journal
https://read.qxmd.com/read/38531570/precise-infliximab-exposure-and-pharmacodynamic-control-to-achieve-deep-remission-in-paediatric-crohn-s-disease-remodel-cd-study-protocol-for-a-multicentre-open-label-pragmatic-clinical-trial-in-the-usa
#21
JOURNAL ARTICLE
Phillip Paul Minar, Ruben J Colman, Nanhua Zhang, Tomoyuki Mizuno, Alexander A Vinks
INTRODUCTION: The only biologic therapy currently approved to treat moderate to severe Crohn's disease in children (<18 years old) are those that antagonise tumour necrosis factor-alpha (anti-TNF). Therefore, it is critically important to develop novel strategies that maximise treatment effectiveness in this population. There is growing evidence that rates of sustained corticosteroid-free clinical remission, endoscopic healing and drug durability considerably improve when patients receive early anti-TNF dose optimisations guided by reactive or proactive therapeutic drug monitoring and pharmacodynamic monitoring...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531569/efficacy-and-safety-of-traditional-chinese-manual-therapy-tuina-in-patients-with-non-specific-chronic-low-back-pain-a-study-protocol-for-a-randomised-controlled-trial
#22
JOURNAL ARTICLE
Ben Cao, Sitong Fang, Zhiwei Wu, Xin Zhou, Lingjun Kong, Qingguang Zhu, Bowen Zhu, Cheng Tang, Min Fang
INTRODUCTION: Non-pharmacological interventions play a crucial role in the management of non-specific chronic low back pain (NSCLBP). One prime example is Tuina, a traditional Chinese manual therapy that incorporates pressing, kneading and rubbing techniques to alleviate physical discomfort and enhance overall well-being. It serves as a widely used technique in China and other East Asian countries. However, the effectiveness and safety of Tuina for managing NSCLBP have not been substantiated through rigorous clinical research...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531568/community-health-workers-for-health-systems-resilience-during-covid-19-protocol-for-qualitative-evidence-synthesis
#23
JOURNAL ARTICLE
Neha Adsul, Jyoti Tyagi, Soumyadeep Bhaumik
INTRODUCTION: COVID-19 exposed the fragility of health systems, where even the most basic health services in high-income and low-income and middle-income nations could not withstand the health systems shock due to the pandemic. Community health workers (CHWs) can contribute to improving the resilience of health systems, specifically to withstand shocks and emergencies and to avoid disruptions of routine service delivery. We aim to explore and understand the 'individual' and 'systems-level' resilience factors that shaped the involvement of CHWs in the COVID-19 response...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531567/nomogram-for-predicting-moderate-to-severe-sleep-disordered-breathing-in-patients-with-acute-ischaemic-stroke-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Yang Gu, Junchao Xie, Xueyuan Liu, Xiaoyu Zhou
OBJECTIVES: Moderate-to-severe sleep-disordered breathing (SDB) is prevalent in patients with acute ischaemic stroke (AIS) and is associated with an increased risk of unfavourable prognosis. We aimed to develop and validate a reliable scoring system for the early screening of moderate-to-severe SDB in patients with AIS, with the objective of improving the management of those patients at risk. STUDY DESIGN: We developed and validated a nomogram model based on univariate and multivariate logistic analyses to identify moderate-to-severe SDB in AIS patients...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531566/comparison-of-the-effects-of-ultrasound-guided-quadratus-lumborum-block-and-erector-spinae-plane-block-on-postoperative-pain-in-abdominal-surgeries-a-protocol-for-systematic-review-and-meta-analysis
#25
JOURNAL ARTICLE
Xiangdong Zhang, Donghang Zhang, Xiaoqing Wang, Yiyong Wei
INTRODUCTION: Ultrasound-guided quadratus lumborum block and erector spinae plane block are widely used for postoperative analgesia in adult patients undergoing abdominal surgeries. This protocol aims to compare the analgesic effects between ultrasound-guided quadratus lumborum block and erector spinae plane block on postoperative pain in abdominal surgeries. METHODS AND ANALYSIS: Four databases, including PubMed, EMBASE, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL), will be searched...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531565/correlates-of-post-traumatic-stress-disorder-among-adult-residents-of-conflict-affected-communities-in-cross-river-state-nigeria-a-cross-sectional-study
#26
JOURNAL ARTICLE
