journal
https://read.qxmd.com/read/38858159/development-of-a-core-outcome-set-for-cardiac-rehabilitation-in-patients-with-myocardial-infarction-a-study-protocol
#41
JOURNAL ARTICLE
Zhiyue Guan, Xinyi Zhang, Yinghui Jin, Ruijin Qiu, Hongcai Shang
INTRODUCTION: Heterogeneous outcome reporting is common in clinical trials focused on cardiac rehabilitation for myocardial infarction (MI); this practice often results in the exclusion of data from clinical trials in systematic reviews. Developing a core outcome set (COS) may solve this problem. METHODS AND ANALYSIS: We will first identify a preliminary list of outcomes through a systematic review. Next, we will conduct semistructured interviews with patients to explore additional potential outcomes deemed important by patients...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858158/trends-in-c-reactive-protein-testing-a-retrospective-cohort-study-in-paediatric-ambulatory-care-settings
#42
JOURNAL ARTICLE
Mohammed Alkhmees, Ann Van Den Bruel, Gail Hayward, Marco H Blanker, Sarah Walker, Gea A Holtman
OBJECTIVES: This study aims to investigate C reactive protein (CRP) testing practices in paediatric ambulatory care across British primary care and accident and emergency (A&E) departments. DESIGN, SETTING, PARTICIPANTS: This retrospective cohort study included children <18 years old having ≥1 CRP test at primary care or A&E departments in Oxfordshire between 2007 and 2021. OUTCOMES: We estimated the frequency and annual changes in CRP testing in both settings and evaluated referral and admission patterns based on CRP levels: low (<20 mg/L), intermediate or high (≥80 mg/L)...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858157/eras-for-ambulatory-turbt-enhancing-bladder-cancer-care-embrace-randomised-controlled-trial-protocol
#43
RANDOMIZED CONTROLLED TRIAL
Michael E Rezaee, Katherine M Mahon, Bruce J Trock, The-Hung Edward Nguyen, Armine K Smith, Noah M Hahn, Sunil H Patel, Max Kates
INTRODUCTION: Transurethral resection of bladder tumour (TURBT) is one of the more common procedures performed by urologists. It is often described as an 'incision-free' and 'well-tolerated' operation. However, many patients experience distress and discomfort with the procedure. Substantial opportunity exists to improve the TURBT experience. An enhanced recovery after surgery (ERAS) protocol designed by patients with bladder cancer and their providers has been developed. METHODS AND ANALYSIS: This is a single-centre, randomised controlled trial to investigate the effectiveness of an ERAS protocol compared with usual care in patients with bladder cancer undergoing ambulatory TURBT...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858156/efficacy-and-safety-of-sbrt-combined-with-sintilimab-and-ibi305-in-patients-with-advanced-hcc-and-previously-failed-immunotherapy-study-protocol-of-a-phase-2-clinical-trial
#44
JOURNAL ARTICLE
Jinfeng Zhang, Yongqiang Yang, Zilong Wu, Sisi Zhang, Zhenyu Lin, Hongli Liu, Jianli Hu, Tao Zhang, Jing Tang, Jun Xue
INTRODUCTION: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in China. The combination of immune checkpoint inhibitors (ICIs) and antiangiogenic drugs, such as bevacizumab and tyrosine kinase inhibitors, has been recommended as first-line treatment for advanced HCC. However, two-thirds of patients did not benefit from this form of immunotherapy. Currently, data on the subsequent regimen for patients previously treated with ICIs are lacking. Studies have shown that the combination of radiotherapy (RT) and ICIs is a potentially effective second-line therapy for HCC...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858155/implementation-barriers-and-facilitators-of-remote-monitoring-remote-consultation-and-digital-care-platforms-through-the-eyes-of-healthcare-professionals-a-review-of-reviews
#45
JOURNAL ARTICLE
Susan J Oudbier, Sylvie P Souget-Ruff, Britney S J Chen, Kirsten A Ziesemer, Hans J Meij, Ellen M A Smets
OBJECTIVES: Digital transformation in healthcare is a necessity considering the steady increase in healthcare costs, the growing ageing population and rising number of people living with chronic diseases. The implementation of digital health technologies in patient care is a potential solution to these issues, however, some challenges remain. In order to navigate such complexities, the perceptions of healthcare professionals (HCPs) must be considered. The objective of this umbrella review is to identify key barriers and facilitators involved in digital health technology implementation, from the perspective of HCPs...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858154/occupational-safety-and-health-of-nurses-during-the-covid-19-pandemic-the-missing-part-of-quality-care-a-qualitative-study
