journal
https://read.qxmd.com/read/25473485/the-role-of-angiogenesis-in-the-pathology-of-multiple-sclerosis
#21
JOURNAL ARTICLE
Justin Lengfeld, Tyler Cutforth, Dritan Agalliu
Angiogenesis, or the growth of new blood vessels from existing vasculature, is critical for the proper development of many organs. This process is inhibited and tightly regulated in adults, once endothelial cells have acquired organ-specific properties. Within the central nervous system (CNS), angiogenesis and acquisition of blood-brain barrier (BBB) properties by endothelial cells is essential for CNS function. However, the role of angiogenesis in CNS pathologies associated with impaired barrier function remains unclear...
2014: Vascular Cell
https://read.qxmd.com/read/25309723/previously-differentiated-medial-vascular-smooth-muscle-cells-contribute-to-neointima-formation-following-vascular-injury
#22
JOURNAL ARTICLE
Brian Paul Herring, April M Hoggatt, Christopher Burlak, Stefan Offermanns
BACKGROUND: The origins of neointimal smooth muscle cells that arise following vascular injury remains controversial. Studies have suggested that these cells may arise from previously differentiated medial vascular smooth muscle cells, resident stem cells or blood born progenitors. In the current study we examined the contribution of the previously differentiated vascular smooth muscle cells to the neointima that forms following carotid artery ligation. METHODS: We utilized transgenic mice harboring a cre recombinase-dependent reporter gene (mTmG)...
2014: Vascular Cell
https://read.qxmd.com/read/25295160/lysosomal-drug-sequestration-as-a-mechanism-of-drug-resistance-in-vascular-sarcoma-cells-marked-by-high-csf-1r-expression
#23
JOURNAL ARTICLE
Brandi H Gorden, Jhuma Saha, Ali Khammanivong, Gary K Schwartz, Erin B Dickerson
BACKGROUND: Human angiosarcoma and canine hemangiosarcoma are thought to arise from vascular tissue or vascular forming cells based upon their histological appearance. However, recent evidence indicates a hematopoietic or angioblastic cell of origin for these tumors. In support of this idea, we previously identified an endothelial-myeloid progenitor cell population with high expression of endothelial cell markers and the myeloid cell marker, colony stimulating factor 1 receptor (CSF-1R)...
2014: Vascular Cell
https://read.qxmd.com/read/25243060/ageing-and-microvasculature
#24
REVIEW
Maria Giovanna Scioli, Alessandra Bielli, Gaetano Arcuri, Amedeo Ferlosio, Augusto Orlandi
A decline in the function of the microvasculature occurs with ageing. An impairment of endothelial properties represents a main aspect of age-related microvascular alterations. Endothelial dysfunction manifests itself through a reduced angiogenic capacity, an aberrant expression of adhesion molecules and an impaired vasodilatory function. Increased expression of adhesion molecules amplifies the interaction with circulating factors and inflammatory cells. The latter occurs in both conduit arteries and resistance arterioles...
2014: Vascular Cell
https://read.qxmd.com/read/25197551/lenvatinib-an-angiogenesis-inhibitor-targeting-vegfr-fgfr-shows-broad-antitumor-activity-in-human-tumor-xenograft-models-associated-with-microvessel-density-and-pericyte-coverage
#25
JOURNAL ARTICLE
Yuji Yamamoto, Junji Matsui, Tomohiro Matsushima, Hiroshi Obaishi, Kazuki Miyazaki, Katsuji Nakamura, Osamu Tohyama, Taro Semba, Atsumi Yamaguchi, Sachi Suzuki Hoshi, Fusayo Mimura, Toru Haneda, Yoshio Fukuda, Jun-Ichi Kamata, Keiko Takahashi, Masayuki Matsukura, Toshiaki Wakabayashi, Makoto Asada, Ken-Ichi Nomoto, Tatsuo Watanabe, Zoltan Dezso, Kentaro Yoshimatsu, Yasuhiro Funahashi, Akihiko Tsuruoka
BACKGROUND: Lenvatinib is an oral inhibitor of multiple receptor tyrosine kinases (RTKs) targeting vascular endothelial growth factor receptor (VEGFR1-3), fibroblast growth factor receptor (FGFR1-4), platelet growth factor receptor α (PDGFR α), RET and KIT. Antiangiogenesis activity of lenvatinib in VEGF- and FGF-driven angiogenesis models in both in vitro and in vivo was determined. Roles of tumor vasculature (microvessel density (MVD) and pericyte coverage) as biomarkers for lenvatinib were also examined in this study...