Theresa Mark Awa, Ugbe Maurice-Joel Ugbe, Obiageli Chiezey Onwusaka, Eucheria Ekugeni Abua, Ekpereonne Babatunde Esu
BACKGROUND: Conflict-affected communities in Nigeria experience a range of problems. These experiences have been associated with different types of mental disorders, most notably, post-traumatic stress disorder (PTSD). AIM: This study sought to assess PTSD and its associated factors among adults in conflict-affected communities in Odukpani Local Government Area (LGA), Cross River State, Nigeria. METHODS: A cross-sectional study was conducted using non-probability and probability sampling techniques...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531564/investigation-of-renal-perfusion-and-pathological-changes-in-patients-with-acute-kidney-disease-and-tubulointerstitial-nephritis-using-intravoxel-incoherent-motion-and-arterial-spin-labelling-mri-a-prospective-observational-study-protocol
#27
JOURNAL ARTICLE
Jiajia Liu, Rui Wang, Jianxing Qiu, Tao Su
INTRODUCTION: Acute kidney injury (AKI) is a critical condition with a complex aetiology and different outcomes, where haemodynamic dysfunction, renal hypoperfusion and inflammation serve as key contributors to its development and progression. Early and accurate diagnosis is vital for initiating targeted treatments like fluid resuscitation, vasoactive agents or steroid therapy, which are essential for improving patient outcomes. Intravoxel incoherent motion (IVIM) MRI assesses both capillary perfusion and tissue water diffusion, while arterial spin labelling (ASL) MRI measures renal blood flow without the need for contrast...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531563/association-between-body-mass-index-and-delirium-incidence-in-critically-ill-patients-a-retrospective-cohort-study-based-on-the-mimic-iv-database
#28
JOURNAL ARTICLE
Jianlei Fu, Xuepeng Zhang, Geng Zhang, Canzheng Wei, Qinyi Fu, Xiying Gui, Yi Ji, Siyuan Chen
OBJECTIVES: Delirium is a form of brain dysfunction with high incidence and is associated with many negative outcomes in the intensive care unit. However, few studies have been large enough to reliably examine the associations between body mass index (BMI) and delirium, especially in critically ill patients. The objective of this study was to investigate the association between BMI and delirium incidence in critically ill patients. DESIGN: A retrospective cohort study...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531562/clinical-practice-guideline-recommendations-to-improve-the-mental-health-of-adult-trauma-patients-protocol-for-a-systematic-review
#29
JOURNAL ARTICLE
Mélanie Bérubé, Nori Bradley, Meaghan O'Donnell, Henry Thomas Stelfox, Naisan Garraway, Helen-Maria Vasiliadis, Valerie Turcotte, Michel Perreault, Matthew Menear, Léonie Archambault, Juanita Haagsma, Hélène Provencher, Christine Genest, Marc-Aurèle Gagnon, Laurence Bourque, Alexandra Lapierre, Amal Khalfi, William Panenka
INTRODUCTION: Mental disorders are common in adult patients with traumatic injuries. To limit the burden of poor psychological well-being in this population, recognised authorities have issued recommendations through clinical practice guidelines (CPGs). However, the uptake of evidence-based recommendations to improve the mental health of trauma patients has been low until recently. This may be explained by the complexity of optimising mental health practices and interpretating CGPs scope and quality...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531561/effectiveness-and-cost-effectiveness-of-a-web-based-cardiac-rehabilitation-programme-for-people-with-chronic-stable-angina-protocol-for-the-activate-angina-controlled-trial-investigating-the-value-of-the-activate-your-heart-therapeutic-e-intervention-randomised
#30
JOURNAL ARTICLE
Nefyn H Williams, Brendan Collins, Terence J Comerford, Susanna Dodd, Michael Fisher, Ben Hardwick, Sophie Hennessy, Kate Jolly, Ian Jones, Deirdre Lane, Gregory Y H Lip, Erica Morgan, Penelope Ralph, Dick Thijssen, Sally J Singh
INTRODUCTION: Chronic stable angina is common and disabling. Cardiac rehabilitation is routinely offered to people following myocardial infarction or revascularisation procedures and has the potential to help people with chronic stable angina. However, there is insufficient evidence of effectiveness and cost-effectiveness for its routine use in this patient group. The objectives of this study are to compare the effectiveness and cost-effectiveness of the 'Activate Your Heart' cardiac rehabilitation programme for people with chronic stable angina compared with usual care...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38521535/return-of-participant-level-clinical-trial-results-to-participants-pilot-of-a-simplified-centralised-approach
