharova, Laura Distefano, Eric Kirkegaard-Biosca
PURPOSE: To report a case of Purpureocillium lilacinum endophthalmitis. METHODS: The case of a fungal endophthalmitis caused by Purpureocillium lilacinum documented in an immunocompetent patient with no apparent trigger. RESULTS: A 64-year-old male with a two-month history of panuveitis in his left eye was referred to our hospital. Initially misdiagnosed as sympathetic ophthalmia due to a previous surgery on his right eye 4 months before the onset of the left ocular picture, the patient received corticosteroid treatment, leading to a rapid deterioration of the left eye condition...
June 12, 2024: Journal of Ophthalmic Inflammation and Infection
Sana Badar Baig, Kalaivani Manokaran, Nagarajan Theruveethi, Vivek Raghavan Muduthan
BACKGROUND: Contamination in the contact lens training area could be due to bacteria, which can lead to the major consequence of ocular infections. We aimed to investigate the contamination caused by bacteria in the contact lens training area in private optical clinics of the Udupi district, India. METHODS: A cross-sectional study evaluated the swabs from the contact lens container, contact lens solution tip, washing area and lens fitting area for bacterial contamination...
June 11, 2024: Journal of Ophthalmic Inflammation and Infection
Jørgen Krohn, Øystein A Power, Haima Mylvaganam, Andreas J Askim, Jarle B Arnes, Bjørn Blomberg
PURPOSE: To report a case of endogenous endophthalmitis caused by the dematiaceous fungus Cladophialophora devriesii. METHODS: Observational case report and literature review. CASE PRESENTATION: A 73-year-old female with a history of chronic obstructive pulmonary disease presented with a red and painful left eye. Examination revealed anterior segment inflammation and vitritis, indicative of endophthalmitis. She underwent core vitrectomy and intravitreal injection of vancomycin and amphotericin B...
June 5, 2024: Journal of Ophthalmic Inflammation and Infection
Igor Kozak, Avinash Gurbaxani, Maya Pandova
BACKGROUND: The 0.19 mg fluocinolone acetonide (FAc) implant (ILUVIEN) has been approved for prevention of relapse in recurrent non-infectious uveitis affecting the posterior segment of the eye (NIU-PS). There is little data assessing the long-term efficacy and safety of the FAc implant in this indication. Therefore, we conducted a retrospective interventional case review of 18 eyes from 13 patients with NIU-PS treated with the FAc implant at three ophthalmology departments in the Middle East between 2018 and 2021...
June 4, 2024: Journal of Ophthalmic Inflammation and Infection
Trakanta Wannapanich, Waraporn Chuenchaem, Patanaree Luanratanakorn, Wipada Laovirojjanakul
PURPOSE: To report the characteristics and epidemiology of uveitis in a university-based referral center in northeastern Thailand and review the uveitis patterns present in various regions worldwide. METHODS: A retrospective review of all medical records for new patients visiting the uveitis clinic at Srinagarind hospital, Khon Kaen University, between August 2016 and June 2021, was conducted. RESULTS: A total of 522 uveitis patients were included in this study...
May 31, 2024: Journal of Ophthalmic Inflammation and Infection
Uwe Pleyer, Carlos Pavesio, Elisabetta Miserocchi, Carsten Heinz, Helen Devonport, Víctor Llorenç, Tomás Burke, Vanda Nogueira, Laurent Kodjikian, Bahram Bodaghi
BACKGROUND: Non-infectious uveitis affecting the posterior segment of the eye (NIU-PS) is an inflammatory disease, which can significantly impair visual acuity if not adequately treated. Fluocinolone-acetonide sustained-release-0.2 µg/day intravitreal (FAc) implants are indicated for prevention of relapse in recurrent NIU-PS. The aim here was to provide treating clinicians with some consensus-based-recommendations for the clinical management of patients with NIU-PS with 0.2 µg/day FAc implants...
May 30, 2024: Journal of Ophthalmic Inflammation and Infection
Zahra Mahdizad, Mohammad Zarei, Hanieh Fakhredin, Reza Samiee, Hora Heidari, Nazanin Ebrahimiadib
BACKGROUND: To report a case of Pediatric-onset MS associated uveitis managed with local and systemic medications. CASE PRESENTATION: An 11-year-old boy who was diagnosed with Pediatric-onset MS (POMS) with the first presentation of left optic neuritis in another center, was referred to our clinic with the complaint of non-improved vision in the left eye despite receiving IV 5gr methylprednisolone. After the ophthalmologic examinations, the patient was diagnosed as bilateral POMS-associated intermediate uveitis, and local treatment with corticosteroid was administered to both eyes...