2014: Vascular Cell
https://read.qxmd.com/read/25114787/evaluation-of-side-effects-of-radiofrequency-capacitive-hyperthermia-with-magnetite-on-the-blood-vessel-walls-of-tumor-metastatic-lesion-surrounding-the-abdominal-large-vessels-an-agar-phantom-study
#26
JOURNAL ARTICLE
Noriyasu Kawai, Daichi Kobayashi, Takahiro Yasui, Yukihiro Umemoto, Kentaro Mizuno, Atsushi Okada, Keiichi Tozawa, Takeshi Kobayashi, Kenjiro Kohri
BACKGROUND: Magnetite used in an 8-MHz radiofrequency (RF) capacitive heating device can increase the temperature of a specific site up to 45°C. When treating a metastatic lesion around large abdominal vessels via hyperthermia with magnetite, heating-induced adverse effects on these vessels need to be considered. Therefore, this study examined hyperthermia-induced damage to blood vessel walls in vitro. METHODS: A large agar phantom with a circulatory system consisting of a swine artery and vein connected to a peristaltic pump was prepared...
2014: Vascular Cell
https://read.qxmd.com/read/25101168/limitations-of-the-dorsal-skinfold-window-chamber-model-in-evaluating-anti-angiogenic-therapy-during-early-phase-of-angiogenesis
#27
JOURNAL ARTICLE
Nikolett M Biel, Jennifer A Lee, Brian S Sorg, Dietmar W Siemann
BACKGROUND: Angiogenesis is an essential process during tumor development and growth. The murine dorsal skinfold window chamber model has been used for the study of both tumor microvasculature and other vascular diseases, including the study of anti-angiogenic agents in cancer therapy. Hyperspectral imaging of oxygen status of the microvasculature has not been widely used to evaluate response to inhibition of angiogenesis in early tumor cell induced vascular development. This study demonstrates the use of two different classes of anti-angiogenic agents, one targeting the Vascular Endothelial Growth Factor (VEGF) pathway involved with vessel sprouting and the other targeting the Angiopoietin/Tie2 pathway involved in vascular destabilization...
2014: Vascular Cell
https://read.qxmd.com/read/25101167/vegfr-1-blockade-disrupts-peri-implantation-decidual-angiogenesis-and-macrophage-recruitment
#28
JOURNAL ARTICLE
Nataki C Douglas, Ralf C Zimmermann, Qian Kun Tan, Chantae S Sullivan-Pyke, Mark V Sauer, Jan K Kitajewski, Carrie J Shawber
BACKGROUND: Angiogenesis and macrophage recruitment to the uterus are key features of uterine decidualization; the progesterone-mediated uterine changes that allow for embryo implantation and initiation of pregnancy. In the current study, we characterized the expression of vascular endothelial growth factor receptor-1 (VEGFR-1) in macrophages and endothelial cells of the peri-implantation uterus and determined if VEGFR-1 function is required for decidual angiogenesis, macrophage recruitment, and/or the establishment of pregnancy...
2014: Vascular Cell
https://read.qxmd.com/read/25071932/in-vitro-pre-vascularisation-of-tissue-engineered-constructs-a-co-culture-perspective
#29
REVIEW
Jeremy Baldwin, Mélanie Antille, Ulrich Bonda, Elena M De-Juan-Pardo, Kiarash Khosrotehrani, Saso Ivanovski, Eugen Bogdan Petcu, Dietmar Werner Hutmacher
In vitro pre-vascularization is one of the main vascularization strategies in the tissue engineering field. Culturing cells within a tissue-engineered construct (TEC) prior to implantation provides researchers with a greater degree of control over the fate of the cells. However, balancing the diverse range of different cell culture parameters in vitro is seldom easy and in most cases, especially in highly vascularized tissues, more than one cell type will reside within the cell culture system. Culturing multiple cell types in the same construct presents its own unique challenges and pitfalls...
2014: Vascular Cell
https://read.qxmd.com/read/25053993/flow-regulated-lymphatic-vasculature-development-and-signaling
#30
REVIEW
Yingdi Wang, Michael Simons
The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymphatic circulation including control of lymphatic vascular growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, we summarize these advances focusing on the role of fluid dynamics in control of lymphatic vasculature formation.