#46
JOURNAL ARTICLE
Farkhondeh Mehboodi, Vahid Zamanzadeh, Azad Rahmani, Iman Dianat, Reza Shabanloie
OBJECTIVE: This study explored the consequences of COVID-19 on the occupational safety and health of nurses. DESIGN: Qualitative conventional content analysis. PARTICIPANTS: 14 nurses selected by purposeful sampling method. SETTING: Five educational and non-educational hospitals in the Northwest of Iran. DATA COLLECTION AND ANALYSIS: Semistructured interviews were used for data collection and analysed using conventional content analysis...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858153/expert-consensus-on-a-protocol-for-conducting-bibliometric-analysis-of-scientific-articles-on-global-migration-health-gmh
#47
JOURNAL ARTICLE
Sweetmavourneen Pernitez-Agan, Mary Ann Cruz Bautista, Janice Lopez, Margaret Sampson, Anuj Kapilashrami, Melissa Garabiles, Charles Hui, Bontha Babu, Roomi Aziz, Lucy P Jordan, Teddy Rowell U Mondres, May Antonnette Lebanan, Kolitha Wickramage
BACKGROUND: Migration and health are key priorities in global health and essential for protecting and promoting the health of migrants. To better understand the existing evidence on migration health, it is critical to map the research publication activity and evidence on the health of migrants and mobile populations. This paper presents a search strategy protocol for a bibliometric analysis of scientific articles on global migration health (GMH), leveraging the expertise of a global network of researchers and academics...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858152/patient-and-proxy-perspectives-in-decision-making-for-geriatric-hip-fracture-management-in-the-netherlands-a-qualitative-study
#48
JOURNAL ARTICLE
Duco Laane, Thamar Kroes, Arda van den Berg, Mariska de Jongh, Regina The, Detlef Van der Velde, Thomas Nijdam
OBJECTIVE: The objective of this study was to explore the perspectives with the decision-making process between surgery and palliative, non-operative management of geriatric hip fracture patients and their proxies. DESIGN: A qualitative interview study was performed. Patients and proxies were asked to participate in semi-structured interviews. Data were analysed using reflexive thematic analysis according to Braun and Clarke's six-step guide. SETTING AND PARTICIPANTS: Hip fracture patients in the Netherlands were eligible for inclusion...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858151/faecal-microbiota-transplantation-fmt-in-norwegian-outpatients-with-mild-to-severe-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-protocol-for-a-12-month-randomised-double-blind-placebo-controlled-trial
#49
JOURNAL ARTICLE
Linn Skjevling, Rasmus Goll, Hege Marie Hanssen, Peter Holger Johnsen
INTRODUCTION: The observed alteration of the intestinal microbiota in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and the effect of transferring a healthy gut flora from a faecal donor using a faecal microbiota transplantation (FMT) will be explored in this trial. METHODS AND ANALYSIS: This is a protocol for a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial, with 12 months follow-up. 80 participants will be included and randomised (1:1:2) to either donor FMT (from two different donors) or placebo (autologous FMT)...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858150/neonatal-resuscitation-online-registry-in-shenzhen-protocol-for-a-prospective-multicentre-open-observational-cohort-study
#50
MULTICENTER STUDY
Hanni Lin, Jing Han, Ping Jiang, Zhangbin Yu, Ping Zhou, Hong Tang, Lu Ding, Jiebo Liu
INTRODUCTION: Preterm birth complications and neonatal asphyxia are the leading causes of neonatal mortality worldwide. Surviving preterm and asphyxiated newborns can develop neurological sequelae; therefore, timely and appropriate neonatal resuscitation is important to decrease neonatal mortality and disability rates. There are very few systematic studies on neonatal resuscitation in China, and its prognosis remains unclear. We established an online registry for neonatal resuscitation in Shenzhen based on Utstein's model and designed a prospective, multicentre, open, observational cohort study to address many of the limitations of existing studies...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858149/pilot-study-to-evaluate-the-use-of-remote-patient-monitoring-to-guide-the-timing-of-valve-intervention-in-patients-with-severe-asymptomatic-aortic-stenosis-apraise-as-study-protocol-for-a-randomised-controlled-trial-delivered-in-two-tertiary-cardiac-centres