May 29, 2024: Journal of Ophthalmic Inflammation and Infection
Celso Soares Pereira Batista, Irene Loscos-Giménez, María Gámez, Raul Altaba, Daniela de Miniac, Neus Martí, Francisca Bassaganyas, Elena Juanes, Alba Rivera, Ferran Navarro
BACKGROUND: Intravitreal injections are a common ophthalmologic procedure. While infections following these injections are rare, they can lead to endophthalmitis, with potentially serious consequences. Various methods have been proposed to prevent endophthalmitis, including the use of antisepsis and antibiotics in patient preparation. PURPOSE: To evaluate the antiseptic efficacy of aqueous chlorhexidine (CHX) and povidone-iodine (PI) when used alone and in combination with lidocaine gel (LG) in vitro...
May 23, 2024: Journal of Ophthalmic Inflammation and Infection
J M Cachero Rodríguez, J Artaraz, Nora Imaz, A Fonollosa
PURPOSE: To report the use of Fluocinolone intravitreal implant (Iluvien) for the treatment of persistent cystoid macular edema (CME) due to immune recovery uveitis syndrome in a patient with previous cytomegalovirus retinitis and acute myeloid leukemia. DESIGN: Case report. METHODS: The clinical history of a patient who received an Iluvien implant in one eye for the treatment of cystoid macular edema due to immune recovery uveitis syndrome, previously treated with peribulbar Triamcinolone and intravitreal Dexamethasone injections, was reviewed...
May 3, 2024: Journal of Ophthalmic Inflammation and Infection
Sruthi Kodali, Behram Khan, Amanda M Zong, Jee-Young Moon, Anurag Shrivastava, Johanna P Daily, Richard P Gibralter
PURPOSE: Corneal ulcers frequently result in ocular morbidity and may lead to permanent visual impairment if severe or untreated. This study aims to evaluate the association of patient factors and ocular exam findings on clinical outcomes for patients diagnosed with a corneal ulcer at a tertiary care center in the Bronx, New York. METHODS: A retrospective chart review was conducted on all ambulatory and admitted patients diagnosed with a corneal ulcer (identified using ICD-10 code H16...
April 24, 2024: Journal of Ophthalmic Inflammation and Infection
Pengcheng Li, Zhuyun Qian, Yong Tao
BACKGROUND: Cat-scratch disease (CSD) is caused by Bartonella henselae infection. In atypical cases of CSD, pathogen determination is challenging. We report a case of Bartonella neuroretinitis with neither a clear history of scratches nor typical general symptoms. The diagnosis was made using metagenomic next-generation sequencing (mNGS), a high-throughput sequencing technology. CASE PRESENTATION: A female patient presented to the ophthalmologist with complaint of blurred vision in her right eye...
April 19, 2024: Journal of Ophthalmic Inflammation and Infection
Nenita Maganti, Samuel A Whittier, Evan J Warner
BACKGROUND: Dupilumab and tralokinumab are interleukin-binding monoclonal antibodies used to treat systemic atopic disease. Use of these medications in management of atopic dermatitis (AD) is known to cause conjunctivitis. Dupilumab therapy has also been associated with more severe ocular surface disease, which has not previously been described in association with tralokinumab. This report describes a case of tralokinumab-associated conjunctivitis and peripheral ulcerative keratitis and reviews the spectrum and proposed mechanisms of ocular surface disease triggered by these medications...
April 16, 2024: Journal of Ophthalmic Inflammation and Infection
Lisa Gittel, Jeany Q Li, Jennifer Dell, Maximilian W M Wintergerst, Carsten Heinz, Robert P Finger, Jan Henrik Terheyden
INTRODUCTION: The National Eye Institute Visual Function Questionnaire (NEI VFQ) is a common patient-reported outcome measure (PROM) in uveitis trials. Its psychometric properties using state-of-the-art scoring based on Rasch models, a latent trait model that improves accuracy of PROMs assessment, has not yet been investigated. METHODS: The study participants were recruited online from uveitis patient organizations, where individuals self-reported their uveitis diagnosis and visual acuity level...
April 16, 2024: Journal of Ophthalmic Inflammation and Infection
Sonny Caplash, Manuel Paez-Escamilla, Mark Westcott, Kunal K Dansingani, Chad Indermill, Nacima Kisma, Eric Frau, Jose-Alain Sahel, Bahram Bodaghi, Vishal Jhanji, Marie-Helene Errera
BACKGROUND: Anterior uveitis, inflammation of the anterior chamber and related structures, is a cohort of diseases that can present to almost any general or sub-specialty Ophthalmology practice. Its features classically involve anterior chamber cell and flare. Below the surface of these two signs exist a panoply of diagnoses. BODY: The purpose of this review is to provide a general framework for diagnoses of anterior uveitis that are often missed as well as non-uveitic pathologies that often mimic anterior uveitis...
April 10, 2024: Journal of Ophthalmic Inflammation and Infection
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