2014: Vascular Cell
https://read.qxmd.com/read/25053992/effects-of-a-novel-cyclic-rgd-peptidomimetic-on-cell-proliferation-migration-and-angiogenic-activity-in-human-endothelial-cells
#31
JOURNAL ARTICLE
Roberto Fanelli, Laura Schembri, Umberto Piarulli, Monica Pinoli, Emanuela Rasini, Mayra Paolillo, Marisa Carlotta Galiazzo, Marco Cosentino, Franca Marino
BACKGROUND: Cyclic RGD peptidomimetics containing a bifunctional diketopiperazine scaffold are a novel class of high-affinity ligands for the integrins αVβ3 and αVβ5. Since integrins are a promising target for the modulation of normal and pathological angiogenesis, the present study aimed at characterizing the ability of the RGD peptidomimetic cyclo[DKP-RGD] 1 proliferation, migration and network formation in human umbilical vein endothelial cells (HUVEC). METHODS: Cell viability was assessed by flow cytometry and annexin V (ANX)/propidium iodide (PI) staining...
2014: Vascular Cell
https://read.qxmd.com/read/24914410/sunitinib-significantly-suppresses-the-proliferation-migration-apoptosis-resistance-tumor-angiogenesis-and-growth-of-triple-negative-breast-cancers-but-increases-breast-cancer-stem-cells
#32
JOURNAL ARTICLE
Edmund Chinchar, Kristina L Makey, John Gibson, Fang Chen, Shelby A Cole, Gail C Megason, Srinivassan Vijayakumar, Lucio Miele, Jian-Wei Gu
The majority of triple-negative breast cancers (TNBCs) are basal-like breast cancers. However there is no reported study on anti-tumor effects of sunitinib in xenografts of basal-like TNBC (MDA-MB-468) cells. In the present study, MDA-MB-231, MDA-MB-468, MCF-7 cells were cultured using RPMI 1640 media with 10% FBS. Vascular endothelia growth factor (VEGF) protein levels were detected using ELISA (R & D Systams). MDA-MB-468 cells were exposed to sunitinib for 18 hours for measuring proliferation (3H-thymidine incorporation), migration (BD Invasion Chamber), and apoptosis (ApopTag and ApoScreen Anuexin V Kit)...
2014: Vascular Cell
https://read.qxmd.com/read/24817999/angiogenic-properties-of-dehydrated-human-amnion-chorion-allografts-therapeutic-potential-for-soft-tissue-repair-and-regeneration
#33
JOURNAL ARTICLE
Thomas J Koob, Jeremy J Lim, Michelle Massee, Nicole Zabek, Robert Rennert, Geoffrey Gurtner, William W Li
BACKGROUND: Chronic wounds are associated with a number of deficiencies in critical wound healing processes, including growth factor signaling and neovascularization. Human-derived placental tissues are rich in regenerative cytokines and have been shown in randomized clinical trials to be effective for healing chronic wounds. In this study, PURION® Processed (MiMedx Group, Marietta, GA) dehydrated human amnion/chorion membrane tissue allografts (dHACM, EpiFix®, MiMedx) were evaluated for properties to support wound angiogenesis...
2014: Vascular Cell
https://read.qxmd.com/read/24690185/the-role-of-rna-interference-in-the-developmental-separation-of-blood-and-lymphatic-vasculature
#34
JOURNAL ARTICLE
Sébastien Gauvrit, Josette Philippe, Matthieu Lesage, Marc Tjwa, Isabelle Godin, Stéphane Germain
BACKGROUND: Dicer is an RNase III enzyme that cleaves double stranded RNA and generates functional interfering RNAs that act as important regulators of gene and protein expression. Dicer plays an essential role during mouse development because the deletion of the dicer gene leads to embryonic death. In addition, dicer-dependent interfering RNAs regulate postnatal angiogenesis. However, the role of dicer is not yet fully elucidated during vascular development. METHODS: In order to explore the functional roles of the RNA interference in vascular biology, we developed a new constitutive Cre/loxP-mediated inactivation of dicer in tie2 expressing cells...
2014: Vascular Cell
https://read.qxmd.com/read/24690161/the-discovery-of-angiogenic-growth-factors-the-contribution-of-italian-scientists
#35
JOURNAL ARTICLE
Domenico Ribatti
Angiogenesis is regulated, under both physiological and pathological conditions, by numerous "non-classic" pro-angiogenic factors, including fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), and placental growth factor (PlGF), and "non-classic" pro-angiogenic factors, including granulocyte colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF), and erythropoietin (EPO). In the context of the most important discoveries in this field, this review article summarizes the important role played by the Italian scientists in the course of the last twenty years...
