journal
https://read.qxmd.com/read/38637131/effect-and-outcome-of-equity-diversity-and-inclusion-programs-in-healthcare-institutions-a-systematic-review-protocol
#1
JOURNAL ARTICLE
Amos Buh, Rachel Kang, Rohan Kiska, Stephen G Fung, Marco Solmi, Mekaylah Scott, Maria Salman, Kathryn Lee, Benjamin Milone, Gamal Wafy, Sarah Syed, Shan Dhaliwal, Maya Gibb, Ayub Akbari, Pierre A Brown, Gregory L Hundemer, Manish M Sood
BACKGROUND: Equity, diversity and inclusion (EDI) in the healthcare field are crucial in meeting the healthcare needs of a progressively diverse society. In fact, a diverse healthcare workforce enables culturally sensitive care, promotes health equity and enhances the understanding of various needs and patients' viewpoints, potentially resulting in more effective patient treatment and improved patient outcomes. Despite this, information on the effectiveness of policies or programmes promoting EDI in health institutions is scarce...
April 18, 2024: BMJ Open
https://read.qxmd.com/read/38637130/cohort-profile-worldwide-collaboration-on-osteoarthritis-prediction-for-the-hip-world-coach-an-international-consortium-of-prospective-cohort-studies-with-individual-participant-data-on-hip-osteoarthritis
#2
JOURNAL ARTICLE
Michiel M A van Buuren, Noortje S Riedstra, Myrthe A van den Berg, Fleur D E M Boel, Harbeer Ahedi, Vahid Arbabi, Nigel K Arden, Sita M A Bierma-Zeinstra, Cindy G Boer, Flavia Cicuttini, Timothy F Cootes, Kay Crossley, David Felson, Willem Paul Gielis, Joshua Heerey, Graeme Jones, Stefan Kluzek, Nancy E Lane, Claudia Lindner, John A Lynch, J Van Meurs, Andrea B Mosler, Amanda E Nelson, M Nevitt, Edwin Oei, Jos Runhaar, Jinchi Tang, Harrie Weinans, Rintje Agricola
PURPOSE: Hip osteoarthritis (OA) is a major cause of pain and disability worldwide. Lack of effective therapies may reflect poor knowledge on its aetiology and risk factors, and result in the management of end-stage hip OA with costly joint replacement. The Worldwide Collaboration on OsteoArthritis prediCtion for the Hip (World COACH) consortium was established to pool and harmonise individual participant data from prospective cohort studies. The consortium aims to better understand determinants and risk factors for the development and progression of hip OA, to optimise and automate methods for (imaging) analysis, and to develop a personalised prediction model for hip OA...
April 18, 2024: BMJ Open
https://read.qxmd.com/read/38637129/participant-recruitment-and-attrition-in-surgical-randomised-trials-with-placebo-controls-versus-non-operative-controls-a-meta-epidemiological-study-and-meta-analysis
#3
JOURNAL ARTICLE
Pragadesh Natarajan, Spiro Menounos, Laura Harris, Masiath Monuja, Alexandra Gorelik, Teemu Karjalainen, Rachelle Buchbinder, Ian A Harris, Justine M Naylor, Sam Adie
OBJECTIVE: To compare differences in recruitment and attrition between placebo control randomised trials of surgery, and trials of the same surgical interventions and conditions that used non-operative (non-placebo) controls. DESIGN: Meta-epidemiological study. DATA SOURCES: Randomised controlled trials were identified from an electronic search of MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials from their inception date to 21 November 2018...
April 18, 2024: BMJ Open
https://read.qxmd.com/read/38637128/-e-xploratory-study-of-using-m-agnetic-resonance-p-rognostic-i-maging-markers-for-r-adiotherapy-i-n-c-ervix-cancer-empiric-a-prospective-cohort-study-protocol
#4
JOURNAL ARTICLE
Mohammed Abdul-Latif, Amani Chowdhury, Hannah Tharmalingam, N Jane Taylor, Amish Lakhani, Anwar Padhani, Peter Hoskin, Yatman Tsang
INTRODUCTION: Radical chemoradiotherapy represents the gold standard for locally advanced cervical cancer. However, despite significant progress in improving local tumour control, distant relapse continues to impact overall survival. The development of predictive and prognostic biomarkers is consequently important to risk-stratify patients and identify populations at higher risk of poorer treatment response and survival outcomes. Exploratory study of using Magnetic resonance Prognostic Imaging markers for Radiotherapy In Cervix cancer (EMPIRIC) is a prospective exploratory cohort study, which aims to investigate the role of multiparametric functional MRI (fMRI) using diffusion-weighed imaging (DWI), dynamic contrast-enhanced (DCE) and blood oxygen level-dependent imaging (BOLD) MRI to assess treatment response and predict outcomes in patients undergoing radical chemoradiotherapy for cervical cancer...
