journal
Journals Journal of Cachexia, Sarcopeni...

Journal of Cachexia, Sarcopenia and Muscle

https://read.qxmd.com/read/38632714/hepatic-signal-transducer-and-activator-of-transcription-3-signalling-drives-early-stage-pancreatic-cancer-cachexia-via-suppressed-ketogenesis
#1
JOURNAL ARTICLE
Paige C Arneson-Wissink, Heike Mendez, Katherine Pelz, Jessica Dickie, Alexandra Q Bartlett, Beth L Worley, Stephanie M Krasnow, Robert Eil, Aaron J Grossberg
BACKGROUND: Patients with pancreatic ductal adenocarcinoma (PDAC) often suffer from cachexia, a wasting syndrome that significantly reduces both quality of life and survival. Although advanced cachexia is associated with inflammatory signalling and elevated muscle catabolism, the early events driving wasting are poorly defined. During periods of nutritional scarcity, the body relies on hepatic ketogenesis to generate ketone bodies, and lipid metabolism via ketogenesis is thought to protect muscle from catabolizing during nutritional scarcity...
April 17, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38632706/adiponectin-to-leptin-ratio-and-incident-chronic-kidney-disease-sex-and-body-composition-dependent-association
#2
JOURNAL ARTICLE
Hye-Sun Park, Sang Ho Park, Yeseul Seong, Hyo Jeong Kim, Hoon Young Choi, Yumie Rhee, Hyeong Cheon Park, Jong Hyun Jhee
BACKGROUND: The association between the adiponectin-to-leptin ratio (A/L ratio) and the risk of incident chronic kidney disease (CKD) is poorly understood. This study aimed to investigate the association between A/L ratio and the risk of incident CKD and to examine whether such a relationship varied according to sex and body composition. METHODS: In this prospective community-based cohort, participants with normal kidney function were analysed (N = 5192)...
April 17, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38632694/lean-body-mass-and-the-cardiorespiratory-phenotype-an-ethnic-specific-relationship-in-hans-chinese-women-and-men
#3
JOURNAL ARTICLE
Meihan Guo, Candela Diaz-Canestro, Nicola Riccardo Pugliese, Francesco Paneni, David Montero
BACKGROUND: Lean body mass (LBM) and the functional capacity of cardiovascular (CV) and respiratory systems constitute a female-specific relationship in European-American individuals. Whether this recent finding be extrapolated to the world's largest ethnic group, that is, Hans Chinese (HC, a population characterized by low LBM), is unknown. METHODS: Healthy HC adults (n = 144, 50% ♀) closely matched by sex, age and physical activity were included...
April 17, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38613258/prognostic-impact-of-muscle-mass-loss-in-elderly-patients-with-oesophageal-cancer-receiving-neoadjuvant-chemoradiation-therapy
#4
JOURNAL ARTICLE
Jeong Yun Jang, Dongryul Oh, Jae Myoung Noh, Jong-Mu Sun, Hong Kwan Kim, Young Mog Shim
BACKGROUND: We aimed to identify the impact of muscle mass on locally advanced oesophageal cancer (LAEC) in elderly patients receiving neoadjuvant chemoradiation therapy (NACRT). METHODS: We reviewed the medical records of 345 patients diagnosed with LAEC who underwent NACRT and surgery. Physical variables, including height, weight, skeletal muscle mass, and laboratory values, were obtained before and after NACRT. Body mass index (BMI, kg/m2 ), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and prognostic nutritional index (PNI) were calculated as height/(weight)2 , ANC/ALC, platelet count/ALC, and (10 × albumin + 0...
April 13, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38613252/effect-of-sirolimus-on-muscle-in-inclusion-body-myositis-observed-with-magnetic-resonance-imaging-and-spectroscopy
#5
JOURNAL ARTICLE
Harmen Reyngoudt, Pierre-Yves Baudin, Ericky de Caldas de Almeida Araújo, Damien Bachasson, Jean-Marc Boisserie, Kubéraka Mariampillai, Mélanie Annoussamy, Yves Allenbach, Jean-Yves Hogrel, Pierre G Carlier, Benjamin Marty, Olivier Benveniste
BACKGROUND: Finding sensitive clinical outcome measures has become crucial in natural history studies and therapeutic trials of neuromuscular disorders. Here, we focus on 1-year longitudinal data from quantitative magnetic resonance imaging (MRI) and phosphorus magnetic resonance spectroscopy (31 P MRS) in a placebo-controlled study of sirolimus for inclusion body myositis (IBM), also examining their links to functional, strength, and clinical parameters in lower limb muscles. METHODS: Quantitative MRI and 31 P MRS data were collected at 3 T from a single site, involving 44 patients (22 on placebo, 22 on sirolimus) at baseline and year-1, and 21 healthy controls...