#31
JOURNAL ARTICLE
Eric Hoffman, Suzanne Gaglianone, Rahel Ketema, Wangshu Tu, Holly Peay, Paula Clemens, Utkarsh Dang, Laurie Conklin
OBJECTIVES: Public access databases such as clinicaltrials.gov achieve dissemination of clinical trial design and aggregated study results. However, return of participant-level data is rarely done. A key barrier includes the proprietary ownership of data by the sponsor. Additionally, investigators may not have access to centralised data, and per International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) Good Clinical Practice, must maintain the confidentiality of participants...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521534/prognostic-factors-and-prediction-models-for-hospitalisation-and-all-cause-mortality-in-adults-presenting-to-primary-care-with-a-lower-respiratory-tract-infection-a-systematic-review
#32
JOURNAL ARTICLE
Merijn H Rijk, Tamara N Platteel, Teun M C van den Berg, Geert-Jan Geersing, Paul Little, Frans H Rutten, Maarten van Smeden, Roderick P Venekamp
OBJECTIVE: To identify and synthesise relevant existing prognostic factors (PF) and prediction models (PM) for hospitalisation and all-cause mortality within 90 days in primary care patients with acute lower respiratory tract infections (LRTI). DESIGN: Systematic review. METHODS: Systematic searches of MEDLINE, Embase and the Cochrane Library were performed. All PF and PM studies on the risk of hospitalisation or all-cause mortality within 90 days in adult primary care LRTI patients were included...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521533/comparing-blastocyst-euploid-rates-between-the-progestin-primed-and-gonadotrophin-releasing-hormone-antagonist-protocols-in-aneuploidy-genetic-testing-a-randomised-trial-protocol
#33
JOURNAL ARTICLE
He Li, Min Yu, Wenbi Zhang, Junling Chen, Hua Chen, Xiang Lu, Lu Li, Ernest H Y Ng, Xiaoxi Sun
INTRODUCTION: Progestin can inhibit the pituitary luteinising hormone (LH) surge during ovarian stimulation for in vitro fertilisation (IVF) and studies show progestin-primed ovarian stimulation (PPOS) is effective in blocking the LH surge in IVF. More and more centres are using PPOS because this regimen appears simpler and cheaper. This study aims to compare the euploidy rate of blastocysts following the PPOS protocol and the gonadotropin-releasing hormone antagonist protocol in women undergoing preimplantation genetic testing for aneuploidy (PGT-A)...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521532/prospective-validity-of-a-clinical-prediction-rule-for-response-to-non-surgical-multidisciplinary-management-of-knee-osteoarthritis-in-tertiary-care-a-multisite-prospective-longitudinal-study
#34
JOURNAL ARTICLE
Peter Window, Maree Raymer, Steven M McPhail, Bill Vicenzino, Andrew Hislop, Alex Vallini, Bula Elwell, Helen O'Gorman, Ben Phillips, Anneke Wake, Adrian Cush, Stuart McCaskill, Linda Garsden, Miriam Dillon, Andrew McLennan, Shaun O'Leary
OBJECTIVES: We tested a previously developed clinical prediction tool-a nomogram consisting of four patient measures (lower patient-expected benefit, lower patient-reported knee function, greater knee varus angle and severe medial knee radiological degeneration) that were related to poor response to non-surgical management of knee osteoarthritis. This study sought to prospectively evaluate the predictive validity of this nomogram to identify patients most likely to respond poorly to non-surgical management of knee osteoarthritis...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521531/association-of-the-triglyceride-glucose-index-with-severity-of-coronary-stenosis-and-in-hospital-mortality-in-patients-with-acute-st-elevation-myocardial-infarction-after-percutaneous-coronary-intervention-a-multicentre-retrospective-analysis-cohort-study
#35
JOURNAL ARTICLE
Xin Lu, Xin Lin, Yingying Cai, Xiaoxiao Zhang, Haoyu Meng, Weiwei Chen, Peng Yu, Xiaohu Chen
OBJECTIVES: To explore the impact of the triglyceride-glucose (TyG) index on the severity of coronary stenosis and the risk of in-hospital mortality in patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). DESIGN: A multicentre retrospective cohort study. SETTING: Patients with STEMI undergoing PCI from three centres in China from 2015 to 2019. PARTICIPANTS: A total of 1491 individuals presenting with STEMI were enrolled...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521530/association-between-immune-inflammatory-indexes-and-lower-urinary-tract-symptoms-an-analysis-of-cross-sectional-data-from-the-us-national-health-and-nutrition-examination-survey-2005-2008