#51
JOURNAL ARTICLE
Nazish Khan, Richard P Steeds, Derek Kyte, Larissa Fabritz, Philip Collis, Winnie Chua, Clive Stubbs, Samir Mehta, Yongzhong Sun, Mary Nulty, Katie Kirkham, James M Cotton
INTRODUCTION: Aortic stenosis (AS) is common affecting >13% of adults over the age of 75 years. In people who develop symptoms, without valve replacement, prognosis is dismal with mortality as high as 50% at 1 year. In asymptomatic patients, the timing of valve intervention is less well defined and a strategy of watchful waiting is recommended. Many, however, may develop symptoms and attribute this to age related decline, rather than worsening AS. Timely intervention in asymptomatic severe AS is critical, since delayed intervention often results in poor outcomes...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858148/covid-19-vaccine-uptake-among-ontario-physicians-a-descriptive-population-based-retrospective-cohort-study
#52
JOURNAL ARTICLE
Cheng-Wei Liu, Nivethika Jeyakumar, Eric McArthur, Jessica M Sontrop, Daniel T Myran, Kevin L Schwartz, Manish M Sood, Peter Tanuseputro, Amit X Garg
OBJECTIVES: To determine COVID-19 vaccine uptake among physicians in Ontario, Canada from 14 December 2020 to 13 February 2022. DESIGN: Population-based retrospective cohort study. SETTING: All registered physicians in Ontario, Canada using data from linked provincial administrative healthcare databases. PARTICIPANTS: 41 267 physicians (including postgraduate trainees) who were Ontario residents and registered with the College of Physicians and Surgeons of Ontario were included...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858147/efficacy-and-safety-of-tirofiban-in-patients-with-acute-branch-atheromatous-disease-related-stroke-brant-a-protocol-for-a-randomised-controlled-trial
#53
MULTICENTER STUDY
Shengde Li, Dingding Zhang, Yuhui Sha, Yicheng Zhu, Lixin Zhou, Bin Peng, Jun Ni
INTRODUCTION: Branch atheromatous disease (BAD)-related stroke is increasingly becoming a clinical entity and prone to early neurological deterioration (END) and poor prognosis. There are no effective regimens to reduce the disability caused by BAD-related stroke in acute phase. Recent studies have indicated the efficacy of tirofiban in acute ischaemic stroke; however, its efficacy has not been validated in patients with BAD-related stroke. Thus, we aim to test whether intravenous tirofiban initiated within 48 hours after the onset would improve the functional outcome in patients with acute BAD-related stroke, in comparison with the standard antiplatelet therapy based on the current guideline...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858146/air-pollution-and-cancer-daily-mortality-in-hangzhou-china-an-ecological-research
#54
JOURNAL ARTICLE
Zongxue Cheng, Kang Qin, Yan Zhang, Zhecong Yu, Biao Li, Caixia Jiang, Jue Xu
BACKGROUND: Long-term exposure to air pollution has been linked to cancer incidence. However, the evidence is limited regarding the effect of short-term exposure to air pollution on cancer mortality. OBJECTIVES: This study aimed to investigate associations between short-term exposure to air pollutants (sulfur dioxide (SO2 ), nitrogen dioxide (NO2 ), particulate matter with an aerodynamic diameter <10 mm (PM10 ) and PM2.5 ) and cancer daily mortality. METHODS: This study used air quality, meteorological and daily cancer death data from 2014 to 2019 in Hangzhou, China...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858145/saba-prescriptions-and-asthma-management-practices-in-singapore-results-from-a-cross-sectional-observational-sabina-iii-study
#55
MULTICENTER STUDY
David Hsien Yung Tan, Tze Lee Tan, Wee Hian Tan, Cheryl Choong, Maarten J H I Beekman, Joanne Huiyi Khor, S Suraj Kumar, Geraldine Ruining Wong, Hui Fang Lim
OBJECTIVES: To evaluate asthma characteristics and treatment patterns, including short-acting β2 -agonist (SABA) prescriptions, in primary and specialist care in the Singapore cohort of the SABA use IN Asthma (SABINA III) study. DESIGN: Cross-sectional, observational study. SETTING: Multicentre study conducted at five sites across Singapore. METHODS: In patients with asthma (aged ≥12 years), data on demographics, disease characteristics and asthma treatment prescriptions were collected using electronic case report forms...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858144/effects-of-peer-education-training-on-cardiopulmonary-resuscitation-knowledge-and-skill-retention-of-secondary-school-students-a-feasibility-study