April 13, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38575520/glycative-stress-inhibits-hypertrophy-and-impairs-cell-membrane-integrity-in-overloaded-mouse-skeletal-muscle
#6
JOURNAL ARTICLE
Tatsuro Egawa, Takeshi Ogawa, Takumi Yokokawa, Kohei Kido, Ryota Iyama, Haiyu Zhao, Eriko Kurogi, Katsumasa Goto, Tatsuya Hayashi
BACKGROUND: Glycative stress, characterized by the formation and accumulation of advanced glycation end products (AGEs) associated with protein glycation reactions, has been implicated in inducing a decline of muscle function. Although the inverse correlation between glycative stress and muscle mass and strength has been demonstrated, the underlying molecular mechanisms are not fully understood. This study aimed to elucidate how glycative stress affects the skeletal muscle, particularly the adaptive muscle response to hypertrophic stimuli and its molecular mechanism...
April 4, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38572511/administration-of-adiponectin-receptor-agonist-adiporon-relieves-cancer-cachexia-by-mitigating-inflammation-in-tumour-bearing-mice
#7
JOURNAL ARTICLE
Isabelle S Massart, Axell-Natalie Kouakou, Nathan Pelet, Pascale Lause, Olivier Schakman, Audrey Loumaye, Michel Abou-Samra, Louise Deldicque, Laure B Bindels, Sonia M Brichard, Jean-Paul Thissen
BACKGROUND: Cancer cachexia is a life-threatening, inflammation-driven wasting syndrome that remains untreatable. Adiponectin, the most abundant adipokine, plays an important role in several metabolic processes as well as in inflammation modulation. Our aim was to test whether administration of AdipoRon (AR), a synthetic agonist of the adiponectin receptors, prevents the development of cancer cachexia and its related muscle atrophy. METHODS: The effect of AR on cancer cachexia was investigated in two distinct murine models of colorectal cancer...
April 4, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38561962/effect-of-liraglutide-on-thigh-muscle-fat-and-muscle-composition-in-adults-with-overweight-or-obesity-results-from-a-randomized-clinical-trial
#8
JOURNAL ARTICLE
Ambarish Pandey, Kershaw V Patel, Matthew W Segar, Colby Ayers, Jennifer Linge, Olof D Leinhard, Stefan D Anker, Javed Butler, Subodh Verma, Parag H Joshi, Ian J Neeland
BACKGROUND: Excess muscle fat is observed in obesity and associated with greater burden of cardiovascular risk factors and higher risk of mortality. Liraglutide reduces total body weight and visceral fat but its effect on muscle fat and adverse muscle composition is unknown. METHODS: This is a pre-specified secondary analysis of a randomized, double-blind, placebo-controlled trial that examined the effects of liraglutide plus a lifestyle intervention on visceral adipose tissue and ectopic fat among adults without diabetes with body mass index ≥30 kg/m2 or ≥27 kg/m2 and metabolic syndrome...
April 1, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38558541/low-skeletal-muscle-mass-and-treatment-outcomes-among-adults-with-haematologic-malignancies-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Nadia M Anabtawi, Monica Sai Pasala, Alyssa A Grimshaw, Prakash Kharel, Susan Bal, Kelly Godby, Ashmita Siwakoti, Thomas W Buford, Smita Bhatia, Luciano J Costa, Grant R Williams, Smith Giri
BACKGROUND: Low skeletal muscle mass (LSMM) and/or, function associated with an increased risk of treatment-related toxicities and inferior overall survival (OS) among adults with solid malignancies. However, the association between LSMM and treatment-related toxicities among adults with haematologic malignancies remains unclear. METHODS: Using a pre-published protocol (CRD42020197814), we searched seven bibliographic databases from inception to 08/2021 for studies reporting the impact of LSMM among adults ≥18 years with a known haematologic malignancy...
April 1, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38556722/mapping-the-causal-associations-of-cytokines-with-sarcopenia-and-aging-traits-evidence-from-bidirectional-mendelian-randomization
#10
JOURNAL ARTICLE
Mingchong Liu, Xiao Fu, Daqian Yu, Meng Li, Yutao Pan, Chensong Yang, Guixin Sun
BACKGROUND: Cytokines and growth factors may serve as a bridge in studying the causal relationships between inflammaging and sarcopenia due to their roles in inflammaging. In this study, we aim to explore the causal association of cytokines with sarcopenia and aging traits and further identify the significant inflammation factors. METHODS: Bidirectional Mendelian randomization (MR) analysis was used to identify the causality. Forty-one kinds of circulation cytokines and growth factors were set as exposures, and the data were from a summary genome-wide association study (GWAS) containing three cohorts with 8293 healthy participants of European ancestry from 1983 to 2011...