#36
JOURNAL ARTICLE
Wen Liu, Jia Wang, Miaomiao Wang, Xin Ding, Miao Wang, Ming Liu
OBJECTIVE: This study aimed to systematically investigate the relationship between immune-inflammatory indexes with lower urinary tract symptoms (LUTSs). DESIGN: Cross-sectional study. SETTING: National Health and Nutrition Examination Survey (NHANES) (2005-2008). PARTICIPANTS: A total of 2709 men with complete information for immune-inflammatory indexes and LUTSs were included from NHANES 2005-2008. OUTCOMES AND ANALYSES: Automated haematology analysing devices are used to measure blood cell counts, and LUTSs were presented by standard questionnaires...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521529/characteristics-of-constipation-screening-and-assessment-tools-a-scoping-review-protocol
#37
JOURNAL ARTICLE
Lene Odgaard, Anne A Rasmussen, Rebecca Feo, Pia Kjær Kristensen
INTRODUCTION: Constipation is a common and significant burden on individuals and healthcare systems. Accurate assessment of constipation severity and symptom improvement are vital aspects of caring for patients with constipation. Therefore, nurses and allied healthcare professionals should possess knowledge regarding the characteristics of constipation assessment tools (ie, aim, scope, definition of constipation, content, structure, mode, administration time and context of use). However, existing reviews summarising characteristics of tools have been restricted to chronic constipation and self-reported measures...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521528/longitudinal-association-of-sleep-duration-with-possible-sarcopenia-evidence-from-charls
#38
JOURNAL ARTICLE
Xiaoling Lv, Wenjia Peng, Bingbing Jia, Ping Lin, Zhouxin Yang
OBJECTIVES: There are limited data on the relationship between sleep duration and possible sarcopenia. Hence, this study aimed to investigate the associations of sleep duration with possible sarcopenia and its defining components based on the China Health and Retirement Longitudinal Study (CHARLS). DESIGN: A retrospective cohort study. SETTING: This study was conducted on participants aged over 45 years applying the 2011 baseline and 2015 follow-up survey from CHARLS covering 450 villages, 150 counties and 28 provinces...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521527/realist-evaluation-of-maternity-waiting-home-intervention-models-in-inhambane-mozambique-protocol-for-a-comparative-embedded-case-study-the-mozambique-canada-maternal-health-project
#39
JOURNAL ARTICLE
Nadege Sandrine Uwamahoro, Jessie Forsyth, Fernanda Andre, Dórcia António Mandlate, Brynne Gilmore, Nazeem Muhajarine
INTRODUCTION: This is a study protocol that tests and refines realist theories regarding the uptake and scale-up of the linked maternity waiting home (hereafter MWH) and facility birth intervention in the Mozambican context. The theories were developed through a realist review of MWH-facility birth literature from low-income and middle-income countries. The aim of the proposed study is to contribute to a contextually refined understanding of the causal chains underlying MWH-facility birth adoption by pregnant women and their families, communities, the health system and donors...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521526/defining-the-hidden-burden-of-disease-in-rural-communities-in-bangladesh-cambodia-and-thailand-a-cross-sectional-household-health-survey-protocol
#40
JOURNAL ARTICLE
Meiwen Zhang, Nan Shwe Nwe Htun, Shayla Islam, Aninda Sen, Akramul Islam, Amit Kumer Neogi, Rupam Tripura, Lek Dysoley, Carlo Perrone, Rusheng Chew, Elizabeth M Batty, Watcharintorn Thongpiam, Jantana Wongsantichon, Chonticha Menggred, Sazid Ibna Zaman, Naomi Waithira, Stuart Blacksell, Marco Liverani, Sue Lee, Richard James Maude, Nicholas P J Day, Yoel Lubell, Thomas Julian Peto
INTRODUCTION: In low-income and middle-income countries in Southeast Asia, the burden of diseases among rural population remains poorly understood, posing a challenge for effective healthcare prioritisation and resource allocation. Addressing this knowledge gap, the South and Southeast Asia Community-based Trials Network (SEACTN) will undertake a survey that aims to determine the prevalence of a wide range of non-communicable and communicable diseases, as one of the key initiatives of its first project-the Rural Febrile Illness project (RFI)...
March 23, 2024: BMJ Open
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