#56
RANDOMIZED CONTROLLED TRIAL
Anastasia Spartinou, Vlasios Karageorgos, Konstantinos Sorokos, Panagiota Darivianaki, Emmanouil C Petrakis, Michalis Papapanagiotou, Othon Fraidakis, Vasileia Nyktari, Alexandra Papaioannou
OBJECTIVES: The need for cardiopulmonary resuscitation (CPR) training dissemination in the community could be resolved by mass school training programmes. However, the availability of instructors remains an unsolved problem. Our purpose was to investigate the effects of three different instructor types: healthcare professionals, schoolteachers and peer students, on CPR skills retention of secondary school students 6 months after training. DESIGN: The study was designed as a prospective randomised single-blinded controlled trial...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858143/feasibility-and-acceptability-of-a-telerehabilitation-intervention-on-patients-undergoing-total-knee-arthroplasty-in-iran-randomised-controlled-trial-protocol
#57
RANDOMIZED CONTROLLED TRIAL
Navvab Farrokhi, Mohammad Mahdi Sarzaeem, Davood Feizi
INTRODUCTION: Telerehabilitation is a promising avenue to enhance post-total knee arthroplasty (TKA) rehabilitation by improving accessibility, convenience and cost-effectiveness. Despite its potential benefits, its application in the context of TKA in Iran is in its early stages, lacking comprehensive studies on feasibility, acceptance and programme adherence. This article outlines a protocol for an open-label, parallel-group, randomised controlled trial investigating the impact of a 4 week telerehabilitation programme alongside usual care...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858142/understanding-the-association-between-family-planning-and-fertility-reduction-in-southeast-asia-a-scoping-review
#58
REVIEW
Anissa Rizkianti, Sari Kistiana, Desy Nuri Fajarningtiyas, Evalina Franciska Hutasoit, Andhika Ajie Baskoro, Herti Maryani, Anastasia Septya Titisari, Diah Puspita Sari, Margareth Maya P Naibaho, Melissa Melissa, Muthmainnah Muthmainnah
OBJECTIVES: We aimed to explore and understand the extent and type of evidence on fertility reduction and its association with family planning (FP) in Southeast Asia. DESIGN: Scoping review, following the methodological principles developed by Arksey and O'Malley and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines for reporting. DATA SOURCE: We searched PubMed/MEDLINE, ProQuest, EBSCO, Scopus, Web of Science, Google Scholar and reference lists of relevant articles between 1 January 2012 and 31 December 2022...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858141/global-prevalence-of-borrelia-burgdorferi-and-anaplasma-phagocytophilum-coinfection-in-ixodes-tick-populations-protocol-for-a-systematic-review-and-meta-analysis
#59
JOURNAL ARTICLE
Suyi Luo, Fukai Bao, Hanxin Wu, Weijie Ma, Liangyu Zhu, Xun Huang, Rui Yang, Li Peng, Li Gao, Xinya Wu, Lei Zhong, Yan Dong, Bingxue Li, Weijiang Ma, Aihua Liu
INTRODUCTION: Ixodes ticks are pivotal in transmitting diseases like Lyme disease and human granulocytic anaplasmosis, caused by Borrelia burgdorferi and Anaplasma phagocytophilum , respectively. These pathogens not only affect humans through single or multiple tick bites but also pose risks to animal hosts, leading to potential coinfections. Despite regional studies indicating significant prevalence, their global coinfection data remain sparse. This study aims to bridge this gap through a systematic review and meta-analysis of B...
June 10, 2024: BMJ Open
https://read.qxmd.com/read/38858140/evaluation-of-a-unique-and-innovative-diabetes-care-model-in-primary-care-in-ontario-canada-protocol-for-a-multiple-methods-study-with-a-convergent-parallel-design
#60
JOURNAL ARTICLE
Maria Mathews, Rhiannon Lyons, Stewart Harris, Lindsay Hedden, Yun-Hee Choi, Jennifer Donnan, Michael E Green, Elisabeth Harvey, Sonja M Reichert, Bridget Ryan, Shannon Sibbald, Leslie Meredith
INTRODUCTION: The growth and complexity of diabetes are exceeding the capacity of family physicians, resulting in the demand for community-based, interprofessional, primary care-led transition clinics. The Primary Care Diabetes Support Programme (PCDSP) in London, Ontario, is an innovative approach to diabetes care for high-risk populations, such as medically or socially complex and unattached patients. In this study, we will employ a quadruple-aim approach to evaluate the health system impacts of the PCDSP...
June 10, 2024: BMJ Open
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