March 31, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38553835/leukocyte-telomere-length-is-associated-with-mri-thigh-fat-free-muscle-volume-data-from-16-356-uk-biobank-adults
#11
JOURNAL ARTICLE
Ben Kirk, Chia-Ling Kuo, Peiran Liu, Meiruo Xiang, Jacob E Earp, Jatupol Kositsawat, George A Kuchel, Gustavo Duque
BACKGROUND: Telomere attrition may share common biological mechanisms with bone and muscle loss with aging. Here, we investigated the association between these hallmarks of aging using data from UK Biobank, a large observational study. METHODS: Leukocyte telomere length (LTL as T/S ratio) was measured using a multiplex qPCR assay at baseline (2006-2010). Bone mineral density (whole body and regional; via dual-energy X-ray absorptiometry), trabecular bone score (via lumbar-spine dual-energy X-ray absorptiometry images), fat-free muscle volume (thighs; via magnetic resonance imaging), and muscle fat infiltration (thighs; via magnetic resonance imaging) were measured during the imaging visit (2014-2018)...
March 29, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38553831/the-regulation-of-mfg-e8-on-the-mitophagy-in-diabetic-sarcopenia-via-the-hspa1l-parkin-pathway-and-the-effect-of-d-pinitol
#12
JOURNAL ARTICLE
Wenqian Zhao, Bin Zhao, Xinyue Meng, Baoying Li, Yajuan Wang, Fei Yu, Chunli Fu, Xin Yu, Xiaoli Li, Chaochao Dai, Jie Wang, Haiqing Gao, Mei Cheng
BACKGROUND: Diabetic sarcopenia is a disease-related skeletal muscle disorder that causes progressive symptoms. The complete understanding of its pathogenesis is yet to be unravelled, which makes it difficult to develop effective therapeutic strategies. This study investigates how MFG-E8 affects mitophagy and the protective role of D-pinitol (DP) in diabetic sarcopenia. METHODS: In vivo, streptozotocin-induced diabetic SAM-R1 (STZ-R1) and SAM-P8 (STZ-P8) mice (16-week-old) were used, and STZ-P8 mice were administrated of DP (150 mg/kg per day) for 6 weeks...
March 29, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38553412/the-effect-of-low-birth-weight-as-an-intrauterine-exposure-on-the-early-onset-of-sarcopenia-through-possible-molecular-pathways
#13
REVIEW
Dilek Celik, Manuela Campisi, Luana Cannella, Sofia Pavanello
Sarcopenia, a musculoskeletal disease characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, presents significant challenges to global public health due to its adverse effects on mobility, morbidity, mortality, and healthcare costs. This comprehensive review explores the intricate connections between sarcopenia and low birth weight (LBW), emphasizing the developmental origins of health and disease (DOHaD) hypothesis, inflammatory processes (inflammaging), mitochondrial dysfunction, circadian rhythm disruptions, epigenetic mechanisms, and genetic variations revealed through genome-wide studies (GWAS)...
March 29, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38553255/quality-of-life-endpoints-in-cancer-cachexia-clinical-trials-systematic-review-3-of-the-cachexia-endpoints-series
#14
REVIEW
Marianne J Hjermstad, Gunnhild Jakobsen, Jann Arends, Trude Balstad, Leo R Brown, Asta Bye, Andrew J S Coats, Olav F Dajani, Ross D Dolan, Marie T Fallon, Christine Greil, Alexandra Grzyb, Stein Kaasa, Lisa H Koteng, Anne M May, James McDonald, Inger Ottestad, Iain Philips, Eric J Roeland, Judith Sayers, Melanie R Simpson, Richard J E Skipworth, Tora S Solheim, Mariana S Sousa, Ola M Vagnildhaug, Barry J A Laird
The use of patient-reported outcomes (PROMs) of quality of life (QOL) is common in cachexia trials. Patients' self-report on health, functioning, wellbeing, and perceptions of care, represent important measures of efficacy. This review describes the frequency, variety, and reporting of QOL endpoints used in cancer cachexia clinical trials. Electronic literature searches were performed in Medline, Embase, and Cochrane (1990-2023). Seven thousand four hundred thirty-five papers were retained for evaluation. Eligibility criteria included QOL as a study endpoint using validated measures, controlled design, adults (>18 years), ≥40 participants randomized, and intervention exceeding 2 weeks...