April 18, 2024: BMJ Open
https://read.qxmd.com/read/38637127/cavitron-ultrasonic-surgical-aspirator-cusa-compared-with-conventional-pancreatic-transection-in-distal-pancreatectomy-study-protocol-for-the-randomised-controlled-cusa-1-pilot-trial
#5
JOURNAL ARTICLE
Magdalena Holze, Martin Loos, Felix Hüttner, Solveig Tenckhoff, Manuel Feisst, Phillip Knebel, Rosa Klotz, Arianeb Mehrabi, Christoph Michalski, Frank Pianka
BACKGROUND: Postoperative pancreatic fistula (POPF) remains the most common and serious complication after distal pancreatectomy. Many attempts at lowering fistula rates have led to unrewarding insignificant results as still up to 30% of the patients suffer from clinically relevant POPF. Therefore, the development of new innovative methods and procedures is still a cornerstone of current surgical research.The cavitron ultrasonic surgical aspirator (CUSA) device is a well-known ultrasound-based parenchyma transection method, often used in liver and neurosurgery which has not yet been thoroughly investigated in pancreatic surgery, but the first results seem very promising...
April 18, 2024: BMJ Open
https://read.qxmd.com/read/38631841/restrictive-use-of-restraints-and-delirium-duration-in-the-intensive-care-unit-r2d2-icu-protocol-for-a-french-multicentre-parallel-group-open-label-randomised-controlled-trial
#6
JOURNAL ARTICLE
Romain Sonneville, Camille Couffignal, Florian Sigaud, Virginie Godard, Juliette Audibert, Damien Contou, Adam Celier, Michel Djibre, Julien Schmidt, Pierre Jaquet, Armand Mekontso Dessap, Claire Bourel, Romane Bellot, Carine Roy, Fariza Lamara, Fatiha Essardy, Jean-François Timsit, Renaud Cornic, Lila Bouadma
INTRODUCTION: Physical restraint (PR) is prescribed in patients receiving invasive mechanical ventilation in the intensive care unit (ICU) to avoid unplanned removal of medical devices. However, it is associated with an increased risk of delirium. We hypothesise that a restrictive use of PR, as compared with a systematic use, could reduce the duration of delirium in ICU patients receiving invasive mechanical ventilation. METHODS AND ANALYSIS: The Restrictive use of Restraints and Delirium Duration in ICU (R2D2-ICU) study is a national multicentric, parallel-group, randomised (1:1) open-label, controlled, superiority trial, which will be conducted in 10 ICUs...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631840/de-imfar-phase-ii-project-a-study-protocol-for-a-cluster-randomised-implementation-trial-to-evaluate-the-effectiveness-of-de-implementation-strategies-to-reduce-low-value-statin-prescribing-in-the-primary-prevention-of-cardiovascular-disease
#7
JOURNAL ARTICLE
Alvaro Sanchez, Jose Ignacio Pijoan, Rita Sainz de Rozas, Itxasne Lekue, Ricardo San Vicente, Jose Antonio Quindimil, Rafael Rotaeche, Arritxu Etxeberria, Carmela Mozo, Monica Martinez-Cengotitabengoa, Monica Monge, Cristina Gómez-Ramírez, Ricardo Samper, Mikel Ogueta Lana, Sara Celorrio, Nerea Merino-Inda, Marta Llarena, Marta Gonzalez Saenz de Tejada, Arturo García-Alvarez, Gonzalo Grandes
INTRODUCTION: This study aims to reduce potentially inappropriate prescribing (PIP) of statins and foster healthy lifestyle promotion in cardiovascular disease (CVD) primary prevention in low-risk patients. To this end, we will compare the effectiveness and feasibility of several de-implementation strategies developed following the structured design process of the Behaviour Change Wheel targeting key determinants of the clinical decision-making process in CVD prevention. METHODS AND ANALYSIS: A cluster randomised implementation trial, with an additional control group, will be launched, involving family physicians (FPs) from 13 Integrated Healthcare Organisations (IHOs) of Osakidetza-Basque Health Service with non-zero incidence rates of PIP of statins in 2021...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631839/defining-predictors-of-responsiveness-to-advanced-therapies-in-crohn-s-disease-and-ulcerative-colitis-protocol-for-the-ibd-response-and-nested-cd-metaresponse-prospective-multicentre-observational-cohort-study-in-precision-medicine
#8
JOURNAL ARTICLE