2014: Vascular Cell
https://read.qxmd.com/read/24628920/embryonic-rat-vascular-smooth-muscle-cells-revisited-a-model-for-neonatal-neointimal-smc-or-differentiated-vascular-stem-cells
#36
JOURNAL ARTICLE
Eimear Kennedy, Roya Hakimjavadi, Chris Greene, Ciaran J Mooney, Emma Fitzpatrick, Laura E Collins, Christine E Loscher, Shaunta Guha, David Morrow, Eileen M Redmond, Paul A Cahill
BACKGROUND: The A10 and A7r5 cell lines derived from the thoracic aorta of embryonic rat are widely used as models of non-differentiated, neonatal and neointimal vascular smooth muscle cells in culture. The recent discovery of resident multipotent vascular stem cells within the vessel wall has necessitated the identity and origin of these vascular cells be revisited. In this context, we examined A10 and A7r5 cell lines to establish the similarities and differences between these cell lines and multipotent vascular stem cells isolated from adult rat aortas by determining their differentiation state, stem cell marker expression and their multipotency potential in vitro...
2014: Vascular Cell
https://read.qxmd.com/read/24581323/effect-of-the-vascular-endothelial-growth-factor-expression-level-on-angiopoietin-2-mediated-nasopharyngeal-carcinoma-growth
#37
JOURNAL ARTICLE
Hai-Hong Chen, Bin-Qi Weng, Ke-Jia Cheng, Hong-Yan Liu, Shen-Qing Wang, Yv-Yv Lu
BACKGROUND: The overexpression of angiopoietin-2 (Ang-2) has both pro-tumorigenic and anti-tumorigenic effects. However, the mechanisms of this protein's dual effects are poorly understood, and it remains unclear how Ang-2 cooperates with vascular endothelial growth factor (VEGF). In the current study, we investigated the effects of Ang-2 overexpression on nasopharyngeal carcinoma growth in the presence of different levels of VEGF. METHODS: Ang-2 was introduced into the CNE2 cell line by liposome transfection, and the expression of endogenous VEGF was inhibited by microRNA-mediated RNA interference...
2014: Vascular Cell
https://read.qxmd.com/read/24512922/correction-the-role-of-tumor-associated-macrophages-in-tumor-vascularization
#38
JOURNAL ARTICLE
Chunqing Guo, Annicole Buranych, Devanand Sarkar, Paul B Fisher, Xiang-Yang Wang
No abstract text is available yet for this article.
2014: Vascular Cell
https://read.qxmd.com/read/24472220/netrin-4-promotes-mural-cell-adhesion-and-recruitment-to-endothelial-cells
#39
JOURNAL ARTICLE
Esma Lejmi, Ilyes Bouras, Serge Camelo, Marie Roumieux, Norbert Minet, Carole Leré-Déan, Tatyana Merkulova-Rainon, Gwennhael Autret, Catherine Vayssettes, Olivier Clement, Jean Plouët, Laurence Leconte
Netrins are secreted molecules involved in axon guidance and angiogenesis. We previously showed that Netrin-4 acts as an anti-angiogenic factor by inhibiting endothelial cell (EC) functions. In this study, we investigated the effects of Netrin-4 on vascular smooth muscle cell (VSMC) activity in vitro and in vivo. We show that exogenous Netrin-4 stimulated VSMC adhesion and migration, and increased their coverage on EC tubes (grown on a Matrigel substrate). siRNA knock-down of endogenous Netrin-4 expression in VSMC decreased their recruitment to EC tubes...
2014: Vascular Cell
https://read.qxmd.com/read/24156373/angiopoietin-1-and-angiopoietin-2-are-altered-in-polycystic-ovarian-syndrome-pcos-during-controlled-ovarian-stimulation
#40
Reshef Tal, David B Seifer, Richard V Grazi, Henry E Malter
Polycystic ovarian syndrome (PCOS) ovaries are characterized by increased angiogenesis and hypervascularity. While angiopoietin-1 (Ang-1) and its antagonist, angiopoietin-2 (Ang-2), are essential for ovarian function and angiogenesis, the levels of Ang-1 and Ang-2 in PCOS are unknown. This was a prospective cohort study of 14 PCOS women and 14 matched controls undergoing controlled ovarian stimulation (COS). Serum was collected on day 3, hCG and retrieval days. Follicular fluid (FF) was collected on retrieval day...
October 24, 2013: Vascular Cell
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