March 29, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533539/lack-of-vitamin-d-signalling-in-mesenchymal-progenitors-causes-fatty-infiltration-in-muscle
#15
JOURNAL ARTICLE
Tohru Hosoyama, Minako Kawai-Takaishi, Hiroki Iida, Yoko Yamamoto, Yuko Nakamichi, Tsuyoshi Watanabe, Marie Takemura, Shigeaki Kato, Akiyoshi Uezumi, Yasumoto Matsui
BACKGROUND: Recent studies have indicated the importance of muscle quality in addition to muscle quantity in sarcopenia pathophysiology. Intramuscular adipose tissue (IMAT), which originates from mesenchymal progenitors (MPs) in adult skeletal muscle, is a key factor affecting muscle quality in older adults, suggesting that controlling IMAT formation is a promising therapeutic strategy for sarcopenia. However, the molecular mechanism underlying IMAT formation in older adults has not been clarified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533530/are-measures-and-related-symptoms-of-cachexia-recorded-as-outcomes-in-gastrointestinal-cancer-chemotherapy-clinical-trials
#16
JOURNAL ARTICLE
Ross Valaire, Frances Garden, Valentina Razmovski-Naumovski
BACKGROUND: Cachexia is prevalent in gastrointestinal cancers and worsens patient outcomes and chemotherapy compliance. We examined to what extent registered gastrointestinal cancer chemotherapy clinical trials record measures and related symptoms of cachexia as outcomes, and whether these were associated with trial characteristics. METHODS: Four public trial registries (2012-2022) were accessed for Phase II and/or III randomized controlled pancreatic, gastric, and colorectal cancer chemotherapy trial protocols...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533529/adar2-deficiency-ameliorates-non-alcoholic-fatty-liver-disease-and-muscle-atrophy-through-modulating-serum-amyloid-a1
#17
JOURNAL ARTICLE
Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, Yun-Wen Chen
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLD. Adenosine-to-inosine editing, catalysed by adenosine deaminase acting on RNA (ADAR), is an important post-transcriptional modification of genome-encoded RNA transcripts. Three ADAR gene family members, including ADAR1, ADAR2 and ADAR3, have been identified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38526005/the-evolution-and-impact-of-sarcopenia-in-severe-aplastic-anaemia-survivors-following-allogeneic-haematopoietic-cell-transplantation
#18
JOURNAL ARTICLE
Dandan Chen, Zhaohu Yuan, Yuan Guo, Weifeng Liu, Zixuan Cheng, Lihua Ye, Wenjian Mo, Xinhua Wei
BACKGROUND: Sarcopenia is a potential risk factor for adverse outcomes in haematopoietic cell transplantation (HSCT) recipients. We aimed to explore longitudinal body changes in muscle and adipose mass and their prognostic value in allogeneic HSCT-treated severe aplastic anaemia (SAA) patients. METHODS: We retrospectively analysed consecutive SAA patients who underwent allogeneic HSCT between January 2017 and March 2022. Measurements of pectoral muscle and corresponding subcutaneous fat mass were obtained via chest computed tomography at baseline and at 1 month, 3 months, 6 months, and 12 months following HSCT...
March 25, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38520252/standardizing-trait-selection-in-mendelian-randomization-studies-concerning-sarcopenia
#19
LETTER
Mingchong Liu, Pengcheng Chen, Chensong Yang, Guixin Sun
No abstract text is available yet for this article.
March 23, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38515400/metabolic-syndrome-and-cardiovascular-disease-in-cancer-survivors
#20
JOURNAL ARTICLE
Kensuke Ueno, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Satoshi Matsuoka, Katsuhito Fujiu, Nobuaki Michihata, Taisuke Jo, Norifumi Takeda, Hiroyuki Morita, Kentaro Kamiya, Junya Ako, Koichi Node, Hideo Yasunaga, Issei Komuro
BACKGROUND: The risk of subsequent cardiovascular disease (CVD) is high in cancer survivors. Although metabolic syndrome is an established risk factor for CVD, its association with cancer survivors has not yet been established. This study aimed to clarify whether metabolic syndrome is associated with subsequent CVD risk in patients with cancer using a nationwide epidemiological dataset. METHODS: We retrospectively analysed 53 510 patients with a history of breast, colorectal, or stomach cancer, which is reportedly a major site for developing cancer in Japan...
March 22, 2024: Journal of Cachexia, Sarcopenia and Muscle
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