Nicola J Wyatt, Hannah Watson, Carl A Anderson, Nicholas A Kennedy, Tim Raine, Tariq Ahmad, Dean Allerton, Michelle Bardgett, Emma Clark, Dawn Clewes, Cristina Cotobal Martin, Mary Doona, Jennifer A Doyle, Katherine Frith, Helen C Hancock, Ailsa L Hart, Victoria Hildreth, Peter M Irving, Sameena Iqbal, Ciara Kennedy, Andrew King, Sarah Lawrence, Charlie W Lees, Robert Lees, Laura Letchford, Trevor Liddle, James O Lindsay, Rebecca H Maier, John C Mansfield, Julian R Marchesi, Naomi McGregor, Rebecca E McIntyre, Jasmin Ostermayer, Tolulope Osunnuyi, Nick Powell, Natalie J Prescott, Jack Satsangi, Shriya Sharma, Tara Shrestha, Ally Speight, Michelle Strickland, James Ms Wason, Kevin Whelan, Ruth Wood, Gregory R Young, Xinyue Zhang, Miles Parkes, Christopher J Stewart, Luke Jostins-Dean, Christopher A Lamb
INTRODUCTION: Characterised by chronic inflammation of the gastrointestinal tract, inflammatory bowel disease (IBD) symptoms including diarrhoea, abdominal pain and fatigue can significantly impact patient's quality of life. Therapeutic developments in the last 20 years have revolutionised treatment. However, clinical trials and real-world data show primary non-response rates up to 40%. A significant challenge is an inability to predict which treatment will benefit individual patients...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631838/randomised-controlled-patient-blinded-multicentre-superiority-trial-to-evaluate-the-efficacy-of-the-line-attached-sheath-type-traction-device-for-endoscopic-submucosal-dissection-in-patients-with-superficial-gastric-neoplasms
#9
JOURNAL ARTICLE
Hirofumi Abe, Tomoya Sako, Yoshinobu Yamamoto, Atsushi Ikeda, Fumiaki Kawara, Takayuki Ose, Toshitatsu Takao, Yasuaki Kitamura, Ryusuke Ariyoshi, Yoshinori Morita, Tsukasa Ishida, Takuya Ikegawa, Ryosuke Ishida, Tetsuya Yoshizaki, Hiroya Sakaguchi, Takashi Toyonaga, Yuzo Kodama
INTRODUCTION: EndoTrac is a line-attached sheath-type traction device that enables us to control the direction and the force of traction during endoscopic submucosal dissection (ESD). The efficacy of EndoTrac for gastric ESD has not been fully verified. METHODS AND ANALYSIS: The G-Trac study is a multicentre (nine general hospitals and two university hospitals in Japan) collaborative trial assessing the efficacy of EndoTrac for gastric ESDs. Patients with superficial gastric neoplasms will be enrolled and randomly assigned to undergo either conventional ESD or EndoTrac ESD...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631837/prevalence-of-work-related-musculoskeletal-disorders-and-associated-factors-affecting-emergency-medical-services-professionals-in-jordan-a-cross-sectional-study
#10
JOURNAL ARTICLE
Mohammad S Nazzal, Alaa O Oteir, Ahmad Alrawashdeh, Mahmoud T Alwidyan, Qussai Obiedat, Khader A Almhdawi, Noor T Ismael, Brett Williams
OBJECTIVES: Emergency medical services (EMSs) personnel are at high risk for developing work-related musculoskeletal disorders (WMSDs). However, no studies have yet investigated the prevalence and effect of these disorders on the Jordanian EMS personnel. Therefore, this study aimed to determine the prevalence of WMSDs among Jordanian EMS personnel and its associated factors. DESIGN: This study used a cross-sectional design. Participants were asked to complete a self-administrated and validated questionnaire to measure the WMSDs, including a demographic survey and the Nordic Musculoskeletal Questionnaire...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631836/scoping-review-of-interventions-to-de-implement-potentially-harmful-non-steroidal-anti-inflammatory-drugs-nsaids-in-healthcare-settings
#11
JOURNAL ARTICLE
Michelle S Rockwell, Emma G Oyese, Eshika Singh, Matthew Vinson, Isaiah Yim, Jamie K Turner, John W Epling
OBJECTIVES: Potentially harmful non-steroidal anti-inflammatory drugs (NSAIDs) utilisation persists at undesirable rates worldwide. The purpose of this paper is to review the literature on interventions to de-implement potentially harmful NSAIDs in healthcare settings and to suggest directions for future research. DESIGN: Scoping review. DATA SOURCES: PubMed, CINAHL, Embase, Cochrane Central and Google Scholar (1 January 2000 to 31 May 2022)...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631835/fetal-alcohol-spectrum-disorder-and-attention-deficit-hyperactivity-disorder-stimulant-trial-in-children-an-n-of-1-pilot-trial-to-compare-stimulant-to-placebo-fasst-protocol
#12
JOURNAL ARTICLE
Alison Crichton, Katrina Harris, James M McGree, Jane Nikles, Peter J Anderson, Katrina Williams
INTRODUCTION: Fetal alcohol spectrum disorder (FASD) is a neurodevelopmental disorder caused by alcohol exposure during pregnancy. FASD is associated with neurodevelopmental deviations, and 50%-94% of children with FASD meet the Diagnostic and Statistical Manual of Mental Disorders-fifth edition diagnostic criteria for attention deficit hyperactivity disorder (ADHD). There is a paucity of evidence around medication efficacy for ADHD symptoms in children with FASD. This series of N-of-1 trials aims to provide pilot data on the feasibility of conducting N-of-1 trials in children with FASD and ADHD...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631834/linking-genetic-counseling-communication-skills-to-patient-outcomes-and-experiences-using-a-community-engagement-and-provider-engagement-approach-research-protocol-for-the-gc-pro-mixed-methods-sequential-explanatory-study
#13
JOURNAL ARTICLE
Elena R Fisher, Deborah Cragun, Robert F Dedrick, Crystal Y Lumpkins, Mariana Ramírez, Kimberly A Kaphingst, Ashley Petersen, Ian M MacFarlane, Krista Redlinger-Grosse, Abdirashid Shire, Kathleen A Culhane-Pera, Heather A Zierhut
INTRODUCTION: In over 50 years since the genetic counseling (GC) profession began, a systematic study of GC communication skills and patient-reported outcomes in actual sessions across multiple clinical specialties has never been conducted. To optimize GC quality and improve efficiency of care, the field must first be able to comprehensively measure GC skills and determine which skills are most critical to achieving positive patient experiences and outcomes. This study aims to characterise GC communication skills using a novel and pragmatic measure and link variations in communication skills to patient-reported outcomes, across clinical specialties and with patients from diverse backgrounds in the USA...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631833/short-duration-aerobic-high-intensity-intervals-versus-moderate-exercise-training-intensity-in-patients-with-peripheral-artery-disease-study-protocol-for-a-randomised-controlled-trial-the-angiof-hiit-study
#14
JOURNAL ARTICLE
Stefano Lanzi, Anina Pousaz, Marco Fresa, Cyril Besson, Benoit Desgraz, Vincent Gremeaux-Bader, Lucia Mazzolai
INTRODUCTION: Supervised exercise training is among the first-line therapies for patients with peripheral artery disease (PAD). Current recommendations for exercise include guidance focusing on claudication pain, programme and session duration, and frequency. However, no guidance is offered regarding exercise training intensity. This study aims to compare the effects of 12-week-long supervised walking exercise training (high-intensity interval training (HIIT) vs moderate-intensity exercise (MOD)) in patients with chronic symptomatic PAD...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631832/effects-of-different-exercise-interventions-on-chemotherapy-related-cognitive-impairment-in-patients-with-breast-cancer-a-study-protocol-for-systematic-review-and-network-meta-analysis
#15
JOURNAL ARTICLE
Yu Dong, Hao Huang, Aiping Wang
INTRODUCTION: Breast cancer stands as the most prevalent type of cancer affecting women globally, and chemotherapy plays a pivotal role in its treatment by diminishing tumour recurrence and enhancing the survival rates of patients. However, chemotherapy-related cognitive impairment (CRCI) often occurs in patients undergoing treatment. Although multiple clinical trials have indicated that exercise therapy can improve CRCI in patients with breast cancer, there are variations in the types of exercise interventions and their effectiveness...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631831/covid-19-vaccine-acceptance-in-the-general-population-and-under-resourced-communities-from-high-income-countries-realist-review
#16
JOURNAL ARTICLE
Nathalia Gonzalez-Jaramillo, Dominik Abbühl, Zayne Milena Roa-Díaz, Cristopher Kobler-Betancourt, Annika Frahsa
OBJECTIVE: To compare vaccination willingness before rollout and 1 year post-rollout uptake among the general population and under-resourced communities in high-income countries. DESIGN: A realist review. DATA SOURCES: Embase, PubMed, Dimensions ai and Google Scholar. SETTING: High-income countries. DEFINITIONS: We defined vaccination willingness as the proportion of participants willing or intending to receive vaccines prior to availability...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631830/effect-of-metacognitive-therapy-on-depression-in-patients-with-chronic-disease-a-protocol-for-a-systematic-review-and-meta-analysis
#17
JOURNAL ARTICLE
Zirui Zhang, Peng Wang, Jinjin Gu, Qiang Zhang, Changqing Sun, Panpan Wang
BACKGROUND: Chronic diseases have a high prevalence worldwide, and patients with chronic diseases often suffer from depression, leading to a poor prognosis and a low quality of life. Metacognitive therapy is a transdiagnostic psychotherapy intervention focused on thinking patterns, with the advantages of reliable implementation effect, short intervention period and low cost. It can help patients change negative metacognition, alleviate depression symptoms, and has a higher implementation value compared with other cognitive interventions...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631829/shared-decision-making-for-non-operative-management-versus-operative-management-of-hip-fractures-in-selected-frail-older-adults-with-a-limited-life-expectancy-a-protocol-for-a-nationwide-implementation-study
#18
JOURNAL ARTICLE
Miliaan L Zeelenberg, Paulieke C Oosterwijk, Hanna C Willems, Taco Gosens, Dennis Den Hartog, Pieter Joosse, Sverre A I Loggers, Thomas Mp Nijdam, Ruth E Pel-Littel, Suzanne Polinder, Henk Jan Schuijt, Hugo H Wijnen, Detlef Van der Velde, Esther M M Van Lieshout, Michael H J Verhofstad
BACKGROUND AND PURPOSE: Recent research has highlighted non-operative management (NOM) as a viable alternative for frail older adults with hip fractures in the final phase of life. This study aims to guide Dutch physicians and hospitals nationwide in a standardised implementation of shared decision-making regarding surgery or NOM in selected frail older adults with a hip fracture. METHODS AND ANALYSIS: The patient population for implementation includes frail older adults aged ≥70 years with an acute proximal femoral fracture, nursing home care or a similar level of care elsewhere and at least one additional criterion (ie, malnutrition, severe mobility impairment or ASA≥4)...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631828/evaluation-of-a-manualised-neurofeedback-training-in-psychosomatic-psychotherapeutic-outpatient-treatment-neuro-pp-out-study-protocol-for-a-clinical-mixed-methods-pilot-study
#19
JOURNAL ARTICLE
Kira Leandra Schmidt, Axel Kowalski, Adam Schweda, Nora Dörrie, Eva Maria Skoda, Alexander Bäuerle, Martin Teufel
INTRODUCTION: Electroencephalographic neurofeedback (NFB), as a non-invasive form of brainwave training, has been shown to be effective in the treatment of various mental health disorders. However, only few results regarding manualised and standardised NFB trainings exist. This makes comparison as well as replication of studies difficult. Therefore, we developed a standard manual for NFB training in patients with mental health disorders attending a psychosomatic outpatient clinic. The current study aims at investigating the conduction of a standardised manual for NFB training in patients with mental health disorders...
April 17, 2024: BMJ Open
https://read.qxmd.com/read/38631827/building-capacity-%C3%A3-for-sustainable-transportation-protocol-for-an-implementation-science-research-program-in-healthy-cities
#20
JOURNAL ARTICLE
Meghan Winters, Daniel Fuller, Marie-Soleil Cloutier, M Anne Harris, Andrew Howard, Yan Kestens, Sara Kirk, Alison Macpherson, Sarah Moore, Linda Rothman, Martine Shareck, Jennifer R Tomasone, Karen Laberee, Zoé Poirier Stephens, Meridith Sones, Darshini Ayton, Brice Batomen, Scott Bell, Patricia Collins, Ehab Diab, Audrey R Giles, Brent E Hagel, Mike S Harris, Patrick Harris, Ugo Lachapelle, Kevin Manaugh, Raktim Mitra, Nazeem Muhajarine, Tiffany Muller Myrdahl, Christopher J Pettit, Ian Pike, Helen Skouteris, David Wachsmuth, David Whitehurst, Ben Beck
INTRODUCTION: Improving sustainable transportation options will help cities tackle growing challenges related to population health, congestion, climate change and inequity. Interventions supporting active transportation face many practical and political hurdles. Implementation science aims to understand how interventions or policies arise, how they can be translated to new contexts or scales and who benefits. Sustainable transportation interventions are complex, and existing implementation science frameworks may not be suitable...
April 17, 2024: BMJ Open
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